Gene DYRK1B (Human)

DYRK1B

Species: Human
Alias: DYRK1B, MIRK
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 19q13.13,

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK1

Sequence

Name Sequence Type Origin Length Description Download
DYRK1B.NA RNA Sugen Kinome 2540 None Fasta, JSON
DYRK1B.AA Protein Sugen Kinome 629 None Fasta, JSON
DYRK1B.kin_dom Protein Kinase Domain Sugen Kinome 321 None Fasta, JSON

Protein domain

Protein domains of DYRK1B.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DYRK1B.AA DYRK1 111-431 81 4.5e-243 813.79 In-house 1-321 (321) Show / Hide 
Range on Protein: 111-431
Range on HMM: 1-321/321
Sequence Identity: 81% (263 aa)

YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS
||||||||||||||||||||||.||.||||||||||.|.||||||.|||||||.||.|||||||||||||||||||||||||||||||||||||||||||
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

LNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGE
||||||.|||.||||||..||||.|||||||||||||||||||||||.|||||||||||||||||||||||||||||..||.||||||||||||||||||
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGE

PLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLR
|||||||||||||.||||||.||..|.||||||.||||..| ..|....|.. .|.|. |.||.|.|.|||.||||||||.||||||..|||.|.||..|
PLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDPDNTWYCKKTRDKKKHYKEPCTRKLHEILGVETGGPGGRRKGEPGHSVEDYLKFKDLIKR

MLEYEPAARISPLGALQHGFF
||.|.|..||.|. ||||.||
MLQYDPKQRITPYYALQHSFF
Kinase DYRK1B.AA DYRK 111-431 51 4.7e-197 660.92 In-house 1-320 (320) Show / Hide 
Range on Protein: 111-431
Range on HMM: 1-320/320
Sequence Identity: 51% (169 aa)

YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGV-
|||.. |||||||||||..||.|.|.||||||.|.|.|..|||||...||..||.| ..||..||....|..|||||.||||||.|||..|.|.||.|. 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

SLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNP-KRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHT
||||.|| |||..|.|.||...| .|||||||||||.|..| ..|.||..||||||. .||||.||||||||.|||.||.||. |||||||||||.|..|
SLNLVRKFAQQILTCLKFLHKNE-NIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFT

GEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQA--PKARKYFERLPGGGWTLRRTKELRKD-YQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQ
|.|||.|.||.||...|.||||.||  |.|..  ....|.|..     ..  .... ... .. ..|..... .. ....|.||| ..|.|  .|.. | 
GWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC---FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQFK

DLVLRMLEYEPAARISPLGALQHGFF
|.....|...|. ||.|  |||| .|
DFIKKCLQWDPHKRITPSQALQHPWF
Kinase DYRK1B.AA DYRK2 111-379 47 3.6e-131 428.96 In-house 1-283 (318) Show / Hide 
Range on Protein: 111-379
Range on HMM: 1-283/318
Sequence Identity: 47% (135 aa)

YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS
|||.. |||||||||||.||| |...||||.| ||| |.|||..|.| |. . ..|    . .||..  |.||||.|..||||| |||..... || | |
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

LNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQ-RIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTG
|.| |. |... ..| ||   .  |||||||||||||  . || ||..||||||   | ||| ||||||||.||| ||..|. ||||||.|||..|. ||
LQLVRRFAHSILQCLRFLH--KNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTG

EPLFSGSNEVDQMNRIVEVLGIPPAAMLDQA-----PKARKYFER---------LPGGGWTLRRTKELRKDYQG-PGTRRLQEVL
 ||| |.||.||.  . ||||.||. ..|..      ... .|..         .. .. .. . .  |..  . ||.. ...||
YPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVL
Kinase DYRK1B.AA CMGC 111-431 21 6.2e-118 389.36 In-house 1-513 (513) Show / Hide 
Range on Protein: 111-431
Range on HMM: 1-513/513
Sequence Identity: 21% (113 aa)

YEIDSLIGKGSFGQVVKAYD--------------HQTQELVAIKIIKNKKAFLNQAQ-------------IELRLLELMN-QHDTEM-----------KY
|||.. ||.|..|.|.|..|              |.|.|.||||.|||.. . .||.              |...|. .| .||. .           . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

YIVHLKRHFMFRN-----------------HLCLVFELLSYNLYDLLRNTH--------------------------FRGVSLNLTRKLAQQLCTALL--
.||.|. .|...|                 ||.||||.. ..||....|..                           .  .. . |  ..|....|   
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

FLATPELSIIHCDLKPENILLCNPKRS------------------AIKIVDFGSSCQLGQR------------------------IYQYIQSRFYRSPEV
..    ..|||.||||||||... ...                   .|| |||........                        ...|...|.||.||.
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

LLGTP----------YDLAIDMWSLGCILVEMHTG--------EPLFSGSNE-----------VDQMNRIVEVLGIPPAAMLDQ-------APKARKYFE
||| .          |. .|||||.|||. || ||        .||| |..|           .||...|..||| |.  |...       ... .....
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPN

RLPGGGWTLRRTKE----LRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSP-------------------------------ADYLRFQDLVLRMLE
...  .. .. .|.     ....   . . .|  .  ..  |   .  .|.|..                                .   . ||. .||.
MIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQ

YEPAARISPLGALQHGFF
|.|. ||..  |||| .|
YDPDKRITAEQALQHPYF
Kinase DYRK1B.AA YAK 111-352 45 1.8e-109 369.95 In-house 1-244 (347) Show / Hide 
Range on Protein: 111-352
Range on HMM: 1-244/347
Sequence Identity: 45% (113 aa)

YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMN-QHDTEMKY---YIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHF
| .    |.| ||||||     | ||.|.|.|||. |.. ||  | ..|.. | ||| . |     |. .   | ..||.|||||.|| |||..| .. |
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

RGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEM
.| | .| |    |   ..  |.  .  |||||||||||.||.| . .|||.|||||||  . .| |||.|.|||||......|  .|||||||||..| 
CGFSFQLIRQWTKQILDGMCVLE--NKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAEL

HTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPG
  | |.| |  | .|. ||...||.||  |.||     ||| .. |
FLGLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYFHCHDG
Kinase DYRK1B.AA S_TKc 111-431 25 3.8e-80 273.5 SMART 1-231 (231) Show / Hide 
Range on Protein: 111-431
Range on HMM: 1-231/231
Sequence Identity: 25% (87 aa)

YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSY---NLYDLLRNTHFR
|||  .||||.||.| |.... |...|||||||      .... |...|.           .||.|. .|   .||..|.|...    .|.|....   .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

G----VSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDL-AIDMWSLGCI
|     .   .|....|.| || ..   .. |||.|||||||||..     ||| |||...||    . .. ...|..||||   .|.  ..|.||.|||
GLRFPFPE-HARFYMYQICCALEYCH--SHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

LVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYL
| || .|.|.|.      ||... ...|                                                                        
LYEMLCGYPPFP------QMQMMFKKIG----------------------------------------------------------------------SP

RFQDLVLRMLEYEPAARISPLGALQ-------HGFF
 . |.. ..|...|. |..   |||       | .|
EAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase DYRK1B.AA HIPK 111-368 39 1e-75 237.85 In-house 1-258 (329) Show / Hide 
Range on Protein: 111-368
Range on HMM: 1-258/329
Sequence Identity: 39% (104 aa)

YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS
||.  ..|.| ||||||.  . |.|.|||||.||   .  | |||...|. . | . .  | .|     |  .|| |||||.|  |||| ... .|    
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENAD-EYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLP

LNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMH
|.  | . ||  |||. |   ||..|| |||||||.|  |.|    .|..||||   . . . . |.|||.|| ||..|| |.  ..|||||||.. | .
LKHIRPILQQVLTALMKLK--ELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELF

TGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQ
 | ||. |..| ||   | .  . |   .| .| |. ..|.|.   .. . | |...   |
LGWPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRDKQSKFRPWRLKHIEEHEQ
Kinase DYRK1B.AA Pkinase 111-431 25 2.3e-61 214.96 Pfam 1-293 (293) Show / Hide 
Range on Protein: 111-431
Range on HMM: 1-293/293
Sequence Identity: 25% (88 aa)

YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQI-----ELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSY-----NLYDL
|.| . ||.||||.| |.... |...||.|||| ...  .. |.     |....  . .|.      || |.. |. ..|...|.|..        |.|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPN-----IVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

LR---NTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAI----KIVDFGSSCQL---GQRIYQYIQSRFYRSPEVLL-GTP
..   .. |   | .  .. . |.. .| ..     .|||.||||||||.   ..  |    || |||...|.   ..  . .  ...|..|||.. |..
ISTWRHGCFY-FSEWECKFYMYQILRGLEYCHS--MGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQY

YDLAIDMWSLGCILVEMHTGEPLFSGS----NEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGG
|. ..||||.|||| || .|.|.|.|.    | .||| .|....| |.    ..    . .| . .                                  
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H------------------------------

PGGRRAGEPGHSPADY---LRFQDLVLRMLEYEPAARISPLGALQHGFF
        . |..  .     ..|.. ..|.. |. |...  .||| .|
--------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase DYRK1B.AA PRP4 111-316 39 3.9e-59 202.79 In-house 1-208 (320) Show / Hide 
Range on Protein: 111-316
Range on HMM: 1-208/320
Sequence Identity: 39% (84 aa)

YEIDSLIGKGSFGQVVKAY-DHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQH--DTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRN-THF
|.. . .|.| |. |...    ...| |||||| |.         ||  |  .|    | . |. .| ..||| .|.|.||||| .| || ..|      
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

RGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLG-QRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVE
 | .|.  |  ||||  ||  |    . |.| |.|| |||  |  .. .|..||||  .   . |  | .|||||.||...| ||| .||||| || | |
VGLHLKAVRSYAQQLFLALKHLK--KCNILHADIKPDNILV-NESKNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYE

MHTGEPLFSGS
. ||  .|.|.
LYTGKIMFPGK
Kinase DYRK1B.AA CDK 111-431 26 2.2e-57 182.11 In-house 1-284 (284) Show / Hide 
Range on Protein: 111-431
Range on HMM: 1-284/284
Sequence Identity: 26% (97 aa)

YEIDSLIGKGSFGQVVKAYDHQTQ-----ELVAIKIIK---N-----KKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFR-----------NHL
||.   || |..|.| || |.||.     ..||.| |.   .     |  |   |  |  ||  .  |.     .|| |.  ..             | |
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--HP-----NIVKLHDVCHTKNMDRNNKDKHENKL

CLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPK---RSAIKIVDFGSSCQLG--------QRIYQ-YI
 .||| . . |. ...            . . .||  .| ..   .  |.| |||| |||. |     .  .|| ||| ..  |        .| |   .
YMVFEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCH--SNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEV

QSRFYRSPEVLL-GTPYD--LAIDMWSLGCILVEMHT---GEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQ
  . ||.||.||  . |.   .|||||.|||..|| |   ..||| |..| ||. .| ...| |   .     |   |                      
VTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY----------------------

GPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFF
                                     ||  .|| |.|. |||   |||| .|
-------------------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase DYRK1B.AA CLK 111-250 31 5.3e-46 135.47 In-house 1-150 (350) Show / Hide 
Range on Protein: 111-250
Range on HMM: 1-150/350
Sequence Identity: 31% (48 aa)

YEIDSLIGKGSFGQVVKAYDHQT-QELVAIKIIKNKKAFLNQAQIELR-LLELMNQH-DTEMKYY--IVHLKRHFMF-RNHLCLVFELLSYNLYDLLRNT
||| .  | | || ||.  ||.    .||.|||.| . .  .|..|..  ..  |.  | . ||   ....   | .  .| |.||||.  ..||... .
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

H------FRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNP
.      ...  .. .|..| |||.|. ||   .....| |||||||.....
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLH--DMKLTHTDLKPENICFVDS
Kinase DYRK1B.AA MAPK 235-431 27 3.6e-38 129.47 In-house 138-328 (328) Show / Hide 
Range on Protein: 235-431
Range on HMM: 138-328/328
Sequence Identity: 27% (62 aa)

IIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR-----------------IYQYIQSRFYRSPEVLLG---TPYDLAIDMWSLGCILVEMHT-GEPLF
.||.||||.|||.   .    || ||| .... .                    .|.  |.||.||..|.   . |. |.||||.|||. || | . |||
VIHRDLKPSNILV--NENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLF

SGSNEVDQMNRIVEVLGIPPAAMLDQAP---KARKYFERLP-GGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVL
 |.. .||.|.|.|||| |.  .. . .   .||.|...|.     . .  ... ... .                                    ||. 
PGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANF-----------------------------NANPQAIDLLE

RMLEYEPAARISPLGALQHGFF
.||.  |  ||.   |||| .|
KMLVFDPDKRITVEEALQHPYF
Kinase DYRK1B.AA CLK 255-349 30 8.2e-19 52.37 In-house 186-287 (350) Show / Hide 
Range on Protein: 255-349
Range on HMM: 186-287/350
Sequence Identity: 30% (31 aa)

IKIVDFGSSC---QLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLG-IPPAAMLDQAP---KARKYF
|...||||     .     .  ...| || ||| || ..    | || ||||.|  ||. || . .... .  . ...| . | .|          .|||
ICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYF

ER
 .
YH
Kinase DYRK1B.AA CLK 406-431 57 1.7e-11 30.0 In-house 325-350 (350) Show / Hide 
Range on Protein: 406-431
Range on HMM: 325-350/350
Sequence Identity: 57% (15 aa)

DLVLRMLEYEPAARISPLGALQHGFF
||. .||||.|..||.   |||| ||
DLIRKMLEYDPSKRITCKDALQHPFF
Kinase DYRK1B.AA MAPK 111-166 29 5.5e-11 34.0 In-house 1-65 (328) Show / Hide 
Range on Protein: 111-166
Range on HMM: 1-65/328
Sequence Identity: 29% (19 aa)

YEIDSLIGKGSFGQVVKAYDHQTQEL------VAIKIIK---NKKAFLNQAQIELRLLELMNQHD
|.|.. ||.|..|.|..|.|  |..       |||| |    ... .   .. |..||  ...|.
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHE
Kinase DYRK1B.AA TyrKc 111-357 18 1.1e-09 -65.86 SMART 1-280 (280) Show / Hide 
Range on Protein: 111-357
Range on HMM: 1-280/280
Sequence Identity: 18% (54 aa)

YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELM-NQHDTEMKYYIVHLK---RHFMFRNHLCLVFELLSY-NLYDLLRNTH
 . .  .| | ||.|.|.      . ||.| .|. .  .     |.|..     .|.   . | | ..   . ||    |..|.|. .. .| | ||...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLRKHR

FRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR-------IYQYI----QSR-----FYRSPEVLLGTP
 . ...    . . | .    .|.  .  .|| ||   |.|. ...   .|| ||| |  ..          |       ...        .||..    
PK-LCMKDLLSFCWQIACGMEYLH--SKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YDLAIDMWSLGCILVEMHT-GEPLFSGS----NEVDQMNRIVEVLGIPPAAML---------------------DQAPKARKYFERLPGGGWTL
.  . | || |  . |. | |..  .|      . ... . |.  . .|                         .  |. |  |. .      .
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI---HECF
Kinase DYRK1B.AA DYRK2 404-431 35 3e-06 15.95 In-house 291-318 (318) Show / Hide 
Range on Protein: 404-431
Range on HMM: 291-318/318
Sequence Identity: 35% (10 aa)

FQDLVLRMLEYEPAARISPLGALQHGFF
| | ..| .| .|. |..|  ||.| ..
FIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase DYRK1B.AA HIPK 399-431 30 7e-06 14.05 In-house 297-329 (329) Show / Hide 
Range on Protein: 399-431
Range on HMM: 297-329/329
Sequence Identity: 30% (10 aa)

ADYLRFQDLVLRMLEYEPAARISPLGALQHGFF
.|.  | ..  .|.  ..  ||.|. ||.| | 
IDRREFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase DYRK1B.AA PRP4 404-431 39 1.9e-05 15.98 In-house 293-320 (320) Show / Hide 
Range on Protein: 404-431
Range on HMM: 293-320/320
Sequence Identity: 39% (11 aa)

FQDLVLRMLEYEPAARISPLGALQHGFF
| ||  ..|   |. ||..  ||.| |.
FKDLLDKCLMLDPKKRITCNEALKHPFI
Kinase DYRK1B.AA Pkinase_Tyr 111-145 28 5.6e-05 17.48 Pfam 1-39 (270) Show / Hide 
Range on Protein: 111-145
Range on HMM: 1-39/270
Sequence Identity: 28% (11 aa)

YEIDSLIGKGSFGQVVKAYDH----QTQELVAIKIIKNK
 ...  .|.|.||.|.|.. .    .|.  ||.|..|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEG
Kinase DYRK1B.AA YAK 404-431 35 0.016221 3.92 In-house 320-347 (347) Show / Hide 
Range on Protein: 404-431
Range on HMM: 320-347/347
Sequence Identity: 35% (10 aa)

FQDLVLRMLEYEPAARISPLGALQHGFF
| |..  .|. .|  | .|  | || | 
FIDFINQLLQLNPRERWKPMQAMQHPFI