Gene CLK2 (Human)

CLK2

Species: Human
Alias: MGC61500, CLK2, hCLK2, clk2
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 1q21-q23.1,

Classification

Group: CMGC
Family: CLK

Sequence

Name Sequence Type Origin Length Description Download
CLK2.NA RNA Sugen Kinome 2178 None Fasta, JSON
CLK2.AA Protein Sugen Kinome 499 None Fasta, JSON
CLK2.kin_dom Protein Kinase Domain Sugen Kinome 317 None Fasta, JSON

Protein domain

Protein domains of CLK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CLK2.AA CLK 163-479 65 4.3e-271 823.49 In-house 1-350 (350) Show / Hide 
Range on Protein: 163-479
Range on HMM: 1-350/350
Sequence Identity: 65% (230 aa)

YEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEIN-VLEKINEK-DPDNKNL--CVQMFDWFDY-HGHMCISFELLGLSTFDFLKDN
||||.||||||||.||.|.||..|...||||||.|||||.|||..||| ...||||| ||.||..  |..|.||||| |||.||.|||.|||..||.|.|
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

N------YLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNS-----DYELTYNLEKK---------RDERSVKSTAVRVVDFGSAT---FD
|      |.||||...||||.|||.|||||||.||||||||||||.||.|     |....|| .||         .....||.| ..|.||||||   ||
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVDSRFTHFDCTFKYNHKKKINKKSNNCVCHYWHVKNTHICVIDFGSATKIRFD

HEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILG-PIPSRMIRKTR----KQKYFYRGRLDWDENTSAGR
||||||||||||||||||||.|||||||||||||||.||.|.||||||||||||||||||||.| |||..||..||    ||||||..|||||...|.||
HEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYFYHNRLDWDWHNSDGR

YVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFF
||.||||||..|......||.||||||. ||||.|.||.|...|||||||
YVMENCKPLKQYMDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase CLK2.AA CMGC 163-479 20 3.5e-112 370.12 In-house 1-513 (513) Show / Hide 
Range on Protein: 163-479
Range on HMM: 1-513/513
Sequence Identity: 20% (109 aa)

YEIVSTLGEGTFGRVVQCVDHRRG-------------GARVALKIIKNVEKYKEAAR-------------LEINVLEKIN-EKDPDN-----------KN
|||.. .||||.| |..|.|.|..             . .||.|.|||.. |.| |.              ||  |...| ..|| |           .|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

LCVQMFDWFDYHG-----------------HMCISFELLGLSTFDFLKDNN--YLP------------------------YPIHQVRHMAFQLCQAVK--
 .|...|.| ...                 |... ||... . ....|.|.  | .                        ..| ..| ...|.....|  
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

FLHDNK--LTHTDLKPENILFVNSDYEL--------TYNLEKKRDERSVKSTAVRVVDFGSATFDHEH------------------------HSTIVSTR
..| ..    |.||||||||. .    .        . .  ..     .|.  ... |||.|.. |.|                        ... |.||
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSED-W-NPC-----QKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTR

HYRAPEVILELG----------WSQPCDVWSIGCIIFEYYVG--------FTLFQTHDN-----------REHLAMMERILGPIPSRMIRKTR-------
.|||||..|  .          ...|.|.||.|||..| | |         .||..|..            ..|... ..||... .||.|..       
WYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCK

-KQKYFYRGRLDWDEN----------------------TSAGRYVRENCKPLRRYLTSEAE--------------------------------EHHQLFD
 .......  |.| ..                       | .|. . ..||...      .                                ...|..|
HEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAID

LIESMLEYEPAKRLTLGEALQHPFF
|.. ||.|.|.||.|  .|||||.|
LLKKMLQYDPDKRITAEQALQHPYF
Kinase CLK2.AA S_TKc 163-479 25 3e-77 263.85 SMART 1-231 (231) Show / Hide 
Range on Protein: 163-479
Range on HMM: 1-231/231
Sequence Identity: 25% (84 aa)

YEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGL---STFDFLKDNNY
|||. ..|.|.||.| .|....  | .||.||||      | .| ||..|.|       .    |...|.|.  .|... .|...    . ||..|....
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

----LPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILE
     |.|  ..|... |.|.|....|...  | ||||||||. .                      . . |||.|..     .|.. |..|.||||.  
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---------------------HIKICDFGLARQL----TTFCGTPWYMAPEVL--

LGWSQ-PCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFD
 |..  .||.||.|||..| ..| ..|.     .. .|...|.                                                    ... |
-GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG---------------------------------------------------SPEAKD

LIESMLEYEPAKRLTLGEALQ-------HPFF
.|. .|...|.||.|  ||||       ||.|
FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CLK2.AA Pkinase 163-479 25 7.8e-75 259.72 Pfam 1-293 (293) Show / Hide 
Range on Protein: 163-479
Range on HMM: 1-293/293
Sequence Identity: 25% (85 aa)

YEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEA---ARL--EINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGL-----STFD
|.|....|.|.||.| .|...  |  .||.|||| ... ..    .|.  || .. ..|      .|  |...||| ...|... .|...      . ||
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-----HPNI-VRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD

FLK---DNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYEL-TYNLEKKRDERSVKSTAVRVVDFGSA----TFDHEHHSTIVST
...   .....  . ....... |........|...  | ||||||||.. ..... .                |.. |||.|    .   .  .|.. |
YISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDA---------------CVKICDFGLAKQFDY-NNS-MTTFCGT

RHYRAPEVIL-ELGWSQPCDVWSIGCIIFEYYVGFTLFQTH----DNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLR
..|.|||||.   ......|.||.|||..| . | ..|. |    . .....|..||.||.... . ...   ||.  |  | .            . ..
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H------------F-HW

RYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFF
.  .   ||   . |.|...|.. |.||.|  ..||||.|
TF-HNWSEE---CKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase CLK2.AA DYRK 163-300 43 9.4e-52 178.26 In-house 1-139 (320) Show / Hide 
Range on Protein: 163-300
Range on HMM: 1-139/320
Sequence Identity: 43% (61 aa)

YEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPY
|||.. .| |.|| ||.| || ...  ||.|||.| ...   |  ||. ||..|..|||.|  ||.|.| | ...|.|| ||||  . ..||| |.  ..
YEILEYIGKGSFGQVVKCWDH-KTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGF

-PIHQVRHMAFQLCQAVKFLHDN-KLTHTDLKPENILFVN
 ..  || .|.|.... |||| | .. | |||||||. ..
FSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQ
Kinase CLK2.AA DYRK1 163-415 32 5.2e-48 165.83 In-house 1-237 (321) Show / Hide 
Range on Protein: 163-415
Range on HMM: 1-237/321
Sequence Identity: 32% (83 aa)

YEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPY
||| | .| | || ||.  || .    ||.|||||   . . |..|| .|| .|..|...|   |..   | .  |.|. ||||    .| |.  ..   
YEIDSLIGKGSFGQVVKAYDHQE-QEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGV

PIHQVRHMAFQLCQAVKFLHDNKLT--HTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQ
 .  .| .| |.|.|. |.    |   | |||||||| .|.                 |  |....||||.    .     .  | ||.|||.|.. .. 
SLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNP-----------------KRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDM

PCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFY
  |.||.|||. |  .|  ||   .  . .  .  .||  |..|| .. | . ..
AIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYF
Kinase CLK2.AA DYRK2 163-297 41 4e-47 151.12 In-house 1-134 (318) Show / Hide 
Range on Protein: 163-297
Range on HMM: 1-134/318
Sequence Identity: 41% (56 aa)

YEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPY
|||.. .| | || || | || . .  ||.|.| |  .. . |  ||..|..| ..|.||   || |.| | . .|.|| ||||...  ...| |..  .
YEILEVIGKGSFGQVVKCYDHKT-KQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGF

PIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENIL
    || .|... |. .||| |.. | ||||||||
SLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENIL
Kinase CLK2.AA Ciliate-E2 163-479 16 1.2e-42 144.2 In-house 1-365 (365) Show / Hide 
Range on Protein: 163-479
Range on HMM: 1-365/365
Sequence Identity: 16% (71 aa)

YEIVSTLGEGTFGRVVQC-VDHRRG------------------GARVALKIIKNVEKY-KEAARLEINVLEKINEKD-----------PDNKNLCVQMFD
|...  .|.|.|| | .| |.  .                   .. . .. .|...|. .|.   ||... .||. .            .| .  ..|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYE

WFD--YHGHMCISFELL-GLSTFDFLKDN----------NYLPYPIHQVRHMAFQLCQ---------------AVKFLHDNK-LTHTDLKPENILFVNSD
.|      .. . .|.. | . ||..|.|            ... . .....  |..|               |...|| ..   | |.|||||||    
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

YELTYNLEKKRDERSVKSTAVRVVDFGSATFDH----------------------------------EHHSTIVSTRHYRAPEVILELG---------WS
                    . ..||| ... .                                  . . ||. | .| |||..   .         ..
--------------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYD

QPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCK-PLRRYLT--------------S
  ||.||.|.|..|   | . |                                                  ..... ...                  |
YKCDIWSLGVILYEMLFGKPPF-------------------------------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKS

EAEEHHQLFDLIES----MLEYEPAKRLT-LGEALQHPFF
  .   .  |||      ||...| ||.|   ..|.||.|
WKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase CLK2.AA DYRK 319-479 31 1.5e-38 134.39 In-house 142-320 (320) Show / Hide 
Range on Protein: 319-479
Range on HMM: 142-320/320
Sequence Identity: 31% (57 aa)

KSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRK---TRKQKYFY
.  .. |.||||..| |.. .| .  |.|||||||| .  . . |.|| |||. | . |  ||.  .. . ||..  .||..|. ||.|   .||.|.| 
NKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFD

RGRLDWDENTSAGRYVR----------------ENCKPLRRYLTSEAEEHHQLF-DLIESMLEYEPAKRLTLGEALQHPFF
.  . ..| ...    .                ..  | || . .. . . ..| |.|. .|...|.||.|  .|||||.|
C--FMYCECDEWTKQNKITDHYMTPKCHPTKRGQRRPPGRRNWDPRHQCDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase CLK2.AA HIPK 163-299 35 2.2e-37 114.98 In-house 1-135 (329) Show / Hide 
Range on Protein: 163-299
Range on HMM: 1-135/329
Sequence Identity: 35% (49 aa)

YEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPY
||..  || |||| || |   |  .  ||.||.||   |    . |. .|... ....|. .. | ... |. . |.|. ||.|    .||.|.|.. | 
YEVLEFLGRGTFGQVVKCW-KRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADEYHF-VRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPL

PIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFV
|.. .| . .|   | . | .  | | |||||||. |
PLKHIRPILQQVLTALMKLKELGLIHADLKPENIMLV
Kinase CLK2.AA YAK 163-381 30 7.3e-37 122.51 In-house 1-205 (347) Show / Hide 
Range on Protein: 163-381
Range on HMM: 1-205/347
Sequence Identity: 30% (69 aa)

YEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEK-DPDNKN---LCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNN
| .   || |||| || |         .| |.|||   |   |..|| .|.  |.. ||.|||     . | | | .  |.|. ||.| .. ...|| |.
YIVLDMLGQGTFGQVVKCQNCDTNEL-FAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNK

YLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGW
.    .  .|    |   .   | . .. | |||||||.  .                 . . .....||||.        | .  ||||.||.|.    
FCGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCK-----------------PNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIY

SQPCDVWSIGCIIFEYYVGFTLF
.   | || |||. | . |  .|
CTSIDMWSLGCIVAELFLGLPIF
Kinase CLK2.AA CAMK 168-372 17 2.6e-34 107.41 In-house 1-325 (425) Show / Hide 
Range on Protein: 168-372
Range on HMM: 1-325/425
Sequence Identity: 17% (59 aa)

TLGEGTFGRVVQCVDHRRGG-----------ARVALKIIKNV-----------------------------EKYKEAARLEINVLEKINEKDP--DNKNL
|||.|.|| |  |.. . .|            .|| |||.                               .| ..  | ||... |.....   | .|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

CVQMFDWFDYHGH-------------------MCISF---ELLGLS----T-FDFLKDNNYL-------------PYPIHQVRHMAFQLCQAVKFLHDNK
 ........ . .                   |.. .   |.          ||..... .               .. ...|..  |.|.||...|...
-IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

LTHTDLKPENILFVNSD-----------YELTYNLEKKRDERSVKSTA-VRVVDFGSAT-FDHEH-------------------------HSTIVSTRHY
  | ||||||||.....           . .              ... . ..||| |. ||. .                          .| . | .|
IVHRDLKPENILLDDNNDDSDPVEHDEIF-D-------------WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEY

RA-PEVIL--------------ELGWSQPCDVWSIGCIIF
 | |||..              . . ...||.||.|.| .
MAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILY
Kinase CLK2.AA DYRK2 323-479 27 1.1e-27 86.86 In-house 143-318 (318) Show / Hide 
Range on Protein: 323-479
Range on HMM: 143-318/318
Sequence Identity: 27% (50 aa)

VRVVDFGSATFDHE-HHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRK------TRKQKYFY
. |.|||| .|.|. .  | . .| |||||||| .  . . | || |||. | | |. ||   .  . .|.|  .||  |. .. .      .|.. .| 
IKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFN

--------------RGRLDWDENTSAGRYVRENCKPLRRYLT-SEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFF
              .  .    . ..|.    . |..  .|. .| |    . | |   .| .|..|.|  .||.||..
SHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCEDE---NFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase CLK2.AA PRP4 163-297 35 4.4e-26 92.5 In-house 1-138 (320) Show / Hide 
Range on Protein: 163-297
Range on HMM: 1-138/320
Sequence Identity: 35% (49 aa)

YEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEK--DPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDN-NY
|....  |.| |. |..| |  || . || ||| | |  .     |. .| |.|..  |.. |  ||.||. | .. |||. || .  .  . ||     
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

LPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENIL
    .  ||  | ||  | | |  ..  | |.|| |||
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNIL
Kinase CLK2.AA HIPK 323-415 30 1.9e-11 31.83 In-house 144-237 (329) Show / Hide 
Range on Protein: 323-415
Range on HMM: 144-237/329
Sequence Identity: 30% (29 aa)

VRVVDFGSATFDHEH-HSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFY
|.|.|||||    .   .| .  |.|||||.|| |   .  |.|| ||.| | . |  |.   |. .    ..   .     .. . .|.. |.
VKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLGWPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFF
Kinase CLK2.AA CAMK 454-479 46 4.7e-11 31.14 In-house 400-425 (425) Show / Hide 
Range on Protein: 454-479
Range on HMM: 400-425/425
Sequence Identity: 46% (12 aa)

DLIESMLEYEPAKRLTLGEALQHPFF
||| .||...| ||.|. ..|.||..
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase CLK2.AA PRP4 326-414 39 2.2e-10 34.28 In-house 149-239 (320) Show / Hide 
Range on Protein: 326-414
Range on HMM: 149-239/320
Sequence Identity: 39% (36 aa)

VDFGSATFDHEHHST--IVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTR-KQKYF
.|||||   ||   |   || | |||||.|.        |.||.|| ..| | |  .|    | . | ..  . | .| .||||   | ..|
CDFGSASHIHENEITPYLVS-RFYRAPEIIIGHPYDYQIDMWSVGCTLYELYTGKIMFPGKTNNHMLKLFMDYKGKMPNKMIRKGQFKDNHF
Kinase CLK2.AA PRP4 450-479 50 6.2e-10 32.62 In-house 291-320 (320) Show / Hide 
Range on Protein: 450-479
Range on HMM: 291-320/320
Sequence Identity: 50% (15 aa)

HQLFDLIESMLEYEPAKRLTLGEALQHPFF
||. ||.. .|   |.|| |. |||.|||.
HQFKDLLDKCLMLDPKKRITCNEALKHPFI
Kinase CLK2.AA TyrKc 163-479 15 8.2e-10 -63.98 SMART 1-280 (280) Show / Hide 
Range on Protein: 163-479
Range on HMM: 1-280/280
Sequence Identity: 15% (56 aa)

YEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKI--NEKDPDNKNL------CVQMFDWFDYHGHMCISFELLGL-STFDF
 .   .|||| ||.|....        || | .|.    .|. . |.... |.  .     ..|.      |.| .  | | . ..| .|.  . .  |.
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA--REDFMREARIMCKLGGH-----HPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEH------HSTIVSTR--
|...     .  .  ....| ..   .||.... | ||   |.| |....                   |.. ||| . . ...      .......   
LRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCL-VGENH------------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHK

HYR--------APEVILELGWSQPCDVWSIGCIIFE-------YYVG-----FTLFQTHDNREHLAMMERILG--PIPSRMIRKTRKQKYFYRGRLDWDE
. .        |||.| .   .   |||| |  ..|        | |      . .. . . ..  .|..     |.                       
GGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------

NTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFF
                    .  . .  .......  ...|..| |  |   | .|
--------------------F-VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase CLK2.AA DYRK1 447-479 48 4.2e-09 27.6 In-house 289-321 (321) Show / Hide 
Range on Protein: 447-479
Range on HMM: 289-321/321
Sequence Identity: 48% (16 aa)

EEHHQLFDLIESMLEYEPAKRLTLGEALQHPFF
|. ..  |||. ||.|.|..|.|  .||||.||
EDYLKFKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase CLK2.AA YAK 452-479 35 7.9e-05 11.91 In-house 320-347 (347) Show / Hide 
Range on Protein: 452-479
Range on HMM: 320-347/347
Sequence Identity: 35% (10 aa)

LFDLIESMLEYEPAKRLTLGEALQHPFF
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FIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase CLK2.AA HIPK 454-479 38 0.000541 7.92 In-house 304-329 (329) Show / Hide 
Range on Protein: 454-479
Range on HMM: 304-329/329
Sequence Identity: 38% (10 aa)

DLIESMLEYEPAKRLTLGEALQHPFF
..   |.  .. ||.|  |||.||| 
HVLKKMCTWDAHKRITPCEALNHPFV