Gene HIPK3 (Human)

HIPK3

Species: Human
Alias: HIPK3, FIST3, YAK1, PKY, DYRK6
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 11p13-p14,

Classification

Group: CMGC
Family: DYRK
Subfamily: HIPK

Sequence

Name Sequence Type Origin Length Description Download
HIPK3.NA RNA Sugen Kinome 4743 None Fasta, JSON
HIPK3.AA Protein Sugen Kinome 1215 None Fasta, JSON
HIPK3.kin_dom Protein Kinase Domain Sugen Kinome 329 None Fasta, JSON

Protein domain

Protein domains of HIPK3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase HIPK3.AA HIPK 197-525 78 3.8e-254 809.75 In-house 1-329 (329) Show / Hide 
Range on Protein: 197-525
Range on HMM: 1-329/329
Sequence Identity: 78% (258 aa)

YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPL
||||.||||||||||||||||||||.||||||||||.||||||||||||..||.||||||.||||||||.|.|||||||||||||||||.|||||.||||
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADEYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLPL

KVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGW
|.||||||||.|||.|||.||||||||||||||||||.|.|||||||||||||||||.||.|||||||||||||||||||||..||||||||||||||||
KHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLGW

PLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADRR
|||||| ||||||||.|||.|| |.||. ..|..|||......... ||||..||||..|..|||||||||||.|||...||...|.|..|...||.|||
PLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRDKQSKFRPWRLKHIEEHEQQTSVKSKEARKYIFNCLDDMPEVNMLVDPERQDYRVEKIDRR

EFVSLLKKMLLIDADLRITPAETLNHPFV
|||..||||. .||. ||||.|.||||||
EFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase HIPK3.AA DYRK 197-525 42 5.2e-178 597.68 In-house 1-320 (320) Show / Hide 
Range on Protein: 197-525
Range on HMM: 1-320/320
Sequence Identity: 42% (141 aa)

YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTE-NADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPL-
||.|...|.|.||||||||...|||.|||||..|.....||.|||..|| .|... . |.|..|..|..|.||||.|.|||.|..|||.|||.|.| .. 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

PLKVIRPILQQVATALKKLKSL-GLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELF
.|...|...||. |.||.|...  .||.|||||||||..| |.....|||||||...... ...||.|||.|||||.|||.|.|.|||||||||..||||
SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQP-RNKSTIKVIDFGSSCFEHQ-RIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELF

LGWPLYPGALEYDQIRYISQTQGLPGEQLLNVG--TKSTRFFCKETDMSHSGWRLKTLEEHEAETG-MKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLA
.||||.||. ||||...| ...|.| . ... |  .. ..|| .           .. .|.. .|.  |..........  ..  ... . . .  | . 
TGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC-----------FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRH

EKADRREFVSLLKKMLLIDADLRITPAETLNHPFV
. .|...|. ..||.| .| . ||||.. |.||..
Q-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase HIPK3.AA CMGC 197-525 23 6.2e-107 352.55 In-house 1-513 (513) Show / Hide 
Range on Protein: 197-525
Range on HMM: 1-513/513
Sequence Identity: 23% (122 aa)

YEVLDFLGRGTFGQVVKCWK--------------RGTNEIVAIKILKNHPSYARQGQ-------------IEVSILARLS------------TENADEYN
||... .|.||.|.|.||.               . ||||||||..|| . | .|..              |..|| .|.            ..| .. |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

FVRAYECFQHRN-----------------HTCLVFEMLEQNLYDFLKQNKFS-------PLPLKV------------IRPIL------QQVATALK--KL
 |. |..|.|.|                 | .|||| ....||...|.|.|        ||.  .            |. ..      .|. ..||   .
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

KSLG--LIHADLKPENIMLVDPVRQP----------------YRVKVIDFGSASHVSKT-----------------------VCSTYLQSRYYRAPEIIL
 | .   || |||||||.. .  . .                .|.|..|||.| ....                          ..| ..|.||||||.|
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GLP----------FCEAIDMWSLGCVIAELFLG--------WPLYP-----------GALEYDQIRYISQTQGLPGEQLLNVGTKST-RFFCKETD----
| .          ....|||||.||..||...|        .|| |           |. ..||.  | .. | |  .... |. .    ||| ..    
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGK-RHFN-FCKHEEEWPN

MSHSGWRLKTLEEHE--AETGMKSKEARKYIFNSLDDV-AHVNTVMDLEGSDLL----------------------------AEKADRREFVSLLKKMLL
|.   |. |... ..  ..|. .|. ||.||.. ..    . ..  .|.  .                              ..| .  ... |||||| 
MIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQ

IDADLRITPAETLNHPFV
.| | |||... |.||. 
YDPDKRITAEQALQHPYF
Kinase HIPK3.AA YAK 197-525 36 8.49999999999e-102 344.49 In-house 1-347 (347) Show / Hide 
Range on Protein: 197-525
Range on HMM: 1-347/347
Sequence Identity: 36% (129 aa)

YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARL--STENADEY---NFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKF
| ||| ||.||||||||| . .|||..|.|..|| . |  |.  |. ||  |    .  ..     ..| |  | |.|| |||||||. |||..||||||
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

SPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAE
  .   .||  . |.  ..  |..  .|| |||||||||   . .|  .|.|||||.    |.|  || |.|.||.||||.. ..| .||||||||..||
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCK-PNKP-EIKIIDFGSSCQEKKMVY-TYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAE

LFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSG-------------------WRLKTLEEHEAETGMKSKEARKY----IF
|||| |..||. ||.||  |  . | |   ... |  ....|       | |                     .|| .. . . . . || ..|      
LFLGLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYF-----HCHDGSNSDDNNNNNNNNNGKPYYYIFKTKQDYQIDEKIQLKESKTYFQYKCL

NSLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFV
| . .       |  .  |   ..  |  |. ..  .|  .   | .|     |||.
NDIKNYMYFKQFMRNQ--DDTKNNRHRDCFIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase HIPK3.AA DYRK2 197-433 39 1.1e-85 278.53 In-house 1-241 (318) Show / Hide 
Range on Protein: 197-433
Range on HMM: 1-241/318
Sequence Identity: 39% (97 aa)

YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENADE-YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLP
||.| ..|.| |||||||    |.. ||||.. |   ...| ..|. || .... . |. .| |.  . |  |||.|..|| |  |||...|.|.|  . 
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

LKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLG
|. .|.  ... ..|. |.   .||.|||||||.|  . |    .|||||||   .      || |||.|||||.|||...  ||||||.||..|||. |
LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRS--GIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTG

WPLYPGALEYDQIRYISQTQGLPGEQLLNVG-----TKSTRFF
 || ||  | ||. ..    |.| ......      ..   ||
YPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFF
Kinase HIPK3.AA S_TKc 197-525 23 3.1e-79 270.46 SMART 1-231 (231) Show / Hide 
Range on Protein: 197-525
Range on HMM: 1-231/231
Sequence Identity: 23% (80 aa)

YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQ---NLYDFLKQNKF--
||.|. .|.|.||.| ||....|..||||||.|      .. . |..|| .      .  | |. |..||. .| ..|.|....   .|.|..|...   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

--SPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLPFCE-AIDMWSLGCV
  .|.|  ..| ...|.. ||. . |.| || |||||||.| .      ..|..|||.| ..     .|.  ...|.|||..   ..   ..|.||.||.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

IAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDL
..|.. | |..|   ..  .. |                                                                             
LYEMLCGYPPFP--QMQMMFKKIG----------------------------------------------------------------------------

LAEKADRREFVSLLKKMLLIDADLRITPAETLN-------HPFV
       .|. ....|.|  | . |.|  | |.       ||..
------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase HIPK3.AA DYRK1 197-459 38 4e-74 252.56 In-house 1-263 (321) Show / Hide 
Range on Protein: 197-459
Range on HMM: 1-263/321
Sequence Identity: 38% (103 aa)

YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENADE-YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLP
||.   .|.| |||||| . . . | |||||.||  ..  | |||. .|  .  . ... |. |.  . | .||| |||||.|  |||| |.  .|    
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

LKVIRPILQQVATALKKLKS--LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELF
| ..| . ||..|||  . .  | .|| |||||||.|. | |    .|.|||||. .. . .   |.|||.||.||..||...  |||||||||.. |. 
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRS--AIKIIDFGSSCQLGQRIY-QYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMH

LGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMK
 | ||. |. | ||.  |    |.| ..... . |. ..| |..| ...  . .  . |  | . .
TGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDPDNTWYCKKTRDKKKHYKEPCTR
Kinase HIPK3.AA PRP4 197-401 41 1.1e-56 194.63 In-house 1-207 (320) Show / Hide 
Range on Protein: 197-401
Range on HMM: 1-207/320
Sequence Identity: 41% (88 aa)

YEVLDFLGRGTFGQVVKCW-KRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTE---NADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQN-KF
|.|  . | | |. |..|  .  .|| |||||. | ..  . |  |. || .|.       | .  || .. |.||.| ||||| .  || . ||.  | 
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

SPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAE
  | ||..|   ||   ||| || .. .|||.|| ||.           | .|||||||..      ||.||.|||||||.| |.  .||||| || ..|
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNILVNE---SKNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYE

LFLGWPLYPG
|. |  ..||
LYTGKIMFPG
Kinase HIPK3.AA Pkinase 197-416 30 1.3e-52 185.89 Pfam 1-232 (293) Show / Hide 
Range on Protein: 197-416
Range on HMM: 1-232/293
Sequence Identity: 30% (74 aa)

YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQI-----EVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQ-----NLYDFL
|...  .|.|.||.| || ..||..|||.||.| .     . |.     |..|..||. .|      || |..|. ..| ..|.| .|       |.|..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPN-----IVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

K---QNKFSPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLV-DPVRQPYRVKVIDFGSAS---HVSKTVCSTYLQSRYYRAPEIIL-GLPFCE
.   ...|. .. .... .. |.. .|. . | | || |||||||... ...  . .||..|||.|    . ... ..|.  ...|.|||.|. | .   
STWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

AIDMWSLGCVIAELFLGWPLYPGA----LEYDQIRYISQTQG
..||||.||...|...| |..||.      .||.  | .. |
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMG
Kinase HIPK3.AA CLK 197-333 33 3.4e-51 151.33 In-house 1-150 (350) Show / Hide 
Range on Protein: 197-333
Range on HMM: 1-150/350
Sequence Identity: 33% (50 aa)

YEVLDFLGRGTFGQVVKCWKRGT-NEIVAIKILKNHPSYARQGQIEVS-ILARLSTE-NADEYNF---VRAYECFQH-RNHTCLVFEMLEQNLYDFLKQN
||... || |||| ||.|| .   .  ||.|| .|.  |  . ..|.. |.  . .  ...  .    .. ...| .  .| |.|||..  ..|||.| |
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

K------FSPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDP
.      . |.|.  || .  |  .|.|.| ...|.| ||||||| .||.
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVDS
Kinase HIPK3.AA DyrkP 197-395 38 8.5e-46 148.41 In-house 1-201 (323) Show / Hide 
Range on Protein: 197-395
Range on HMM: 1-201/323
Sequence Identity: 38% (78 aa)

YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTE-NADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNK----F
| ....||   | . ..|  . || .. .||. |   |  |   |. .|  .      || | .| |. | |. |  .. |.|..|||.| | |.     
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQQ

SPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAE
    .  .  | ||.  ||  . || ||| |||||||..    .   .||.|||||.  .   . | | ||| |||||.|.|  .   ||||||||..||
RYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKC--QVKIIDFGSSCFIHDHLSS-YVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAE

LFLG
|. |
LWTG
Kinase HIPK3.AA RCK 262-408 32 8e-33 101.26 In-house 64-223 (298) Show / Hide 
Range on Protein: 262-408
Range on HMM: 64-223/298
Sequence Identity: 32% (52 aa)

YECFQHRN--HTCLVFEMLEQNLYDFLKQ--NKFSPLPLKV--IRPILQQVATALKKLKSLGLIHADLKPENIMLVD-----PVRQPYRVKVIDFGSA-S
.| .....  .  .||| ...||| ..|    .  .|| ..  |. |. |.. .|. . . |  | ||||||||. .       . ....|..|||.. .
KEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCRE

HVSKTVCSTYLQSRYYRAPEIILGL-PFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQI
  ||     |  .|.|||||..|      . .|.|..||...||   .||.||. | |||
IRSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDIWAVGCIMYELYMLRPLFPGSSEIDQI
Kinase HIPK3.AA CLK 340-401 43 6.2e-22 61.9 In-house 186-249 (350) Show / Hide 
Range on Protein: 340-401
Range on HMM: 186-249/350
Sequence Identity: 43% (28 aa)

VKVIDFGSAS--HVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPG
..|||||||      ..  ||  ..| |||||.||||.. .  | || ||.. || .|  |...
ICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQT
Kinase HIPK3.AA RCK 197-231 45 2.6e-11 31.85 In-house 1-35 (298) Show / Hide 
Range on Protein: 197-231
Range on HMM: 1-35/298
Sequence Identity: 45% (16 aa)

YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNH
| ... ||.||.| |.|  .  |.|||||| .|..
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQK
Kinase HIPK3.AA TyrKc 197-505 18 1.5e-08 -84.18 SMART 1-280 (280) Show / Hide 
Range on Protein: 197-505
Range on HMM: 1-280/280
Sequence Identity: 18% (65 aa)

YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARL--STENADEYNFVRAYECFQHR-------NHTCLVFEMLEQ-NLYDFL
 . .. ||.| ||.|.|.  .   . ||.| ||..    .    | .|. .|  . .     | || | .  .           ..|.|  .  .| |.|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHP-----NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KQNKFSPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKT-VC----STYL-----QSR-----YYRAPEII
. ..   |..|    .  |.|     | | ..|| ||   |... ..     .||. ||| .  .     .    ..|      ...        ||| |
RKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

LGLPFCEAIDMWSLGCVIAELF-LGWPLYPG-----ALEYDQIRYISQTQGLPGEQL----LNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSK
    | .. | || | .. |.| .| . |||        .. |.|. |   .|  .                                            
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------------------

EARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADRR-EFVSLLKKM
      |      . . ..|    ..  .|... |  |  . ...
------F--VCCPDEMYQIM----KQCWHEDPEDRPTFSEIHECF
Kinase HIPK3.AA RCK 497-525 37 2.2e-07 19.18 In-house 270-298 (298) Show / Hide 
Range on Protein: 497-525
Range on HMM: 270-298/298
Sequence Identity: 37% (11 aa)

EFVSLLKKMLLIDADLRITPAETLNHPFV
. ..|..||| .| . |||... |.||. 
DCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase HIPK3.AA CLK 488-525 34 2e-06 14.39 In-house 313-350 (350) Show / Hide 
Range on Protein: 488-525
Range on HMM: 313-350/350
Sequence Identity: 34% (13 aa)

LLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFV
.. .. . |..  |..||| .|   ||| .. | ||| 
MDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase HIPK3.AA DYRK1 493-525 42 6e-06 16.36 In-house 289-321 (321) Show / Hide 
Range on Protein: 493-525
Range on HMM: 289-321/321
Sequence Identity: 42% (14 aa)

ADRREFVSLLKKMLLIDADLRITPAETLNHPFV
.|   |  |.|.||  |   |||| . | |.|.
EDYLKFKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase HIPK3.AA PRP4 501-525 52 6e-06 17.91 In-house 296-320 (320) Show / Hide 
Range on Protein: 501-525
Range on HMM: 296-320/320
Sequence Identity: 52% (13 aa)

LLKKMLLIDADLRITPAETLNHPFV
|| |.|  |   |||. | | |||.
LLDKCLMLDPKKRITCNEALKHPFI
Kinase HIPK3.AA Pkinase_Tyr 197-231 33 2.3e-05 18.77 Pfam 1-39 (270) Show / Hide 
Range on Protein: 197-231
Range on HMM: 1-39/270
Sequence Identity: 33% (13 aa)

YEVLDFLGRGTFGQVVKCWKR----GTNEIVAIKILKNH
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ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEG
Kinase HIPK3.AA DYRK2 509-525 41 7.1e-05 11.42 In-house 302-318 (318) Show / Hide 
Range on Protein: 509-525
Range on HMM: 302-318/318
Sequence Identity: 41% (7 aa)

DADLRITPAETLNHPFV
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DPSERMTPSQALKHPWI
Kinase HIPK3.AA Pkinase 496-525 30 0.000292 16.15 Pfam 264-293 (293) Show / Hide 
Range on Protein: 496-525
Range on HMM: 264-293/293
Sequence Identity: 30% (9 aa)

REFVSLLKKMLLIDADLRITPAETLNHPFV
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EECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase HIPK3.AA DyrkP 492-525 32 0.003838 5.43 In-house 290-323 (323) Show / Hide 
Range on Protein: 492-525
Range on HMM: 290-323/323
Sequence Identity: 32% (11 aa)

KADRREFVSLLKKMLLIDADLRITPAETLNHPFV
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RTDDHMFIDFVRQCLQIDFTRRPTAKEALQHPWF