Gene BLK (Human)

BLK

Species: Human
Alias: MGC10442, BLK
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 8p23.1,

Classification

Group: TK
Family: Src
Subfamily: SrcB

Sequence

Name Sequence Type Origin Length Description Download
BLK.kin_dom Protein Kinase Domain Sugen Kinome 251 None Fasta, JSON
BLK.AA Protein Sugen Kinome 505 None Fasta, JSON
BLK.NA RNA Sugen Kinome 2642 None Fasta, JSON

Protein domain

Protein domains of BLK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 BLK.AA SH3 61-117 41 2.1e-21 78.32 SMART 1-58 (58) Show / Hide 
Range on Protein: 61-117
Range on HMM: 1-58/58
Sequence Identity: 41% (24 aa)

HFVVALYDYTAMNDRDLQMLKGEKLQVLKG-TGDWWLARSLVTGREGYVPSNFVARVE
 .|.|||||.| |. .| . ||....||.   ..|| .|   ||.||..|||.|....
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 BLK.AA SH3_1 64-110 42 6.3e-21 73.46 Pfam 1-49 (49) Show / Hide 
Range on Protein: 64-110
Range on HMM: 1-49/49
Sequence Identity: 42% (21 aa)

VALYDYTAMNDRDLQMLKGEKLQVLK-GTG-DWWLARSLVTGREGYVPS
||||||.|... .|.. ||....|..   . ||| .|.. ||.||..||
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH3_2 BLK.AA SH3_2 62-116 22 3.8e-11 41.92 Pfam 1-68 (68) Show / Hide 
Range on Protein: 62-116
Range on HMM: 1-68/68
Sequence Identity: 22% (15 aa)

FVVALYDYTA-MNDRD-----LQMLKGEKLQVL----KGTGDWWLA-RSLVTGRE--GYVPSNFVARV
..... ||..  . ..     |.  ||... |.    |  ..||.. ... .||.  |..||..|. .
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC
SH2 BLK.AA SH2 124-205 50 9.6e-44 130.26 Pfam 1-81 (81) Show / Hide 
Range on Protein: 124-205
Range on HMM: 1-81/81
Sequence Identity: 50% (41 aa)

WFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKIRCLDEGGYYISPRITFPSLQALVQHY
|....  |.||||.|..| |. |.||.||||...| ..|||.|  . |. .|||.|...|.|||||. | .|.||| ||.||
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGP-GDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 BLK.AA SH2 122-211 41 2.4e-33 118.02 SMART 1-87 (87) Show / Hide 
Range on Protein: 122-211
Range on HMM: 1-87/87
Sequence Identity: 41% (38 aa)

ERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKIRCLDEGGYYISP--RITFPSLQALVQHYSKKGDG
. |..    |.|||. |..| .. |.||.|.||.|.|...|||..     . .|||.||..|.|.|||    | .||||  ||.||..  .|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK----GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase BLK.AA SrcB 241-491 83 3.5e-201 674.66 In-house 1-251 (251) Show / Hide 
Range on Protein: 241-491
Range on HMM: 1-251/251
Sequence Identity: 83% (211 aa)

LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYAVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDM
|.||.|||.|||||||||||.|.||||.||.|.|||||||||.||||||.|||.||||||||||||||||.|||||.|||||||||||||.||||.||||
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKEPIYIITEYMAKGCLLDFLKTDEGSKLSLPKLIDM

SAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDS-EYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGM
|||||||||||||||.||||||||||||||.||||||||||||||.. ||||.|||||||||||||||.||.||||.||||||.||||.|||||.|||||
SAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYPGM

SNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVLE
.||||||||||||||||||.||.|||. ....||..||||||||..|||||.
TNPEVIRNLERGYRMPRPDNCPEELYN-IMMMCWKERPEERPTFDYLQSVLD
Kinase BLK.AA Src 241-490 67 2.5e-191 641.91 In-house 1-255 (255) Show / Hide 
Range on Protein: 241-490
Range on HMM: 1-255/255
Sequence Identity: 67% (171 aa)

LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYAVVTKE-PIYIVTEYMARGCLLDFLK-TDEGSRLSLPRLI
..|.||||.||||||||||...|.|||.||||.||||||||| ||..|| |.||.||.||||...| |||||||||..|.|||.|| ..||..|.||.||
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

DMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARIID--S-EYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVP
||.||.||||||.|.|| |||||.|.|.||.| ..||.|||||||.|.    ||.|..||||||||||||||..|.||||.||||||.||.|.|||||||
DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVP

YPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVL
||||.|.||....|||||||.|..||.|||  .. .||...||.|||||.||..|
YPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase BLK.AA SrcA 241-490 69 6.00000000001e-165 525.54 In-house 1-250 (250) Show / Hide 
Range on Protein: 241-490
Range on HMM: 1-250/250
Sequence Identity: 69% (175 aa)

LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYAVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDM
.|| |.|| |.||||||| .  . |||||||| ||||||||| || .|| |.|..||.|||||  ||||||||||..| |||||| .||  | ||.|.||
IRLERRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVSEEPIYIVTEYMCKGSLLDFLKDEEGKYLKLPQLVDM

SAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGM
.||.||||||.|||| |||||||||||| | | ||||||||||.| | ||||. |||||||||||||  .| ||||.||||||.|| |.|| ||||||||
AAQVAEGMAYMERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGM

SNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVL
 | ||.   ||||.|| |. ||  |.  .. .|||  ||||||||.||| |
NNREVLEQVERGYHMPCPQDCPESLHE-LMCQCWRKDPEERPTFEYLQSFL
Kinase BLK.AA SFK-Src 241-494 56 1.7e-163 488.84 In-house 1-259 (259) Show / Hide 
Range on Protein: 241-494
Range on HMM: 1-259/259
Sequence Identity: 56% (148 aa)

LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYAVVT-KEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLID
 || .||||||||.|| |   |   ||.|||| |.|| | || || ||| |.|..|..|||| | .|||||.|| |. | |||.|.  .|  | .| |.|
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVD

MSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARII--DSE-YTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPY
| ||.| |||| |  | .|||| | |.|| .   ||..|||..|..  |.| |||.||||||||||||||     | || ||||||.|.||.|||||.||
MAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPY

PGMSNPEVIRNLER--GYRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVLEDFY
|||.| ||.. ..|  ||||| |  ||.|.|  .  .||. .|..||||| |.  .|||.
PGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYK-IMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase BLK.AA Pkinase_Tyr 241-490 49 1.2e-146 497.25 Pfam 1-270 (270) Show / Hide 
Range on Protein: 241-490
Range on HMM: 1-270/270
Sequence Identity: 49% (133 aa)

LRLVRKLGSGQFGEVWMGYYK-----NNMKVAIKTLKEGTMSP----EAFLGEANVMKAL-QHERLVRLYAVVT--KEP--IYIVTEYMARGCLLDFLKT
... .|||.|.||||..|..|     ....||.|.||||.|..    |.|. ||..|| | .|. .||||.|.|  .||  ||||.|||. |.|||.|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

D--EGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARII--DSEY-TAQEGAKFPIKWTAPEAIHFGVFTIKADVWSF
   .. .|....|..|..|||.||.| |..| |||||.| |.||.| ...||.|||||| |  |..| ....|.|.||||.|||.|..|.||.| |||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GVLLMEVVTYGRVP-YPGMSNPEVIRNL-ERGYRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVL
|||. |..|||. | |||||| ||.. . |.|||||.|. ||.|.|.  . .||.  ||.||||. ... |
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDL-MKQCWHYDPEDRPTFSEIHEQL
Kinase BLK.AA Src-Unclassified 241-490 44 3.3e-136 458.8 In-house 1-284 (284) Show / Hide 
Range on Protein: 241-490
Range on HMM: 1-284/284
Sequence Identity: 44% (125 aa)

LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEG---TMSPEAFL--------GEANVMKALQHERLVRLYAVVTKE-PIYIVTEYMARGCLLDFLKTDE
..|.|||| ||||||| | ...   ||.||...|   ||||||||         ||..|| ..| .|| |||| ..| |.||.||||  | ||..|... 
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

GSRLSLPRL------------IDMSAQIAEGMAYIERMNSIHRDLRAANILVSEAL-----CCKIADFGLAR---IIDSEYTAQEGAKFPIKWTAPEAIH
|. | .. .            .|..||.| || | |    .|||| | |.|. .         |..||||||   . | .| .  ||.||.||.|||.. 
GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFI

FGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRP--DTCPPELYRGVIAECWRSRPEERPTFEFLQSVL
 | |.|| ||||.|.||.|. |.|..||||| | ||. ..|||||||.|    ||  .|  .   ||  .|. ||||..|   .
YGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase BLK.AA Frk 241-494 56 6.7e-131 441.18 In-house 1-260 (260) Show / Hide 
Range on Protein: 241-494
Range on HMM: 1-260/260
Sequence Identity: 56% (148 aa)

LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYAVVTKE-PIYIVTEYMARGCLLDFLK--TDEGSRLSLPRL
..|.|.|||||||||| | . |.. ||.|||| ||| |. || || .|| |.| .|..|||| | | ||||.|| | .| |...|.  .|.|... .. |
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

IDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLAR--IIDSE--YTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGR
.||.||.| ||||.| .| ||||| | |.|| | . ||||||||||  . | |  | .. ||.||||||||||..   ||||.||||||.||.|..||||
VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGR

VPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVLEDFY
.||||| | ||.  ...|||||.|  ||..||  .. |||.| |..||||| ||  |||..
MPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYE-IMLECWHSDPMKRPTFETLQWKLEDYF
Kinase BLK.AA TyrKc 241-490 42 3.3e-129 436.45 SMART 1-280 (280) Show / Hide 
Range on Protein: 241-490
Range on HMM: 1-280/280
Sequence Identity: 42% (122 aa)

LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKAL--QHERLVRLYAVVTK--------EPIYIVTEYMARGCLLDFLKTDEGS
..| .|||.|.||||. | .|  ..||.|.|||..   |.|. ||..|. |  .|. .||||.|.|.        ||..||.|||. |.|.|.|.  .. 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

RLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSE---------YTAQE--GAK--FPIKWTAPEAIHFGVFTIKAD
 |... |.... |||.||.|....| ||||| | |.||.| ...||.||||.| |...         |...|  |.|  .||.|.|||.| .|.||.| |
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

VWSFGVLLMEVVTYGRVPYPG-----MSNPEVIRNLERGYRMPRPDT--------CPPELYRGVIAECWRSRPEERPTFEFLQSVL
||||||.. |. |||  ||||     ||| |||.....|||||.|.         ||.|.|. .. .||.  ||.||||. . . .
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase BLK.AA TK 241-490 26 4.1e-120 404.6 In-house 1-486 (486) Show / Hide 
Range on Protein: 241-490
Range on HMM: 1-486/486
Sequence Identity: 26% (129 aa)

LRLVRKLGSGQFG---EVWMGYYKNN--------------------------MKVAIKTLKEG-TMSPEA--------------FLGEANVMKALQ----
..|..|||.||||   ||..| ...                           ..||.|.|||| .||.|.              || ||..|| ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HERLVRLYAVVTKE-------------PIYIVTEYMARGC----LLDFLKTDEG---------------------------------------------
 |. .||||.|.|..             |..||.|||. |.    |.|.|..  .                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----------------------------SRLSLPRLIDMSAQIAEGMAYIERM------NSIHRDLRAANILVSEALC-----------CKIADFG---
                             ..|....|. |..|||.||.|....      | .|||| | |.||.| .            |||||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARIIDS--EYTAQE------------------------GAKFPIKWTAPEAIH---------FGVFTIKADVWSFGVLLMEVVTYGRVPYPG-M
     ||| |.|  .|....                        |.|.||.|.|||..          .|.||.| ||||||||. |..|||..||.| |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN---------PEVIRNLERG--------------YRMPRPDTCPP-------------ELYRGVIAECWRSRPEERPTFEFLQSVL
||          ||...|.||              .|||.|. ||.             |.|  .. .||.  ||.||||. |.. |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase BLK.AA Src-Echino1 241-490 53 2.7e-118 399.31 In-house 1-252 (252) Show / Hide 
Range on Protein: 241-490
Range on HMM: 1-252/252
Sequence Identity: 53% (136 aa)

LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYAVVTKE-PIYIVTEYMARGCLLDFLKTDEGSRLSLPRLID
||. .|.|.|..|||| | .. | .||.|||||.|||| .|| |||||| ..|| .|..|||   . ||||||| | .| |.|.|| ... .. ...|||
LRMDKKIGKGHCGEVWKGVWNGNTPVAVKTLKEKTMSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHVKMTTLID

MSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPG
| |.|| || |... | .|||| | |.|| .   ||||||||||.. . .| ...|||.|||||||||. .| ||||.||||||.|. |.||.||.||||
MGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGRYPYPG

MSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVL
| | ||. ...||||||... ||  ||  ..  ||   |  ||||||| . .
MMNREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF
Kinase BLK.AA Tec 241-492 44 6.9e-115 387.97 In-house 1-254 (254) Show / Hide 
Range on Protein: 241-492
Range on HMM: 1-254/254
Sequence Identity: 44% (115 aa)

LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYAVVTKE-PIYIVTEYMARGCLLDFLKTDEGSRLSLPR--L
| ... ||||||| | .|..... .||||..|||.|| | |. || ||. |.|..||.|| | ... |||||||||..||||..|.. .. ...     |
LTFMKELGSGQFGVVHLGKWRHQYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKH-HFQKNMAIL

IDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLAR-IIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPY
..|  .. ||||| || . ||||| | | ||... . |..|||..| ..| .||   |.|||.|| .||  |.  .  | |||.||||  || . |..||
LEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPY

PGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVLED
. ||| ||.    .|.|. ||. |. ..|. .  .||. .|||||||. | . ...
ENMSNSEVVEHVSQGHRLYRPHLCSMHIYQ-IMYHCWHEKPEERPTFQQLLRQITE
Kinase BLK.AA SRM 241-491 46 2.2e-113 380.71 In-house 1-253 (253) Show / Hide 
Range on Protein: 241-491
Range on HMM: 1-253/253
Sequence Identity: 46% (118 aa)

LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGT-MSPEAFLGEANVMKALQHERLVRLYAVVTK-EPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLI
  | ||||.| ||||| |  |  ..||||  |    |  . .  |   || | |....||.||..  .|.||.|| |..| |. .|.. ..  |..| |.
FTLCRKLGEGYFGEVWEGLWKGQVHVAIKVIKRDNLMHQHMLQKEIQAMKKLRHKHIIRLHAVCSVGDPVYIITELMRKGNLQQYLRDSDEKALPIPHLL

DMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYP
|.  |.||||.| |  | ||||| | |.|| . . ||..|||||| | |  |    . . |.|||||||.  ... .| ||||||.|| |. ||| .|||
DFACQVAEGMCYLEEQNYIHRDLAARNVLVGDNNLCKVGDFGLARLIKDDIYSPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHEMFTYGQCPYP

GMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVLE
||.| | .   .||||||.|  |||| .     |||.. ||.||.|  |   | 
GMTNHETFQQIDRGYRMPCPAECPPEVHK-LMLECWCRDPEQRPCFKDLREKLT
Kinase BLK.AA S_TKc 241-495 26 2.4e-52 181.16 SMART 1-231 (231) Show / Hide 
Range on Protein: 241-495
Range on HMM: 1-231/231
Sequence Identity: 26% (71 aa)

LRLVRKLGSGQFGEVWMGYYKN-NMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYAVVTKEPIYIVTEYMAR--GCLLDFLKTDEG----SRLS
 ...||.|.| ||.|. .. |. . .|||| .|      | .. | ...|  .|. .|.|| |   . .|.|.||.    | |.|..|   .    ....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

LPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTI-KADVWSFGVLLMEVVTYG
  .   . .||.....|. ... |||||  .|||..|  . ||.||||||..               . ||| .    ..  |.|.||.|..| | .. |
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-G

RVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFLQS----VLEDFYT
. |.|   ..... .. .          .||.    |  |..  ||.|||   .      .  . . 
YPPFP---QMQMMFKKIG----------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase BLK.AA Pkinase 241-493 28 5.8e-43 152.99 Pfam 1-293 (293) Show / Hide 
Range on Protein: 241-493
Range on HMM: 1-293/293
Sequence Identity: 28% (85 aa)

LRLVRKLGSGQFGEVWMGYYKNNMK-VAIKTLKEGTMSPEAF-----LGEANVMKALQHERLVRLYAVV-TKEPIYIVTEYMARG----CLLDFLKTDEG
....||.||| ||.|. .. |.. | ||.|..|  . ...       | |. .|| |.|.  |||| .. .|  ||.|.||.  |     | |...|...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

SRL--SLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCC----KIADFGLARIIDSEYTAQEGAKFP---IKWTAPEAIH-FGVFTIKADVW
 ..  |   ....  ||..|..|. .|. |||||  .|||...   .    ||.|||||. .|  |  .. .. .   . . ||| |      . |.|.|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SFGVLLMEVVTYGRVPYPGM-------SNPEVIRNLERGYRMPRPDTCP------------------PELYRGVIAECWRSRPEERPTFEFLQSVLED--
|.|..| |... || |.||         .  . |.... .. ..| .|.                  .|  . .|  |..  |..|||    . .|..  
SCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQHPW

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