Gene MAP3K3 (Human)

MAP3K3

Species: Human
Alias: MAP3K3, MEKK3, MAPKKK3
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 17q23.2-q24,

Classification

Group: STE
Family: STE11
Subfamily: MEKK2

Sequence

Name Sequence Type Origin Length Description Download
MAP3K3.NA RNA Sugen Kinome 4843 None Fasta, JSON
MAP3K3.AA Protein Sugen Kinome 657 None Fasta, JSON
MAP3K3.kin_dom Protein Kinase Domain Sugen Kinome 261 None Fasta, JSON

Protein domain

Protein domains of MAP3K3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PB1 MAP3K3.AA PB1 75-154 21 2.6e-21 78.04 SMART 1-95 (95) Show / Hide 
Range on Protein: 75-154
Range on HMM: 1-95/95
Sequence Identity: 21% (20 aa)

DVRIKFEH-NGERRIIAFSRPVKYEDVEHKVTTVFGQ----PLDLHYM--NNEL--SILLKNQDDLDKAIDILDR------SSSMKSLRILLLSQ
.|..|. . .|. |.....|.....|. .||. ..|.    | .|.|   ....   .......||.......|.      ||..|.||...   
PVDVKCRYVGGDTRRFSVPRDWSFDDLMSKVAQRCGHDNDQPFTLKYQLPDEDGDAWVTITCDEDLQEMMEMYDSLESQNKSSCWKTLRLHVFPF
PB1 MAP3K3.AA PB1 75-154 24 2.6e-20 74.7 Pfam 1-86 (86) Show / Hide 
Range on Protein: 75-154
Range on HMM: 1-86/86
Sequence Identity: 24% (21 aa)

DVRIKFEHNGERRI--IAFSRPVKYEDVEHKVTTVFGQ--PLDLHYMNNEL--SILLKNQDDLDKAIDILDRS-SSMKSLRILLLSQ
.||||... |..|.  | ..|....||. |||. ....  .....| ....   .......||...... ..| .|| .||...  .
TVRIKCRYGGDIRRFIIHVRRNISFEDLMHKVEQRCKCDHTFKYQYPDEDGDDWVTITCDEDLQEMMEEYRSSEKSM-TLRLHVFPS
Kinase MAP3K3.AA MEKK2 393-653 88 7.50000000001e-218 730.01 In-house 1-262 (262) Show / Hide 
Range on Protein: 393-653
Range on HMM: 1-262/262
Sequence Identity: 88% (233 aa)

WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGAL
||||||||||||||||.|||||||||||.||||||||.|||.|||.||||||||||||||||||||||||||..||||.|||||||||||||||||||||
WRRGKLLGQGAFGRVYVCYDVDTGRELAVKQVQFDPDNPETRKEVQALECEIQLLKNLQHERIVQYYGCLRDNQEKTLSIFMEYMPGGSVKDQLKAYGAL

TESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEML
||.|||||||||||||.|||..||||||||||||||||.|||||||||||||||||||..|||.||||||||||||||.||||||||||||.||||||||
TETVTRKYTRQILEGMHYLHDHMIVHRDIKGANILRDSSGNVKLGDFGASKRLQTICMHITGMKSVTGTPYWMSPEVINGEGYGRKADVWSIGCTVVEML

TEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQ-RPSAEELLTHHFA
||||||||||||||||||||||||||||.|.|.|.||||.|.|||..| ||||||||.|||.
TEKPPWAEYEAMAAIFKIATQPTNPQLPQHVSQHARDFLKRCFVEIKQDRPSAEELLRHHFV
Kinase MAP3K3.AA STE11 393-653 47 1.4e-166 559.74 In-house 1-303 (303) Show / Hide 
Range on Protein: 393-653
Range on HMM: 1-303/303
Sequence Identity: 47% (143 aa)

WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDS---PETSKEVSA------LECEIQLLKNLQHERIVQYYG-CLRDRAEKTLTIFMEYMPGGSV
|..|...|.||||.||.|..||||...| ||.......   ....||...      ...||.|.|.|.|..||.||| ||.|...... |||||.||||.
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

KDQLK-AYGA--LTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGN-VKLGDFGASKRLQTICMSGTG-------MRSVTGTPY--------
.. |.  .|.  ..|.|.||||.|||||..||||..|.||||||||||.|| || .||.|||..|||..||.....       ..|.|||||        
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPM

WMSPEVISGEG---YGRKADVWSLGCTVVEMLTEKPPWAEYEA--MAAIFKIATQ-PTNPQLPSHIS------EHGRDFLRRIFVEARQ-RPSAEELLTH
||.||||..||   ||||||.|||||||.||.| ||||..|..  |||.|||...  . |..|.|.|      |..|||||. |.   . ||.| .|| |
WMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQH

HFA
.| 
PFI
Kinase MAP3K3.AA STE11-Unclassified 393-653 41 5.9e-112 378.24 In-house 1-308 (308) Show / Hide 
Range on Protein: 393-653
Range on HMM: 1-308/308
Sequence Identity: 41% (128 aa)

WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDS---PETSKE-VSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKA
|  |...|.|.||.||.| ...||  .| ||.    ..   ..  || . ... |...||.| |. |||||||  ...|. . ||||||||||.   |. 
WQKGEFIGKGSFGQVYKCMNCNTGEFMAVKQIEIHDYNSQQEDMQKEMIQSIQKEMKVLKQLNHKNIVQYYGCEIHKHEDCINIFMEYMPGGSIWSMLNK

YGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQ------------------TIC---MSGTGMR-SVTGTPY---
||.. |.|..|||.||||| .||||. |.|||||||||| |. |..|| |||..|                     .||    |. ... |  ||||   
YGCFDEMVIKKYTKQILEGLAYLHSHGIIHRDIKGANILIDFDGICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHINSQQNHCKSMQGTPYQPF

WMSPEVIS---GEGYGRKADVWSLGCTVVEMLTEKPPWAEYEA---MAAIFKIATQPTNPQLPSHIS-----------EHGRDFLRRIF-VEARQRPSAE
||.||||.    .|..||.|.|||||||.|| | |.||. ...   |.||.||.   . ||.|.| |           . ..||||. | .    ||.| 
WMAPEVIKNSTQTGHCRKSDIWSLGCTVIEMATGKHPWSNCQNDNFMWAIMKIVMSNQIPQIPEHLSPVCDFISCWISQECKDFLRKCFQIDPKKRPTAN

ELLTHHFA
.|| | | 
QLLQHPFI
Kinase MAP3K3.AA STE 393-653 30 8.9e-106 357.72 In-house 1-359 (359) Show / Hide 
Range on Protein: 393-653
Range on HMM: 1-359/359
Sequence Identity: 30% (110 aa)

WRRGKLLGQGAFGRVYLCYDVD---------------TGRELASKQVQFDPDSPETSK-------------EVSALECEIQLLKNLQ--HERIVQYYGCL
|.. . .|.|||| ||......               ||.  | ||. .......  .             |.  .. ||...|...  |. ||.|||| 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

R-----DRAEKTLTIFMEYMPGGSVKDQLK-AYGALT-------------ESVTRKYTRQILEG-MSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGAS
      . .. .| |.||||.|||. | .|  || .              ||. ....||||.| ..||||. |.|||||.||||      ||| ||| .
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC

KRLQTICM------------SGTGMR-SVTGTPYWMSPEVISG------EGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQ----------
..|. ..             .. ..| ...||| ||.||||..       ||..|.|.||||||..||.| ||||...  | |.| |..           
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

----PTNPQLPSHIS-------------------EHGRDFLRRIFVEARQ-RPSAEELLT--HHFA
    .. |.||.|.|                   .. .||... ..   . ||.|..||   | | 
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MAP3K3.AA S_TKc 393-653 31 9.6e-98 331.95 SMART 1-231 (231) Show / Hide 
Range on Protein: 393-653
Range on HMM: 1-231/231
Sequence Identity: 31% (88 aa)

WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPG--GSVKDQLKAYG
.. ....|.||||.||.|....|||. | |..               .. |||.||. .|. ||..|.. .|   . | ..|||..|  |...| .| .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRG

A------LTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGR-KADVWS
       ..| ..|.|..||.... |.||. |.|||.| .||| |.  ..|..||| ...|          ... |||..|.|||.   |||. |.|.||
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWS

LGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFV-EARQRPSAEELLT-------HHFA
.||.. |||. .||.     |...||.             |. ..||.|.... . ..||.| |.|.       | . 
CGCILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MAP3K3.AA MEKK15 393-653 45 4.4e-96 325.51 In-house 1-264 (264) Show / Hide 
Range on Protein: 393-653
Range on HMM: 1-264/264
Sequence Identity: 45% (123 aa)

WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDP-DSPETSKEVSALECEIQLLKNLQHERIVQYYG-CLRDRAEKTLTIFMEYMPGGSVKDQLKAYG
|..|..||.||.| || |   .||  .| |||. |  |  .. ..   |  |..||| |.|  || | | ||    . .. |||...||||.   .  .|
WKKGNILGKGAYGTVY-CGLTNTGQLIAVKQVELDEIDKEKAKQQYRKLQEEVDLLKTLKHKNIVAYLGVCLE---DNVVNIFMQFVPGGSISSIINRFG

ALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTG---MRSVTGTPYWMSPEVISGEGYGRKADVWSLGCT
.| | |  |||.|||.|. ||| | .|||||||.|..  . | .|| |||  |||    ...|    ..|. |||||| ||||   |||||.|.||.|||
PLDEMVFCKYTKQILQGVQYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLCWQGINRTHSDMLKSMRGTPYWMAPEVIMETGYGRKSDIWSIGCT

VVEMLTEKPPWAEYEAMAAIFKIATQ-PTNPQLPSHISEHGRDFLRRIFV-EARQRPSAEELLTHHFA
| || | |||||. . |||.| | ..    |||| . ||  |.| |     .   ||.| .|| | | 
VFEMATRKPPWADMDRMAAMFYIGAHRDPMPQLPVKFSEDARMFVRMCLTRDQHERPTASQLLKHPFI
Kinase MAP3K3.AA Pkinase 393-653 30 7.4e-81 279.72 Pfam 1-293 (293) Show / Hide 
Range on Protein: 393-653
Range on HMM: 1-293/293
Sequence Identity: 30% (92 aa)

WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGG----SVKDQLK-
...|. .|.|.||.||.|....||.. | |..  . ....  ..   |  |||..|.|.|. ||..|.. .|  .. . . |||..||    . .| .. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

-AYGAL--TESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNV----KLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVIS-GEGYGRKA
 ..|..  .| . ..| .|||.|. |.||. |.|||.| .||| |. |..    |..||| .| ..    ... | ...|||..|.||||  |..||.|.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVWSLGCTVVEMLTEKPPWAEY------EAMAAIFKIATQPTNPQLPSHIS-------------------EHGRDFLRRIF-VEARQRPSAEELLTHHFA
|.||.||.. |||. .||. .       . |. |..|   |.  . |  .|                   | ..||..... .   .||.||..| | . 
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MAP3K3.AA ASK 398-653 41 7.7e-72 238.18 In-house 1-254 (254) Show / Hide 
Range on Protein: 398-653
Range on HMM: 1-254/254
Sequence Identity: 41% (110 aa)

LLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKA-YGALT--E
 ||.|..| ||   | .| . .| | ..        |..|  |  ||.| |.|.|. |||| ||  .  .. . |||| .||||. . |.. .| .   |
VLGKGTYGIVYAGRDMHTQVRIAIKEIPE-----RDSRYVQPLHEEIALHKQLRHRNIVQYLGC--CSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNE

SVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDS-AGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVI--SGEGYGRKADVWSLGCTVVEM
.  . ||.|||||..||| | |||||||| |.|    .| ||. ||| .|||  |        . |||  .| ||||     |||. ||.||.|||.|||
NTMNFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTCKRLAGINPC---TETFTGTLQYMAPEVIDQGQRGYGKPADIWSFGCTMVEM

LTEKPPWAEY-EAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIF-VEARQRPSAEELLTHHFA
 | |||. |  |. ||.||.    . |..|. .|.. ..|..| | .....|.||..||   | 
ATGKPPFHELGEPQAAMFKVGMYKKHPEIPEELSAECKNFILRCFEPDPCKRASAQDLLQDPFL
Kinase MAP3K3.AA STE20 393-653 33 2.4e-69 236.67 In-house 1-288 (288) Show / Hide 
Range on Protein: 393-653
Range on HMM: 1-288/288
Sequence Identity: 33% (98 aa)

WRRGKLLGQGAFGRVYLCYDVDTGRE----LASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEK-T-LTIFMEYMPGGSVKDQL
.   . .|||..| ||..|...||..     | |..  .....|  .|.  .. ||. .|...|. ||.|||.     .. . | | |||. |||. | .
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQ-DEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIM

K---AYG------ALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQT--ICMSGT-GMRSVTGTPYWMSPEVISG--
|     |       ..|.     .|..|.| .||||| |.|||||..||| .. |.||| ||| .  |..     .      .. ||||||.||||..  
KHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGR-DTMQFKRNTFVGTPYWMAPEVIQCME

---EGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIA--TQPTNPQL---PSHISEHGRDFLRRIFV-EARQRPSAEELLTHHFA
    ||. |.|.|||| |  ||.. .|| ... .| |.|.|.  . |. .     |.. | . .||. .  . .  .||.|..||.| | 
GPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase MAP3K3.AA MEKK4 393-653 37 3.7e-66 225.8 In-house 1-271 (271) Show / Hide 
Range on Protein: 393-653
Range on HMM: 1-271/271
Sequence Identity: 37% (103 aa)

WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGAL
| ||   |.| || || | ..||.. .| | . | ..   . |..     ||  .  . |.  | |||    | |  . |||||   |  .   .  | .
WQRGDHIGEGQFGKVYTCMNMDTHEVMAMKEMRFQRNDHKAIKNIAD---EIKIFEGIKHPNLVRYYGVEVHREE--MYIFMEYCSQGTLERVCHLGGNM

TESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTIC--MSGTGMRSVTGTPYWMSPEVIS---GE-------GYGRKAD
 | ..|.|| |.| ...|||.  |||||||.|||  |. . .|||||| | .||     | |  . |  ||. .| |||..   ..       |.|| ||
QEHMIRQYTKQLLRAVNYLHQHGIVHRDIKPANIFLDKCTVLKLGDFGCSVKLQNHSQTMPGE-FQSTMGTAAYMAPEVYTYTEKDETTGSYSGHGRAAD

VWSLGCTVVEMLTEKPPWA---EYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIF-VEARQRPSAEELLTHHFA
.|||||.|||| | | ||.   .|.   .|      .. |. |   |  |.||.   .     .|. | ||| | |.
IWSLGCVVVEMMTGKRPWHGQTQYDHNFQIMYKVGMGHYPHIPDKMSPEGKDFFDHCLEHDPKDRWTANELLDHTFC
Kinase MAP3K3.AA MEKK1 393-652 38 5.6e-61 208.9 In-house 1-266 (266) Show / Hide 
Range on Protein: 393-652
Range on HMM: 1-266/266
Sequence Identity: 38% (102 aa)

WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQF-DPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGA
| .|  .| |||   |   || ||  .| ||. .    | .    . ..  ||...  . |  |.   |   . .     .| | ||||||   || |||
WTKGQQIGTGAFSSCYMAQDVKTGTLMAVKQITYCRNNSSDQEDVMEEIRKEIRMMAHFNHPHIIRMMGATCHDSH--YNVFIEWMPGGSVAHLLKDYGA

LTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGN-VKLGDFGASKRLQT-ICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVV
  .||. .|. |.. |.|||| | |.|||.|||| | || |      |||.  |.   |   .       ||   | |||  |. |||  |.|| || ..
FKNSVVINYIHQVCRGLSYLHDNQIIHRDVKGANLLMDSTGHHLRIADFGTAARMNSDITRTDEFQGQFLGTIAFMAPEVLRGQQYGRSCDIWSVGCCII

EMLTEKPPWAEYEA---MAAIFKIATQPTNPQLPSHISEHGRDF-LRRIFVEARQRPSAEELLTH-HF
|| . ||||        .. |||||   | |  |.| |   ||  ||   ..   ||   ||| |  |
EMCCTKPPWNNEKHSNHYQLIFKIASANTPPPIPEHLSPGLRDITLRCLEAQPQDRPPVMELLKHPVF
Kinase MAP3K3.AA STE-Unique 469-653 26 2.4e-52 180.24 In-house 368-616 (616) Show / Hide 
Range on Protein: 469-653
Range on HMM: 368-616/616
Sequence Identity: 26% (66 aa)

TLTIFMEYMPGGSVKDQLKAYGA---------LTESVTRKYTRQILEGMSYLHSNM--IVHRDIKGANILRDSAG-----NVKLGDFGASKRLQTI----
.. ||||| ..|.... .|. |.         . |.   .||.|||||  ||||    |.|||.| .||. .. |     .||..||| ....| .    
WVWIFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFEK

-------------------------------CMSGTGMRSVTGTPYWMSPEVISGE-----GYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIAT
                                 .  .| .  ||| .|.||||...     .|..|.|.|||||.. .|..  ||| ..  | | . .. 
DNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCI

QPTNPQL-------PSHISEHGRDFLRRIFV-EARQRPSAEELLTHHFA
  . ...       |.  .   ..|..  .  .  .||||..|| | . 
HIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase MAP3K3.AA Pkinase_Tyr 393-600 29 5.5e-30 102.18 Pfam 1-218 (270) Show / Hide 
Range on Protein: 393-600
Range on HMM: 1-218/270
Sequence Identity: 29% (68 aa)

WRRGKLLGQGAFGRVYLCYDV----DTGRELASKQVQFDPDSPETSKE---VSALECEIQLLKNL-QHERIVQYYGCLRDRAEK-TLTIFMEYMPGGSVK
 . || ||.||||.||...      .|. . | | .      . ...|     ..  |....|.| .|. ||..||.  |. |   . | |||||.|. .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

DQLKAY----GALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRL-----QTICMSGTGMRSVTGTPYWMSPEVISGEG
| |..     ..|| .   .. .|| .||.||.|. ..|||.   |.| .. . || .||| .. .       . ..| |.  .     ||.||.|.   
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIK----WMAPECINYGK

YGRKADVWSLGCTVVEMLT-EKPP-WAE
.  | |||| | .  |..|  . | ...
FTTKSDVWSFGVLMWEIFTYGEQPTYPG
Kinase MAP3K3.AA TyrKc 393-652 25 1.3e-18 69.09 SMART 1-280 (280) Show / Hide 
Range on Protein: 393-652
Range on HMM: 1-280/280
Sequence Identity: 25% (76 aa)

WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNL--QHERIVQYYGCLRDRAE-----KTLTIFMEYMPGGSVKDQ
 . || || ||||.||..      .. | | .. |         . ..  |......|  .|. ||. ||. ..  .     . | | |||||.|. || 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LKAYGA-LTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRL----------QTICM----SGTGMRSVTGTPYWMSPEVI
|....  |. .   ..  || .||.||||. ..|||.   |.| .. . || .||| |. .          ... .    .| .|  .     ||.||.|
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI----RWMAPECI

SGEGYGRKADVWSLGCTVVEMLTE-KPPWAE-----YEAMAAIFKIATQPTNPQLPS-------HISEHGRDFLRRIFVE-ARQRPSAEELLTHHF
    .  | |||| | .  |..|  ..|. .      ..  .| .. .    || |.       . ..   .  ..   | . .||. .|.  . |
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase MAP3K3.AA STE-Unique 394-460 27 1.7e-09 29.28 In-house 1-68 (616) Show / Hide 
Range on Protein: 394-460
Range on HMM: 1-68/616
Sequence Identity: 27% (19 aa)

RRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPE-TSKEVSALECEIQLLKNLQHERIVQYYG
.    .|.|.|| |..| .  ... .| | .  .  ...     |. .  ||...| | |..|| |||
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYG