Gene DYRK2 (Human)

DYRK2

Species: Human
Alias: DYRK2
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 12q14.3,

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK2

Sequence

Name Sequence Type Origin Length Description Download
DYRK2.NA RNA Sugen Kinome 6159 None Fasta, JSON
DYRK2.AA Protein Sugen Kinome 601 None Fasta, JSON
DYRK2.kin_dom Protein Kinase Domain Sugen Kinome 314 None Fasta, JSON

Protein domain

Protein domains of DYRK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DYRK2.AA DYRK2 222-535 68 7.70000000001e-244 801.46 In-house 1-318 (318) Show / Hide 
Range on Protein: 222-535
Range on HMM: 1-318/318
Sequence Identity: 68% (218 aa)

YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFS
||.|.||||||||||||.|||| .||||.||.||.||||.||.||||||.|.|.||||||||..|||. |.||||.|.|||||||||||.||||.|||||
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

LPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQ-RVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYP
| |||.|||||||||..||||.|||||||||||||||..|||||||||||||.||| |.||||||||||||||||| .|||.|||||.|||.|||.||||
LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYP

LLPGEDEGDQLACMIELLGMPSQKLLDAS-----KRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQC
|.|||.|.||.|||.|.||||..|..| .     .|.|.|. |.....||  |...|.|.........|.. |.||.|..|...||||.|..|.||.|.|
LFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFEWYC--TFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCEDENFIDFIKRC

LEWDPAVRMTPGQALRHPWL
.||||. |||| |||.|||.
FEWDPSERMTPSQALKHPWI
Kinase DYRK2.AA DYRK 222-535 57 2.4e-209 701.76 In-house 1-320 (320) Show / Hide 
Range on Protein: 222-535
Range on HMM: 1-320/320
Sequence Identity: 57% (187 aa)

YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGF-
||.|..|||||||||||..||| ...||.|..||.||||||| .||.|||.|..||.|......||.. |..||| |..||||||||||..|.|.|||| 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

SLPLVRKFAHSILQCLDALHKN-RIIHCDLKPENILLKQQ-GRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTG
|| ||||||..||.||. |||| .|||||||||||.|||. ..|.||||||||||.||||.||||||||||||||||| .|...|||||||||||||.||
SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTG

YPLLPGEDEGDQLACMIELLGMPSQKLLDAS--KRAKNFVSSKGYPRYCTVTTLSDGSV------VLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLD
.||.|||.| |||||..|.||||.....|..  .|...|  .   ..||.... .....      .... ...| . |.||..| |..... ||| .|.|
WPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC---FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQFKD

FLKQCLEWDPAVRMTPGQALRHPWL
|.|.||.|||. |.|| |||.|||.
FIKKCLQWDPHKRITPSQALQHPWF
Kinase DYRK2.AA CMGC 222-535 22 6.6e-129 426.09 In-house 1-513 (513) Show / Hide 
Range on Protein: 222-535
Range on HMM: 1-513/513
Sequence Identity: 22% (114 aa)

YEVLKVIGKGSFGQVVKAYD--------------HKVHQHVALKMVRNEKRFHRQAA-------------EEIRILEHLR-KQDKDN-----------TM
||..|.||.|..|.|.|..|              |.  ..||.| ..|.. ...||               ||.||.||. ..|. |             
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

NVIHMLENFTFRN-----------------HICMTFELLSMNLYELIKKNK--------------------------FQGFSLPLVRKFAHSILQCLD--
|...... |...|                 |... ||.. ..||..||.|.                           . |.. ..| ... ||..|.  
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

ALHKNR--IIHCDLKPENILLKQQGRS------------------GIKVIDFGSSCYEHQR------------------------VYTYIQSRFYRAPEV
 .|...  |||.||||||||. .....                   .|..|||.....|..                         ..|...|.|||||.
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

ILGAR----------YGMPIDMWSLGCILAELLTG--------YPLLPGEDE-----------GDQLACMIELLGMPSQKLLDASK-------RAKNFVS
.||..          |. ||||||.|||.||..||        .|| ||..|            |||......||.|. ......|       . ... .
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPN

SKGYPRYCT---------VTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKG-------------------------------CDDPLFLDFLKQCLE
 ...|.| .         .|.  . .. .   . .| . . |.  ...   ..                                |.||...|.||..|.
MIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQ

WDPAVRMTPGQALRHPWL
.||. |.|. |||.||..
YDPDKRITAEQALQHPYF
Kinase DYRK2.AA DYRK1 222-535 46 4.6e-113 381.91 In-house 1-321 (321) Show / Hide 
Range on Protein: 222-535
Range on HMM: 1-321/321
Sequence Identity: 46% (149 aa)

YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFS
||.   |||||||||||||||. ...||.|...| | |  ||  |||.|| . |.||..  ...|. . | ||||.|. ||||| |||.|..  .|.| |
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

LPLVRKFAHSILQCLDALHKN--RIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGY
| |.||||. ... |  .      |||||||||||||    || ||.|||||||   ||.| ||||||||.|||.|| .| | |||||||||| |. || 
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGE

PLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRR-----GKLRGPPESREWGNALKGCDDPL-FLDFLK
||  | .| ||.  ..| |||| ....| . .|. .   |   .  ..    |.    .  . |.     |   | |..|  | .     |.| | | .|
PLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYF-EKDPDNTWYCKKTRDKKKHYKEPCTRKLHEILGVETGGPGGRRKGEPGHSVEDYLKFKDLIK

QCLEWDPAVRMTPGQALRHPWL
. |..||. |.|| .||.|...
RMLQYDPKQRITPYYALQHSFF
Kinase DYRK2.AA YAK 222-447 46 6.5e-95 321.63 In-house 1-230 (347) Show / Hide 
Range on Protein: 222-447
Range on HMM: 1-230/347
Sequence Identity: 46% (107 aa)

YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMN----VIHMLENFTFRNHICMTFELLSMNLYELIKKNKF
| || . |.| ||||||         .| | . |   .  ||  ||.||. | .|   |  |    .. |.  | ..|| |. ||.||.||||..| |||
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

QGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLT
 |||  |.| .  .||  .  |   .|||||||||||.|..  .  ||.|||||||.| . ||||||.|.||.||.|..  |   |||||||||.|||  
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFL

GYPLLPGEDEGDQLACMIELLGMPSQKLLD
| |. ||  | .|.   |. || |   ..|
GLPIFPGNSEYNQIKRIIDMLGYPPSWMID
Kinase DYRK2.AA S_TKc 222-535 26 8.1e-94 318.9 SMART 1-231 (231) Show / Hide 
Range on Protein: 222-535
Range on HMM: 1-231/231
Sequence Identity: 26% (88 aa)

YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSM---NLYELIKKNKFQ
||.|..||||.||.| |....| ...||.|...      ...  ||.||..    . .|  . . . ..    .|..| .|...    .|...|||.. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK----HHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDLFDYIKKRGRH

G----FSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGM-PIDMWSLGCILA
|    |.   .|.... |.. |. .|...|||.||||||||| .     ||..|||...      .|.. ...|.||||.    ||  ..|.||.||||.
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLK
|.|.|||. |      |.. |....|                                                                 .| ..||..
EMLCGYPPFP------QMQMMFKKIG-----------------------------------------------------------------SPEAKDFIR

QCLEWDPAVRMTPGQALR-------HPWL
.||..||. |.|  .||.       |||.
KCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase DYRK2.AA HIPK 222-455 41 9.4e-74 231.52 In-house 1-236 (329) Show / Hide 
Range on Protein: 222-455
Range on HMM: 1-236/329
Sequence Identity: 41% (99 aa)

YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFS
|||| ..|.| ||||||.  .  .  ||.|. .|.  . ||   |..||. |.... |. .... ..| |  .||.|. ||.|  |||.  |.|||    
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADE-YHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLP

LPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSG--IKVIDFGSSCYEHQRVY-TYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTG
|  .|     .|  |  | .  .|| |||||||.|  . |    .|||||||  .  . |  ||.|||.|||||.||| ..   .|||||||..|||  |
LKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLG

YPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNF
 || || || ||   ...  . | . || |  ... |
WPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRF
Kinase DYRK2.AA CDK 222-535 25 1.3e-66 212.11 In-house 1-284 (284) Show / Hide 
Range on Protein: 222-535
Range on HMM: 1-284/284
Sequence Identity: 25% (92 aa)

YEVLKVIGKGSFGQVVKAYDHKVH-----QHVALKMVRNEK--------RFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFR-----------NHI
|| |. || |..|.| || |.. .     | ||||..| |.         |   |  || .| .|         |..  .. ..             | .
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-------HPNIVKLHDVCHTKNMDRNNKDKHENKL

CMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQG---RSGIKVIDFGSSCYEH--------QRVYT-YIQS
 | || . . |.....           .. . . .|. |. .|.|.|.| |||| |||.  .|   .  .|. ||| ..  .        .|.||  .  
YMVFEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVT

RFYRAPEVILGAR-YG--MPIDMWSLGCILAELLT---GYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNG
. |||||. ||.. |.   ||||||.|||.||..|   . ||.||. | ||| . ....| |. .     .   ..                        
LWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------

GRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL
                              |.| ..|  ||. |..  ||| ||..
------------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase DYRK2.AA Pkinase 222-441 31 9.8e-61 212.88 Pfam 1-234 (293) Show / Hide 
Range on Protein: 222-441
Range on HMM: 1-234/293
Sequence Identity: 31% (76 aa)

YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAE-----EIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSM-----NLYEL
|.....||.||||.| |.....  . ||.| .. ... . .  .     ||.|. .|.        |.. ... |. ..||.| .|.. .      |...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN------HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

IK---KNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSG--IKVIDFGSSC---YEHQRVYTYIQSRFYRAPEVIL-GARYGMP
|.   ...|  ||   .....  ||. |. .|...|||.||||||||....|  .  .|..|||...   | ... .|.  ...|.|||||. |  || .
ISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPK

IDMWSLGCILAELLTGYPLLPGE----DEGDQLACMIELLGMP
.||||.||||.|.|.|.|. ||.    .  ||.... . .| |
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPP
Kinase DYRK2.AA DyrkP 222-418 40 6.6e-58 189.0 In-house 1-201 (323) Show / Hide 
Range on Protein: 222-418
Range on HMM: 1-201/323
Sequence Identity: 40% (82 aa)

YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNK----F
| ..  .|   | . ..  | .  | . .|.. | | .  |. .||..|  .         ||... . |  . |. .  |||  ||||  | |.     
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQQ

QGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLT
. | .  . |    ||  || .|  |.|||||||||||.| . .  .|.|||||||. |  .  |.||| |||||||.| .|   ||||||||||||| |
RYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWT

G
|
G
Kinase DYRK2.AA PRP4 222-424 39 1.8e-54 187.28 In-house 1-207 (320) Show / Hide 
Range on Protein: 222-424
Range on HMM: 1-207/320
Sequence Identity: 39% (82 aa)

YEVLKVIGKGSFGQVVKAYDHKVHQ-HVALKMVRNEKRFHRQAAEEIRILEHLRKQ--DKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKN-KF
|.|   .|.| |. |... |    .  || | .||    |.    |. ||  |  .  ||.    .. | . | .|.|.|. || .|||| |..||  | 
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

QGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGS-SCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELL
 |..|  || .|  ..  |  | |. |.| |.|| |||     .. .| .|||| |  . . .  | .||||||||.|.| .|   ||||| || |.|| 
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNILVNES-KNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELY

TGYPLLPG
||  . ||
TGKIMFPG
Kinase DYRK2.AA CLK 222-356 31 8.2e-52 153.24 In-house 1-147 (350) Show / Hide 
Range on Protein: 222-356
Range on HMM: 1-147/350
Sequence Identity: 31% (46 aa)

YEVLKVIGKGSFGQVVKAYDHKV-HQHVALKMVRNEKRFHRQAAEEIR-ILEHLRKQ-DKDNTMN--VIHMLENFTF-RNHICMTFELLSMNLYELIKKN
||.... | | || ||.  |||   ..|||| .|| ...  .|  ||. |.... .  |..|.    ...|.. | .  .|||. |||.  ..|...|.|
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

K------FQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILL
.      .... .  .|..|. ... .  ||.....| |||||||..
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICF
Kinase DYRK2.AA CLK 364-441 48 3.5e-27 77.93 In-house 186-266 (350) Show / Hide 
Range on Protein: 364-441
Range on HMM: 186-266/350
Sequence Identity: 48% (39 aa)

IKVIDFGSSC---YEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMP
|.||||||     ..|   .| ...| |||||||||  .  | | || |||| || ||. | .. |. . || | ...|||
ICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMP
Kinase DYRK2.AA TyrKc 222-539 16 6.1e-11 -45.81 SMART 1-280 (280) Show / Hide 
Range on Protein: 222-539
Range on HMM: 1-280/280
Sequence Identity: 16% (59 aa)

YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHL-RKQDKDNTMNVIHMLENFTFR-------NHICMTFELLSM-NLYELI
 . .|..| | ||.|.|.      . || ||.....  ..   .|.||. .|       .  |.. ..   |           ... .|. .  .| . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGG-----HHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQR-------VYTYI----QSR-----FYRAPEVILG
.|.. . ....   .|.. | .  . ||....|| ||   |.|.. ..   .|. ||| | . .          |       ...        |||.|  
RKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

ARYGMPIDMWSLGCILAELLT-GYPLLPGE----DEGDQLACMIELLGMPSQKLL----DASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKL
 ..    | || |  . |..| | .  ||.     . ...   ..  ... |                                                
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------------------------

RGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRL
              .| | ..    ||| . ||. | |  .       ....
-----------F-VCCPDEMYQ-IMKQCWHEDPEDRPTFSEI------HECF
Kinase DYRK2.AA DyrkP 504-535 50 9.7e-10 27.55 In-house 292-323 (323) Show / Hide 
Range on Protein: 504-535
Range on HMM: 292-323/323
Sequence Identity: 50% (16 aa)

DDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL
|| .|.|| .|||  |   | |   ||.|||.
DDHMFIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase DYRK2.AA CLK 508-535 39 7.6e-09 21.9 In-house 323-350 (350) Show / Hide 
Range on Protein: 508-535
Range on HMM: 323-350/350
Sequence Identity: 39% (11 aa)

FLDFLKQCLEWDPAVRMTPGQALRHPWL
. | ....|| ||. |.| ..|| ||. 
LFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase DYRK2.AA YAK 507-535 41 4.7e-08 23.05 In-house 319-347 (347) Show / Hide 
Range on Protein: 507-535
Range on HMM: 319-347/347
Sequence Identity: 41% (12 aa)

LFLDFLKQCLEWDPAVRMTPGQALRHPWL
.|.||. | |. .|  | .| ||  || .
CFIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase DYRK2.AA PRP4 508-535 46 1.1e-07 24.25 In-house 293-320 (320) Show / Hide 
Range on Protein: 508-535
Range on HMM: 293-320/320
Sequence Identity: 46% (13 aa)

FLDFLKQCLEWDPAVRMTPGQALRHPWL
| |.| .||  ||. | |. .||.|| .
FKDLLDKCLMLDPKKRITCNEALKHPFI
Kinase DYRK2.AA Pkinase 508-535 50 1e-06 24.67 Pfam 266-293 (293) Show / Hide 
Range on Protein: 508-535
Range on HMM: 266-293/293
Sequence Identity: 50% (14 aa)

FLDFLKQCLEWDPAVRMTPGQALRHPWL
..||.| ||..||. | |. |.| |||.
CKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase DYRK2.AA HIPK 508-535 42 9e-06 13.62 In-house 302-329 (329) Show / Hide 
Range on Protein: 508-535
Range on HMM: 302-329/329
Sequence Identity: 42% (12 aa)

FLDFLKQCLEWDPAVRMTPGQALRHPWL
| . ||. . ||.  |.|| .||.||. 
FVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase DYRK2.AA Pkinase_Tyr 222-255 28 4.9e-05 17.68 Pfam 1-38 (270) Show / Hide 
Range on Protein: 222-255
Range on HMM: 1-38/270
Sequence Identity: 28% (11 aa)

YEVLKVIGKGSFGQVVKAYDH----KVHQHVALKMVRN
 . .|..|.|.||.|.|.. .    . ...|| ||...
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE