Gene MCK1 (Bakers Yeast)

MCK1

Species: Bakers Yeast
Alias: MCK1
External Links: Saccharomyces Genome Database Link ,
Annotation:

Classification

Group: CMGC
Family: GSK

Sequence

Name Sequence Type Origin Length Description Download
MCK1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 293 Kinase domain by global Sugen HMM Fasta, JSON
MCK1.AA Protein Refseq_NP 375 `Disp. for mitosis, required for chr. segregation, benomyl resist., basal IME1 transcript. in mitosis, IME1 induction in meiosis & ascus mat. independ. of IME1; maybe in mitotic chr. segregation specific to CDEIII; Mck1p [Saccharomyces cerevisiae]` Fasta, JSON

Protein domain

Protein domains of MCK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MCK1.AA GSK 35-327 48 1.5e-196 606.49 In-house 1-328 (328) Show / Hide 
Range on Protein: 35-327
Range on HMM: 1-328/328
Sequence Identity: 48% (160 aa)

VKEYRKIGRGAFGTVVQAYLT----QDKKNWLGPFAIKKVPAHTEYK-SRELQILRIA---DHPNIVKLQYFFT-HLSPQDN-KVYQH-LAMECLPETLQ
..|...||.|.||.|.|||..    ..|..||||.|||||  ...|| .|||||...    ||||||.|.|||  |.. .|. .||.. | ||..|.||.
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYKCNRELQIMKMLGKLDHPNIVRLKYFFYMHYEKKDENHVYCNCLVMEYMPQTLY

IEINRYVTNKLEMPLKHIRLYTYQIARGMLYLHGLGVCHRDIKPSNVLVDPETGVLKICDFGSAKKLEH--NQPSISYICSRFYRAPELIIGCTQYTTQI
 .|..||.|| .||..||.||.||. ||. |||..|.|||||||.|.||||.|||||||||||||.||.  |.|.|||||||.|||||||.|||.||.||
QVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGCTNYTCQI

DIWGLGCVMGEMLIGKAIFQGQEPLLQLREIAKLLGPPDK---RFIFFSNPAYDGPLFSKPLFSGSSQQR-------------------FEKYFGHSGPD
|.| .||||.|||.|. .|.|.. . ||.||.|.|| |.|   .....|.| .. |..|.. . . ..|.                   . |....  .|
DVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPYWSFQQIKPHPWQKNDTKYEYQTYYHKKYRTVYMFKWCHTDMQD

GIDLLMKILVYEPQQRLSPRRILAHQFF
 |||..|.|||.|..||||....||.||
WIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase MCK1.AA CMGC 35-327 19 2.1e-103 340.75 In-house 1-513 (513) Show / Hide 
Range on Protein: 35-327
Range on HMM: 1-513/513
Sequence Identity: 19% (100 aa)

VKEYRKIGRGAFGTVVQAYLTQDK----------KNWLGPFAIKKVPAHTEYKS----------------RELQILRIA-----------------DHPN
 .  .|||.|..|.|.... .. .          ...    ||||.     |.                 ||..||.                   .|.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVKLQYFFTHLSPQDN-----------KVYQHLAMECLPETLQIEINRYVT-----NKLEMPLKH------------IRLYT------YQIARGML--YL
||||...|.|  .. |            .. .| .|... .|   | .. .     ......  |            |. ..      ||| ||.   |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HGLG--VCHRDIKPSNVLVDPET-------------------GVLKICDFGSAKKLEHN----------------------QPSISYICSRFYRAPELII
|  .  ..|||.||.|.|.....                   |.|||||||.|......                      .|  .|...|.|||||...
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GCTQYT---------TQIDIWGLGCVMGEMLIG--------KAIFQGQEP-----------LLQLREIAKLLGPPD---------------KRFIFFSNP
|...||         |.||.|..||...||. |        | .|.|.             . || .| |.||.|.               .. ..  ..
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

AYDGPLFSKPL----------------------FSGSSQQRFEKYFGH-----------------------------------SGPDGIDLLMKILVYEP
 .. ..| |.                       |     . ... |                                       |..||||.|.|.|.|
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

QQRLSPRRILAHQFF
..|...  .|.| .|
DKRITAEQALQHPYF
Kinase MCK1.AA S_TKc 35-327 27 1.3e-83 285.01 SMART 1-231 (231) Show / Hide 
Range on Protein: 35-327
Range on HMM: 1-231/231
Sequence Identity: 27% (83 aa)

VKEYRKIGRGAFGTVVQAYLTQDKKNWLGPFAIKKVPAHTEYKSRELQILRIADHPNIVKLQYFFTHLSPQDNKVYQHLAMECLPE---TLQIEINRYVT
 .  ||||.||||.| ... .         .|||...   |   ||.|||.  .||||||| ..| .        . .. ||...    .|   | .. .
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGR

NKLE--MPLKHIRLYTYQIARGMLYLHGLGVCHRDIKPSNVLVDPETGVLKICDFGSAKKLEHNQPSISYICSRFYRAPELIIGCTQYTT-QIDIWGLGC
..|   .|  |.| |.|||.... |.| .|..|||.||.|.|.|    ..||||||.|..|       ... ...|.|||..    .|..  .|.| .||
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGC

VMGEMLIGKAIFQGQEPLLQLREIAKLLGPPDKRFIFFSNPAYDGPLFSKPLFSGSSQQRFEKYFGHSGPDGIDLLMKILVYEPQQRLSPRRILA-----
.. ||| |.  |.      |. .. |..|                                        |...|...|.|...|..|..   .|.     
ILYEMLCGYPPFP------QMQMMFKKIG---------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDI

--HQFF
  |..|
KCHPWF
Kinase MCK1.AA Pkinase 35-327 26 8.7e-75 259.57 Pfam 1-293 (293) Show / Hide 
Range on Protein: 35-327
Range on HMM: 1-293/293
Sequence Identity: 26% (84 aa)

VKEYRKIGRGAFGTVVQAYLTQDKKNWLGPFAIKKVPAHTEYKSR--------ELQILRIADHPNIVKLQYFFTHLSPQDNKVYQHLAMECLPE--TLQI
 .  ||||.|.||.| ...   . |     .|.|... ..| ..         |.||..  .|||||.| ..|.     ....|  . ||...   .  .
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIY--MVMEYCEGGLY-VM

EINRYVT--NKLEM--PLKHIRLYTYQIARGMLYLHGLGVCHRDIKPSNVLVDPETGVL----KICDFGSAKK--LEHNQPSISYICSRFYRAPELIIGC
.  .|..  ..  .  . .... | |||.||. |.|  |..|||.||.|.|.| ..|..    ||||||.||.  . .|.   .. ....|.|||.| |.
DLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGG

TQYTTQIDIWGLGCVMGEMLIGKAIFQGQ----EPLLQLREIAKLLGPPDKRFIFFSNPAYDGPLFSKPLFSGSSQQRFEKYFGHSGPDGIDLLMKILVY
. |.. .|.|..||.. ||| |. .|.|.    . . |.  |.. .||| .. .. ... .. . |.    .    . ...      ....|.. ..| .
QYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H----F-HWTF-HNWSEECKDFIKWCLCK

EPQQRLSPRRILAHQFF
 |..|.... || | .|
DPKKRPTAEQILQHPWF
Kinase MCK1.AA CDK 79-327 27 1.3e-53 169.87 In-house 57-284 (284) Show / Hide 
Range on Protein: 79-327
Range on HMM: 57-284/284
Sequence Identity: 27% (75 aa)

RELQILRIADHPNIVKLQYFFTHLSPQ-------DNKVYQHLAMECLPETLQIEINRYVTNKLEMPLKHIRLYTYQIARGMLYLHGLGVCHRDIKPSNVL
||  .|.   |||||||   ... ..        .||.|  . .| ..  |   .              |. |..|. ||. |.|  .. |||.||.| |
REISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLY--MVFEYMDHDLKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNIL

VDPETGV-----LKICDFGSAKKLEH------NQPSIS-YICSRFYRAPELIIGCTQYT--TQIDIWGLGCVMGEMLI---GKAIFQGQEPLLQLREIAK
.. ..|.     ||| ||| |..         ..   .  .  . ||||||  |...|.  |.||.|..||...||.    .|..|.|.  . ||  | .
IN-NNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFR

LLG-PPDKRFI-FFSNPAYDGPLFSKPLFSGSSQQRFEKYFGHSGPDGIDLLMKILVYEPQQRLSPRRILAHQFF
..| | ..    . . | |                              |||.| |.|.|..|.|    | |..|
ICGTPTEDNWPGVTKLPDY------------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase MCK1.AA MAPK 139-327 33 5.3e-50 171.04 In-house 115-328 (328) Show / Hide 
Range on Protein: 139-327
Range on HMM: 115-328/328
Sequence Identity: 33% (71 aa)

KHIRLYTYQIARG--MLYLHGLGVCHRDIKPSNVLVDPETGVLKICDFGSAKKLEHNQPSI---------------SYICSRFYRAPELIIG--CTQYTT
.||.  .||| ||  . |.|  .| |||.||||.||. | . ||||||| | ... ..  .                |.  |.|||||.. .   . ||.
DHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVN-ENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTK

QIDIWGLGCVMGEMLI-GKAIFQGQEPLLQLREIAKLLGPPDKRFI-FFS-NPAYDGPLFSKPLFSGSSQQRFEKYFG----HSGPDGIDLLMKILVYEP
..|.| .|| ..|||  .| .|.|. .. |.  | ..|| |.. || . . ....   . | ...    .. .|| |     .  |. |||| | ||  |
AVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDP

QQRLSPRRILAHQFF
..|..    |.| .|
DKRITVEEALQHPYF
Kinase MCK1.AA ERK7 140-327 32 8e-47 158.0 In-house 101-292 (292) Show / Hide 
Range on Protein: 140-327
Range on HMM: 101-292/292
Sequence Identity: 32% (63 aa)

HIRLYTYQIARGMLYLHGLGVCHRDIKPSNVLVDPETGVLKICDFG-----SAKK--LEHNQPSISYICSRFYRAPELIIGCTQYTTQIDIWGLGCVMGE
| .   ||. | . |.|   | |||.||||.|.| |  ..|.||||     . ..   |.|.    |.  | |||||  .| ..||  .| |..||..||
HKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSEC-MVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGE

MLIGKAIFQGQEPLLQLREIAKLLGPPDKRFIFFSNPAYDGPLFSKPLFSGSSQQRFEKYFGHSGPDGIDLLMKILVYEPQQRLSPRRILAHQFF
||.||..|.|   . |.  | .... | .  |   .. |   . ..     . .. ... . .. .|.|||| ..||. |..||.    |.| . 
MLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMN--QQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase MCK1.AA Ciliate-E2 35-327 21 6e-45 152.22 In-house 1-365 (365) Show / Hide 
Range on Protein: 35-327
Range on HMM: 1-365/365
Sequence Identity: 21% (85 aa)

VKEYRKIGRGAFGTVVQA--YLTQDK-----------------KNWLGPFAIKKV-PAHTEYKSRELQILR----------------IADHPNIVKLQYF
 |  .|||.|.||.| ..  ...| .                 |.    .|.| . .   |....|..|.|                . .||||.|. ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FTHLSPQDNKVYQHLAMECLPE-TLQIEIN---RYVTNKLE----MPLKHIRLYTYQIAR---------------GMLYLHGLG-VCHRDIKPSNVLVDP
|   . .||..|  | || .   .|.  |.      ....|    . .|.|. ...||..               .. |||  . ..||||||.|.|.  
FQ--EKDDNNIY--LVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--

ETGVLKICDFGSAKKLEHNQPSISY--------------------------------ICSRFYRAPELIIGCT--------QYTTQIDIWGLGCVMGEML
    .||.||| .||.  ..  ...                                ...  | ||| . |          .|....||| ||... |||
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

IGKAIFQGQEPLLQLREIAKLLGPPDKRFIFFSNPAYDGPLFSKPLFSGSSQQRFE--KYFGHSGPDGIDLLMK----ILVYEPQQRLS-PRRILAHQFF
 ||  |                     . |   .  .. | . |. .     | ..  ... .| ....||. |    .|...|..|.. .  || |..|
FGKPPF--------------------QQQIKQCKIDFPCPEWQKD-TQ-CI-Q-CKWKSWKKWS-QECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MCK1.AA CDC2 36-243 31 2.5e-43 130.67 In-house 2-212 (301) Show / Hide 
Range on Protein: 36-243
Range on HMM: 2-212/301
Sequence Identity: 31% (70 aa)

KEYRKIGRGAFGTVVQAYLTQDKKNWLGPFAIKKVPAHTEYKS--------RELQILRIAD-HPNIVKLQYFFTHLSPQDNKVYQHLAMECLPETLQIEI
.  .||| | .| | ..  .|...      |.||.   .|           ||. .|   . |||||||.  .       ||.|  .  |.|   |    
QKIEKIGEGTYGVVYKCKDMQTNQ----IVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-----NKLY--MVFEYLDMDLKKYM

NRYVTNKLEMPLKHIRLYTYQIARGMLYLHGLGVCHRDIKPSNVLVDPETGVLKICDFGSAKKLEHNQPSISYICS-----RFYRAPELIIGCTQYTTQI
 ..   . .||.  .. |.||| .|. ..|  .. |||.||.| |.| ..|..|| ||| |.    . |.  |        . |||||.  || .|.| .
DMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILID-KKGNIKIADFGLARAF--GIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPV

DIWGLGCVMGEM---LIGKAIFQGQ
|.| .||.. ||      |..|.|.
DMWSIGCIFAEMFMDVTKKPLFHGD
Kinase MCK1.AA ERK5 138-327 36 4.9e-41 142.64 In-house 102-295 (295) Show / Hide 
Range on Protein: 138-327
Range on HMM: 102-295/295
Sequence Identity: 36% (72 aa)

LKHIRLYTYQIARGMLYLHGLGVCHRDIKPSNVLVDPETGVLKICDFGSAKKL------EHNQPSISYICSRFYRAPELIIGCTQYTTQIDIWGLGCVMG
| ||| . ||| ||. |.|   | |||.||||.||  |   ||| ||| |. |      .|     .|.  |.||||||..   .||  ||.|  ||..|
LEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVN-ENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG

EMLIGKAIFQGQEPLLQLREIAKLLGPPDKRFIFFSNPAYDGPLFSKPLFSGSSQQRFEKYFGHSGPDGIDLLMKILVYEPQQRLSPRRILAHQFF
||.  . .| |. .. ||. | . || |    |  .  |     . .  |.    . .|| .    . ..||| ..|..|| .|..  . | | | 
EMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMI-QAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase MCK1.AA CAMK 40-230 16 2e-40 127.47 In-house 1-324 (425) Show / Hide 
Range on Protein: 40-230
Range on HMM: 1-324/425
Sequence Identity: 16% (55 aa)

KIGRGAFGTVVQAYLTQDK---------KNWLGPFAIKKVP-------------------------------AHTEY-KSRELQILRI-------ADHPN
..|||.||.|  .. ....          |    .||| ..                               ....    ||..|..         ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN

IVKLQYFFTHLS---------PQDN-----KVYQHLAM---ECLPET-LQIEINRYVTNKLE---------------MPLKHIRLYTYQIARGMLYLHGL
|.||  ..   .           ..     . . .. |   |  .   | ...  |.. .                 .. .  | |  ||. .. |.| .
IIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

GVCHRDIKPSNVLVDPET----------------GVLKICDFGSAKKLEH------------------------NQPSISYICSRFYRA-PELIIG----
...|||.|| |.|.|                   . .||.||| |.|...                        .|.   .  .  | | ||.. |    
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

---------CTQYTTQIDIWGLGCVM
          . |. ..|.| .|...
NMQNATDEEKPYYGPKCDMWSCGVIL
Kinase MCK1.AA RCK 141-263 33 1.8e-38 119.48 In-house 107-237 (298) Show / Hide 
Range on Protein: 141-263
Range on HMM: 107-237/298
Sequence Identity: 33% (44 aa)

IRLYTYQIARGMLYLHGLGVCHRDIKPSNVLVDPE--------TGVLKICDFGSAKKLEHNQPSISYICSRFYRAPELIIGCTQYTTQIDIWGLGCVMGE
|. . |||. |. ..|  |  |||.|| | .. ..        ....||.|||...  . ..|   |. .| |||||..  ||.|....|||..||.| |
IKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDIWAVGCIMYE

MLIGKAIFQGQEPLLQLREIAKLLGPPDKRF
  . .. | |.  . |. .| | .| |.|..
LYMLRPLFPGSSEIDQIFKICKVMGTPNKKD
Kinase MCK1.AA TyrKc 35-327 18 7.4e-14 1.4 SMART 1-280 (280) Show / Hide 
Range on Protein: 35-327
Range on HMM: 1-280/280
Sequence Identity: 18% (61 aa)

VKEYRKIGRGAFGTVVQAYLTQDKKNWLGPFAIKKVPAHTEYKS--RELQILRIA--DHPNIVKLQYFFTHLS------PQDNKVYQHLAMECLPETLQI
..  .|.|.||||.|... ..        . |.|.. ...  .   ||..|..    .|||||.|    |. .      ..   |  . .  .| . |. 
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

EINRYVTNKLEMPLKHIRLYTYQIARGMLYLHGLGVCHRDIKPSNVLVDPETGVLKICDFGSAKKLEHN----QPSISYI-----CSR-----FYRAPEL
  ..        ..|.   . .|||.|| |||  .. |||.   |.||. .  . ||.||| ......       .  |      ...        ||| 
HRPK-------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

IIGCTQ-YTTQIDIWGLGCVMGEMLIGKAIFQGQEPL--LQLREIAKLLGPPDKRFIFFS----NPAYDGPLFSKPLFSGSSQQRFEKYFGHSGPDGIDL
|   .  .||. |.|  | .| |..   .     . .  .  .|. ...   . . .  .                             | .  ..  ..
I--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------------FVCCPDEMYQI

LMKILVYEPQQRLSPRRILAHQFF
  .   ..| .| . . |  |..|
MKQCWHEDPEDRPTFSEI--HECF
Kinase MCK1.AA CDC2 298-327 53 3.4e-12 33.26 In-house 272-301 (301) Show / Hide 
Range on Protein: 298-327
Range on HMM: 272-301/301
Sequence Identity: 53% (16 aa)

PDGIDLLMKILVYEPQQRLSPRRILAHQFF
|.||||||..|.|.||.|.| ...|.| .|
PEGIDLLMQMLQYDPQKRISAKEALQHPYF
Kinase MCK1.AA Pkinase_Tyr 35-95 30 2e-08 29.16 Pfam 1-69 (270) Show / Hide 
Range on Protein: 35-95
Range on HMM: 1-69/270
Sequence Identity: 30% (21 aa)

VKEYRKIGRGAFGTVVQAYLTQDKKNWLGPFAIKKVPAHTEYKS-------RELQILRIA-DHPNIVKL
..  .|.|.||||.|...... |..|   | |.|... ..  .        ||..|..   .|||||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRL
Kinase MCK1.AA RCK 298-327 36 7.2e-08 20.74 In-house 269-298 (298) Show / Hide 
Range on Protein: 298-327
Range on HMM: 269-298/298
Sequence Identity: 36% (11 aa)

PDGIDLLMKILVYEPQQRLSPRRILAHQFF
.|.|.|..| | . || | ..  .| |..|
QDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase MCK1.AA CAMK 298-327 26 3.8e-07 18.33 In-house 396-425 (425) Show / Hide 
Range on Protein: 298-327
Range on HMM: 396-425/425
Sequence Identity: 26% (8 aa)

PDGIDLLMKILVYEPQQRLSPRRILAHQFF
.. .||. |.|...|..|..   .|.|...
QECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MCK1.AA Pkinase_Tyr 131-185 41 9.4e-07 23.49 Pfam 103-156 (270) Show / Hide 
Range on Protein: 131-185
Range on HMM: 103-156/270
Sequence Identity: 41% (23 aa)

TNKLEMPLKHIRLYTYQIARGMLYLHGLGVCHRDIKPSNVLVDPETGVLKICDFG
..|   ..|..  . .|||.|| ||.  .  |||.   |.||. |..| ||||||
EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVT-ENNVVKICDFG
Kinase MCK1.AA MAPK 35-96 31 2.7e-05 14.01 In-house 1-71 (328) Show / Hide 
Range on Protein: 35-96
Range on HMM: 1-71/328
Sequence Identity: 31% (23 aa)

VKEYRKIGRGAFGTVVQAYLTQ----DKKNWLGPFAIKKVP----AHTEYKS--RELQILRIA-DHPNIVKLQ
 .  ..|| ||.|.|. |. .     .|..     ||||..     .|  |   ||. .||   .|.||.||.
YQILKPIGQGAYGVVCSAIDKRTNQKTKCG--KKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLL
Kinase MCK1.AA RCK 36-95 29 0.003286 5.71 In-house 2-63 (298) Show / Hide 
Range on Protein: 36-95
Range on HMM: 2-63/298
Sequence Identity: 29% (20 aa)

KEYRKIGRGAFGTVVQAYLTQDKKNWLGPFAIKKVPAHTEYKS-------RELQILRIAD-HPNIVKL
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QIIKQLGDGTYGCVMKAQNKETGEI----VAIKKMK--QKFYSWEECMNLREIKSLRKLNPHPNIIKL
Kinase MCK1.AA ERK5 36-93 39 0.032278 3.82 In-house 2-61 (295) Show / Hide 
Range on Protein: 36-93
Range on HMM: 2-61/295
Sequence Identity: 39% (25 aa)

KEYRKIGRGAFGTVVQAYLTQDKKNWLGPFAIKKVPAH----TEYKS--RELQILRIADHPNIV
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KIIEKIGNGAYGVVCSARRRKNGQQ----VAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNII