Gene KIN28 (Bakers Yeast)

KIN28

Species: Bakers Yeast
Alias: KIN28
External Links: Saccharomyces Genome Database Link ,
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDK7

Sequence

Name Sequence Type Origin Length Description Download
KIN28.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 284 Kinase domain by global Sugen HMM Fasta, JSON
KIN28.AA Protein Refseq_NP 306 `serine-threonine kinase, subunit of transcription factor TFIIK, a subcomplex of TFIIH; Kin28p [Saccharomyces cerevisiae]` Fasta, JSON

Protein domain

Protein domains of KIN28.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase KIN28.AA CDK7 7-290 60 4.5e-279 753.72 In-house 1-288 (288) Show / Hide 
Range on Protein: 7-290
Range on HMM: 1-288/288
Sequence Identity: 60% (175 aa)

YTKEKKVGEGTYAVVYLGCQHSTGRKIAIKEIK----TSEFKDGLDMSAIREVKYLQEMQHPNVIELIDIFMAYDNLNLVLEFLPTDLEVVIKDKSILFT
|.|.|..|||..|.||..|.|.||...|||.||    .||.|||....||||.|.||||||.|||.||||||...|..||..|...|||||||||||..|
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

PADIKAWMLMTLRGVYHCHRNFILHRDLKPNNLLFSPDGQIKVADFGLARAIPAPHEILTSNVVTRWYRAPELLFGAKHYTSAIDIWSVGVIFAELMLRI
||.|||.|.|||.|...||||.||||||||||||....||.|.|||||||....|..|.|..|||||||||||||||.||....|.||||.||||||||.
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

PYLPGQNDVDQMEVTFRALGTPTDRDWPEVSSFMTYNKLQIYPPPSRDELRKRFIAASEYALDFMCGMLTMNPQKRWTAVQCLESDYF
|||||..|.||....|..|||||...||.....|.|.|....|..||..||..|.|||...||.||||.||||.||||..|||...||
PYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase KIN28.AA CDK 7-290 36 1.2e-145 469.01 In-house 1-284 (284) Show / Hide 
Range on Protein: 7-290
Range on HMM: 1-284/284
Sequence Identity: 36% (116 aa)

YTKEKKVGEGTYAVVYLGCQHSTG-----RKIAIKEIKTSE-----FKDGLDMSAIREVKYLQEMQHPNVIELIDIFMAY-----------DNLNLVLEF
| | .|.|||||.||| .  . ||     . .|.|.|..        |.|. ..||||...|.|. |||.. |.|...              .| .| |.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

LPTDLEVVIKDKSILFTPADIKAWMLMTLRGVYHCHRNFILHRDLKPNNLLFSPDGQ-----IKVADFGLARAIPA------PHEILTSNVVTRWYRAPE
...||  ...          || .|.. |||...||.|.|.||||||.|.| . .|.     .|.||||||||         |   .|..|||.||||||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

LLFGAKHYT--SAIDIWSVGVIFAELML---RIPYLPGQNDVDQMEVTFRALGTPTDRDWPEVSSFMTYNKLQIYPPPSRDELRKRFIAASEYALDFMCG
||.|.|||.   .||.|||| ||||...   | | .||... ||..  || .||||. .||.|...  |                          |....
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY--------------------------DLLNK

MLTMNPQKRWTAVQCLESDYF
||...|.||..| |.|...||
MLCYDPKKRISAEQALQHPYF
Kinase KIN28.AA CMGC 7-290 24 5.2e-123 406.36 In-house 1-513 (513) Show / Hide 
Range on Protein: 7-290
Range on HMM: 1-513/513
Sequence Identity: 24% (126 aa)

YTKEKKVGEGTYAVVYLGCQ--------------HSTGRKIAIKEIK---TSEF------KDGLDMSAIREVKYLQEMQ-----------------HPNV
|.. ||.|||||.||| .                | |....||| ||     |       |||. ..|.||.|.|....                 |.|.
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

IELIDIFMAYD-----------------NLNLVLEFLPTDLEVVIKDKS--------ILFTPAD------------IKAWM------LMTLRGVY--HCH
. |.|||.  .                 .|.|| |....||  .||...        . ...              ||  |       . |||.   .||
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

RNF--ILHRDLKPNNLLFSPD--------------------GQIKVADFGLARAIPAP---------------------HEILTSNVVTRWYRAPELLFG
..   |.|||||| |.|....                    |..|..||||||..  .                      . .|..||||||||||.|.|
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

AKHYT---------SAIDIWSVGVIFAELMLR--------IPYLPGQND-----------VDQMEVTFRALGTPT---------------DRDWPEVSSF
.||||         ..||.|||| ||||....         |  ||...           .||..  |. |||||               ...||.... 
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

MTYNK---------------------------LQIYPPPSRDELRKR-------------------FIAAS-------------EYALDFMCGMLTMNPQ
 .|||                           .. .||..  .| ..                   . ..|             . |.|....||...|.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

KRWTAVQCLESDYF
||.|| |.|. .||
KRITAEQALQHPYF
Kinase KIN28.AA Pkinase 7-290 30 2.6e-112 384.23 Pfam 1-293 (293) Show / Hide 
Range on Protein: 7-290
Range on HMM: 1-293/293
Sequence Identity: 30% (94 aa)

YTKEKKVGEGTYAVVYLGCQHSTGRKIAIKEIKTSEFKDGLDMSAIR--EVKYLQEMQHPNVIELIDIFMAYDNLNLVLEFLPTDLEVVIKDK-------
|....|.|.|....||... ..||.. |.|.|| .. |.. |....|  |........|||...|.|.|.  |.. .|.|... .|. |.  .       
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTWR

SILF--TPADIKAWMLMTLRGVYHCHRNFILHRDLKPNNLLFSPDGQI----KVADFGLARAI-PAPHEILTSNVVTRWYRAPELLFGAKHYTSAIDIWS
.  |  .. ..| .|. .|||...||.. |.|||||| |.|.. .|.|    |..|||||. .   . . .|. ..|.||.|||.. |...|....|.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

VGVIFAELMLRIPYLPGQ----NDVDQMEVTFRALGTPTDRDWPEVSSFMTYNKLQIYPPPSRDELRKRFIAASEYALDFMCGMLTMNPQKRWTAVQCLE
.|.|..|.... |  ||.    | .|||.. .| .|.|...|||. .| .... ... . .  . .... ...|| ..||....|...|.||.|| |.|.
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQ

SDYF
...|
HPWF
Kinase KIN28.AA CDC2 7-290 36 1.8e-101 312.66 In-house 1-301 (301) Show / Hide 
Range on Protein: 7-290
Range on HMM: 1-301/301
Sequence Identity: 36% (112 aa)

YTKEKKVGEGTYAVVYLGCQHSTGRKIAIKEIKTSEFKDG--LDMSAIREVKYLQEMQ-HPNVIELIDIFMAYDNLNLVLEFLPTDLEVVIK-DKSI--L
|.| .|.||||| ||| .    |.. .|.| |..  . .|     .||||  .|.|.. |||.. | |...   .| .| |.|  ||    .  ..    
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

FTPADIKAWMLMTLRGVYHCHRNFILHRDLKPNNLLFSPDGQIKVADFGLARAIPAPHEILT--SNVVTRWYRAPELLFGAKHYTSAIDIWSVGVIFAEL
..|. .|  |   |.|| .||.. |.|||||| |.| . .|.||.||||||||.. |.  .|   .|||.||||||.|.|.|.|. ..|.||.| ||||.
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---MLRIPYLPGQNDVDQMEVTFRALGTPTDRDWPEVSSFMTYNKLQIYPPPSRDELRKRFIA---------ASEYALDFMCGMLTMNPQKRWTAVQCLE
   . . |  .|.   ||    || ||||.. .||.|...  |.  . .|   .  |.| .           . . ..|    ||  .|||| .| . |.
FMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYK--NTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQ

SDYF
  ||
HPYF
Kinase KIN28.AA CDK5 7-290 36 1.6e-94 299.06 In-house 1-287 (287) Show / Hide 
Range on Protein: 7-290
Range on HMM: 1-287/287
Sequence Identity: 36% (106 aa)

YTKEKKVGEGTYAVVYLGCQHSTGRKIAIKEIKTSEFKDGLDMSAIREVKYLQEMQHPNVIELIDIFMAYDNLNLVLEFLPTDLEVVIKDKSILFTPADI
| |  |.|||||..|| .    |.  .|.|...  .   |   .||||.  |.|..|.|.. |.|.  .   | || ||.  ||   . .      .. |
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

KAWMLMTLRGVYHCHRNFILHRDLKPNNLLFSPDGQIKVADFGLARAIPAPHEILTSNVVTRWYRAPELLFGAKHYTSAIDIWSVGVIFAELM-LRIPYL
|  |.  |.|.  || . .||||||| ||| .  |. | ||||||||   |    .. ||| |||.|  |.|.|||.  ||.||.| ||||..    |  
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

PGQNDVDQMEVTFRALGTPTDRDWPEVSSFMTYN-KLQIYPPPSRDE-LRKRFIAASEYALDFMCGMLTMNPQKRWTAVQCLESDYF
|| .. ||.   |. .|||.   || ..    |. . | ||.    . . .     .|  .|.. .|| .||..| .| . |.  ||
PGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase KIN28.AA S_TKc 7-290 28 4.4e-93 316.46 SMART 1-231 (231) Show / Hide 
Range on Protein: 7-290
Range on HMM: 1-231/231
Sequence Identity: 28% (85 aa)

YTKEKKVGEGTYAVVYLGCQHSTGRKIAIKEIKTSEFKDGLDMSAIREVKYLQEMQHPNVIELIDIFMAYDNLNLVLEFLPT---DLEVVIKDKSIL---
|.. .|.|.|....||..  ..|||. |||.||          ...||.. |.. .|||.. |.|.|   |.| .|.|....   ||  .||..      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--FTPADIKAWMLMTLRGVYHCHRNFILHRDLKPNNLLFSPDGQIKVADFGLARAIPAPHEILTSNVVTRWYRAPELLFGAKHYTS-AIDIWSVGVIFAE
  |.. ... .|  ..... .||.. |.|||||| |.|..   .||..|||||| .       |. ..|.||.|||.|    .|.  ..|.||.|.|..|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

LMLRIPYLPGQNDVDQMEVTFRALGTPTDRDWPEVSSFMTYNKLQIYPPPSRDELRKRFIAASEYALDFMCGMLTMNPQKRWTAVQCLE-------SDYF
.. . |  |      ||...|. .|                                     |. |.||....|...|.||.|| ..|.         .|
MLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase KIN28.AA PITSLRE 7-290 37 1e-88 301.06 In-house 1-295 (295) Show / Hide 
Range on Protein: 7-290
Range on HMM: 1-295/295
Sequence Identity: 37% (111 aa)

YTKEKKVGEGTYAVVYLGCQHSTGRKIAIKEIKTS--EFKDGLDMSAIREVK-YLQEMQHPNVIELIDIFM--AYDNLNLVLEFLPTDLEVVIKDKS---
. .  ...|||| ||| .    |.. .|.| .|      |.|    ..||..  | ..||||.. .  | |    |   .|.|..  ||  ..   .   
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

ILFTPADIKAWMLMTLRGVYHCHRNFILHRDLKPNNLLFSPDGQIKVADFGLARAIPAPHEILTSNVVTRWYRAPELLFGAKHYTSAIDIWSVGVIFAEL
  |.|  ||  |.  |||| | | | |.|||||  ||| |  |. |..||||||    | . .|..||| |||||||| |.| |. ..|.|||| ||||.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

MLRIPYLPGQNDVDQMEVTFRALGTPTDRDWPEVSSFMTYNKLQ-IYPPPSRDELRKRFI---AASEYALDFMCGMLTMNPQKRWTAVQCLESDYF
..  | ..|....||..  | ..|||| . || ....   .... . . |    |||||      |. ..| ...||| ||..| || . |  ..|
ITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYP-YNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase KIN28.AA CDK10 7-290 37 3e-75 256.32 In-house 1-285 (285) Show / Hide 
Range on Protein: 7-290
Range on HMM: 1-285/285
Sequence Identity: 37% (108 aa)

YTKEKKVGEGTYAVVYLGCQHSTGRKIAIKEIKTSEFKDGLDMSAIREVKYLQEMQHPNVIELIDIFM--AYDNLNLVLEFLPTDLEVVIKDKSILFTPA
. |  .|||||| .||      .   .|.| ..  . |||| .|..||.. | ...|.|..|| .. .    | . ||...   ||  ..   .  || .
FEKLNRVGEGTYGIVYRARDMRSDEIVALKKVRMDKEKDGLPISGLREIMLLIQCRHENIVELHEVVVGQHLDSIFLVMQYCEQDLASLLDNMPQPFTET

DIKAWMLMTLRGVYHCHRNFILHRDLKPNNLLFSPDGQIKVADFGLARAIPAPHEILTSNVVTRWYRAPELLFGAKHYTSAIDIWSVGVIFAELMLRIPY
..|  ||  |||.   |.||..|||||  |||.. .| ||||||||||.   |   .|  .|| ||||||||.|..  | |||.| || | .||..  | 
QVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVADFGLARMYGVPVKPMTPKMVTLWYRAPELLLGCRTQTTAIDMWAVGCILGELLVHKPL

LPGQNDVDQMEVTFRALGTPTDRDWPEVSSFMTYNKLQIYPPPSRDELRKRFIAASEYALDFMCGMLTMNPQKRWTAVQCLESDYF
.||. .. |...    |||| .  ||  |     ..  .   |    |...|   |.  .  .  ..  ||.|| || .|||| ||
MPGNSEIHQIDMIIDLLGTPSENIWPGFSDLPMVQNFTLKKQP-YNNLKHKFHWLSQSGRRLLNFLFMYNPKKRATAEECLESSYF
Kinase KIN28.AA CCRK 7-290 39 1.2e-73 251.0 In-house 1-285 (285) Show / Hide 
Range on Protein: 7-290
Range on HMM: 1-285/285
Sequence Identity: 39% (114 aa)

YTKEKKVGEGTYAVVYLGCQHSTGRKIAIKEIKTSEFKDGLDMSAIREVKYLQEMQHPN-VIELIDIFMAYDNLNLVLEFLPTDLEVVIKDKSILFTPAD
|.   ..|||   .|.      ||  .|.| .      ||.   |.||.| |||.     |..| |.|       || ||.  ||  |...     ..| 
YCILDRIGEGAHGIVFKAKHVETGEIVALKKVALRRLDDGIPNQALREIKALQEIEDNQYVVQLKDVFPHGTGFVLVFEFMLSDLAEVVRHAQRPLAEAQ

IKAWMLMTLRGVYHCHRNFILHRDLKPNNLLFSPDGQIKVADFGLARAI-PAPHEILTSNVVTRWYRAPELLFGAKHYTSAIDIWSVGVIFAELMLRIPY
.|..|.| |.|| ||| | |.|||||| ||| |  |..|.|||||||   .      |  | ||||||||||.||..|   .|.|.|| |. ||.   | 
VKSYMQMLLKGVAHCHENNIMHRDLKPANLLISESGHLKIADFGLARVFSNDEGRQYTHQVATRWYRAPELLYGARQYDQGVDLWAVGCIMGELLNNSPI

LPGQNDVDQMEVTFRALGTPTDRDWPEVSSFMTYNKLQIYPPPSRDELRKRFIAASEYALDFMCGMLTMNPQKRWTAVQCLESDYF
 ||.||..|. .  | |||||.. |||.     |||.  ..      | .    ||  ||| .   |   |..| .| | |  .||
FPGENDIEQLCCVLRILGTPTPKVWPEMKDLPDYNKIS-FKEQPPMPLEQVVPDASPQALDLLKQFLVYPPRQRIAASQALLHQYF
Kinase KIN28.AA PFTAIRE 7-290 36 1e-72 247.89 In-house 1-287 (287) Show / Hide 
Range on Protein: 7-290
Range on HMM: 1-287/287
Sequence Identity: 36% (105 aa)

YTKEKKVGEGTYAVVYLGCQHSTGRKIAIKEIKTSEFKDGLDMSAIREVKYLQEMQHPNVIELIDIFMAYDNLNLVLEFLPTDLEVVIKDKSILFTPADI
| | .| |||.|| || |    ... .| |||.  .   |    ||||.  |....| |.. | ||      | .| |.. |||   .        |  .
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQQ-EEGTPFTAIREASLLKNLKHANIVCLHDIIHTKETLTFVFEYVHTDLCQYMDKHPGGMHPNNV

KAWMLMTLRGVYHCHRNFILHRDLKPNNLLFSPDGQIKVADFGLARAIPAPHEILTSNVVTRWYRAPELLFGAKHYTSAIDIWSVGVIFAELMLRIPYLP
.  .   |||   ||.  .||||||| ||| |  |  | ||||||||   |     . ||| ||| |  | |.  | . .|.| || || |.|   |  |
RLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMWGQPAFP

GQ-NDVDQMEVTFRALGTPTDRDWPEVSSFMTYNKLQIY-PPPSRDELRKRFIAAS--EYALDFMCGMLTMNPQKRWTAVQCLESDYF
|  .  ||.|  |. |||||.  || |... .|.. ..    .. ..|.. .   .    | | | .|| ..|..|  |.. .. .||
GMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase KIN28.AA MAPK 125-290 35 4.2e-61 209.32 In-house 138-328 (328) Show / Hide 
Range on Protein: 125-290
Range on HMM: 138-328/328
Sequence Identity: 35% (68 aa)

ILHRDLKPNNLLFSPDGQIKVADFGLARAIPA-PHEI-------------LTSNVVTRWYRAPELLFG--AKHYTSAIDIWSVGVIFAELML-RIPYLPG
..|||||| |.|   ... |..|||||| |    |..             .| .|.||||||||....  ..||| |.|.|||| ||||..  | | .||
VIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPG

QNDVDQMEVTFRALGTPTDRDWPEVS-SFMTYNKLQIY---PPPSRDELRKRFIA----ASEYALDFMCGMLTMNPQKRWTAVQCLESDYF
.. .||..  .  ||||.. ..  .. | . .| .| .   |.. .  ..| |      |.  |.|... ||...|.||.|. ..|.  ||
KDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase KIN28.AA MAPK 7-95 28 7.8e-13 40.49 In-house 1-107 (328) Show / Hide 
Range on Protein: 7-95
Range on HMM: 1-107/328
Sequence Identity: 28% (31 aa)

YTKEKKVGEGTYAVVYLGCQHS------TGRKIAIKEIKTSEFKDGLDMSAIREVKYLQEM-QHPNVIELIDIFMA-----------YDNLNLVLEFLPT
|.  |..|.| | ||    . .      .|.|.||| |     .  .   ..||.| |... .|.|.| |.|||..           .. . .| |.  |
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLEVVIK
||  .||
DLHQIIK
Kinase KIN28.AA TyrKc 7-290 20 4.4e-12 -27.29 SMART 1-280 (280) Show / Hide 
Range on Protein: 7-290
Range on HMM: 1-280/280
Sequence Identity: 20% (63 aa)

YTKEKKVGEGTYAVVYLGCQHSTGRKIAIKEIKTSEFKDGLDMSAIREVKYLQEM--QHPNVIELIDIFMAY-------DNLNLVLEFLPT-DLEVVIKD
 |..|| ||| . .||.|      .. |.| .| .       .  .|| . . .   .|||.. |. . .         . | .|.|. |  ||   ...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

KSILFTPADIKAWMLMTLRGVYHCHRNFILHRDLKPNNLLFSPDGQIKVADFGLARAIPAP------HEILT------SN--VVTRWYRAPELLFGAKHY
.   ....|   ...   .|  . |.. . ||||   | | . ....|..||||.|.|         ..  .      ..  .  ||. ||| .   . .
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKF

TSAIDIWSVGVIFAELMLR--IPYLP-GQNDVDQMEVTFRALGTPTDRDWPEV----SSFMTYNKLQIYPPPSRDELRKRFIAASEYALDFMCGMLTMNP
|.. |.|| ||   |.. .   ||    |. .   .  .. . .   .. |.     |                      |  ...   . |      .|
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------FVCCPDEMYQIMKQCWHEDP

QKRWTAVQCLESDYF
 .| |  ..   ..|
EDRPTFSEI--HECF
Kinase KIN28.AA Pkinase_Tyr 7-70 28 9.2e-05 16.75 Pfam 1-70 (270) Show / Hide 
Range on Protein: 7-70
Range on HMM: 1-70/270
Sequence Identity: 28% (21 aa)

YTKEKKVGEGTYAVVYLGCQH----STGRKIAIKEIKTSEFKDGLDMSA------IREVKYLQEM-QHPNVIELI
 |. || ||| . .||.|  .    .|. . |.| .|     .| . ..      .||.| . .. .|||.. |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase KIN28.AA Pkinase_Tyr 140-190 30 0.004125 11.16 Pfam 147-199 (270) Show / Hide 
Range on Protein: 140-190
Range on HMM: 147-199/270
Sequence Identity: 30% (17 aa)

DGQIKVADFGLARAIPAPHEIL-TSN----VVTRWYRAPELLFGAKHYTSAIDIWS
....|..||||||.|  . .   ..     .  .|. ||| ..  | .|.. |.||
NNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWM-APECINYGK-FTTKSDVWS