Gene CDK4 (Human)

CDK4

Species: Human
Alias: PSK-J3, CDK4, CMM3, MGC14458
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 12q13-q14.1,

Classification

Group: CMGC
Family: CDK
Subfamily: CDK4

Sequence

Name Sequence Type Origin Length Description Download
CDK4.AA Protein Sugen Kinome 303 None Fasta, JSON
CDK4.kin_dom Protein Kinase Domain Sugen Kinome 290 None Fasta, JSON
CDK4.NA RNA Sugen Kinome 1474 None Fasta, JSON

Protein domain

Protein domains of CDK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDK4.AA CDK4 6-295 69 4.1e-233 780.72 In-house 1-290 (290) Show / Hide 
Range on Protein: 6-295
Range on HMM: 1-290/290
Sequence Identity: 69% (202 aa)

YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDR-EIKVTLVFEHVDQDLRTYL
|..|||||.|||||||.|||.|.|||||||.||.|.|.  |||.|.||.||....|.|..|||||.|.|||||....||| |.|.|.||||.|.||.|||
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEE-GGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYL

DKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIF
||.||||.|..|||..|.|.|||.||||...|.||||||.|||||| |.|||||||||||||.||||||||||||||||||||||.|.||||||||||||
DKCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMALTPVVVTLWYRAPEVLLQSYYNTPVDMWSVGCIF

AEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL
|||..|.|||||.||.|||.||||..|||||||||||||||...||.|.|||.....|.|...|..||..||..|.|||.||...|||.|.
AEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLPWDHFPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase CDK4.AA CDK 6-295 44 1.6e-153 494.63 In-house 1-284 (284) Show / Hide 
Range on Protein: 6-295
Range on HMM: 1-284/284
Sequence Identity: 44% (143 aa)

YEPVAEIGVGAYGTVYKARDPHSG-----HFVALKSVRVPNG--GGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDRE------IKVTLV
|| ...|| |.||.|||||| ..|     ..|||| .|. |      . |.||...||..||. |    |||.|.|.||| |. .||.       |...|
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL----HPNIVKLHDVCHTKNMDRNNKDKHENKLYMV

FEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGT-----VKLADFGLARIYSY-------QMALTPVVVTLWY
||..|.|| .|.|           || .|.| ||||...| | |.|||||| |||... |.     .|.|||||||...        ....|..||||||
FEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWY

RAPEVLL-QSTYA--TPVDMWSVGCIFAEMFR---RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLE
||||.|| ...|   ||.|||||||||||||.   ||||| |.|| ||| |||...| | ||.||  ..||                        .||  
RAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY----------------------DLLNK

MLTFNPHKRISAFRALQHSYL
||...|.|||||  |||| |.
MLCYDPKKRISAEQALQHPYF
Kinase CDK4.AA CMGC 6-295 25 3e-123 407.14 In-house 1-513 (513) Show / Hide 
Range on Protein: 6-295
Range on HMM: 1-513/513
Sequence Identity: 25% (133 aa)

YEPVAEIGVGAYGTVYKARDPHSG--------------HFVALKSVR---VPNGGG---GGGGLPISTVREVALLRRLEA--------------FEHPNV
|| .  || |.||.|||.|| ...               .||.| ..    ....     . |.||.. ||. .|..|                  |.|.
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VRLMDVCATSRTDRE------------IKVTLVFEHVDQDLRTYLDKAP-------PPGLPAET------------IKDLM------RQFLRGLD--FLH
|.| |.. .. .|..             .. ||||..|.||  |... .       | .|.               || .|      .| ||||.  ..|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

ANC--IVHRDLKPENILVTSG--------------------GTVKLADFGLARIYSY----------------------QMALTPVVVTLWYRAPEVLLQ
 ..  |.||||||||||...                     |..|..||||||.|.                       ....|. |||.||||||.|| 
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

ST----------YATPVDMWSVGCIFAEMFRR--------KPLFCGNSE-----------ADQLGKIFDLIGLPP---------------EDDWPRDVSL
..          | ||.||||||||||||...        |||| |.||            ||| |||...| |.               |..||  ..|
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

PRG----------------------------AFPPRGPRPVQSVVPE-----------------------------------MEESGAQLLLEMLTFNPH
|.                              ||.. |.| ....|                                    . . .  ||  ||...|.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

KRISAFRALQHSYL
|||.|  |||| |.
KRITAEQALQHPYF
Kinase CDK4.AA CDC2 6-295 43 3.7e-118 364.87 In-house 1-301 (301) Show / Hide 
Range on Protein: 6-295
Range on HMM: 1-301/301
Sequence Identity: 43% (134 aa)

YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLD
|. .  || | || |||..|  ..  |||| .|. .   |  | | ...||  .|  |   .|||.|.| ||          |. .||| .|.||. |.|
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGD-GVPSTAIREISCLKELK--DHPNIVKLHDVIHQ------NKLYMVFEYLDMDLKKYMD

-KAPP-PGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPV--VVTLWYRAPEVLL-QSTYATPVDMWS
 . |.   .| ...|..| | |.|..|.|.. |.|||||| |||. . |..|.|||||||  .. . ..|.   ||||||||||.|| ...| |||||||
MSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWS

VGCIFAEM---FRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLP--RGAFPPRGPRPVQSVVPE---------MEESGAQLLLEMLTFNPHKRIS
.|||||||     .|||| | || ||| |||  .| | |..||   .||     ||   |   ....|          ... | .|| .||  .| ||||
IGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRIS

AFRALQHSYL
| .|||| |.
AKEALQHPYF
Kinase CDK4.AA CDK5 6-295 45 3.1e-110 349.61 In-house 1-287 (287) Show / Hide 
Range on Protein: 6-295
Range on HMM: 1-287/287
Sequence Identity: 45% (135 aa)

YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLD
|| .  || | ||||||||.  .. .|||| ||  .      | | . .||..||. |    |.|.||| ||  .     | | |||||..||||. |.|
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSED---EGVPSTAIREICLLKEL---KHKNIVRLHDVIHS-----EKKLTLVFEFCDQDLKKYMD

KAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWYRAPEVLLQS-TYATPVDMWSVGCI
.    .. ...|| .| | |.|| | |.. . |||||| | |.   |. ||||||||| .       .  |||||||.| ||. | .| |..||||.|||
SCNG-EMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCI

FAEMF-RRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRG-----AFPPRGPRP-VQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL
||||    .||| ||.. ||| .||...| | || ||    ||       ..|.. ...  |..||...| |  || .|| .||..||||  ||.| | 
FAEMANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDK4.AA S_TKc 6-295 29 2.6e-99 337.14 SMART 1-231 (231) Show / Hide 
Range on Protein: 6-295
Range on HMM: 1-231/231
Sequence Identity: 29% (89 aa)

YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ---DLRT
|| . .|| ||.|.|||.|. ..|. ||.| ..            ... ||...|..     |||.|.| ||. .       .. .|.|..|.   ||..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK----HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFD

YLDKAPPPG----LPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYAT-PVDM
|..| ...|    .|  ... .|.| ...|...| . |.||||||||||...  ..|..||||||..      | ...|.||.|||||    | . ..|.
YIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDW

WSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQ------
||.|||..||. ..|.|.      |. ..|..||                                  ... ...  .|...| ||..|  |||      
WSCGCILYEMLCGYPPFP------QMQMMFKKIG---------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK

-HSYL
 | ..
CHPWF
Kinase CDK4.AA PITSLRE 6-295 41 4.9e-81 275.54 In-house 1-295 (295) Show / Hide 
Range on Protein: 6-295
Range on HMM: 1-295/295
Sequence Identity: 41% (125 aa)

YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGG--GGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTY
.. .  |. |.|| ||.|.|   .  |||| . .   .      | ||  .||.  .  | |  |||.| .  .   |  |   |. .|.| |. ||.  
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKM---ERQKEKEGFPITSLREINMI--LMALQHPNIVNVKEIVMGSNMD---KIYMVMEYVEHDLKSL

LDKAP---PPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQ-MALTPVVVTLWYRAPEVLL-QSTYATPVDMW
...      | .| | || || | ||| ...| | | |||||  |.| .  |  |..|||||| | .  ...||.||||||||||.|| . .| ||||||
MENMKRRNQPFKPGE-IKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMW

SVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLP---RGA-FPPRGPRPVQSVVP---EMEESGAQLLLEMLTFNPHKRISAFRALQ
||||||||.   |||| |.|| ||. .|| . | | |  ||   .||   .   ||.  .    . .|      . |  ||  |||.|| .||.|  ||.
SVGCIFAEFITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALK

HSYL
| . 
HPWF
Kinase CDK4.AA Pkinase 6-295 30 7e-81 279.81 Pfam 1-293 (293) Show / Hide 
Range on Protein: 6-295
Range on HMM: 1-293/293
Sequence Identity: 30% (95 aa)

YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVR--EVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-----
|. .  || |..|.|||...  .|. ||.| ....   .   . ... .|  |.....||    |||.||| |.. .   ...|   .|.|...      
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR---HEKSWKDQTHRRLSEIQIMKRLN---HPNIVRLYDWFED---KDHIY--MVMEYCEGGLYVM

DLRTYLDKAPPPGL--PAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTV----KLADFGLAR---IYSYQMALTPVVVTLWYRAPEVLL-Q
|| .|.      ..  . ...|. |.| ||||...|.. |.||||||||||. . |..    |..|||||.   . ...  .| ...|.||.||||.. .
DLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGG

STYATPVDMWSVGCIFAEMFRRKPLFCGN----SEADQLGKIFDLIGLPPEDDWPRDVSLP--RGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHK
. | ..|||||.|||..||. ..|.|.|     . .||. .|.   | |.. ||| . | .     .. . ..  . . ....|.. ...  .|...|.|
QYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKK

RISAFRALQHSYL
|..|  .||| ..
RPTAEQILQHPWF
Kinase CDK4.AA PFTAIRE 6-295 40 2.8e-80 273.01 In-house 1-287 (287) Show / Hide 
Range on Protein: 6-295
Range on HMM: 1-287/287
Sequence Identity: 40% (122 aa)

YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLD
|| .   | | | ||||..    . ||||| .|  .      | |   .||. ||. |    | |.| | |.  | .|      |.||| |. || .|.|
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQQ----EEGTPFTAIREASLLKNL---KHANIVCLHDIIHTKET-----LTFVFEYVHTDLCQYMD

KAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSY-QMALTPVVVTLWYRAPEVLLQST-YATPVDMWSVGCI
|  | |.  . ..  . | |||| . |   . |||||| | |..  |  |||||||||  |         ||||||| | ||| || | | .||| ||||
KH-PGGMHPNNVRLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCI

FAEMFRRKPLFCGN-SEADQLGKIFDLIGLPPEDDWPRDVSLP---RGAFP--PRGPRPVQSVVPEME--ESGAQLLLEMLTFNPHKRISAFRALQHSYL
| ||.  .|.| |     |||.||| . | | || ||   .||     .|.     |.. . ..| ..    . .|. .||  .| .|.||  |.|| |.
FVEMMWGQPAFPGMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase CDK4.AA CDK10 6-295 41 2.6e-73 249.85 In-house 1-285 (285) Show / Hide 
Range on Protein: 6-295
Range on HMM: 1-285/285
Sequence Identity: 41% (123 aa)

YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLD
.| .  .| |.|| ||.||| .|   |||| ||.        ||||| .||. || ..    |.|.|.| .|      |    . || .. .|||   ||
FEKLNRVGEGTYGIVYRARDMRSDEIVALKKVRMDK---EKDGLPISGLREIMLLIQC---RHENIVELHEVVVGQHLD---SIFLVMQYCEQDLASLLD

KAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA-LTPVVVTLWYRAPEVLLQS-TYATPVDMWSVGCI
  | |   .. .| .| | |||| .|| | ..|||||  |.|.|  | .|.||||||| |.  .  .|| .|||||||||.|| . |  | .||| ||||
NMPQPFTETQ-VKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVADFGLARMYGVPVKPMTPKMVTLWYRAPELLLGCRTQTTAIDMWAVGCI

FAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRP---VQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL
 .|.   |||. ||||  |.  | ||.| | |  ||    ||          |   ..   . . .|| .||  .. .|| ||  |  .|. || 
LGELLVHKPLMPGNSEIHQIDMIIDLLGTPSENIWPGFSDLPMVQNFTLKKQPYNNLKHKFHWLSQSGRRLLNFLFMYNPKKRATAEECLESSYF
Kinase CDK4.AA MAPK 53-295 34 6e-68 232.04 In-house 51-328 (328) Show / Hide 
Range on Protein: 53-295
Range on HMM: 51-328/328
Sequence Identity: 34% (96 aa)

TVREVALLRRLEAFEHPNVVRLMDVCATSR----TDRE--IKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRG--LDFLHANCIVHRDLKPE
| ||. |||..   .|.|...| |.   .      ..|    . .|.|  . ||.  .   .   |  . |. .| | |||  | ..|  ...||||||.
TYREIKLLRHFH--HHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMETDLHQIIKSQQ--PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPS

NILVTSGGTVKLADFGLARIYSYQ---------------MALTPVVVTLWYRAPEVLLQ---STYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGK
||||.. ...|..||||||.   .               | .|. |.| ||||||..|      | . ||||||||||||| . ||||| |..  ||. .
NILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNL

IFDLIGLPPEDDWPRDV-S-LP----RGA--FPPRGPRPVQSVVPE----MEESGAQLLLEMLTFNPHKRISAFRALQHSYL
|....| |.|... .   |  .    ..   .|.. ..| ... |            ||  ||.|.|.|||..  |||| |.
IMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase CDK4.AA CRK7 6-239 35 6.3e-68 231.99 In-house 1-278 (343) Show / Hide 
Range on Protein: 6-239
Range on HMM: 1-278/343
Sequence Identity: 35% (100 aa)

YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCAT---SRTDREIK--VTLVFEHVDQDL
|| ...|| | || ||||.. | |  |||| ||  |      | ||  .||. .|| |   .|.|.|.|...          .. |  . .||| .| ||
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQL---NHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDL

RTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSY---QMALTPVVVTLWYRAPEVLL-QSTY-----
   |.         . .| .|.| | |.| .| . . |||.|  |||.   | ||.||||||| |     .  .|  |.|||||.|| ||    |     
MGLLESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHI

---------------------------------ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP
                                  . .||||.|||..| | .||.| || | .|| ||. . | |  . ||
LKELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWP
Kinase CDK4.AA Pkinase_Tyr 66-199 30 5.6e-15 51.35 Pfam 60-199 (270) Show / Hide 
Range on Protein: 66-199
Range on HMM: 60-199/270
Sequence Identity: 30% (45 aa)

F-EHPNVVRLMDVCATSRTDREIK--VTLVFEHVDQ-DLRTYLDKA--PPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADF
.  |||.|||. ||     |..    . .|.|..   ||..|| |   ... |. ... .  .|  .|...|... ..||||   |.|||....|| .||
LGHHPNIVRLYGVCT----DQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDF

GLARIYSYQMALTPVVVTL-------WYRAPEVLLQSTYATPVDMWS
||||   |      ....        |. |||..  . . |  | ||
GLARDI-YNDDYY-YRKRGGGKLPIKWM-APECINYGKFTTKSDVWS
Kinase CDK4.AA TyrKc 6-295 20 2.7e-13 -7.66 SMART 1-280 (280) Show / Hide 
Range on Protein: 6-295
Range on HMM: 1-280/280
Sequence Identity: 20% (68 aa)

YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL-EAFEHPNVVRLMDVCATS--RTDREI----KVTLVFEHVDQ
 .   ..| ||.|.|||..       || |...                ||  ....|    .|||.|||  || ..  .          . .|.|... 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------REDFMREARIMCKLGG--HHPNIVRLYGVCTQQGRN----FMYIEPLMIVMEYMPH

-DLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY----------SYQMA----LTPVVVTLWYRAP
 ||. || |  |  |. ..  . . |  .| ..|| ....||||   |.||....||| .||||.|            .| ..     .  .. .   ||
GDLKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

EVLLQSTYATPVDMWSVGCI------FAEMFRRKPLF--CGNSEADQLGKIFDLIGLPPE----DDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQL
|..  ... |  | || |        . ..    . .  . |.|. .. |  .    ||.                           .  ... .   |.
ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------F--VCCPDEMYQI

LLEMLTFNPHKRISAFRALQHSYL
 ..   ..|..| . |... |...
MKQCWHEDPEDRPT-FSEI-HECF
Kinase CDK4.AA CRK7 270-295 42 3.3e-09 27.68 In-house 318-343 (343) Show / Hide 
Range on Protein: 270-295
Range on HMM: 318-343/343
Sequence Identity: 42% (11 aa)

QLLLEMLTFNPHKRISAFRALQHSYL
.|| .||. .| ||..|  .||| ..
DLLDKMLCLDPKKRFTAEECLQHDWF
Kinase CDK4.AA MAPK 6-35 38 1.4e-08 25.53 In-house 1-36 (328) Show / Hide 
Range on Protein: 6-35
Range on HMM: 1-36/328
Sequence Identity: 38% (14 aa)

YEPVAEIGVGAYGTVYKARDPH------SGHFVALK
|...  || ||||.| .|.|        .| .||.|
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIK
Kinase CDK4.AA Pkinase_Tyr 6-24 36 7.19905 0.18 Pfam 1-19 (270) Show / Hide 
Range on Protein: 6-24
Range on HMM: 1-19/270
Sequence Identity: 36% (7 aa)

YEPVAEIGVGAYGTVYKAR
 .   ..| ||.|.|||..
ITFGKKLGEGAFGEVYKGT