Gene DYRK3 (Human)

DYRK3

Species: Human
Alias: REDK, DYRK3, DYRK5, RED
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 1q32,

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK2

Sequence

Name Sequence Type Origin Length Description Download
DYRK3.NA RNA Sugen Kinome 2207 None Fasta, JSON
DYRK3.AA Protein Sugen Kinome 588 None Fasta, JSON
DYRK3.kin_dom Protein Kinase Domain Sugen Kinome 314 None Fasta, JSON

Protein domain

Protein domains of DYRK3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DYRK3.AA DYRK2 209-522 63 4.5e-237 779.08 In-house 1-318 (318) Show / Hide 
Range on Protein: 209-522
Range on HMM: 1-318/318
Sequence Identity: 63% (204 aa)

YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFS
||.|..|||||||||...||||..|.||.||.||.||||.||.||||||.|...|||...||..|||..|.||||.|..|||||..|||.||||.|||||
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

VQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ-KLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQP
.||||.||.||||.|..||||.||||||||||||||...||. |||||||||||.| ..|||||||||||||.||| .|...||.||||||.|||.||.|
LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYP

LFPGEDEGDQLACMMELLGMPPPKLLEQS-----KRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRC
|||||.|.||.|||||.|||||.|.....     .|.|||.||.....||  |...|..... .....|..||.|||||.|...||||.|..||.|.|||
LFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFEWYC--TFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCEDENFIDFIKRC

LHWDPSARLTPAQALRHPWI
..|||| |.||.|||.||||
FEWDPSERMTPSQALKHPWI
Kinase DYRK3.AA DYRK 209-522 54 6.30000000001e-201 673.8 In-house 1-320 (320) Show / Hide 
Range on Protein: 209-522
Range on HMM: 1-320/320
Sequence Identity: 54% (176 aa)

YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGF-
||.|..|||||||||....|||  ..||.|..||.||||||| .||.|||.|..||.. .....||...|..|||.|. |||||..|||..|.|.|||| 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

SVQLVRKFAQSILQSLDALHKN-KIIHCDLKPENILLKHH-GRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTG
|..|||||||.||..|. |||| .|||||||||||.||.. ..|  ||||||||||| |..|||||||||||||.||| .|...||.||.|||||||.||
SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTG

QPLFPGEDEGDQLACMMELLGMPPPKLLEQS--KRAKYFINSKGIPRYCSVTTQADGRV------VLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIE
 ||||||.| |||||.||.|||||.......  .|...|...   ..|| .... ....      .. . ...| ..|.|||...|. ... ||| .|. 
WPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC---FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQFKD

FLKRCLHWDPSARLTPAQALRHPWI
|.|.|| |||. |.||.|||.|||.
FIKKCLQWDPHKRITPSQALQHPWF
Kinase DYRK3.AA CMGC 209-522 22 2.3e-128 424.27 In-house 1-513 (513) Show / Hide 
Range on Protein: 209-522
Range on HMM: 1-513/513
Sequence Identity: 22% (116 aa)

YEVLKIIGKGSFGQVARVYD--------------HKLRQYVALKMVRNEKRFHRQAA-------------EEIRILEHLK-KQDKTG-----------SM
||..| ||.|..|.| . .|              |.  ..||.| ..|.. ...||               ||.||.||. ..|. .             
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

NVIHMLESFTFRN-----------------HVCMAFELLSIDLYELIKKNK--------------------------FQGFSVQLVRKFAQSILQSLD--
|.......|...|                 |... ||..  |||..||.|.                           . |.. ..| ... ||..|.  
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

ALHKNK--IIHCDLKPENILLKHHGRS------------------STKVIDFGSSCFEYQK------------------------LYTYIQSRFYRAPEI
 .|...  |||.||||||||. | ...                    |..|||..... .                         ...|...|.||||||
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

ILGSR----------YSTPIDIWSFGCILAELLTG--------QPLFPGEDE-----------GDQLACMMELLGMPPPKLLEQSK-------RAKYFIN
.||..          |.||||.||.|||.||..||        .|||||..|            |||......||.|. ......|       . . ..|
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPN

SKGIPRYCS---------VTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKG-------------------------------CDDYLFIEFLKRCLH
 .. |.|           .|.. .  . .   . .| ... |.  |..   ..                                |.| ..|..||..|.
MIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQ

WDPSARLTPAQALRHPWI
.||. |.|..|||.||..
YDPDKRITAEQALQHPYF
Kinase DYRK3.AA DYRK1 209-522 45 2.5e-107 362.86 In-house 1-321 (321) Show / Hide 
Range on Protein: 209-522
Range on HMM: 1-321/321
Sequence Identity: 45% (147 aa)

YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFS
||.   |||||||||.. |||. ..|||.|...| | |  ||  |||.|| . |.||    ...|. . | ||||.|. |||||  ||.|..  .|.| |
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

VQLVRKFAQSILQSLDALHKN--KIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQ
. |.||||| ....|  .     .|||||||||||||    ||  |.|||||||   |..| ||||||||.||..|| .|.. ||.|| |||| |. || 
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGE

PLFPGEDEGDQLACMMELLGMPPPKLLEQSKRA-KYFINSKGIPRYCSVTTQADGRVVLVGGRSRR---GKKRGPPGSKDWGTALKGCDDYL-FIEFLKR
||| | .| ||.  ..| ||||| ....|. .| |||   .    ||  | .   . .  . |  .   | . | ||..  | .     ||| | . .||
PLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDPDNTWYCKKTRDKKKHYKEPCTRKLHEILGVETGGPGGRRKGEPGHSVEDYLKFKDLIKR

CLHWDPSARLTPAQALRHPWI
 |..|| .|.|| .||.|...
MLQYDPKQRITPYYALQHSFF
Kinase DYRK3.AA YAK 209-442 43 3.9e-94 319.06 In-house 1-239 (347) Show / Hide 
Range on Protein: 209-442
Range on HMM: 1-239/347
Sequence Identity: 43% (105 aa)

YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHL-KKQDKTGSM---NVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKF
| || . |.| ||||.          .| | . |   .  ||  ||.||. | .. | ..      .. |. .| ..|| |. ||.||. |||..| |||
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

QGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLT
 |||.||.| .  .|| ..  |   .|||||||||||.|.   .   |.||||||| | . .|||||.|.||.||||..  |.| || || |||.|||  
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFL

GQPLFPGEDEGDQLACMMELLGMPPPKLLEQSK-RAKYF
| |.|||  | .|.    . || ||  ...| . . |||
GLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYF
Kinase DYRK3.AA S_TKc 209-522 25 4e-94 319.91 SMART 1-231 (231) Show / Hide 
Range on Protein: 209-522
Range on HMM: 1-231/231
Sequence Identity: 25% (84 aa)

YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI---DLYELIKKNKFQ
||.|..||||.||.| .....|  ..||.|...      ...  ||.||..       .  |.......|   .|..| .|...    ||...|||.. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

G----FSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYST-PIDIWSFGCILA
|    |.   .|.... |.. |. .|...|||.||||||||| .      |..|||....     .|.. ...|.|||..    |.. ..|.||.||||.
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLK
|.|.|.|.||      |.. |....|                                                                 .  ...|..
EMLCGYPPFP------QMQMMFKKIG-----------------------------------------------------------------SPEAKDFIR

RCLHWDPSARLTPAQALR-------HPWI
.||..||. |.|  .||.       |||.
KCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase DYRK3.AA CDK 209-522 25 1e-67 215.7 In-house 1-284 (284) Show / Hide 
Range on Protein: 209-522
Range on HMM: 1-284/284
Sequence Identity: 25% (92 aa)

YEVLKIIGKGSFGQVARVYDHK-----LRQYVALKMVRNEK--------RFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFR-----------NHV
|| |. || |..|.| .  |..       |.||||..| |.         |   |  || .| .|         |..  .. ..             | .
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-------HPNIVKLHDVCHTKNMDRNNKDKHENKL

CMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHG---RSSTKVIDFGSSCFEY--------QKLYT-YIQS
 | || .  ||.....           .. . . .|. |. .|.|.|.| |||| |||. . |   . . |. ||| ..           .. ||  .  
YMVFEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVT

RFYRAPEIILGSR-YS--TPIDIWSFGCILAELLT---GQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVG
. |||||. |||. ||  ||||.||.|||.||..|   ..|||||. | ||| .  ...| | ..     .   ..                        
LWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------

GRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWI
                              ..| ..|  ||. |..  ||| ||. 
------------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase DYRK3.AA Pkinase 209-445 26 1.7e-67 235.38 Pfam 1-272 (293) Show / Hide 
Range on Protein: 209-445
Range on HMM: 1-272/293
Sequence Identity: 26% (75 aa)

YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAE-----EIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-----DLYEL
|.....||.||||.| . .... .. ||.| .. ... . .  .     ||.|. .|.      . |.. ....|. ..|..| .|..       ||...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN------HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

IK---KNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSST----KVIDFGSSCF---EYQKLYTYIQSRFYRAPEIIL-GSRYS
|.   ...|  || . .....  ||. |. .|...|||.||||||||....|   .    |..|||....    .. ..|.  ...|.|||.|. |. |.
ISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGH--IDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQYYG

TPIDIWSFGCILAELLTGQPLFPGE----DEGDQLACMMELLGMPPPKLLEQS---------------------KRAKYFINS
...|.||.||||.|.|.|.|.|||.    .  ||.... . .| |..   ...                     . .| ||..
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKW
Kinase DYRK3.AA HIPK 209-442 39 3.3e-66 207.32 In-house 1-236 (329) Show / Hide 
Range on Protein: 209-442
Range on HMM: 1-236/329
Sequence Identity: 39% (93 aa)

YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFS
|||| ..|.| ||||..   .     ||.|. .|.  . ||   |..||. |....    .... ..| |  .||.|. ||.|   ||.  |.|||    
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQEN-ADEYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLP

VQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSS--TKVIDFGS-SCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTG
.. .|   | .|  |  | .  .|| |||||||.|    |     ||||||| | .      ||.|||.||||||||| ..   .|.|| ||..|||  |
LKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLG

QPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYF
 ||.|| || ||   . .  . | . ||..  ... |
WPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRF
Kinase DYRK3.AA DyrkP 209-409 40 4.1e-55 179.66 In-house 1-205 (323) Show / Hide 
Range on Protein: 209-409
Range on HMM: 1-205/323
Sequence Identity: 40% (82 aa)

YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNK----F
| ..  .|   | .     | .  | . .|.. | | .  |. .||..|  .         ||... . |  . |. .  |||   |||  | |.     
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQQ

QGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLT
. | |  . |  | || .|| .|  ..|||||||||||.| . .   |.||||||||    |  |.||| |||||.|.| .|   ||.|| ||||||| |
RYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWT

GQPLF
|  ||
GNVLF
Kinase DYRK3.AA PRP4 209-437 37 1.8e-52 180.66 In-house 1-233 (320) Show / Hide 
Range on Protein: 209-437
Range on HMM: 1-233/320
Sequence Identity: 37% (87 aa)

YEVLKIIGKGSFGQVARVYDHKLRQ-YVALKMVRNEKRFHRQAAEEIRILEHLKKQ--DKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKN-KF
|.|   .|.| |. | |  |    .  || | .||    |.    |. ||  |  .  ||     .. | ..| .|.| |. || .|  | |..||  | 
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

QGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGS-SCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELL
 |...  || .|| ..  |  | |..|.| |.|| |||     ..  | .|||| |  . . .  | .||||||||||.| .|   ||.|| || |.|| 
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNILVNES-KNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELY

TGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSK
||  .|||    . |  .|.. |  | |..  ..
TGKIMFPGKTNNHMLKLFMDYKGKMPNKMIRKGQ
Kinase DYRK3.AA CLK 209-343 30 1.4e-51 152.56 In-house 1-147 (350) Show / Hide 
Range on Protein: 209-343
Range on HMM: 1-147/350
Sequence Identity: 30% (45 aa)

YEVLKIIGKGSFGQVARVYDHKL-RQYVALKMVRNEKRFHRQAAEEIR-ILEHLKKQ-DKTGSMN--VIHMLESFTF-RNHVCMAFELLSIDLYELIKKN
||...  | | || | .. |||   .||||| .|| ...  .|  ||. |......  |. .     ...|...| .  .|.|. |||.   .|...|.|
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

K------FQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILL
.      ....  . .|..|  .....  ||..|..| |||||||..
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICF
Kinase DYRK3.AA CLK 352-446 43 1.1e-33 97.87 In-house 187-289 (350) Show / Hide 
Range on Protein: 352-446
Range on HMM: 187-289/350
Sequence Identity: 43% (45 aa)

KVIDFGSSC---FEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKR-----AKYFI
.||||||     |.. . .| ...| |||||.|||  .|.| |.||.|||| || ||  ||.. |. . || | ...||| |.   |. |      |||.
CVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYFY

NSK
. .
HNR
Kinase DYRK3.AA TyrKc 209-522 18 1.2e-12 -18.01 SMART 1-280 (280) Show / Hide 
Range on Protein: 209-522
Range on HMM: 1-280/280
Sequence Identity: 18% (66 aa)

YEVLKIIGKGSFGQV--ARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHL--KKQDKTGSMNVIHMLESFTFR-------NHVCMAFELLS-IDLY
 . .|..| | ||.|  .. .     . || ||.....  ..   .|.||. .|  .        |.. ..   |           ... .|. .  || 
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA--REDFMREARIMCKLGGH------HPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

ELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQK-------LYTYI----QSR-----FYRAPEI
. ..|.. . ....   .|.  | .  . ||....|| ||   |.|... .    |. ||| | . | .        |       ...        ||| 
DYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

ILGSRYSTPIDIWSFGCILAELLT-GQPLFPGE----DEGDQ-LACMMELLGMPPPKL----LEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSR
|  ....|  |.||||  . |..| ||.  ||.     . .. ... ..   ||.|.                                           
INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------------------

RGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWI
                  .| | ..    |.| | ||. | | ..   |  .
---------------F-VCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase DYRK3.AA Pkinase 495-522 46 7e-10 36.03 Pfam 266-293 (293) Show / Hide 
Range on Protein: 495-522
Range on HMM: 266-293/293
Sequence Identity: 46% (13 aa)

FIEFLKRCLHWDPSARLTPAQALRHPWI
...|.|.||..||. |.|..|.| |||.
CKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase DYRK3.AA DyrkP 491-522 46 1.6e-08 23.5 In-house 292-323 (323) Show / Hide 
Range on Protein: 491-522
Range on HMM: 292-323/323
Sequence Identity: 46% (15 aa)

DDYLFIEFLKRCLHWDPSARLTPAQALRHPWI
||..||.| ..||  |   | |   ||.|||.
DDHMFIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase DYRK3.AA HIPK 495-522 42 3.7e-08 21.27 In-house 302-329 (329) Show / Hide 
Range on Protein: 495-522
Range on HMM: 302-329/329
Sequence Identity: 42% (12 aa)

FIEFLKRCLHWDPSARLTPAQALRHPWI
|.. ||. . ||.  |.||..||.||..
FVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase DYRK3.AA CLK 495-522 35 4.8e-08 19.45 In-house 323-350 (350) Show / Hide 
Range on Protein: 495-522
Range on HMM: 323-350/350
Sequence Identity: 35% (10 aa)

FIEFLKRCLHWDPSARLTPAQALRHPWI
... ....|  |||.|.| ..|| ||. 
LFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase DYRK3.AA PRP4 498-522 48 2.3e-07 23.1 In-house 296-320 (320) Show / Hide 
Range on Protein: 498-522
Range on HMM: 296-320/320
Sequence Identity: 48% (12 aa)

FLKRCLHWDPSARLTPAQALRHPWI
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LLDKCLMLDPKKRITCNEALKHPFI
Kinase DYRK3.AA YAK 494-522 41 3e-06 16.62 In-house 319-347 (347) Show / Hide 
Range on Protein: 494-522
Range on HMM: 319-347/347
Sequence Identity: 41% (12 aa)

LFIEFLKRCLHWDPSARLTPAQALRHPWI
.|| |.   |  .|  | .| ||  || |
CFIDFINQLLQLNPRERWKPMQAMQHPFI