Gene CDK6 (Human)

CDK6

Species: Human
Alias: MGC59692, PLSTIRE, CDK6
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 7q21.3 ,

Classification

Group: CMGC
Family: CDK
Subfamily: CDK4

Sequence

Name Sequence Type Origin Length Description Download
CDK6.NA RNA Sugen Kinome 11733 None Fasta, JSON
CDK6.AA Protein Sugen Kinome 326 None Fasta, JSON
CDK6.kin_dom Protein Kinase Domain Sugen Kinome 288 None Fasta, JSON

Protein domain

Protein domains of CDK6.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDK6.AA CDK4 13-300 68 3e-230 771.19 In-house 1-290 (290) Show / Hide 
Range on Protein: 13-300
Range on HMM: 1-290/290
Sequence Identity: 68% (198 aa)

YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEE--GMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDR-ETKLTLVFEHVDQDLTTYL
|.|||||||||||.|..||||..| .|||||.||...|||  |||.|||||..|.|||..|||||.|.|.|||.|..||| |.|.|.||||.|.||.|||
YQCVAEIGEGAYGTVYRARDLHTG-HFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYL

DKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIF
||.|.||.|..|||.||.|||||.|||||||..|||||||||||||.|..||||||||||||||||||.||||||||||||||||.|.||||.|||||||
DKCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMALTPVVVTLWYRAPEVLLQSYYNTPVDMWSVGCIF

AEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
|||..|.|||.|.|..|||.||.||.|||.|.||||||.||...|......|...|.......|.|||.|.|..|..||.|||..|.||||
AEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLPWDHFPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase CDK6.AA CDK 13-300 44 4.1e-160 516.09 In-house 1-284 (284) Show / Hide 
Range on Protein: 13-300
Range on HMM: 1-284/284
Sequence Identity: 44% (142 aa)

YECVAEIGEGAYGKVFKARDLKNG----GRFVALKRVRVQT-----GEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRE------TKLTLV
||....||||.||.|.||||...|    |..||||..|...      .||.| ..|||.. |..|    |||.|.|.|||. . .||.      .||..|
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL----HPNIVKLHDVCHTKNMDRNNKDKHENKLYMV

FEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ-----IKLADFGLARIYS-------FQMALTSVVVTLWY
||..|.|| .|.|           || .|.||||||...||....||||||||||... |.     .|.|||||||...        ....|..||||||
FEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWY

RAPEVLL-QSSYA--TPVDLWSVGCIFAEMFR---RKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLK
||||.|| .. |   ||.|.|||||||||||.   ||||| |.|. ||| || ...| | |..||  . ||                        ||| |
RAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY----------------------DLLNK

CLTFNPAKRISAYSALSHPYF
.|...|.|||||  ||.||||
MLCYDPKKRISAEQALQHPYF
Kinase CDK6.AA CMGC 13-300 25 4e-131 433.52 In-house 1-513 (513) Show / Hide 
Range on Protein: 13-300
Range on HMM: 1-513/513
Sequence Identity: 25% (131 aa)

YECVAEIGEGAYGKVFKARDLKNG-------------GRFVALKRVR---VQTG------EEGMPLSTIREVAVLRHLET--------------FEHPNV
||..  ||||.||.|.|.|| ...             ...||.|...    ...      ..|.| ...||.  |.||                  |.|.
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VRLFDVCTVSRTDRE------------TKLTLVFEHVDQDLTTYLDKVP--EPG------------------------VPTETIKDMMFQLLRGLD--FL
|.|.|... . .|..             .| ||||..|.||  |... .  ..|                         .   |. .|.|.||||.  ..
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYC

HSHR--VVHRDLKPQNILVTSS--------------------GQIKLADFGLARIYSF----------------------QMALTSVVVTLWYRAPEVLL
|||.  ..||||||.|||...                     |..|..||||||.|.                       ....|. |||.||||||.||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

QSS----------YATPVDLWSVGCIFAEMFRR--------KPLFRGSSD-----------VDQLGKILDVIGLPG---------------EEDWPRDVA
 ..          | ||.| ||||||||||...        |||| |.|.           .||| || .|.| |                ||.||  . 
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

LPRQ----------------------------AFHSKSAQPIEKFVTD-----------------------------------IDELGKDLLLKCLTFNP
||.                              |  .  .|..... .                                   .|... ||| |.|...|
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

AKRISAYSALSHPYF
.|||.|  ||.||||
DKRITAEQALQHPYF
Kinase CDK6.AA CDC2 13-300 43 1.2e-126 391.44 In-house 1-301 (301) Show / Hide 
Range on Protein: 13-300
Range on HMM: 1-301/301
Sequence Identity: 43% (136 aa)

YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEG--MPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLD
|...  |||| ||.|.|..|.. .   ||||..|. . .||   | ..|||   |  |   .|||.|.|.||          || .||| .|.||  |.|
YQKIEKIGEGTYGVVYKCKDMQTNQ-IVALKKIRLEQEDEGDGVPSTAIREISCLKELK--DHPNIVKLHDVIHQ------NKLYMVFEYLDMDLKKYMD

-KVPE-PGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM-ALT--SVVVTLWYRAPEVLL-QSSYATPVDLWS
 . |    .| ...|. |.|.|.|..|.|..|..||||||||||. ..|.||.|||||||  .. . ..|    ||||||||||.|| .. | ||||.||
MSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWS

VGCIFAEM---FRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALP--RQAFHSKSAQPIEKFVTD---------IDELGKDLLLKCLTFNPAKRIS
.|||||||     .|||| | |  ||| ||  ..| | |..||    ||   . |    .| ..| . .         .|. | ||| . |  .|.||||
IGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRIS

AYSALSHPYF
| .||.||||
AKEALQHPYF
Kinase CDK6.AA CDK5 13-300 47 2e-118 375.95 In-house 1-287 (287) Show / Hide 
Range on Protein: 13-300
Range on HMM: 1-287/287
Sequence Identity: 47% (140 aa)

YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKV
|| .  |||| || |.|||. |. . .|||||||     ||.| . |||...|. |    |.|.|||.||        | |||||||..||||  |.|..
YEKMEKIGEGTYGTVYKARN-KETHEIVALKRVRLDSEDEGVPSTAIREICLLKEL---KHKNIVRLHDVIHS-----EKKLTLVFEFCDQDLKKYMDSC

PEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM-ALTSVVVTLWYRAPEVLLQS-SYATPVDLWSVGCIFA
 . ..  ..|| .|.|||.|| | |.|.| |||||||| |.   |. ||||||||| .       .. |||||||.| ||. |  | |..|.||.|||||
NG-EMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFA

EMF-RRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQ-----AFHSKSAQP-IEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
||    .||| |... ||| .| ...| | |. ||    ||       .. .  |..  .. |   || | ||| | | .||..||||  || ||||
EMANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDK6.AA S_TKc 13-300 32 1.2e-101 344.92 SMART 1-231 (231) Show / Hide 
Range on Protein: 13-300
Range on HMM: 1-231/231
Sequence Identity: 32% (97 aa)

YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ---DLTTYL
|| . .||.||.|||.|.|. |  || ||.|...          ...||...|..     |||.|.|.||.        ..| .|.|..|.   || .|.
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK---------EHIRREIQILKK----HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYI

DKVPEPG----VPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYAT-PVDLWS
.| . .|     |  ... .| |....|...|||...||||||.|||...  .||..||||||..      |....|.||.|||||   .| . ..| ||
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWS

VGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALS-------H
.|||..||. ..|.|.      |. .....||                                 .. .||.. |||...|.||..|  ||        |
CGCILYEMLCGYPPFP------QMQMMFKKIG---------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCH

PYF
|.|
PWF
Kinase CDK6.AA Pkinase 13-300 30 4e-89 307.2 Pfam 1-293 (293) Show / Hide 
Range on Protein: 13-300
Range on HMM: 1-293/293
Sequence Identity: 30% (97 aa)

YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR--EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-----DL
|...  ||.|..|.|.|... ..|   ||.|...... ..... . .|  |......|    |||.|||.|...      .... .|.|...      ||
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN---HPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDL

TTYLDKVPEPGV--PTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQI----KLADFGLARI--YSFQMALTSVVVTLWYRAPEVLL-QSSY
 .|.    . ..  . ...|..| |.||||...||....||||||.|||. . |.|    |..|||||.   |  .  .|....|.||.||||.. .. |
FDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYY

ATPVDLWSVGCIFAEMFRRKPLFRGS----SDVDQLGKILDVIGLPGEEDWP------RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPA
 ..|| ||.|||..||. ..|.|.|.    . .||. .|  . | | ..|||      ..  ...   |    .  ..| . ..| .||.. .||...|.
GPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H----F-HWTF-HNWSEECKDFIKWCLCKDPK

KRISAYSALSHPYF
||..|  .| ||.|
KRPTAEQILQHPWF
Kinase CDK6.AA PITSLRE 13-300 40 5.8e-89 301.87 In-house 1-295 (295) Show / Hide 
Range on Protein: 13-300
Range on HMM: 1-295/295
Sequence Identity: 40% (124 aa)

YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQ--TGEEGMPLSTIREVA-VLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYL
..|.  |.||.|| |..|.| |  .. |||||. .      || |.  .||.  .|. |    |||.| .  .   |  |   |  .|.| |. ||   .
FQCLNRIHEGTYGVVYRAKD-KRTDEIVALKRLKMERQKEKEGFPITSLREINMILMAL---QHPNIVNVKEIVMGSNMD---KIYMVMEYVEHDLKSLM

DKVP---EPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ-MALTSVVVTLWYRAPEVLL-QSSYATPVDLWS
..      |  | | || .| ||||| ...|.. . |||||  |.| . .|. |..|||||| |    ...|..||||||||||.|| .  | ||||.||
ENMKRRNQPFKPGE-IKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWS

VGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPR-QAFHSKSAQPI----EKFV--TDIDELGKDLLLKCLTFNPAKRISAYSALSH
|||||||.   |||| |.|..||. .|    | | |  ||    ||   .. . . .|     ..|   . | . | ||| . ||.||..||.|  || |
VGCIFAEFITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKH

PYF
|.|
PWF
Kinase CDK6.AA PFTAIRE 13-300 43 3.2e-87 296.07 In-house 1-287 (287) Show / Hide 
Range on Protein: 13-300
Range on HMM: 1-287/287
Sequence Identity: 43% (129 aa)

YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKV
|| .   ||| | .|.|..   | ..||||| .| |  ||| |   |||.  |. |    | |.| | |.    .|     ||.||| |. || .|.|| 
YEKLEKLGEGSYATVYKGISCIN-QQFVALKEIRLQQ-EEGTPFTAIREASLLKNL---KHANIVCLHDIIHTKET-----LTFVFEYVHTDLCQYMDKH

PEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF-QMALTSVVVTLWYRAPEVLLQSS-YATPVDLWSVGCIFA
|  |   . ..  .||||||| . |  || |||||||| |..  |  |||||||||  |       . ||||||| | ||| |  | | .|.| ||||| 
PG-GMHPNNVRLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFV

EMFRRKPLFRGSSDV-DQLGKILDVIGLPGEEDWPRDVALP---RQAFH--SKSAQPIEKFVTDID--ELGKDLLLKCLTFNPAKRISAYSALSHPYF
||.  .|.| | .|. |||.||  | | | |. ||    ||    ..|     . .. .. .  |.    . ||. | |  .| .|.||  |..||||
EMMWGQPAFPGMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase CDK6.AA MAPK 13-300 35 2.5e-84 286.44 In-house 1-328 (328) Show / Hide 
Range on Protein: 13-300
Range on HMM: 1-328/328
Sequence Identity: 35% (117 aa)

YECVAEIGEGAYGKVFKARDLK-----NGGRFVALKRV-RVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSR----TDRE--TKLTLVFEH
|. .  ||.|||| |..|.| .     . |..||.|.. |. . .  .   |.||.  |||.   .|.|...|.|. | .      ..|    . .|.| 
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCK-RTYREIKLLRHFH--HHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMEL

VDQDLTTYLDKVPEPGVPTETIKDMMFQLLRG--LDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ---------------MALTSVVVTL
 . ||   .   .      . |.  |.|.|||  | ..|| .|.|||||| ||||.. .. |..||||||.   .               | .|  |.| 
METDLHQIIKSQQ--PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATR

WYRAPEVLLQ---SSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV--ALPRQAFHS------KSAQPIEKFVTD---
||||||..|      | . || |||||||||| . |||||.|.. .||. .|..|.| | ||.. .      .|. ..|      . ..| ||   .   
WYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANF

-IDELGKDLLLKCLTFNPAKRISAYSALSHPYF
  . .  ||| | |.|.| |||..  ||.||||
NANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase CDK6.AA CRK7 13-300 31 9.7e-77 261.26 In-house 1-343 (343) Show / Hide 
Range on Protein: 13-300
Range on HMM: 1-343/343
Sequence Identity: 31% (111 aa)

YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTG---EEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTV---SRTDRETK--LTLVFEHVDQD
|| ...|||| ||.| ||..... |  ||||.|| .     .|| |   |||. .|| |   .|.|.|.| .. |        ...|    .||| .| |
YEMIMQIGEGTYGQVYKAKNKHT-GEMVALKKVRMDNEKIKKEGFPITAIREIKILRQL---NHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHD

LTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF---QMALTSVVVTLWYRAPEVLL-QSSY----
|   |.         . .| .| ||| |.| .|   . |||.|  |||.  .|..|.||||||| |     .  .|  |.|||||.|| ||    |    
LMGLLESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQH

----------------------------------ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL-------PRQAFH
                                   . .| ||.|||..| | .||.|.|.   .|| ||  . | |  . ||    |       |.. . 
ILKELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYN

SKSAQPIE-KFV-TDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
...    . ..    ...   ||| | |. .| ||..|  .| |..|
RRLREEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase CDK6.AA CDKL 13-236 39 4.1e-68 231.97 In-house 1-217 (286) Show / Hide 
Range on Protein: 13-236
Range on HMM: 1-217/286
Sequence Identity: 39% (90 aa)

YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKV
||  . .|||.||.|.| |. |. |. || |.      ..     . ||.  |. |    |.| | |  |.      |  || |||| .|  .  .|.. 
YEKLGKVGEGSYGVVMKCRN-KETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQL---KHENIVNLIEVFR-----RKRKLHLVFEYCDHTVLHELEEY

PEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT-SSGQIKLADFGLARIYSFQM-ALTSVVVTLWYRAPEVLLQ-SSYATPVDLWSVGCIF
|. ||. . ..  |.|.|....|.|.| ..||| || |||.| ..||.|| |||.||. . .  ..|  | | |||||| |.   .| .|||.|..||..
PN-GVDEHVVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVM

AEMFRRKPLFRGSSDVDQLGKILDVIG
|||..  ||. |.||.||| .|  ..|
AEMIDGQPLWPGQSDIDQLYHIQKCLG
Kinase CDK6.AA Pkinase_Tyr 13-168 30 1.9e-19 66.5 Pfam 1-159 (270) Show / Hide 
Range on Protein: 13-168
Range on HMM: 1-159/270
Sequence Identity: 30% (51 aa)

YECVAEIGEGAYGKVFKARDL---KNGGRFVALKRVRVQTGEEG-MPLSTIREVAVLRHL-ETFEHPNVVRLFDVCT-VSRTDRETKLTLVFEHVDQ-DL
 .   ..||||.|.|.|..     .|..  || | .. .. .|  .  . .||......|     |||.|||  |||  ..     .. .|.|..   ||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGH---HPNIVRLYGVCTDQGEPN---QIYIVMEYMPHGDL

TTYLDKV--PEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR
 .|| |   ... ...... .| .|  .|...|.|.. .||||   |.|||.....| .||||||
LDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase CDK6.AA TyrKc 13-300 21 1.7e-14 11.74 SMART 1-280 (280) Show / Hide 
Range on Protein: 13-300
Range on HMM: 1-280/280
Sequence Identity: 21% (70 aa)

YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHL-ETFEHPNVVRLFDVCTVS--RTDRE---TKLTLVFEHVDQ-DL
 .   ..||||.|.|.|..      . || | ..  .         .||  ....|    .|||.|||. ||| .  .         | .|.|...  ||
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-----REDFMREARIMCKLGG--HHPNIVRLYGVCTQQGRN---FMYIEPLMIVMEYMPHGDL

TTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY----------SFQMALT--SVV--VTLWYRAPEVL
  || |  .  .....  ....|  .| ..|||....||||   |.||.. ...| .||||.|            .  .. .  .    . .   |||..
KDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

LQSSYATPVDLWSVGCIFAEMFRR-KPLFRG-----SSDVDQLGKILDVIGLPGEED----WPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCL
  . . |  | || |    |.| . ..   |      |. . . .. .   .|  ..                          ||.  ||. . . ..| 
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------------------FVCCPDEMYQ-IMKQCW

TFNPAKRISAYSALSHPYF
 ..|..| .      | .|
HEDPEDRPTFSEI--HECF
Kinase CDK6.AA CDKL 257-300 28 3.1e-09 27.72 In-house 242-286 (286) Show / Hide 
Range on Protein: 257-300
Range on HMM: 242-286/286
Sequence Identity: 28% (13 aa)

KSAQPIEKFVTDID-ELGKDLLLKCLTFNPAKRISAYSALSHPYF
.  .|.|| . ..  ..  |.. |||  .|..|...  ...||||
EHMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF