Gene SKY1 (Bakers Yeast)

SKY1

Species: Bakers Yeast
Alias: SKY1
External Links: Saccharomyces Genome Database Link ,
Annotation:

Classification

Group: CMGC
Family: SRPK

Sequence

Name Sequence Type Origin Length Description Download
SKY1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 312 Kinase domain by global Sugen HMM Fasta, JSON
SKY1.AA Protein Refseq_NP 742 SRPK1-like Kinase in Yeast (SRPK1 is a human serine kinase that specifically phosphoryates arginine-serine rich domains found in the SR family of splicing factors.); Sky1p [Saccharomyces cerevisiae] Fasta, JSON

Protein domain

Protein domains of SKY1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SKY1.AA SRPK 315-706 28 3.8e-163 424.21 In-house 290-554 (554) Show / Hide 
Range on Protein: 315-706
Range on HMM: 290-554/554
Sequence Identity: 28% (111 aa)

EALDKQKREAKRLQRHVSRSSDITANDSSDEKWAECQTSMPCGSSSNSKSRSIEKDLSKRCFRRPRRHTIITGSQPLPSPISSSNFFEMRAHFCGSSHNS
.. || ..| .  | ..                                                                                   
QHKDKKEQECQNVQKQNND---------------------------------------------------------------------------------

FSSVSGNRNIPSSINNNSINNGIGIKNSNNSFLNSVPHSVTRMFINEDSNDNNNNDNSKNKNNNNNNSNNNNNEDIMNTPLHEEQLADSLSTFDISNISQ
                             ..|. ..  | .  . |.  | ...  ... .   .  .|.  ....  .   ||.   | . ..      
-----------------------------PNFESQN-DSQMEQETNSCNNQEHKQEKTMQCQDSTKQQNKQ-DQQKEGQKQSEESECESEDMQEQ-----

SSDTNGPYISNTMDSNSNVSTDINSPENLIQIKIADLGNACWYDEHYTNSIQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDEGHSYTK
          ..   . ..   .  ..  |.|||||||||||...|.|..||||.||||||..||.....||||||||..|||.|||.||||..|..|..
----------AGKFLVWWKNPRNADLDHKIKIKIADLGNACWVHHHFTEDIQTRQYRSPEVIIGAGYNTPADIWSTACMAFELATGDYLFEPHSGEDYSR

DDDHIAQIIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKEISDFLSPMLQLDPRKRADAGGLVNHPWL
||||||.||||.|..|......|||.|.|||..| ||.|.|||.|||..||.|||..|..|||...|||.|||...|.|||.|. ...||||
DDDHIAHIIELCGKIPWHFALSGKYSREFFNKKGELRHIPKLKPWPLMNVLIEKYEWSHEEAKQFEDFLMPMLHYNPEKRATAKECLQHPWL
Kinase SKY1.AA SRPK 158-306 53 1.4e-135 351.55 In-house 1-167 (554) Show / Hide 
Range on Protein: 158-306
Range on HMM: 1-167/554
Sequence Identity: 53% (90 aa)

YILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADNT------------------KEDSMGANHILKLLDHFNHKGPNG
|...|||||||||||||..|| ....||||||.....|||.|.|||||||.|...|..                  ||......|...|||||.|.||||
YHVIRKLGWGHFSTVWLCWDMQYDRYVAMKIVKSAPHYTETAVDEIKLLQCVRKHDPNPQWMHFLKEYYEDYKRDCKEFDPNRCHVVQLLDHFKHRGPNG

VHVVMVFEVLGENLLALIKKYEHRGIPLIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIGD
.|..|||||||.|||..||.|...|.|...||||..|.| ||||.||.||||||||||||||... .
NHYCMVFEVLGHNLLKWIKHYNYQGMPMHCVKQIARQVLIGLDYLHRKCGIIHTDIKPENVLLCVNQ
Kinase SKY1.AA CMGC 158-706 14 8.60000000001e-113 372.15 In-house 1-513 (513) Show / Hide 
Range on Protein: 158-706
Range on HMM: 1-513/513
Sequence Identity: 14% (105 aa)

YILVRKLGWGHFSTVWLAKD--------------MVNNTHVAMKIVRGDKVYTEAAE-------------DEIKLLQRVNDADNTKE-----DSMGANH-
|  ..|.|.|....|. ..|              . .| .||.|... .. |.| |              .|||.|...|..... .     |... .| 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

-ILKLLDHFNHKGPNGV-------------HVVMVFEVLGENLLALIKKYEH--------------------------RGIPLIYVKQISKQLLLGLD--
 |.||.|.| ||...|              |. .||| .. .|. .||.. .                          . ... ... ...|.| ||.  
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

YMHRRCG-IIHTDIKPENVLMEI-GDV--------EGIVQMVEALDKQKREAKRLQRHVSRSSDITANDSSDEKWAECQTSMPCGSSSNSKSRSIEKDLS
|.|...| |||.|.||||.|.   ...        |                                                                
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSE----------------------------------------------------------------

KRCFRRPRRHTIITGSQPLPSPISSSNFFEMRAHFCGSSHNSFSSVSGNRNIPSSINNNSINNGIGIKNSNNSFLNSVPHSVTRMFINEDSNDNNNNDNS
                                                                                                    
----------------------------------------------------------------------------------------------------

KNKNNNNNNSNNNNNEDIMNTPLHEEQLADSLSTFDISNISQSSDTNGPYISNTMDSNSNVSTDINSPENLIQIKIADLGNACWYDEH------------
                                                       | . |.           ..||.| |.|.||..|            
-------------------------------------------------------D-W-NPC------QKNGRLKICDFGLARWYHPHSDHHFQQQPQSF

------------YTNSIQTREYRSPEVLLGAP----------WGCGADIWSTACLIFELITG--------DFLFEPDEGH-----SYTKDDDHIAQIIEL
            ||. ..|| ||.||.|||..          .... |.|| .| ..|..||        . || .. ..     ..... |....|...
KNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKV

LGELPSYLLRNGK-------YTRTFFNSRGLLRNISKLK------------------------F-WPLEDVLTEKYKFSKD-------------------
||  . .....||       ......|  .|.... ..|                        | |.    ..........                   
LGTPT-WMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKF

-------------EAKEISDFLSPMLQLDPRKRADAGGLVNHPWL
             . ..  |.|. |||.|| ||  |    .||..
KSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase SKY1.AA CLK 158-604 15 2.2e-52 155.01 In-house 1-247 (350) Show / Hide 
Range on Protein: 158-604
Range on HMM: 1-247/350
Sequence Identity: 15% (74 aa)

YILVRKLGWGHFSTVWLAKDMVN-NTHVAMKIVRGDKVYTEAAEDEIK-LLQRVNDADNTKEDSMGANHILKLLDHFNH-KGPNGVHVVMVFEVLGENLL
|  | .|| | |..|   .|. | ...|| ||.|. . |.|||  ||.  .. .| ...   ...   |..|..| |.. .|    |. .||| .| .. 
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYW--EHCWKMNDWFDYGHG----HICIVFELYGLSIY

ALIKKYE------HRGIPLIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIG-----DVEGIVQMVEALDKQKREAKRLQRHVSRSSDITANDSS
 ..|.         .. |.  ......||.  .  .|   ...||| |||| . .       | .   . .  ..                         
DFMKSNNSKMPNKYIPYPIDHIRHMAYQLCEAVKFLH-DMKLTHTDLKPENICFVDSRFTHFDCTFKYNHKKKIN-------------------------

DEKWAECQTSMPCGSSSNSKSRSIEKDLSKRCFRRPRRHTIITGSQPLPSPISSSNFFEMRAHFCGSSHNSFSSVSGNRNIPSSINNNSINNGIGIKNSN
                                                                                                    
----------------------------------------------------------------------------------------------------

NSFLNSVPHSVTRMFINEDSNDNNNNDNSKNKNNNNNNSNNNNNEDIMNTPLHEEQLADSLSTFDISNISQSSDTNGPYISNTMDSNSNVSTDINSPENL
                                                                                     | .| . .. ...|.
-----------------------------------------------------------------------------------KKS-NNCVCHYWHVKNT

IQIKIADLGNAC---WYDEHYTNSIQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLF
  |.. | |.|      .|| .  ..|| || ||| || .|    |.|| .| .||| ||. ||
-HICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLF
Kinase SKY1.AA S_TKc 158-706 12 4.6e-52 180.19 SMART 1-231 (231) Show / Hide 
Range on Protein: 158-706
Range on HMM: 1-231/231
Sequence Identity: 12% (74 aa)

YILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGE---NLL
| ..||.| | |..|.....   . .||.||..      | .. ||..|..            .  .| ||.|.| .      |. ||.| ..    .|.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK------------HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLF

ALIKKYEHRG----IPLIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIGDVE------GIVQMVEALDKQKREAKRLQRHVSRSSDITANDSSD
 .|||. ..|    .|   .. . .|....|.|.|.. |||| |.||||.|.     .      |.   .                              
DYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE---HIKICDFGLARQL------------------------------

EKWAECQTSMPCGSSSNSKSRSIEKDLSKRCFRRPRRHTIITGSQPLPSPISSSNFFEMRAHFCGSSHNSFSSVSGNRNIPSSINNNSINNGIGIKNSNN
                                                                                                    
----------------------------------------------------------------------------------------------------

SFLNSVPHSVTRMFINEDSNDNNNNDNSKNKNNNNNNSNNNNNEDIMNTPLHEEQLADSLSTFDISNISQSSDTNGPYISNTMDSNSNVSTDINSPENLI
                                                                                                    
----------------------------------------------------------------------------------------------------

QIKIADLGNACWYDEHYTNSIQTREYRSPEVLLGAPWGC-GADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQIIELLGELPSYLLRNGKYTRTF
                 |  . |..|..||||   ..|.  .|.||  |...|...|  .|.            .........|                
-----------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP------------QMQMMFKKIG----------------

FNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKEISDFLSPMLQLDPRKRADAGGLVN-------HPWL
                                 .|  ||.. .|| ||.||  |  . .       |||.
--------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase SKY1.AA DYRK 158-302 32 3.7e-36 126.46 In-house 1-137 (320) Show / Hide 
Range on Protein: 158-302
Range on HMM: 1-137/320
Sequence Identity: 32% (47 aa)

YILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALI
|  .  .| | |. |  ..|  .| .||.||.|  | .   | .|||.|.. |..     |.    |.....|.|.|..    |. .||| |  ||  ..
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQ-----DPDDKYHCVHMYDYFYHRN----HLCIVFELLSMNLYEFL

KKYEHRGI-PLIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLM
|..  .|  .| .|... .|.|..|...|.   ||| |.||||...
KNNHFQGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIML
Kinase SKY1.AA Pkinase 158-302 27 1.4e-22 80.95 Pfam 1-141 (293) Show / Hide 
Range on Protein: 158-302
Range on HMM: 1-141/293
Sequence Identity: 27% (43 aa)

YILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAED-----EIKLLQRVNDADNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGE-
| ..||.| | |..|.....  ..  ||.||.. ..   .  .      ||....|.|             .|..|.| |      . |. ||.| ..  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-----------HPNIVRLYDWFED----KDHIYMVMEYCEGG

----NLLALIKKYEHRGI--PLIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLM
     | ..|.  .|...  .   .| . .|.| ||.|.|. .|||| |.||||.|.
LYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILI
Kinase SKY1.AA DYRK 545-706 25 4.3e-22 79.52 In-house 145-320 (320) Show / Hide 
Range on Protein: 545-706
Range on HMM: 145-320/320
Sequence Identity: 25% (50 aa)

QIKIADLGNACWYDEHYTNSIQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQIIELLGELPSYLLRNG--KYTRT
.||..| | .|  ... .  || | ||.|||.|| | .   |.||  | . || ||  ||    | ..    | .| |.|.||  |. ....|  .....
TIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLF---PGENE---YDQLACIMEVLGMPPKWMIDKGRCRRKHK

FFNSRGLLRNISKLKFWPLEDVLTE-----------------------------KYKFSKDEAKEISDFLSPMLQLDPRKRADAGGLVNHPWL
||..          ...   |  |.                             ....   . ..  ||.  .||.||.||  .    .|||.
FFDC----------FMYCECDEWTKQNKITDHYMTPKCHPTKRGQRRPPGRRNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase SKY1.AA PRP4 158-301 34 5.9e-22 77.19 In-house 1-138 (320) Show / Hide 
Range on Protein: 158-301
Range on HMM: 1-138/320
Sequence Identity: 34% (50 aa)

YILVRKLGWGHFSTVWLAKDMVNNT-HVAMKIVRGDKVYTEAAEDEIKLLQRVNDADNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLAL
|  . . | | ||.|  ..|  .    || ||.|   .     . |.  ||. |||   |.|     |.... .||||.     |  .||| .  ||  .
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKF---HCVRMFRHFNHR----QHMCLVFECMSMNLREV

IKKY-EHRGIPLIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVL
.|||    |  |  |   ..||.| |  .  .|.|.| |||| |.|
LKKYGKDVGLHLKAVRSYAQQLFLALKHL-KKCNILHADIKPDNIL
Kinase SKY1.AA DYRK2 158-301 30 2.5e-21 65.82 In-house 1-134 (318) Show / Hide 
Range on Protein: 158-301
Range on HMM: 1-134/318
Sequence Identity: 30% (44 aa)

YILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALI
| ..  .| | |  |  . |  ...||| |..|  | . . |  ||. |..       . |  ..  . ..|| |   .    |. ..|| |. ||  .|
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIR-----RQDKDNTMNCVHMLDYFYFRN----HHCITFELLSMNLYEYI

KKYEHRGIPLIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVL
|| .  |. |  |    ...| .|.  |..  ||| | ||||.|
KKNHFQGFSLQLVRRFAHSILQCLRFLHKNN-IIHCDLKPENIL
Kinase SKY1.AA DYRK1 158-302 31 5.6e-21 70.0 In-house 1-137 (321) Show / Hide 
Range on Protein: 158-302
Range on HMM: 1-137/321
Sequence Identity: 31% (46 aa)

YILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALI
|     .| | |  |  | | ..  .||.||..  | . . |  ||.||  .| .|. ..      .|..|  || ..     |. .|||.|  ||  |.
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMK-----YYIVHLKRHFMFR----NHLCLVFELLSYNLYDLL

KKYEHRGIPLIYVKQISKQLLLGLDYMHR-RCGIIHTDIKPENVLM
.  . ||. |  .... .|..  | .|      ||| |.||||.|.
RNTHFRGVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILL
Kinase SKY1.AA CAMK 163-302 15 7.1e-19 56.78 In-house 1-212 (425) Show / Hide 
Range on Protein: 163-302
Range on HMM: 1-212/425
Sequence Identity: 15% (33 aa)

KLGWGHFSTVWLAKDMVNN------------THVAMKIVRGD-----------------------------KVYTEAAEDEIKLLQRVNDADNTKEDSMG
.|| | |..| |...  ..            ..||.||.  .                              .  .  . ||........ .|     . 
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGN----KLD

ANHILKLLDHFNHKG---------PNGV-------HVVMVF---EVLGEN-----LLALIKKYEH-------------RGIPLIYVKQISKQLLLGLDYM
  .|.||....  .                     |..||.   |          |.  |.. ..             . ..   .... .|.. ...|.
HPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYC

HRRCGIIHTDIKPENVLM
| .  |.| |.||||.|.
HSHN-IVHRDLKPENILL
Kinase SKY1.AA DyrkP 158-302 32 1e-17 54.32 In-house 1-139 (323) Show / Hide 
Range on Protein: 158-302
Range on HMM: 1-139/323
Sequence Identity: 32% (48 aa)

YILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALI
| ..  ||   ||     .| . |  . |||.   | | . . ||||||. .|      |       .|.  | | ||     |. .. |.| .||    
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDE-----KNVLRYYDYFYHK----EHLFIITELLKDNLYEFY

K----KYEHRGIPLIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLM
|      . |   .  ...| .|.|..|||.|    .|| |.||||.||
KFNRENEQQRYFTVGRLQKITQQILIALDYIH-SLRLIHCDLKPENILM
Kinase SKY1.AA DyrkP 545-650 33 1.4e-17 53.83 In-house 146-245 (323) Show / Hide 
Range on Protein: 545-650
Range on HMM: 146-245/323
Sequence Identity: 33% (35 aa)

QIKIADLGNACWYDEHYTNSIQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQIIELLGELPSYLLRNGKYTRTFF
|.|| | | .|.  .|    .| | || |||..|  .    |.||  |.. || ||  ||  |.          .| .| ..| .| .... |.  . ||
QVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWTGNVLFQNDNIQGL------LARVIGIIGPFPEWMMQEGRLVQNFF

NSRGLL
  . ||
TRKRLL
Kinase SKY1.AA DYRK1 545-645 34 2.7e-17 56.85 In-house 144-238 (321) Show / Hide 
Range on Protein: 545-645
Range on HMM: 144-238/321
Sequence Identity: 34% (35 aa)

QIKIADLGNACWYDEHYTNSIQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQIIELLGELPSYLLRNGKYTRTFF
.||| | | .|  ..   . || | ||||||||| ..    |.||  |.. |. ||. ||      | . . | . .|.| ||  |....  .  .. .|
AIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGEPLF------SGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYF

N
.
E
Kinase SKY1.AA Pkinase 545-706 22 3.4e-17 61.89 Pfam 146-293 (293) Show / Hide 
Range on Protein: 545-706
Range on HMM: 146-293/293
Sequence Identity: 22% (39 aa)

QI----KIADLGNAC---WYDEHYTNSIQ-TREYRSPEVLL-GAPWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQIIELLGELPSYLLR
.|    ||.| | |.   .   . ....  |..|..|||.. | ..|  .|.||  |...|...| ..|  ...    . .|... | . .|  ...   
HIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHC-WHDN-HDQMQMICRIMGPPLHFDWP

NGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKEISDFLSPMLQLDPRKRADAGGLVNHPWL
.    ..||  |                  .   .| .   .|  ||.. .|..|| ||  |  ...|||.
WWCSISYFF-FRH-W-H-------------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase SKY1.AA Ciliate-E2 543-706 16 5.3e-17 54.88 In-house 193-365 (365) Show / Hide 
Range on Protein: 543-706
Range on HMM: 193-365/365
Sequence Identity: 16% (38 aa)

LIQIKIADLGNACWYDEHYTNSIQ----------------------------------TREYRSPEVLLGAP---------WGCGADIWSTACLIFELIT
|. |||.|.|..  ||. . | ..                                  | .| .||.| | .         ..  .||||  ....|...
LF-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GDFLFEPDEGHSYTKDDDHIAQIIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFS------------------KDEAKEISD
| . |                                                        ..  .  |..|.                  |.  .|  |
GKPPF--------------------------------------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKD

FLSP----MLQLDPRKRAD-AGGLVNHPWL
...     ||| || || . .  . ||||.
LIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase SKY1.AA Ciliate-E2 158-302 23 5.8e-17 54.74 In-house 1-194 (365) Show / Hide 
Range on Protein: 158-302
Range on HMM: 1-194/365
Sequence Identity: 23% (46 aa)

YILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDK----------------------VYTEAAEDEIKLLQRVNDAD----NTKE--DSMGANHILKLL
|....|.| | |..|...|.  ..  .|.|| . .|                         |. . ||......|. .    | |.   ..  ..|.|. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMY

DHFN--HKGPNGVHVVMVFE-VLGENLLALIK---KYEHRGIP------LIYVKQISKQLLL---------------GLDYMHRRCGIIHTDIKPENVLM
..|    .     .. .|.| . | .|. .||   | ..  |.      .  .|.|.||.|                .| |.| .  ||| ||||||.|.
ECFQEKDDN----NIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF
Kinase SKY1.AA DYRK2 546-648 33 8.7e-16 47.5 In-house 143-245 (318) Show / Hide 
Range on Protein: 546-648
Range on HMM: 143-245/318
Sequence Identity: 33% (36 aa)

IKIADLGNACWYDE-HYTNSIQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQIIELLGELPSYLLRNG-----KY
||..| |  |  .. .    ||.| ||.||| || . |   |.||  | . || ||  ||  .        .| .| ..|.||  |. .. .      ..
IKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLFPGEN------ENDQFACMMEVLGMPPKKFFDTWFYIHCFR

TRTFFNSRG
...||||..
RKYFFNSHC
Kinase SKY1.AA CAMK 545-706 18 5.6e-15 44.01 In-house 234-425 (425) Show / Hide 
Range on Protein: 545-706
Range on HMM: 234-425/425
Sequence Identity: 18% (41 aa)

QIKIADLGNACWYDEH--------------------------YTNSIQTREYRS-PEVLLG--------------APWGCGADIWSTACLIFELITGDFL
.|||.| | |. .|.                           .. .  | || . ||||.|               . |  .|.||  .. . . .| . 
NIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPP

FEPD---------EGHSYTKDDDHIAQIIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFW-PLEDVL------TEKYKFSKDEA------KEISD
|. |         .                                 . .| . |...| | |.. | . .       .. .  .  .       .|  |
FYGDCDNEICEDEW---------------------------------IGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

FLSPMLQLDPRKRADAGGLVNHPWL
... ||| || ||. .    ||||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase SKY1.AA PRP4 566-645 27 8.5e-11 35.82 In-house 167-240 (320) Show / Hide 
Range on Protein: 566-645
Range on HMM: 167-240/320
Sequence Identity: 27% (22 aa)

QTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQIIELLGELPSYLLRNGKYTRTFFN
. | ||.||...| |   . |.||..| ..|| || ..|    | .     . .  . .. | .|  ..|.|..  ..|.
VSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELYTGKIMF---PGKT---NNHMLKLFMDYKGKMPNKMIRKGQFKDNHFD
Kinase SKY1.AA TyrKc 158-391 13 0.000176 -150.17 SMART 1-280 (280) Show / Hide 
Range on Protein: 158-391
Range on HMM: 1-280/280
Sequence Identity: 13% (41 aa)

YILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRV--NDADNTKEDSMGANHILKLLDHFNHK-------GPNGVHVVMVFE-
  | .||| |.| .|....     . || | .. |.   |.  .|.... ..  .             .|..|.    ..       .|    . .|.| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGH-----------HPNIVRLYGVCTQQGRNFMYIEP----LMIVMEY

VLGENLLALIKKYEHRGIPLIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIGD-VE----GIVQMVEAL--------DKQKRE--AKR------
. . .|.  ..|.... ...    ... |   | .| |.. ..|| |.   |.|   .  |     |    ..           . |.|   ..      
MPHGDLKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR

------LQRH------------------VSRSSDITAN-----DSSDEKWAECQTS--MPCGSS-----SNSKSRSIEKDLSKRCFRR--PRRHTIITGS
      .. .                   ..      .      | .|  .  ..   ||.  .     .   .  . . . |.| ..    | |  .  
WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIH

QPL
. .
ECF
Kinase SKY1.AA DyrkP 681-706 38 0.000271 9.29 In-house 298-323 (323) Show / Hide 
Range on Protein: 681-706
Range on HMM: 298-323/323
Sequence Identity: 38% (10 aa)

DFLSPMLQLDPRKRADAGGLVNHPWL
||   .||.|  .|  |   ..|||.
DFVRQCLQIDFTRRPTAKEALQHPWF
Kinase SKY1.AA CLK 673-706 29 0.000535 7.08 In-house 317-350 (350) Show / Hide 
Range on Protein: 673-706
Range on HMM: 317-350/350
Sequence Identity: 29% (10 aa)

KDEAKEISDFLSPMLQLDPRKRADAGGLVNHPWL
..|. .  | .. ||  || ||  ..    ||. 
DPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase SKY1.AA PRP4 681-706 38 0.000838 9.9 In-house 295-320 (320) Show / Hide 
Range on Protein: 681-706
Range on HMM: 295-320/320
Sequence Identity: 38% (10 aa)

DFLSPMLQLDPRKRADAGGLVNHPWL
|.|  .|.||| ||        || .
DLLDKCLMLDPKKRITCNEALKHPFI
Kinase SKY1.AA DYRK2 668-706 25 0.012826 3.96 In-house 280-318 (318) Show / Hide 
Range on Protein: 668-706
Range on HMM: 280-318/318
Sequence Identity: 25% (10 aa)

KYKFSKDEAKEISDFLSPMLQLDPRKRADAGGLVNHPWL
|... . | .   ||..  .. || .|  .    .|||.
KSVLKGCEDENFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase SKY1.AA DYRK1 681-706 30 0.023712 3.49 In-house 296-321 (321) Show / Hide 
Range on Protein: 681-706
Range on HMM: 296-321/321
Sequence Identity: 30% (8 aa)

DFLSPMLQLDPRKRADAGGLVNHPWL
| .  ||| ||..|      . |...
DLIKRMLQYDPKQRITPYYALQHSFF