Gene HCK (Human)

HCK

Species: Human
Alias: HCK, p59hck, p56hck, JTK9
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 20q11.21,

Classification

Group: TK
Family: Src
Subfamily: SrcB

Sequence

Name Sequence Type Origin Length Description Download
HCK.NA RNA Sugen Kinome 2105 None Fasta, JSON
HCK.AA Protein Sugen Kinome 526 None Fasta, JSON
HCK.kin_dom Protein Kinase Domain Sugen Kinome 251 None Fasta, JSON

Protein domain

Protein domains of HCK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 HCK.AA SH3 81-137 50 8e-24 86.39 SMART 1-58 (58) Show / Hide 
Range on Protein: 81-137
Range on HMM: 1-58/58
Sequence Identity: 50% (29 aa)

IIVVALYDYEAIHHEDLSFQKGDQMVVLEE-SGEWWKARSLATRKEGYIPSNYVARVD
  |.|||||.| ....|||.||| . |||. ...|||.|   | .||..|||||...|
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 HCK.AA SH3_1 84-130 51 2e-23 81.87 Pfam 1-49 (49) Show / Hide 
Range on Protein: 84-130
Range on HMM: 1-49/49
Sequence Identity: 51% (25 aa)

VALYDYEAIHHEDLSFQKGDQMVVLEESGE--WWKARSLATRKEGYIPS
||||||.| . ..|||.|||.. |.|.| .  |||.|.. |..||..||
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH3_2 HCK.AA SH3_2 82-136 20 1.8e-10 39.54 Pfam 1-68 (68) Show / Hide 
Range on Protein: 82-136
Range on HMM: 1-68/68
Sequence Identity: 20% (14 aa)

IVVALYDYEA-IHHED-----LSFQKGDQMVVL----EESGEWWKA-RSLATRKE--GYIPSNYVARV
 .... ||..    ..     |.|.|||. .|.    .....||.. ........  |..||..|. .
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC
SH2 HCK.AA SH2 144-226 56 1.5e-51 153.19 Pfam 1-81 (81) Show / Hide 
Range on Protein: 144-226
Range on HMM: 1-81/81
Sequence Identity: 56% (47 aa)

WFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHY
|... |||..|||.|..|||. |.|..|.||.|.|.|.||||| .|  || ||||.|...||||.||. | .|..|||||.||
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGP--GDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 HCK.AA SH2 142-232 43 2e-36 128.25 SMART 1-87 (87) Show / Hide 
Range on Protein: 142-232
Range on HMM: 1-87/87
Sequence Identity: 43% (40 aa)

EEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISP--RSTFSTLQELVDHYKKGNDG
..|..  |||..||. |..||.  |.|..||||...|.|.||||.      . ||||.||..|.|..||    | .|..| |||.||..  .|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK-----GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase HCK.AA SrcB 262-512 87 2.3e-207 695.16 In-house 1-251 (251) Show / Hide 
Range on Protein: 262-512
Range on HMM: 1-251/251
Sequence Identity: 87% (219 aa)

LKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDF
|||.|||||||||||||..||.|.||||||||.|.||.||||||||||||||||.||.|.|||||||||||||.||||.||||||.|||||..||||||.
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKEPIYIITEYMAKGCLLDFLKTDEGSKLSLPKLIDM

SAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGM
|||||||||.||..|||||||||||||||..|.||||||||||.|||||||||||||||||||||||||||.||||||||||||||||||||||||||||
SAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYPGM

SNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLD
.||||||.||||||||||.|||||||||||.|||.||||||||.|.|||||
TNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase HCK.AA Src 262-511 67 3.1e-197 661.55 In-house 1-255 (255) Show / Hide 
Range on Protein: 262-511
Range on HMM: 1-255/255
Sequence Identity: 67% (172 aa)

LKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKE-PIYIITEFMAKGSLLDFLK-SDEGSKQPLPKLI
.||..|||.||||||||...|..|||||||.|||.||.||||.||..||.|.|.|||.|.||...| ||||.||.|..|||||.|| ..||.. .||.||
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

DFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIE--DNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIP
|..||.|||||..|..|||||||.|.|.||. ..|||.|||||||.|.  |.||.||.|||||||||||||||.|.||||||||||||||.|||||||.|
DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVP

YPGMSNPEVIRALERGYRMPRPENCPEELYN-IMMRCWKNRPEERPTFEYIQSVL
||||.|.||....|||||||.|.|||.|||. ||..||...||.||||||.|..|
YPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase HCK.AA SFK-Src 262-515 59 2.5e-179 536.7 In-house 1-259 (259) Show / Hide 
Range on Protein: 262-515
Range on HMM: 1-259/259
Sequence Identity: 59% (155 aa)

LKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVT-KEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID
 .||||||.||||.||  . |. | |||||.|||.|| | ||.|| ||| |.|..|..|.|| | .|||||||| |. |||||.|.. .|    .|.|.|
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVD

FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIE-DNE-YTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPY
  ||.| |||. |  |..|||| | |.||  . |||..|||..||.. |.| |||.|||||||||||||| |   | |||||||||||.|||||||||||
MAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPY

PGMSNPEVIRALER--GYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFY
|||.| ||.. ..|  ||||| | |||.|.|.||. ||. .|..|||||  .  ..||.
PGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase HCK.AA SrcA 262-511 69 9.80000000001e-173 550.59 In-house 1-250 (250) Show / Hide 
Range on Protein: 262-511
Range on HMM: 1-250/250
Sequence Identity: 69% (174 aa)

LKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDF
..||..|| |.|||||| |.|  ||||.||.||| || |||| || .|| |.|||||.| |||  |||||.||.|.||||||||| .|| .  ||.|.| 
IRLERRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVSEEPIYIVTEYMCKGSLLDFLKDEEGKYLKLPQLVDM

SAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGM
.||.|||||..|  ||||||||||||||   |.||||||||||.||||||||| |||||||||||||  .| |||||||||||||| |.|| ||.|||||
AAQVAEGMAYMERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGM

SNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVL
 | ||.   ||||.|| |..||| |...|..||.  |||||||||.|| |
NNREVLEQVERGYHMPCPQDCPESLHELMCQCWRKDPEERPTFEYLQSFL
Kinase HCK.AA Pkinase_Tyr 262-511 48 1e-153 521.23 Pfam 1-270 (270) Show / Hide 
Range on Protein: 262-511
Range on HMM: 1-270/270
Sequence Identity: 48% (132 aa)

LKLEKKLGAGQFGEVWMATYN-----KHTKVAVKTMKPGSMSV----EAFLAEANVMKTL-QHDKLVKLHAVVT--KEP--IYIITEFMAKGSLLDFLKS
... ||||.|.||||...|..     ....||||..|.|.|.     |.|..||..||.| .|...|.|..|.|  .||  |||..|.|..|.|||.|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

D--EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVI-EDNEY-TAREGAKFPIKWTAPEAINFGSFTIKSDVWSF
   .. . ... |.....|||.||.. |..|.|||||.| |.||. ..|.||.|||||| | .| .| ..|.|.|.||||.|||.||.| ||.|||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GILLMEIVTYGRIP-YPGMSNPEVIRAL-ERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVL
|.|. ||.|||..| |||||| ||.... |.|||||.|||||.|.|..|..||.  ||.||||..|.. |
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase HCK.AA Src-Unclassified 262-511 45 5.6e-139 468.01 In-house 1-284 (284) Show / Hide 
Range on Protein: 262-511
Range on HMM: 1-284/284
Sequence Identity: 45% (128 aa)

LKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPG---SMSVEAFL--------AEANVMKTLQHDKLVKLHAVVTKE-PIYIITEFMAKGSLLDFLKSDE
..| .||| ||||||| . .     ||||||.||    || ||||        .||..|| ..| .||.| || ..| |.|||||.| .||||..|. . 
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

GSKQPLPKL------------IDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASL-----VCKIADFGLA--RVIEDNEYTAREGAKFPIKWTAPEAIN
|.  ... .            .| .||.| ||   | . |.|||| | |.|.         | |..|||||  ....| .| .| ||.||.||.|||.. 
GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFI

FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRP--ENCPEELYN-IMMRCWKNRPEERPTFEYIQSVL
 | |.|||||||.||||.|| |.|..||||| | ||.  .|||||||.|  . ||. .|  || .||  .|. ||||.     .
YGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase HCK.AA Frk 262-515 57 3.4e-136 458.78 In-house 1-260 (260) Show / Hide 
Range on Protein: 262-515
Range on HMM: 1-260/260
Sequence Identity: 57% (150 aa)

LKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKE-PIYIITEFMAKGSLLDFLK--SDEGSKQPLPKL
..| ..||.|||||||   .|  | |||||.|||.|  . ||.|| .|| |.| ||..|.|| | | ||||||| | .|||...|.  .|.|..  ...|
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

IDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLAR-VIEDNE--YTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGR
.| .||.| |||..|..||||||| | |.||  ...|||||||||| .. |||  | .| ||.||||||||||.|  .||||||||||||||.||.||||
VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGR

IPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFY
.||||| | ||.  ...|||||.| |||..||.||. ||.  |..||||| .|  |.|..
MPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase HCK.AA TyrKc 262-511 42 2.9e-135 456.58 SMART 1-280 (280) Show / Hide 
Range on Protein: 262-511
Range on HMM: 1-280/280
Sequence Identity: 42% (122 aa)

LKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTL--QHDKLVKLHAVVTK--------EPIYIITEFMAKGSLLDFLKSDEGS
..|.|||| |.||||. .|..  ..||||..|...  .|.|. ||..|. |  .|. .|.|..|.|.        ||..|..|.|..|.|.|.|.. .. 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

KQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDN--------EYTARE--GAK--FPIKWTAPEAINFGSFTIKSD
  ....|..|. |||.||......|.||||| | |.||.. ...||.||||.| |.|          |...|  |.|  .||.|.|||.||.| ||.|||
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

VWSFGILLMEIVTYGRIPYPG-----MSNPEVIRALERGYRMPRPEN--------CPEELYNIMMRCWKNRPEERPTFEYIQSVL
|||||... || |||  ||||     ||| |||. ...|||||.|.|        ||.|.|.|| .||.  ||.||||. | . .
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase HCK.AA Src-Echino1 262-511 52 3.8e-126 425.38 In-house 1-252 (252) Show / Hide 
Range on Protein: 262-511
Range on HMM: 1-252/252
Sequence Identity: 52% (132 aa)

LKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKE-PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID
|...||.| |..||||   .|  |.|||||.|...||  .|||||||||...|. .|...||   . ||||.|| | .|.|.|.||.... .  ...|||
LRMDKKIGKGHCGEVWKGVWNGNTPVAVKTLKEKTMSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHVKMTTLID

FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPG
  |.|| || .....|..|||| | |.||    |||||||||||......| ...|||.|||||||||. .|.|||||||||||||. |.||.||.||||
MGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGRYPYPG

MSNPEVIRALERGYRMPRPENCPEELYNI-MMRCWKNRPEERPTFEYIQSVL
| | ||.  ..||||||....||. ||.. ||.||   |  |||||.. . .
MMNREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF
Kinase HCK.AA TK 262-511 25 5.69999999999e-124 417.73 In-house 1-486 (486) Show / Hide 
Range on Protein: 262-511
Range on HMM: 1-486/486
Sequence Identity: 25% (124 aa)

LKLEKKLGAGQFG---EVWMATYNKH--------------------------TKVAVKTMKPG-SMSVEAFLA--------------EANVMKTLQ----
..|.||||.||||   ||...... .                          |.||||..|.| .|| |.|..              ||..|| ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HDKLVKLHAVVTKE-------------PIYIITEFMAKGS----LLDFLK--SDEGSK-----------------------------------------
 |. .|.|..|.|..             |..|..|.|..|.    |.|.|.  ......                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------QPLPKLIDFSAQIAEGMAFIEQR------NYIHRDLRAANILVSASLV-----------CKIADFG---
                                ... |. ...|||.||......      |..|||| | |.||. ..|           |||||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARVI-EDNEYTARE------------------------GAKFPIKWTAPEAIN---------FGSFTIKSDVWSFGILLMEIVTYGRIPYPG-M
     ||| | .| .|....                        |.|.||.|.|||..|         .| ||.||||||||.|. ||.|||. ||.| |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN---------PEVIRALERG--------------YRMPRPENCP--------------EELYNIMMRCWKNRPEERPTFEYIQSVL
||          ||.. |.||              .|||.|..||              ||.| .|..||.  ||.||||. ... |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase HCK.AA SRM 262-512 46 3.6e-116 390.14 In-house 1-253 (253) Show / Hide 
Range on Protein: 262-512
Range on HMM: 1-253/253
Sequence Identity: 46% (118 aa)

LKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGS-MSVEAFLAEANVMKTLQHDKLVKLHAVVTK-EPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLI
  | .|||.| ||||| .      .||.|  |    |  . . .|   || | | ....||||..  .|.||||| |.||.|. .|.. ..   |.|.|.
FTLCRKLGEGYFGEVWEGLWKGQVHVAIKVIKRDNLMHQHMLQKEIQAMKKLRHKHIIRLHAVCSVGDPVYIITELMRKGNLQQYLRDSDEKALPIPHLL

DFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYP
||  |.||||.. | .||||||| | |.||   ..||..|||||| | |  |    . . |.|||||||.| . . .||||||||||| |. ||| .|||
DFACQVAEGMCYLEEQNYIHRDLAARNVLVGDNNLCKVGDFGLARLIKDDIYSPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHEMFTYGQCPYP

GMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLD
||.| | .   .||||||.|  || | .  |. ||.  ||.||.|      | 
GMTNHETFQQIDRGYRMPCPAECPPEVHKLMLECWCRDPEQRPCFKDLREKLT
Kinase HCK.AA Tec 262-513 42 1.6e-110 373.46 In-house 1-254 (254) Show / Hide 
Range on Protein: 262-513
Range on HMM: 1-254/254
Sequence Identity: 42% (108 aa)

LKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKE-PIYIITEFMAKGSLLDFLKSDEGSKQPLP-KLI
|.. | || |||| | .. .  . .||.|..| |||| | |. || ||. |.| |||.|  | ... ||||.||.|..|.||..|.. ..  |     |.
LTFMKELGSGQFGVVHLGKWRHQYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQKNMAILL

DFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYP
.   .. ||||. |. ..||||| | | ||.   | |..|||..| . | .||   |.|||.|| .||  ..  .  |||||.||.|  |. . |..||.
EMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPYE

GMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDD
 ||| ||. .  .|.|. ||. |....| || .||. .|||||||.   . . .
NMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase HCK.AA S_TKc 262-516 23 1.1e-55 192.21 SMART 1-231 (231) Show / Hide 
Range on Protein: 262-516
Range on HMM: 1-231/231
Sequence Identity: 23% (64 aa)

LKLEKKLGAGQFGEVWMATYNK-HTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAK--GSLLDFLKSDEG----SKQP
 .. .|.| | ||.|. .. .| . .||.| .|      | .. | ...|  .|. .|||. |   . .|...|..    |.|.|..|.  .    .. |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

LPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTI-KSDVWSFGILLMEIVTY
      . .||....... ... |||||  .|||..   . ||.||||||..                . ||| .   ...  |.|.||.|..| | .. 
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-

GRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQS----VLDDFYT
|. |.|     .. . ...          ..|. .....|..  ||.|||   .      .  . . 
GYPPFP-----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase HCK.AA Pkinase 262-514 24 1.4e-42 151.63 Pfam 1-293 (293) Show / Hide 
Range on Protein: 262-514
Range on HMM: 1-293/293
Sequence Identity: 24% (74 aa)

LKLEKKLGAGQFGEVWMATYNKHTK-VAVKTMKPGSMSVEAF-----LAEANVMKTLQHDKLVKLHAVV-TKEPIYIITEFMAKG----SLLDFLKSDEG
.....|.|.| ||.|. ..  .  | ||||..|  . . .       |.|. .|| |.|.  |.|. .. .|  ||...|.. .|    .| |... ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

SKQ--PLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVC----KIADFGLARVIEDNEYTAREGAKFP---IKWTAPEAIN-FGSFTIKSDV
 .   .   ....  ||..|.... ... |||||  .|||..   ..    ||.|||||....   |   . .. .   . . ||| |.     . |.|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSFGILLMEIVTYGRIPYPGM----SNPEVIRALERGYRMPRPENCP-----------------------EELYNIMMRCWKNRPEERPTFEYIQSVLDD
||.|..| | .. || |.||     .  . .  ..|  . | ....|                       ||.  .. .|..  |..|||   .. .| .
WSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQH

--F
  |
PWF