Gene DYRK4 (Human)

DYRK4

Species: Human
Alias: DYRK4
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 12p13,

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK2

Sequence

Name Sequence Type Origin Length Description Download
DYRK4.NA RNA Sugen Kinome 2084 None Fasta, JSON
DYRK4.AA Protein Sugen Kinome 634 None Fasta, JSON
DYRK4.kin_dom Protein Kinase Domain Sugen Kinome 297 None Fasta, JSON

Protein domain

Protein domains of DYRK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DYRK4.AA DYRK2 219-515 61 6.7e-225 738.85 In-house 1-318 (318) Show / Hide 
Range on Protein: 219-515
Range on HMM: 1-318/318
Sequence Identity: 61% (194 aa)

YEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGFS
||.|| |||||||||.||.|||....||.|.||||||||.||..|..||...|..|||||.|.|||.|.||||||.|||||||..||||..|.|.|||||
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

LSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQASVKVIDFGSSCYEHQ-KVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYP
|..||||. |.|.||..|. ..|||||||||||.|.|... ..|||||||||.||| ..||||||||||.||||||..|..||||||.||| ||||||||
LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYP

LFPGENEVEQLACIMEVLGLPPAGFIQTA-----SRRQTFFD--------------SKGFPKNITNNRGKKRYPDSKDLTMVLK-TYDTSFLDFLRRCLV
|||||||..|.||.|||||.||. |..|.     .||..||.              |. .||...|..||.|.|.||....||| ..| .|.||..||..
LFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCEDENFIDFIKRCFE

WEPSLRMTPDQALKHAWI
|.|| ||||.|||||.||
WDPSERMTPSQALKHPWI
Kinase DYRK4.AA DYRK 219-515 56 8.70000000001e-198 663.36 In-house 1-320 (320) Show / Hide 
Range on Protein: 219-515
Range on HMM: 1-320/320
Sequence Identity: 56% (181 aa)

YEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGF-
||.|| |||||||||.|| |||.||.||.|||||.||||.||. |.|||| |...|.|..|..|||.|.||.|||.||.|||| .||||..|||.|||| 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

SLSIVRRFTLSVLKCLQMLSVE-KIIHCDLKPENIVLYQK-GQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTG
||. ||.|. ..|.|| .|. . .|||||||||||.| |. ..  .|||||||||.|||..||||||||||.||||||.||..|||||||||| |||.||
SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTG

YPLFPGENEVEQLACIMEVLGLPPAGFIQTA--SRRQTFFD-------------SK------GFPKNITNNRGKKRYPDSKDLTMVLKTYDTSFLDFLRR
.||||||||..||||||||||.||  .|...  .|...|||             .|      . ....|.. |..|.|..... ..... |  |.||...
WPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDCFMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQCDDHQFKDFIKK

CLVWEPSLRMTPDQALKHAWI
||.|.|. |.|| |||.| |.
CLQWDPHKRITPSQALQHPWF
Kinase DYRK4.AA CMGC 219-515 21 1.6e-121 401.38 In-house 1-513 (513) Show / Hide 
Range on Protein: 219-515
Range on HMM: 1-513/513
Sequence Identity: 21% (112 aa)

YEVLETIGKGSFGQVAKCLD--------------HKNNELVALKIIRNKKRFHQQAL-------------MELKILEALR-KKDKDN-----------TY
||... ||.|..|.| || |              |..||.||.|.|.|.. .. ||.              |.|||. |. ..|. |             
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

NVVHMKDFFYFRN-----------------HFCITFELLGINLYELMKNNN--------------------------FQGFSLSIVRRFTLSVLKCLQ--
|.|...|.||..|                 |... ||... .||...|||.                           . |..  .| ..  .|..|   
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

MLSVEK--IIHCDLKPENIVLYQKGQ------------------ASVKVIDFGSSCYEHQK------------------------VYTYIQSRFYRSPEV
 .   .  |||.||||||| . ....                    .|..|||.....|.                          ..|...|.||.||.
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

ILGHP----------YDVAIDMWSLGCITAELYTG--------YPLFPGENE-----------VEQLACIMEVLGLPPAGFIQT-------ASRRQTFFD
.|| .          |. .|||||.||| ||.|||        .|||||..|           ..||..|..||| |.  .||.       ... .....
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPN

SKG----------------------FPKNITNN---RGKKRYPDSKDLTMVLKT--------------------------------YDTSFLDFLRRCLV
 ..                      | .|  ..    ....... |.|   ...                                 |  ..|.| ..|.
MIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQ

WEPSLRMTPDQALKHAWI
..|. |.|..|||.| ..
YDPDKRITAEQALQHPYF
Kinase DYRK4.AA DYRK1 219-454 53 2.9e-108 365.97 In-house 1-238 (321) Show / Hide 
Range on Protein: 219-454
Range on HMM: 1-238/321
Sequence Identity: 53% (128 aa)

YEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGFS
||.   |||||||||.|  ||.. |.||.|||.||| | .||..|...|| . |.||.. |..||.|  | |||| |. ||||  |||.|..| .|.| |
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

LSIVRRFTLSVLKCLQMLSVE--KIIHCDLKPENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGY
| ..|.|   ... |  .|    .|||||||||||.|     . .|.|||||||   |..| ||||||||||||.|| .||.||||||||||  |. || 
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGE

PLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFD
||| | |||.|.  |.||||.||. .|. | . . .|.
PLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFE
Kinase DYRK4.AA YAK 219-443 48 7.4e-106 357.98 In-house 1-229 (347) Show / Hide 
Range on Protein: 219-443
Range on HMM: 1-229/347
Sequence Identity: 48% (112 aa)

YEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYN----VVHMKDFFYFRNHFCITFELLGINLYELMKNNNF
| ||   |.| ||||.||     |||.| |.| |.  . |||  | .||. | ..   |  |    .. | ||| ..||||. ||.| .||||..|.|.|
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

QGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYT
 ||| ...| .| ..|  .  |   .||||||||||| | .  .  .|.|||||||.| . ||||||.|.|||||.|.. .|  .||||||||| |||. 
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFL

GYPLFPGENEVEQLACIMEVLGLPPAGFI
| |.|||  | .|.  | ..|| ||   |
GLPIFPGNSEYNQIKRIIDMLGYPPSWMI
Kinase DYRK4.AA S_TKc 219-515 25 5e-84 286.38 SMART 1-231 (231) Show / Hide 
Range on Protein: 219-515
Range on HMM: 1-231/231
Sequence Identity: 25% (80 aa)

YEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGI---NLYELMKNNNFQ
||.|..||||.||.| || ..| ...||.|||.      .... |..||.        .  |.|...|.|.  .|... .|...    .|....|... .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

G----FSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDV-AIDMWSLGCITA
|    |.   .|...  ... |. .   .|||.||||||| | .     .|..|||...      .|.. ...|..|||.   .|.  ..|.||.||| .
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSKDLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQAL
|...|||.||      |.. .....|                                                . ...||.|.||...|. |.|  .||
EMLCGYPPFP------QMQMMFKKIG------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EAL

K-------HAWI
.       | |.
QDEWDIKCHPWF
Kinase DYRK4.AA HIPK 219-454 43 3.1e-78 245.91 In-house 1-238 (329) Show / Hide 
Range on Protein: 219-454
Range on HMM: 1-238/329
Sequence Identity: 43% (103 aa)

YEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGFS
||||| .|.| ||||.||  .  ||.||.||..|   .  |  .|..||. |.... |. |..| . ..|  .||.|. ||.|  |||. .|.|.|    
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADE-YHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLP

LSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQAS--VKVIDFGSSCYEHQKVY-TYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTG
|  .|  .. ||. |  |    .|| ||||||| |  . .    ||||||||  .  . |  ||.|||.|| ||.||| |.  ..|||||||. |||. |
LKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLG

YPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFD
 ||.|| .| .|   | .  .||    .. |.. . |||
WPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFD
Kinase DYRK4.AA Pkinase 219-515 27 2.7e-66 231.35 Pfam 1-293 (293) Show / Hide 
Range on Protein: 219-515
Range on HMM: 1-293/293
Sequence Identity: 27% (87 aa)

YEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQA-----LMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGI-----NLYEL
|.....||.||||.| || .......||.|||. ... ...      |.|..|.  |.        |.| ..|.|. ..| .. .|...       |...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN------HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

MK---NNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQA--SVKVIDFGSSC---YEHQKVYTYIQSRFYRSPEVIL-GHPYDVA
..   ...|  ||   .... . .|. |. .  ..|||.||||||| . ..|.   .||..|||...   | ..  .|.  ...|..||||. | .|. .
ISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPK

IDMWSLGCITAELYTGYPLFPGE----NEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSKDLTMVLKTYDTSFLDFLRRC
.||||.||| .|...|.|.|||.    | ..|...| ...| |.   ... ... .||  .  .               . .. . .  . ...||...|
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-------------F-HWTF-HNWSEECKDFIKWC

LVWEPSLRMTPDQALKHAWI
| . |. | |..|.|.| |.
LCKDPKKRPTAEQILQHPWF
Kinase DYRK4.AA DyrkP 219-456 39 4.4e-60 196.31 In-house 1-242 (323) Show / Hide 
Range on Protein: 219-456
Range on HMM: 1-242/323
Sequence Identity: 39% (95 aa)

YEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMK----NNNF
| ..| .|   | .  .|.| . | .. .||| | | .  |.. |.|.|  .         ||... |.|| . |  |  |||  ||||  |    |   
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQQ

QGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYT
. | .  . . |  .|  |  .   ..||||||||||..  . .. ||.|||||||. |  .  |.||| || ||||.|  ||  ||||||||| |||.|
RYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWT

GYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSK
|  ||  .|    || .. ..|  |   .|     | ||  |
GNVLFQNDNIQGLLARVIGIIGPFPEWMMQEGRLVQNFFTRK
Kinase DYRK4.AA PRP4 219-454 38 1.3e-55 191.09 In-house 1-240 (320) Show / Hide 
Range on Protein: 219-454
Range on HMM: 1-240/320
Sequence Identity: 38% (92 aa)

YEVLETIGKGSFGQVAKCL-DHKNNELVALKIIRNKKRFHQQALMELKILEALRKK--DKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNN-NF
|.|   .|.| |. | .|    . || || |||||.   |.  | || ||  |  .  ||.  . .| |.. |..|.| |. || .  || |..|     
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

QGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQASVKVIDFGS-SCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELY
 |..|  || ..   .  |. |   .|.| |.|| ||.     .   | .|||| |  . . .  | .|||||.||.|.||||| .||||| ||  .|||
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNILVNES-KNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELY

TGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFD
||  .|||    . |  .|.. |  |   |.    . ..||
TGKIMFPGKTNNHMLKLFMDYKGKMPNKMIRKGQFKDNHFD
Kinase DYRK4.AA Ciliate-E2-Unclassified 219-515 19 5.1e-52 178.73 In-house 1-352 (352) Show / Hide 
Range on Protein: 219-515
Range on HMM: 1-352/352
Sequence Identity: 19% (78 aa)

YEVLETIGKGSFGQVAKCLDHKNNELV-----ALKIIRNKKRFHQQA---LMELKILEALRKKDKDN------------TYNVVHMKDFFYF--RNHFCI
|.....||.|.||.| || . |.. ..     . ||. .|..  ..    ..|.|... . | . ..             .. . .|.|..|  .....|
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

TFELL-GINLYELMKNNNF---------------QGFSLSIVR-----RFTLSVLKCLQMLSVEK-IIHCDLKPENIVLYQKGQ-ASVKVIDFGSS----
  |.. | .| . .|....               . |.   ..     ...  .|..|. |  .. ||| |.|||||.. ..|.   .|.||||.|    
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

--------------CYEHQKVYTYIQSRFYR----SPEVILGHPYD----VAIDMWSLGCITAELYTGYPLFPGENEVE----------------QLACI
               . .|. .| ...  |     .|||. |. ||     ..|.||||.|  |. .||. |...|. .                ..  |
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

MEV-------------LGLPPAG--FIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSKDLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWI
..               ...| .  ||.                                             |.|...|.. |. |.|..|.|.| |.
KQKNIQFPKFPWQQIPKHWSPEAKDFIN---------------------------------------------DLLQKMLKKNPNKRITFEQILNHPWF
Kinase DYRK4.AA CLK 219-353 36 1.1e-51 152.9 In-house 1-147 (350) Show / Hide 
Range on Protein: 219-353
Range on HMM: 1-147/350
Sequence Identity: 36% (54 aa)

YEVLETIGKGSFGQVAKCLDHKN-NELVALKIIRNKKRFHQQALMELK-ILEALRKK-DKDNTYN--VVHMKDFFYF-RNHFCITFELLGINLYELMKNN
||.. | | | || | .| |||| . .|||||||| ...  .|  |.. |.... .| |..|.|   ...| | | .  .|.|| |||.| ..|..|| |
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

N------FQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVL
|      .... .. .|...   .. .. |   |..| ||||||| .
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICF
Kinase DYRK4.AA CLK 361-515 33 4.2e-36 105.2 In-house 186-350 (350) Show / Hide 
Range on Protein: 361-515
Range on HMM: 186-350/350
Sequence Identity: 33% (55 aa)

VKVIDFGSSC---YEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACIMEVLGLP-PAGFIQTAS---RRQTFF
..||||||     ..| . .| ...| || |||||| .. .  | || |||  |||||. ||.. ...| || . ...|.| |   ||.       | .|
ICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYF

DSKGFPKNITNNRGKKRYPDSKDLTMVLKTYD---TSFLDFLRRCLVWEPSLRMTPDQALKHAWI
   .   . .|  |..     | |   ..  |    .. | .|..|  .|| |.| ..||.| . 
YHNRLDWDWHNSDGRYVMENCKPLKQYMDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase DYRK4.AA TyrKc 219-513 14 7.2e-08 -95.44 SMART 1-280 (280) Show / Hide 
Range on Protein: 219-513
Range on HMM: 1-280/280
Sequence Identity: 14% (48 aa)

YEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEAL-RKKDKDNTYNVVHMKDFFYFR-------NHFCITFELL-GINLYELM
 . ....| | ||.| |.      . || | ... .  ..  . |..|.  |       .  |.| .                 .| .|.  . .| .  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGG-----HHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQASVKVIDFGSSCYEHQK-------VYTYI----QSR-----FYRSPEVILG
...  . ....    | . . .  . |.  ..|| ||   |. .  ..   ||. ||| | . . .        |       ...        .||.|  
RKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

HPYDVAIDMWSLGCITAELYT-GYPLFPGE----NEVEQLACIMEVLGLPPAGFI----QTASRRQTFFDSKGFPKNITNNRGKKRYPDSKDLTMVLKTY
. .  . | || |    |..| | .  ||.     . ...    .  . .|                                               . 
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------------------F--VCC

DTSFLDFLRRCLVWEPSLRMTPDQALKHA
 .   .  ..|   .|. | |  .  .  
PDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase DYRK4.AA DyrkP 472-515 38 9.7e-07 17.49 In-house 280-323 (323) Show / Hide 
Range on Protein: 472-515
Range on HMM: 280-323/323
Sequence Identity: 38% (17 aa)

PDSKDLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWI
|    |   |.| |  |.|| |.||  .   | |   ||.| |.
PKHSNLRARLRTDDHMFIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase DYRK4.AA PRP4 488-515 46 5e-06 18.18 In-house 293-320 (320) Show / Hide 
Range on Protein: 488-515
Range on HMM: 293-320/320
Sequence Identity: 46% (13 aa)

FLDFLRRCLVWEPSLRMTPDQALKHAWI
| |.| .||.  |. | |. .||||  |
FKDLLDKCLMLDPKKRITCNEALKHPFI
Kinase DYRK4.AA HIPK 487-515 31 2.6e-05 12.15 In-house 301-329 (329) Show / Hide 
Range on Protein: 487-515
Range on HMM: 301-329/329
Sequence Identity: 31% (9 aa)

SFLDFLRRCLVWEPSLRMTPDQALKHAWI
.| . |.. ..|..  |.|| .||.| ..
EFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase DYRK4.AA DYRK1 488-515 39 6.6e-05 12.62 In-house 294-321 (321) Show / Hide 
Range on Protein: 488-515
Range on HMM: 294-321/321
Sequence Identity: 39% (11 aa)

FLDFLRRCLVWEPSLRMTPDQALKHAWI
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FKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase DYRK4.AA YAK 488-515 39 0.004189 5.95 In-house 320-347 (347) Show / Hide 
Range on Protein: 488-515
Range on HMM: 320-347/347
Sequence Identity: 39% (11 aa)

FLDFLRRCLVWEPSLRMTPDQALKHAWI
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FIDFINQLLQLNPRERWKPMQAMQHPFI