Gene CLK1 (Human)

CLK1

Species: Human
Alias: CLK/STY, CLK1, STY, CLK
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 2q33.2-q34,

Classification

Group: CMGC
Family: CLK

Sequence

Name Sequence Type Origin Length Description Download
CLK1.AA Protein Sugen Kinome 526 None Fasta, JSON
CLK1.kin_dom Protein Kinase Domain Sugen Kinome 317 None Fasta, JSON
CLK1.NA RNA Sugen Kinome 2213 None Fasta, JSON

Protein domain

Protein domains of CLK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CLK1.AA CLK 203-519 60 8.3e-261 792.06 In-house 1-350 (350) Show / Hide 
Range on Protein: 203-519
Range on HMM: 1-350/350
Sequence Identity: 60% (210 aa)

YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQ-VLEHLNTT-DPNSTFR--CVQMLEWFEH-HGHICIVFELLGLSTYDFIKEN
||||.|||||.|||||||.||| |...||.||..||..|.|||..||. .....|.. |||....  |..|..||.. ||||||||||.|||.|||.|.|
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

G------FLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQS-----DYTEAYNPKIK---------RDERTLINPDIKVVDFGSAT---YD
.      ..|...||||.||||.|..|.|||..||||||||||||.||.|     |.|  ||.| |         ...... |..|.|.||||||   .|
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVDSRFTHFDCTFKYNHKKKINKKSNNCVCHYWHVKNTHICVIDFGSATKIRFD

DEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILG-PLPKHMIQKTR----KRKYFHHDRLDWDEHSSAGR
.|||||.|||||||||||||.||||||||||||||||.|.|.|||.|.|||..|||||||||.| |.|..|||.||    |.|||.|.|||||.|.|.||
HEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYFYHNRLDWDWHNSDGR

YVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFF
|| ..|||||..|...| ||..|||||.|||||||.||||...||.||||
YVMENCKPLKQYMDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase CLK1.AA CMGC 203-519 22 2.1e-113 374.23 In-house 1-513 (513) Show / Hide 
Range on Protein: 203-519
Range on HMM: 1-513/513
Sequence Identity: 22% (118 aa)

YEIVDTLGEGAFGKVVECID-------------HKAGGRHVAVKIVKNVDRYCEAAR-------------SEIQVLEHLNTT---------DPNSTFR--
|||.. .|||..|.|..|.|             |. ....||.|..||.  | | |.              ||. |.||| .         ||..  .  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

CVQMLEWFEHHG-----------------HICIVFELLGLSTYDFIKENGF-------LPFRLDH------------IRKMA------YQICKSVN--FL
.|.....| |..                 |...|||... . |..||.| |       .|.   |            |...       |||.....  ..
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSNK--LTHTDLKPENILFVQSDY----------TEAYNPKIKRDERTLINPDIKVVDFGSATYDDEH------------------------HSTLVSTR
||..    |.||||||||. .             .   ||.       . |  .|. |||.|.. ..|                        ... |.||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSED-W-NPC-------QKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTR

HYRAPEVILALG----------WSQPCDVWSIGCILIEYYLG--------FTVFPTHDS-----------KEHLAMMERILGPLPKHMIQKTR-------
.|||||..|  .          ...|.|.||.|||. | |.|         . ||.|..            ..|... ..||. . .||||..       
WYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCK

-KRKYFHHDRLDWDEH----------------------SSAGRYVSRRCKPLKEFMLSQDV--------------------------------EHERLFD
 ..... .  |.| .                       .| .|.  ...||.|...  ..                                 ... ..|
HEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAID

LIQKMLEYDPAKRITLREALKHPFF
|..|||.|||.||||  .||.||.|
LLKKMLQYDPDKRITAEQALQHPYF
Kinase CLK1.AA Pkinase 203-519 27 1.2e-91 315.53 Pfam 1-293 (293) Show / Hide 
Range on Protein: 203-519
Range on HMM: 1-293/293
Sequence Identity: 27% (94 aa)

YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARS-----EIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGL-----STYD
|.|. ..|.|.||.| .|.... |   |||||.| ... ..  ..     |||.. .||     . .  |....||| ..||..|.|...      . .|
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-----HPN-IVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD

FIK---ENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSA----TYDDEHHSTLVSTR
.|.   ...|. |  .......|||.. ....||..  | ||||||||... ....|               ..|. |||.|    .  ..  .|.. |.
YISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA---------------CVKICDFGLAKQFDY-NNS-MTTFCGTP

HYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFTVFPTH----DSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKE
.|.|||||. . ......|.||.||||.| ..| . || |    .  ....|..||.|| ..  ..... . ||. .|  | .               . 
WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---------------F-

FMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFF
...  .  .| . |.| ..|..||.||.| ...|.||.|
HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase CLK1.AA S_TKc 203-519 28 6.6e-83 282.65 SMART 1-231 (231) Show / Hide 
Range on Protein: 203-519
Range on HMM: 1-231/231
Sequence Identity: 28% (96 aa)

YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGL---STYDFIKENGF
|||....|.||||||  |...|  ||.||.||.|      | .|.|||.|..            |.....|.. .|...|.|...    . .|.||..| 
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

----LPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILA
     ||   |.|...||||. ....||..  | ||||||||. .                      ||. |||.|.      .|.. |..|.||||.  
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---------------------HIKICDFGLARQL----TTFCGTPWYMAPEVL--

LGWSQ-PCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFD
 |..  .||.||.||||.| . | . ||     .. .|...|.                                                    . . |
-GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG---------------------------------------------------SPEAKD

LIQKMLEYDPAKRITLREALK-------HPFF
.|.|.|..||.||.|  |||.       ||.|
FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CLK1.AA DYRK 203-340 46 1.1e-59 204.61 In-house 1-139 (320) Show / Hide 
Range on Protein: 203-340
Range on HMM: 1-139/320
Sequence Identity: 46% (65 aa)

YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPF
|||.. .| | ||.|| | ||  .. .||.||..|  |.   |  ||. ||.||. ||. ...||.|.. | |..| |||||||  . |.|.|.|.| .|
YEILEYIGKGSFGQVVKCWDH-KTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGF

-RLDHIRKMAYQICKSVNFLHSN-KLTHTDLKPENILFVQ
  | ..||.|.||...  |||.| .. | |||||||. .|
FSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQ
Kinase CLK1.AA DYRK2 203-337 45 1.7e-54 175.49 In-house 1-134 (318) Show / Hide 
Range on Protein: 203-337
Range on HMM: 1-134/318
Sequence Identity: 45% (61 aa)

YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPF
|||.  .| | || ||.| |||  . |||.|.. |  |. . |  ||..|.|. . |...|. || ||. |   .|.||.||||... |..||.| |  |
YEILEVIGKGSFGQVVKCYDHKT-KQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGF

RLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENIL
 |  .|..|..| .. .||| |.. | ||||||||
SLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENIL
Kinase CLK1.AA DYRK1 203-457 35 2.9e-50 173.31 In-house 1-240 (321) Show / Hide 
Range on Protein: 203-457
Range on HMM: 1-240/321
Sequence Identity: 35% (91 aa)

YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPF
|||   .| |.||.||   ||.    .||.||.||   . . |. ||..|| .|  |... .. |.. . | .  |.|.|||||    || ..   |   
YEIDSLIGKGSFGQVVKAYDHQE-QEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGV

RLDHIRKMAYQICKSVNFLHSNKLT--HTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQ
 |  .||.| |.|... |. .  |   | |||||||| .        |||            ||..||||.   ..     .  | ||.|||.| . .. 
SLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLC--------NPKRSA---------IKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDM

PCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRK-RKYFHHD
  |.||.||||.|   |  .|   .  . .  .  .||  |||||... | .|||..|
AIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKD
Kinase CLK1.AA YAK 203-422 35 9.2e-48 160.14 In-house 1-206 (347) Show / Hide 
Range on Protein: 203-422
Range on HMM: 1-206/347
Sequence Identity: 35% (79 aa)

YEIVDTLGEGAFGKVVECIDHKAGGRH-VAVKIVKNVDRYCEAARSEIQVLEHLNT-TDPNSTF---RCVQMLEWFEHHGHICIVFELLGLSTYDFIKEN
| . | || | || || |   . .    .|||..||   |   |. |||.|. ||   |||      . . |.  | |  | |.|||.| .. |...| |
YIVLDMLGQGTFGQVVKC--QNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQN

GFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALG
 |  |    ||    ||  .   | . .. | |||||||.  . .                  |.||..||||. .      | .  ||||.||.|.   
KFCGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPN-----------------KPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMI

WSQPCDVWSIGCILIEYYLGFTVFP
 .   | || |||. | .||  .||
YCTSIDMWSLGCIVAELFLGLPIFP
Kinase CLK1.AA CAMK 208-411 20 9.3e-41 128.58 In-house 1-324 (425) Show / Hide 
Range on Protein: 208-411
Range on HMM: 1-324/425
Sequence Identity: 20% (69 aa)

TLGEGAFGKVVECIDHKAGG-----------RHVAVKIVKNV-----------------------------DRYCEAARSEIQVLEHLN-----TTDPNS
|||.|.|||| .||. . .|           ..||.||..                               .. ..  |.||... .|.        || 
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN-

TFRCVQMLEWFEHHGH-------------------ICIVF---ELLGLS----T-YDFIKENGFL-------------PFRLDHIRKMAYQICKSVNFLH
    ....|..| . .                   ...|.   |.          .|.|.|.|                |  .  |..  |||  |...|
---IIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCH

SNKLTHTDLKPENILFVQS---------DYTEAYNPKIKRDERTLINPDIKVVDFGSATY--------------------------DDEHHSTLVSTRHY
|..  | ||||||||....         |  | . .        . | .||..||| |..                          ...  .| . | .|
SHNIVHRDLKPENILLDDNNDDSDPVEHD--EIF-D--------WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEY

RA-PEVILA--------------LGWSQPCDVWSIGCIL
 | |||..                . ...||.||.|.||
MAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase CLK1.AA HIPK 203-339 38 8.4e-39 119.49 In-house 1-135 (329) Show / Hide 
Range on Protein: 203-339
Range on HMM: 1-135/329
Sequence Identity: 38% (53 aa)

YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPF
||... || | ||.|| |   .. .  ||.|| ||   |    . |...|. | . ...  .  | ..| |.|. |.|.|||.|    ||| |.| | | 
YEVLEFLGRGTFGQVVKCW-KRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADE-YHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPL

RLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFV
 | ||| .  |. .    | .  | | |||||||. |
PLKHIRPILQQVLTALMKLKELGLIHADLKPENIMLV
Kinase CLK1.AA STE 203-413 20 9.4e-39 134.49 In-house 1-260 (359) Show / Hide 
Range on Protein: 203-413
Range on HMM: 1-260/359
Sequence Identity: 20% (60 aa)

YEIVDTLGEGAFGKVVECIDHKAGGRH--------------VAVKIVKNVD------------------RYCEAARSEIQVLEHLN-TTDPNSTFRCVQM
.|... .|.||||.|. ...|| .  |              .|.|...  .                     .    ||... ..| .  ||     |. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHM-HPN----IVKY

LEWFEHHG-------HICIVFELLG-LSTYDFIKENGFLPFR------------LDHIRKMAYQICKS-VNFLHSNKLTHTDLKPENILFVQSDYTEAYN
.  ... |       ...|. |...  |  |.||...  ...             . |.....||.|   ..|||..  | |.|| |||.          
YGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----------

PKIKRDERTLINPDIKVVDFGSATYDDE-------------------HHSTLVSTRHYRAPEVILA------LGWSQPCDVWSIGCILIE
              .| .||| ..  ..                   .  |.| |  . |||||.        | .  ||.||.|| .||
--------------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIE
Kinase CLK1.AA DYRK 360-519 32 1e-38 134.97 In-house 143-320 (320) Show / Hide 
Range on Protein: 360-519
Range on HMM: 143-320/320
Sequence Identity: 32% (59 aa)

NPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQK---TRKRKYFHH
...|||.||||... ... .| .  |.|||||||| .  . . |.|| |||| | ..|   ||  .  . ||..  .||. ||.||.|   .||.|.|  
KSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC

DRLDWDEHSSAGRYVS-----------------RRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFF
  . ..|. ..                      || .  . .   .. . . . |.|.|.|..||.||||  .||.||.|
--FMYCECDEWTKQNKITDHYMTPKCHPTKRGQRRPPGRRNWDPRHQCDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase CLK1.AA DYRK2 362-519 29 3.2e-35 111.77 In-house 142-318 (318) Show / Hide 
Range on Protein: 362-519
Range on HMM: 142-318/318
Sequence Identity: 29% (53 aa)

DIKVVDFGSATYDDE-HHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQK------TRKRKYF
.|||.|||| ..... .  | . .| |||||||| .  . . | || |||. | | |.  ||  . .. .|.|  .||  ||.....      .|.. .|
GIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFF

H--------------HDRLDWDEHSSAGRYVSRRCKPLKEFML-SQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFF
                . .     ...|.      |..|...  ..|   | . | |.. .| ||..|.| ..|||||..
NSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCED---ENFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase CLK1.AA PRP4 203-337 31 1.4e-23 83.16 In-house 1-138 (320) Show / Hide 
Range on Protein: 203-337
Range on HMM: 1-138/320
Sequence Identity: 31% (44 aa)

YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTT--DPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENG-F
|...   |.| |. |. | |   |   ||.||. | .        |. .|  || .  |.|  | ||.| . |.|. |.|.||| .  .  . .|. |  
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

LPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENIL
  . |. .|  |.|.      |  ..  | |.|| |||
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNIL
Kinase CLK1.AA HIPK 363-422 42 1.4e-13 38.62 In-house 144-204 (329) Show / Hide 
Range on Protein: 363-422
Range on HMM: 144-204/329
Sequence Identity: 42% (26 aa)

IKVVDFGSATYDDEH-HSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFP
.||.||||| .  .   .| .  |.|||||.||.|   .  |.|| ||.. | .||   .|
VKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLGWPLYP
Kinase CLK1.AA CAMK 494-519 53 6.9e-13 37.15 In-house 400-425 (425) Show / Hide 
Range on Protein: 494-519
Range on HMM: 400-425/425
Sequence Identity: 53% (14 aa)

DLIQKMLEYDPAKRITLREALKHPFF
|||.|||..|| ||.|. ..|.||..
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase CLK1.AA PRP4 494-519 65 1.8e-11 38.32 In-house 295-320 (320) Show / Hide 
Range on Protein: 494-519
Range on HMM: 295-320/320
Sequence Identity: 65% (17 aa)

DLIQKMLEYDPAKRITLREALKHPFF
||. |.|  ||.||||. |||||||.
DLLDKCLMLDPKKRITCNEALKHPFI
Kinase CLK1.AA TyrKc 203-519 16 9.6e-11 -48.96 SMART 1-280 (280) Show / Hide 
Range on Protein: 203-519
Range on HMM: 1-280/280
Sequence Identity: 16% (60 aa)

YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHL--NTTDPNSTFRCVQMLEWFEHH-------GHICIVFELLGL-STYD
 .  ..|||||||.|....      . |||| .|.     |. ..|.... .|  .   ||     |...    ..       . ..||.|.  . .  |
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA--REDFMREARIMCKLGGHH--PN----IVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEH------HSTLVSTR-
......   . ...  ....||..  ..|||... | ||   |.| | ...                   .|. ||| . . ...      ... ...  
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCL-VGENH------------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEH

-HYR--------APEVILALGWSQPCDVWSIGCIL-------IEYYLG-----FTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEH
 . .        |||.|     .   |||| |  .        . | |      . .  .   ..  .|..   ..   |                    
KGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS-------------------

SSAGRYVSRRCKPLKEFMLSQDVE-HERLFDLIQKMLEYDPAKRITLREALKHPFF
                |     |. .. .......  ..||..| | .|   | .|
----------------F-----VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase CLK1.AA DYRK1 487-519 48 2.4e-10 32.07 In-house 289-321 (321) Show / Hide 
Range on Protein: 487-519
Range on HMM: 289-321/321
Sequence Identity: 48% (16 aa)

VEHERLFDLIQKMLEYDPAKRITLREALKHPFF
..  .  |||..||.|||..|||  .||.|.||
EDYLKFKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase CLK1.AA PRP4 363-422 46 8.1e-10 32.19 In-house 146-206 (320) Show / Hide 
Range on Protein: 363-422
Range on HMM: 146-206/320
Sequence Identity: 46% (29 aa)

IKVVDFGSATYDDEHHST--LVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFP
.| .|||||    |   |  ||| | |||||.|.        |.||.|| | | | |   ||
LKMCDFGSASHIHENEITPYLVS-RFYRAPEIIIGHPYDYQIDMWSVGCTLYELYTGKIMFP
Kinase CLK1.AA STE 492-519 46 2.7e-07 21.92 In-house 330-359 (359) Show / Hide 
Range on Protein: 492-519
Range on HMM: 330-359/359
Sequence Identity: 46% (14 aa)

LFDLIQKMLEYDPAKRITLREALK--HPFF
. | |.| |..|| || |  . ||  |||.
FKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase CLK1.AA HIPK 482-519 34 2e-06 15.72 In-house 292-329 (329) Show / Hide 
Range on Protein: 482-519
Range on HMM: 292-329/329
Sequence Identity: 34% (13 aa)

MLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFF
.. . .  .   ..  ||.  |. ||||  |||.||| 
YRVEKIDRREFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase CLK1.AA YAK 479-519 30 1.9e-05 14.02 In-house 302-347 (347) Show / Hide 
Range on Protein: 479-519
Range on HMM: 302-347/347
Sequence Identity: 30% (14 aa)

KEFMLSQDVE-----HERLFDLIQKMLEYDPAKRITLREALKHPFF
| ||  || .      . . |.|  .|. .| .| .   | .||| 
KQFMRNQDDTKNNRHRDCFIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase CLK1.AA Pkinase_Tyr 203-237 34 2.5e-05 18.69 Pfam 1-38 (270) Show / Hide 
Range on Protein: 203-237
Range on HMM: 1-38/270
Sequence Identity: 34% (13 aa)

YEIVDTLGEGAFGKVVECIDH---KAGGRHVAVKIVKN
 ..  .|||||||.|.... .   . .. .||||..|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE
Kinase CLK1.AA Pkinase_Tyr 274-331 23 0.00803 10.18 Pfam 75-137 (270) Show / Hide 
Range on Protein: 274-331
Range on HMM: 75-137/270
Sequence Identity: 23% (15 aa)

EHHGH--ICIVFELLGL-STYDFIKEN--GFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDL
.. ..  |.||.|.  . . .|. ...  .  |. . .. .|..||.|  ..|.|... | ||
DQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL