Gene JNK3 (Human)

JNK3

Species: Human
Alias: SAPKbeta, JNK3A, p54bSAPK, JNK3, JNK3A2, FLJ33785, MGC50974, p493F12, P493F12, FLJ12099, MAPK10, P54BSAPK, PRKM10
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 4q21-q22.1,

Classification

Group: CMGC
Family: MAPK
Subfamily: JNK

Sequence

Name Sequence Type Origin Length Description Download
JNK3.NA RNA Sugen Kinome 4186 None Fasta, JSON
JNK3.AA Protein Sugen Kinome 464 None Fasta, JSON
JNK3.kin_dom Protein Kinase Domain Sugen Kinome 296 None Fasta, JSON

Protein domain

Protein domains of JNK3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase JNK3.AA JNK 64-359 70 9.3e-246 822.72 In-house 1-309 (309) Show / Hide 
Range on Protein: 64-359
Range on HMM: 1-309/309
Sequence Identity: 70% (219 aa)

YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP--FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ---
|||||.||.|||||||.|.|.|....|||||..||  |||..|.||||||...|||.||||||...|.||||.|||||||||.|||.||.||||||.   
YQNLKFIGQGAQGIVCMAFDQVTNQRVAIKKMMRPDNFQNWMHWKRAYREFICMKCINHKNIIKMYNCFTPQETLEEFQDVYIVMEYMDWNLCQVIHSTF

MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMG--YKENVDIWSVGCIMGEM
|||||||||||.|||.||||||||.||||||||||||||..||||||.|||.|||....||||||||||||||||||.||.  ||||||||||||||.||
MELDHERMSYLFYQMCCGIKHLHSMGIIHRDLKPSNIVVNQDCTLKICDFGHARTEDPTFMMTPYVVTRYYRAPEVICGMMDNYKENVDIWSVGCIMAEM

VRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENR---PKYAGLTFPKLFPDSLFP--ADSEHN-KLKASQARDLLSKMLVIDPAKRISV
.||..||||.|.||||||.||.||||.|.||...||.||||||||   |.|.. .| ..|||.|||  ..||.. .|....|||||..||||.| .||||
IRHHVLFPGKDHIDQWNKIIEFLGTPDPHFMMQMQPHVRNYVENRNMDPYYQPYNFHEHFPDTLFPDVMQSEPKDHLTCHMARDLLFRMLVINPDDRISV

DDALQHPYI
|||||||||
DDALQHPYI
Kinase JNK3.AA MAPK 64-359 48 3.6e-191 641.39 In-house 1-328 (328) Show / Hide 
Range on Protein: 64-359
Range on HMM: 1-328/328
Sequence Identity: 48% (162 aa)

YQNLKPIGSGAQGIVCAAYDAVLDRN------VAIKKLSRPFQNQTHAKRAYRELVLMKCV-NHKNIISLLNVFTP-----QKTLEEFQDVYLVMELMDA
||.|||||.||.|.||.|.|  ....      |||||.||||||.||.||.|||. |...  .|.|||.||..|||     |..||||.|.|.|||||..
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

NLCQVIQ-ME-LDHERMSYLLYQMLCG--IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS---------------FMMTPYVVTRYYRAP
.|.|.|. .  |......|..||.|.|  .|..|||..||||||||||.| ..|.|||.||||||.. ..               ..||.||.||.||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EVILG---MGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQ-P-TVRNYVENR---PKYAGLTFPKLFPDSLFPADSE
|..|.   |.|...||.||||||..||.. .|.||||.|||||||...|.|||| .||..... .  .|||....   ||| . .. |.||...|     
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANF-----

HNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI
   .. .||.|||.||||.|| |||.|..||||||.
---NANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase JNK3.AA p38 64-359 49 2.7e-139 469.08 In-house 1-289 (289) Show / Hide 
Range on Protein: 64-359
Range on HMM: 1-289/289
Sequence Identity: 49% (150 aa)

YQNLKPIGSGAQGIVCAAYDAVLDRN---VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTP-QKTLEEFQDVYLVMELMDANLCQVIQM
||||.|.|||| | ||.|.|.  .     ||||||.||||   ||||.|||| | |. .| |.|.||.||||  . ...|||||.|...|.| | ... .
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

E-LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMV
. |  ..  .|.||.| | |  ||||||||||||||| |  || |.|||||||| . ..  || ||.|| |||||..|  | | . |||||||||| |..
QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCDDE--MTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAELI

RHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV-RNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQH
  ..|||| |.||| ..... .||| .||..|.|    |||....|..    | ..|.                || ||| |||..|| |||.. .|.||
TGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMG------------ANPQAIDLLEKMLELDPDKRITAEEAMQH

PYI
||.
PYF
Kinase JNK3.AA CMGC 64-359 26 6.7e-135 446.15 In-house 1-513 (513) Show / Hide 
Range on Protein: 64-359
Range on HMM: 1-513/513
Sequence Identity: 26% (135 aa)

YQNLKPIGSGAQGIVCAAYDAVLDRN--------------VAIKKLSRPFQNQTHAK----------RAYRELVLMKCVN-----------------HKN
|...|.||.|. |.|. ..|   ...              |||||...|| ....||          ||.||. ..|..|                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IISLLNVFTPQ---KTLEE--------FQDVYLVMELMDANLCQVIQM-----------ELDHER------------MSYLL------YQMLCGIK--HL
|..|...|..    ....|        |...|||.|.|| .|.|.|..           .|..                |..      ||.|.|.|  ..
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSAG--IIHRDLKPSNIVVKSDCTL--------------------KILDFGLARTAGT----------------------SFMMTPYVVTRYYRAPEVIL
||..  ||||||||.|| . ..|.|                    || ||||||  ..                      . ..|.|||||.|||||..|
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

G----------MGYKENVDIWSVGCIMGEMVR--------HKILFP-----------GRDYIDQWNKVIEQLGTP----------------CPEFMKKLQ
|          |.| . .|.||||||..||..        .|.|||           |...|||..| .. ||||                  |......
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

---------------------PTVRNYVEN---RPKYAGLTFPKLFPDSLFPADSEHNK-------------------------LKASQARDLLSKMLVI
                     . .|||...    |.. . .. .|||.. ...| . ||                         .  .||.|||.|||..
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDD-N-NKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQY

DPAKRISVDDALQHPYI
||.|||....||||||.
DPDKRITAEQALQHPYF
Kinase JNK3.AA ERK 64-359 40 7.29999999999e-113 381.26 In-house 1-307 (307) Show / Hide 
Range on Protein: 64-359
Range on HMM: 1-307/307
Sequence Identity: 40% (130 aa)

YQNLKPIGSGAQGIVCAAYDAV-----LDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN-HKNIISLLNVFTP-QKTLEEFQDVYLVMELMDANLCQV
|| .|.|| || |.||.| |        .  ||||| ...| .   .||..||. |..  . |.|||.|.... | ...  .. |.|.| |||.  | |.
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPE--QYNDIYCVEELMETDLHQI

IQME--LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR---------TAGTSFMMTPYVVTRYYRAPEVILGM-GYKENV
|. .  |  .   |..||.|||.|..|||..|||||||||| | |.|.||| ||||||         . ... .|| ||.||.|||||..|    | . .
INSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAM

DIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTP-CPEFMKKL-QPTVRNYVENRPK--YAGLTFPKLFPD-SLFPADSEHNKLKASQARDLLSKM
||||.|||. ||.. | ||||.||..| | ... .|||   | ...   . ...|. | |.  ...  . ..||. .             .|| |||.||
DIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNAN-----------CNPQAIDLLEKM

LVIDPAKRISVDDALQHPYI
||.|| |||.|...|.||| 
LVFDPDKRITVEECLEHPYF
Kinase JNK3.AA ERK5 64-359 40 2.4e-90 306.44 In-house 1-295 (295) Show / Hide 
Range on Protein: 64-359
Range on HMM: 1-295/295
Sequence Identity: 40% (124 aa)

YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME--L
|. .  || || |.||.|      . |||||.   |   | ||| .||| ...   | ||| . ..  |.. . |..||| |..||.. | |.|  .  .
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGT------SFMMTPYVVTRYYRAPEVILGM-GYKENVDIWSVGCIMG
  | . | |||.| |.| .||| .|||||||||..|   | ||| |||.||   |       . || || ||.|||||... .  |   .|.||||||.|
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG

EMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP-TVRNYVEN-RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDD
||.  . .|||. ||.| . ... ||.| |  ..      |.||.    |      . |..|     ||         || |||..||. .|..||.|  
EMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPK----AD--------RQALDLLARMLRFEPSERITVNK

ALQHPYI
|||||..
ALQHPFL
Kinase JNK3.AA S_TKc 64-359 27 2.5e-90 307.3 SMART 1-231 (231) Show / Hide 
Range on Protein: 64-359
Range on HMM: 1-231/231
Sequence Identity: 27% (87 aa)

YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA---NLCQVIQME
|. |..||.|| | |. ...   .| ||||...         ....||. ..|  .|.||. |. ||         ...|.|||..|    .| ..|.  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKR

--------LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKE-NVDIWSVGC
        ..  .  ...||..|.....|| |||||||||.|| . .  ..|| ||||||        | ...|..|.||||.   ||    .|.||.||
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

IMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVD
|. ||.  . .||      | .......|                                                 ..|.|...|.|. ||.||... 
ILYEMLCGYPPFP------QMQMMFKKIG------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-

DALQ-------HPYI
.|||       ||..
EALQDEWDIKCHPWF
Kinase JNK3.AA nmo 65-359 41 2.8e-88 271.53 In-house 2-292 (292) Show / Hide 
Range on Protein: 65-359
Range on HMM: 2-292/292
Sequence Identity: 41% (123 aa)

QNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI--QMELD
|  .||| || |.| .  |    . ||.||.   |||   .|| .||| ..   .| |..|.|..  | . .. ||..| | ||| . | ..|    .| 
QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPH-KDFFQEIYVVTELMQSDLHKIIVSPQHLS

HERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART--AGTSFMMTPYVVTRYYRAPEVILGM-GYKENVDIWSVGCIMGEMVRH
 . .   |||.| |.| ||||.|.|||.|| |..| |.| ||| ||||||.    .|  ||  ||| ||||||...|   | . ||||||||| .|..  
SDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLGR

KILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI
.|||  .  |.| . ... ||||  | ||      .. .  .|. .   ...|.  |  | .  |       | .||..||. || ||||. |||.|||.
RILFQAQSPIQQLQMITDLLGTPSMEDMKYACEGAKAHMLRMPHKPP-CLQVLYTLSS-PDHATH------EAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase JNK3.AA ERK1 64-359 42 7.2e-84 284.93 In-house 1-289 (289) Show / Hide 
Range on Protein: 64-359
Range on HMM: 1-289/289
Sequence Identity: 42% (130 aa)

YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM-ELD
| ||. || || |.||.||| |  . |||||.| ||  ||. .|  ||. ...  .| ||| . ..    .|.|...|||.| .||.  | ....  .| 
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKIS-PFEHQTYCQRTLREIKILTRFKHENIINIQDIIR-ADTIEQMRDVYIVQCLMETDLYKLLKTQHLS

HERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMV
 . . | |||.| |.| .||| ..||||||||...   | ||| |||||| |         .| || ||.|||||..|   ||   .||||||||. ||.
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML

RHKILFPGRDYIDQWNKVIEQLGTPCPEFMKK-LQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQH
  . .|||. |.|| |...  || |  . ..  .    |||..  |  . . . .|||.    ||        |.| ||| |||   | ||| |..|| |
SNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPK----AD--------SKALDLLDKMLTFNPHKRITVEEALAH

PYI
||.
PYL
Kinase JNK3.AA ERK7 64-359 38 1.3e-80 274.1 In-house 1-292 (292) Show / Hide 
Range on Protein: 64-359
Range on HMM: 1-292/292
Sequence Identity: 38% (119 aa)

YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN-HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ--ME
|. .| .| || |||  |||      ||.||    |.||| | | .|| ....  . | |||.|.||.      .  .|.||| | |.. |  ||.    
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVI----RADNDRDIYLVFEFMETDLHAVIRKGNI

LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-------MMTPYVVTRYYRAPEVILG-MGYKENVDIWSVGCI
|      | .||.|  ||..||. .|||||||||| . |.|..|. ||||||. .          |.| || || |||||. ||   |   || ||.|||
LKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCI

MGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYV-ENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVD
.|||.| | .|||   ..| .|..| .. |  | .. ... ..  . |. ..    |. ...|..              .| ||| ..||  | ||....
LGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQC------------CDDAIDLLKRLLVFNPKKRLTAE

DALQHPYI
.||||||.
QALQHPYV
Kinase JNK3.AA Pkinase 64-359 27 7.8e-75 259.73 Pfam 1-293 (293) Show / Hide 
Range on Protein: 64-359
Range on HMM: 1-293/293
Sequence Identity: 27% (87 aa)

YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYR--ELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-----NLCQV
|. ...||||. | |. ...    . ||.|..... ..    ... |  |. .|| .||.||. |. .|.        ...|.|||...       |. .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDY

IQ-------MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL----KILDFGLART--AGTSFMMTPYVVTRYYRAPEVIL-GMGYKE
|.       . .. .     .||.|.|....|| |||||||||.|| .......    || |||||.      .  || ...|..|.|||||. | .|  
ISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

NVDIWSVGCIMGEMVRHKILFPGR----DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK
 ||.||.|||. ||.  . .|||.    . .||  .. . .|.| ..   .. .  . .  .. . .             .  ..  ..  . ..|....
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-------------F-HWTF-HNWSEECKDFIKW

MLVIDPAKRISVDDALQHPYI
.|  ||.||.. ...||||..
CLCKDPKKRPTAEQILQHPWF
Kinase JNK3.AA MAPK-Unclassified 64-212 43 2.6e-57 196.73 In-house 1-157 (575) Show / Hide 
Range on Protein: 64-212
Range on HMM: 1-157/575
Sequence Identity: 43% (68 aa)

YQNLKPIGSGAQGIVCAAYDAVL-DRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLE-EFQDVYLVMELMDA---NLCQVIQ
|   | ||||| |.|| | |  .  . |||||. . |.|.| .||. ||. .    || ||| . ..|..   .  ||.|.|.||..|     .| |.|.
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

MEL---DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR
  .    |.   |..|| | |.| ||||.||||||||||. .  ||...| |||..|
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase JNK3.AA MAPK-Unclassified 220-359 31 8.6e-38 131.88 In-house 405-575 (575) Show / Hide 
Range on Protein: 220-359
Range on HMM: 405-575/575
Sequence Identity: 31% (57 aa)

MTPYVVTRYYRAPEVILGMG-YKENVDIWSVGCIMGEMVR-----------HKILFPGRD--------------------YIDQWNKVIEQLGTPCPEFM
|| |||||.||||| .| |. |   |||||.||| .||.            |..||||.|                    ..|| .  .. ||.|  | .
MTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDC

KKLQ-PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKAS----------QARDLLSKMLVIDPAKRISVDDALQHPYI
   . . .| |..   . . . |  |..             ||.          ...|...|||...| |||. |.||.|||.
NFITCDSARKYIQSFKCKTPVHFTDLMF------------CKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase JNK3.AA TyrKc 64-313 23 4.8e-13 -11.82 SMART 1-280 (280) Show / Hide 
Range on Protein: 64-313
Range on HMM: 1-280/280
Sequence Identity: 23% (69 aa)

YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV--NHKNIISLLNVFTPQKTLEEF---QDVYLVMELMDA-NLCQVI
 . .| .|.|| |.|. .      ..||.|.|          .  .||. .|. .  .|.||. |. | | |.    |   . ...|||.|.  .| . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--FMYIEPLMIVMEYMPHGDLKDYL

-QME--LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS---------FMM-----TPYVVTRYYRAPEVILGMGY
   .  | .. . .  .|  ||  .||| ..|||||   |. |... | || ||||.|  .            ..     . ...     |||.|    .
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

KENVDIWSVGCIMGEMVRHKILFPGRDYID------QWNKVIEQLGTP----------------CPEFMKKLQPTVRNY-VENRPKYAGLTFPKLF
 .  |.|| |  | |.      . .  | .       .  |||.. .                 ||. | ..  .  ..  |.||  . .   ..|
TTKSDVWSFGVCMWEIFT----YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase JNK3.AA Pkinase_Tyr 64-213 27 1.6e-07 26.14 Pfam 1-160 (270) Show / Hide 
Range on Protein: 64-213
Range on HMM: 1-160/270
Sequence Identity: 27% (46 aa)

YQNLKPIGSGAQGIVCAAYDA----VLDRNVAIKKLSRPFQNQTH--AKRAYRELVLMKCV-NHKNIISLLNVFTPQKTLEEFQD--VYLVMELMDA-NL
 . .| .|.|| | |. ..        .  ||.|.| ..   . .   .   ||. .||   .|.||..|. | |     .. .   .|.|||.|   .|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT-----DQGEPNQIYIVMEYMPHGDL

CQVIQME------LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART
    .        |.....    .|  .|  .|.| ..|||||   |. |... . || ||||||.
LDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD