Gene PTK2 (Bakers Yeast)

PTK2

Species: Bakers Yeast
Alias: PTK2
External Links: Saccharomyces Genome Database Link ,
Annotation:

Classification

Group: Other
Family: HAL

Sequence

Name Sequence Type Origin Length Description Download
PTK2.AA Protein Refseq_NP 818 Putative serine/threonine protein kinase that enhances spermine uptake; Ptk2p [Saccharomyces cerevisiae] Fasta, JSON
PTK2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 305 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of PTK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PTK2.AA HAL 258-562 39 1.9e-198 665.59 In-house 4-363 (363) Show / Hide 
Range on Protein: 258-562
Range on HMM: 4-363/363
Sequence Identity: 39% (143 aa)

NKPIGSGGSSEVRKVKSS-------------YRQKDVYALKKLN--MIYHESPEKFYKRCSKEFIIAKHLSHN-----------VHITNTFYLLKVPTTT
||..|.|...||......             ||.|.|.|.|...  |.|.|||||..|.|..||.|...|.|.           |||.|....|......
NKVLGWGAYGEVKICQRCRNKKDVPPYDTYHYRDKKVFAVKEFRKPMKYNESPEKYCKKCTSEFCIGHTLHHHHFNAKKPPKHVVHIPNICETLDIFYDS

YTTRGWGFIMELGVK-DLFQLMERTG-------WKNVPFNEKYCLFKQVAQGIKFCHDNGIAHRDLKPENVLISKEGICKLTDFGISDWYHVIPHDYTSP
|||..|...||.... |||....|.|       |......|..|.|||...|.|..||.|||||||||||......|||||.|||||||.|..|||....
YTTDKWCEVMEYCPYGDLFAMVMRNGGKSRLKGWRKMHYMEICCCFKQLCHGVKYMHDMGIAHRDLKPENCVMTPDGICKLCDFGISDWFHYPPHDWEKN

VKTCQGMIGSPPYTPPEVMYFDAKKHYPEKFQKPYNPLAMDSYALGIMLITMINNIIPFIDSCNTDARFREFEVSYDNFINHQNP----HFRDKGCHKPG
|..|.|..||.||..|||||||.||||.||||..|.|...|....||....||....|....|..|..||.|...||.||.|.|.    .|..|||..|.
VHMCHGIVGSDPYLAPEVMYFDEKKHYDEKFQQEYDPRCVDCWSCGIIYCCMIMKRFPWKIPCKEDDSFRMFCYHYDCFIFHHNVTRTQEFPEKGCYHPF

PGSE-----------------YSLARNFKNTDATRIAWRLADPNPATRYTMDDLFNDPFF
...|                 ....|.|.......|.||..|..||.|.||||.||||..
EEMEPENTPNNVQGKNNVNMGPHHIRHFLPHHCRHIMWRMLDWEPAKRITMDDIFNDPWM
S_TKc PTK2.AA S_TKc 255-562 17 5.2e-39 136.84 SMART 1-231 (231) Show / Hide 
Range on Protein: 255-562
Range on HMM: 1-231/231
Sequence Identity: 17% (57 aa)

DTDNKPIGSGGSSEVRKVKSSYRQKDVYALKKLNMIYHESPEKFYKRCSKEFIIAKHLSHNVHITNTFYLLKVPTTTYTTRGWGFIMELGVK---DLFQL
 .  ..||.|. ..|.|..     . ..|.|...           ..  .|  | |.  |  .| . ..               ..||.      |||..
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK-----------EHIRREIQILKK--HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDY

MERTG----WKNVPFNEKYCLFKQVAQGIKFCHDNGIAHRDLKPENVLISKEGICKLTDFGISDWYHVIPHDYTSPVKTCQGMIGSPPYTPPEVMYFDAK
... |     .  |  .  ....|.......||..|| ||||||||.|...    |..|||..  .                ..|.| | .|||.     
IKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------TTFCGTPWYMAPEVL-----

KHYPEKFQKPYNPLAMDSYALGIMLITMINNIIPFIDSCNTDARFREFEVSYDNFINHQNPHFRDKGCHKPGPGSEYSLARNFKNTDATRIAWRLADPNP
         .|.. . | ...|..|. |.    ||    . .. |.                                        .|  .  .. . .|
---------GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----------------------------------SPEAKDFIRKCLQKDP

ATRYTMDDLFN-------DPFF
. |.|  ....       .|.|
EKRPTA-EALQDEWDIKCHPWF
Pkinase PTK2.AA Pkinase 256-482 25 8.4e-31 109.99 Pfam 2-212 (293) Show / Hide 
Range on Protein: 256-482
Range on HMM: 2-212/293
Sequence Identity: 25% (62 aa)

TDNKPIGSGGSSEVRKVKSSYRQKDVYALKKLNMIYHESPEKFYKRCS-KEFIIAKHLSHNVHITNTFYLLKVPTTTYTTRGWGFIMELGVK-----DLF
.  ..||||....|.| .    .| ..|.|...   ||...| . .    |  | |.|.|   |  ...    ..  |      ..||.  .     |||
HIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIK-KRHEKSWKDQTHRRLSEIQIMKRLNHPN-IVRLYDWFEDKDHIY------MVMEYCEGGLYVMDLF

QLMERTGWKNVPF--NEKYC--LFKQVAQGIKFCHDNGIAHRDLKPENVLISKEGIC----KLTDFGISDWYHVIPHDYTSPVKTCQGMIGSPPYTPPEV
 ....  |.. .|   |. |   ..|...|...||..|| ||||||||.||...| .    |..|||..  .       . .   ...  |.|.| .|||
DYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEV

MYFDAKKHYPEKFQKPYNPLAMDSYALGIMLITMINNIIPF
               .| . . | ...|..|. |..   ||
IR-----------GGQYYGPKVDMWSCGCILYEMLCGRPPF
Kinase PTK2.AA CAMK 368-562 15 2e-28 88.11 In-house 184-425 (425) Show / Hide 
Range on Protein: 368-562
Range on HMM: 184-425/425
Sequence Identity: 15% (42 aa)

LFKQVAQGIKFCHDNGIAHRDLKPENVLISKE-----------------GICKLTDFGISDWYHVIPHDY--------------TSP--VKTCQGMIGSP
.|.|.......||...|.||||||||.|...                  .  |..||| .  .     ..              |.|   . .. . |.|
YFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTP

PYTP-PEVMYFDAKKHYPEKFQ-----KPYNPLAMDSYALGIMLITMINNIIPFIDS--------------------CNTDARFR-EFE-----------
.| . |||     .. ..   .     ||| . . |  ..|..| .|     || ..                      . .... . .           
EYMAAPEVLNGKGHCNMQ---NATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGP

-----VSYDNFINHQNPHFRDKGCHKPGPGSEYSLARNFKN----TDATRIAWRLADPNPATRYTMDDLFNDPFF
     .| .                             |      ...     ..  ..|  |.| ..  |.|..
EWWDDISDE-----------------------------F-HHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase PTK2.AA CAMKL 368-476 33 1.3e-24 75.38 In-house 132-230 (297) Show / Hide 
Range on Protein: 368-476
Range on HMM: 132-230/297
Sequence Identity: 33% (37 aa)

LFKQVAQGIKFCHDNGIAHRDLKPENVLISKEG--ICKLTDFGISDWYH-VIPHDYTSPVKTCQGMIGSPPYTPPEVMYFDAKKHYPEKFQKPYNPLAMD
.|.|.  ....||..||.|||.||||.|... |    |..||| | .|  .|      | ...    ||||| .||.             .|||.  . |
YFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCI----FGPGQKLKTFCGSPPYMAPEIFQGN---------NKPYDGPKVD

SYALGIMLITMI
  ..|..| .|.
IWSCGVILYAMV
Kinase PTK2.AA Ciliate-E2 346-562 15 2.4e-24 80.44 In-house 119-365 (365) Show / Hide 
Range on Protein: 346-562
Range on HMM: 119-365/365
Sequence Identity: 15% (47 aa)

KDLFQLMERT---------GWKNVPFNEKYCL--FKQVAQ---------------GIKFCHDNG-IAHRDLKPENVLISKEGICKLTDFGISDWYHVIPH
.|||....             .  .|.|| ..  .||..|               .....| .. | |||.||||.|.     .|..|||.|  |.    
GDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQ

DYT-----------SPVKTCQG-------------MIGSPPYTPPEVMYFDAKKHYPEKFQKPYNPLAMDSYALGIMLITMINNIIPFIDSCNTDARFRE
..|           .  ....|              .|.|.| .||.             .. .   . | ..||..|  |. .  ||           .
NRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ---QKQKGYDYKCDIWSLGVILYEMLFGKPPF------QQQIKQ

FEVSYD--------------------------NFINH--QNPHFRDKGCHKPGPGSEYSLARNFKNTDATRIAWRLADPNPATRYT-MDDLFNDPFF
 .....                          ..|.   .                                  |. . .|  |.| .....| |.|
CKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGK----------------------------------RMLQKDPEKRITGWEQILNHPWF
Kinase PTK2.AA Ciliate-E2-Unclassified 256-482 22 9.6e-24 79.25 In-house 2-270 (352) Show / Hide 
Range on Protein: 256-482
Range on HMM: 2-270/352
Sequence Identity: 22% (64 aa)

TDNKPIGSGGSSEVRKVKSSYRQKDVYALKKLN--MIYH----ESPEKFYKRCSKEFIIAKHLSHNV----------------HITNTFYLLKVPTTTYT
. .| ||.|| ..|.|.. .  .  .||.| ..  .||.    .. .  .... ||  . |. .|.                 .| . ||  .   . | 
KIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIY-

TRGWGFIMELGV-KDLFQLME-------------RTGWKNVPFNEKYCL-------FKQVAQGIKFCHDNG-IAHRDLKPENVLISKEG---ICKLTDFG
     ..||.   .||.| ..             ..  ..  | |. ..       |.|. ||....| .. | |||.||||.|....|    .|..|||
-----IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFG

ISDWYHVIPHDYTS--------PVKTCQGMIGSPPYT----PPEVMYFDAKKHYPEKFQKPYNPLAMDSYALGIMLITMINNIIPF
||  |   . ..|.        . . .. ..|.| |     .|||.    .... .|.       . | ..||. |  |. .  ||
ISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQG--QNYDHSKA------YKCDIWSLGVILYEMLFGYYPF
Kinase PTK2.AA CMGC 256-415 19 6.5e-22 67.97 In-house 2-256 (513) Show / Hide 
Range on Protein: 256-415
Range on HMM: 2-256/513
Sequence Identity: 19% (49 aa)

TDNKPIGSGGSSEVRKVKS-------------SYRQKDVYALKKLN--MIYHES------PEKFYKRCSKEFIIAKHLS----------------HNVHI
.  |.||.|  ..| | .                . . ..|.||.     |.|        . | .|.  |  | |||.                |  .|
EIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

TNTFYLLKVPTTTYT-----------TRGWGFIMELGVKDLFQLMERTGW-----KNVPFNEKY--------------CLF------KQVAQGIK--FCH
 . .. .. . .. .            .   ...|.  .||.|.....       ...|..|                ...      .|. .|.|  .||
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

DNG--IAHRDLKPENVLISKEGIC--------------------KLTDFGISDWYHV
 ..  | ||||||||.||.... .                    |. ||| . |||.
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHP
Kinase PTK2.AA CDK 339-410 32 9.2e-19 56.51 In-house 95-160 (284) Show / Hide 
Range on Protein: 339-410
Range on HMM: 95-160/284
Sequence Identity: 32% (25 aa)

FIMELGVKDLFQLMERTGWKNVPFNEKYCLFKQVAQGIKFCHDNGIAHRDLKPENVLISKEGI-----CKLTDFGIS
...|    || ..|.             |...|  .|. .||.|.| |||||| | ||.. |.      |..||| .
MVFEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLA
Kinase PTK2.AA Ciliate-E1 261-411 23 1.1e-18 57.76 In-house 1-157 (202) Show / Hide 
Range on Protein: 261-411
Range on HMM: 1-157/202
Sequence Identity: 23% (38 aa)

IGSGGSSEVRKVKSSYRQKDVYALKKLNMIYHESPEKFYKRCSKEFIIAKHLSHNVHITNTFYLLKVPTTTYTTRGWGFIMELGVKDLFQLME-------
||.|..| | | |.   .. ..|.|  |... .. ..|..   ... | | .  .  | . .  .|.     ..    .|.|.  . |.. ..       
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICI----IIFECCCCSLKDYLQNHNRLEY

----RTGWKNVPFNEKYCLFKQVAQGIKFCHDNGIAHRDLKPENVLISKEGICKLTDFGISD
    ..  ..  | .| ....|  .|.   |...| |||.||.|.||...|.....|||||.
WQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISK
Kinase PTK2.AA MARK 368-408 44 1.9e-18 57.04 In-house 109-151 (262) Show / Hide 
Range on Protein: 368-408
Range on HMM: 109-151/262
Sequence Identity: 44% (19 aa)

LFKQVAQGIKFCHDNGIAHRDLKPENVLISKEG--ICKLTDFG
.|.|.  ....||...|.|||.||||.|| ..|    |..|||
IFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFG
Kinase PTK2.AA STE11-Unclassified 370-441 33 1.8e-16 54.92 In-house 114-206 (308) Show / Hide 
Range on Protein: 370-441
Range on HMM: 114-206/308
Sequence Identity: 33% (31 aa)

KQVAQGIKFCHDNGIAHRDLKPENVLISKEGICKLTDFGISDWYH------------------VIPHDYTSPVKTCQGMIGSPP---YTPPEV
||. .|... | .|| |||.|..|.|| ..|||||||||..                       |  .  |  . |. | |.|.   .. |||
KQILEGLAYLHSHGIIHRDIKGANILIDFDGICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHINSQQNHCKSMQGTPYQPFWMAPEV
TyrKc PTK2.AA TyrKc 255-502 17 5e-06 -125.71 SMART 1-280 (280) Show / Hide 
Range on Protein: 255-502
Range on HMM: 1-280/280
Sequence Identity: 17% (53 aa)

DTDNKPIGSGGSSEVRKVKSSYRQKDVYALKKLNMIYHESPEKFYKRCSKEFIIAKHL-SHNVHITNTFYLLKVP-------TTTYTTRGWGFIMELGVK
 | .| .|.|   ||.| . .    .| | |.|.           .   .|  | ..|  |. .| . .     .          .       .||.  .
ITLGKKLGEGAFGEVYKGTWK---IQV-AVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLM------IVMEYMPH

-DLFQLMERTGWKNVPFNEKYCLFKQVAQGIKFCHDNGIAHRDLKPENVLISKEGICKLTDFGISDWYHVI-----PHDYTSP-----VKT---------
 || .   ... | ..  ..     |.|.|  . |.... ||||   |.|.......| .||| |   .        .|| ..      ||         
GDLKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

---CQG-------------------MIGSPPY--------TPPEVMYFDAKKHYPEKFQKPYNPLAMDSYALGIMLITMINNIIPFIDSCNTD-ARFR-E
     |                     | .||        .. ||. .  . ..... . .| |  | .        ..   .   . .|    .  |  
ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P--MSF-------VCCPDEMYQIMKQCWHEDPEDRPT

FEVSYDNF
|.  .. |
FSEIHECF
Kinase PTK2.AA CAMKL 545-562 33 0.000697 8.11 In-house 280-297 (297) Show / Hide 
Range on Protein: 545-562
Range on HMM: 280-297/297
Sequence Identity: 33% (6 aa)

PNPATRYTMDDLFNDPFF
.||  |.|.... |.|..
VNPEKRPTIHQIMNHPWM
Kinase PTK2.AA Ciliate-E2-Unclassified 546-562 41 0.001697 8.02 In-house 336-352 (352) Show / Hide 
Range on Protein: 546-562
Range on HMM: 336-352/352
Sequence Identity: 41% (7 aa)

NPATRYTMDDLFNDPFF
||  |.|.....| |.|
NPNKRITFEQILNHPWF
Kinase PTK2.AA CAMK 260-288 12 0.0206 2.78 In-house 1-40 (425) Show / Hide 
Range on Protein: 260-288
Range on HMM: 1-40/425
Sequence Identity: 12% (5 aa)

PIGSGGSSEVRKVKSSYRQK-----------DVYALKKLN
 .|.|. ..|....    ..             .| | ..
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIID
Kinase PTK2.AA MARK 545-562 27 0.022427 3.77 In-house 245-262 (262) Show / Hide 
Range on Protein: 545-562
Range on HMM: 245-262/262
Sequence Identity: 27% (5 aa)

PNPATRYTMDDLFNDPFF
.||  | |.... ..|..
VNPEERPTIEEIMKHPWM
Kinase PTK2.AA STE11-Unclassified 546-562 35 0.025663 4.09 In-house 292-308 (308) Show / Hide 
Range on Protein: 546-562
Range on HMM: 292-308/308
Sequence Identity: 35% (6 aa)

NPATRYTMDDLFNDPFF
.|  |.| . |...|| 
DPKKRPTANQLLQHPFI
Kinase PTK2.AA Pkinase 544-562 26 0.030491 9.01 Pfam 275-293 (293) Show / Hide 
Range on Protein: 544-562
Range on HMM: 275-293/293
Sequence Identity: 26% (5 aa)

DPNPATRYTMDDLFNDPFF
...|. |.| ......|.|
CKDPKKRPTAEQILQHPWF
Kinase PTK2.AA MARK 432-494 25 0.063541 2.27 In-house 167-218 (262) Show / Hide 
Range on Protein: 432-494
Range on HMM: 167-218/262
Sequence Identity: 25% (16 aa)

GSPPYTPPEVMYFDAKKHYPEKFQKPYNPLAMDSYALGIMLITMINNIIPFIDSCNTDARFRE
|.||| .||..            .|||.  . | ..||. | .|.    || ......   ..
GTPPYMAPEIF-----------LKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYK