Gene MAP3K4 (Human)

MAP3K4

Species: Human
Alias: MTK1, MAP3K4, KIAA0213, MEKK4, FLJ42439, MAPKKK4, PRO0412
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 6q26-q27,

Classification

Group: STE
Family: STE11
Subfamily: MEKK4

Sequence

Name Sequence Type Origin Length Description Download
MAP3K4.NA RNA Sugen Kinome 5501 None Fasta, JSON
MAP3K4.AA Protein Sugen Kinome 1608 None Fasta, JSON
MAP3K4.kin_dom Protein Kinase Domain Sugen Kinome 259 None Fasta, JSON

Protein domain

Protein domains of MAP3K4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MAP3K4.AA MEKK4 1343-1601 70 4e-229 767.46 In-house 1-271 (271) Show / Hide 
Range on Protein: 1343-1601
Range on HMM: 1-271/271
Sequence Identity: 70% (192 aa)

WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLG--LQEHVI
||||..|||||.||||||...||.|.|||||.|||.||||.||..|||.||||||||||||||.|||.||||||||||||..||||.|..||  .|||.|
WQRGDHIGEGQFGKVYTCMNMDTHEVMAMKEMRFQRNDHKAIKNIADEIKIFEGIKHPNLVRYYGVEVHREEMYIFMEYCSQGTLERVCHLGGNMQEHMI

RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGE-------GHGRAADIWSLGC
|.|.||...|.|.||.|||||||||.|||||......|||||||||||.|..||||||..||.||||||||||.|.....       |||||||||||||
RQYTKQLLRAVNYLHQHGIVHRDIKPANIFLDKCTVLKLGDFGCSVKLQNHSQTMPGEFQSTMGTAAYMAPEVYTYTEKDETTGSYSGHGRAADIWSLGC

VVIEMVTGKRPWH---EYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFV
||.||.|||||||   .|.|||||||||||||.|.||...|||||||..||||.|||.||||..||||.|.
VVVEMMTGKRPWHGQTQYDHNFQIMYKVGMGHYPHIPDKMSPEGKDFFDHCLEHDPKDRWTANELLDHTFC
Kinase MAP3K4.AA STE11 1343-1601 46 2.3e-162 545.71 In-house 1-303 (303) Show / Hide 
Range on Protein: 1343-1601
Range on HMM: 1-303/303
Sequence Identity: 46% (141 aa)

WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND------------HKTIKETADELKIFEGIKHPNLVRYFGVELH---REEMYIFMEYCDEGTL
||.|..||.|..|.||.|. ||||||||.|.|..|.|.            ||..|. ..|.|......|.|.|||.|..||   .....|||||| .|.|
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

EEVSRLG-----LQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGL-IKLGDFGCSVKLKNNAQT-------------MPGEVN-STLGTAA
... |..     ..|.||| | |||  ... ||.|||.|||||||||.| | |  .||.||||...|......             |.|... |..||..
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPM

YMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEH-NFQIMYKVGMGHK--PPIPERLS------PEGKDFLSHCLESDPKMRWTASQLLDH
.||||||.. ...|.||.||||||||.||||.|||.|||.|.| ....|.|.|||||  |||||..|      .|..|||.||.| |||.|.||.|||.|
WMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQH

SFV
.|.
PFI
Kinase MAP3K4.AA STE 1343-1601 30 5.9e-104 351.66 In-house 1-359 (359) Show / Hide 
Range on Protein: 1343-1601
Range on HMM: 1-359/359
Sequence Identity: 30% (110 aa)

WQRGNKIGEGQYGKVYTCISVD---------------TGELMAMKEIRFQPND---------------HKTIKETADELKIFEGIK--HPNLVRYFGVEL
|..  |||.| .|.||... ..               |||.||.|........               |. ...   |.||    .  ||| |.|.| ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

H-------REEMYIFMEYCDEGTLEEVSR------LGLQ----------EHVIRLYSKQITIA-INVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSV
.       ..| .|.|||.| |.|... .       .|.          |..|. . .||  .  . ||.|.|.|||||.|||.|     .|| |||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

KLKNNAQ------------TMPGEVNSTLGTAAYMAPEVITRAK---GEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHN---FQIM--YKVGM------
.| ..              || .. |.  ||  .||||||.. .     |... .|||||||..|||.||| |||.. .    |.|.  |....      
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---GHKPPIPE-------------------RLSPEGKDFLSHCLESDPKMRWTASQLLD--HSFV
   |. ||.|.                   ..||| |||...||. ||. |.||||||   |.|.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MAP3K4.AA S_TKc 1343-1601 32 1.1e-96 328.44 SMART 1-231 (231) Show / Hide 
Range on Protein: 1343-1601
Range on HMM: 1-231/231
Sequence Identity: 32% (89 aa)

WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDE--GTLEEVSRLG------
.. ..|||.| .|||| |. ..||...|.|.|.         . .  |..| .  .|||.|....|  . ...|..|||||   |.| .. .        
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGR-AADIWSL
  . | ..| | .||  |.. .|.|||.|||.| .||.|..   ||..||| . .|           ..  ||  ||||||.      |.|. ..|.||.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL------GYGKCKCDWWSC

GCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLD-------HSFV
||...||..|. |..    . | |.|. .          |||.|||...||. ||. |.|| ..|        | ..
GCILYEMLCGYPPFP----QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MAP3K4.AA STE11-Unclassified 1343-1601 36 7.9e-96 324.66 In-house 1-308 (308) Show / Hide 
Range on Protein: 1343-1601
Range on HMM: 1-308/308
Sequence Identity: 36% (113 aa)

WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND--HKTIKET-----ADELKIFEGIKHPNLVRYFGVE--LHREEMYIFMEYCDEGTLEEVSRL
|| |. ||.| .|.||.|. ..|||.|| |.|. . ..   ......     ..|.|. .   |.| |.| |.|   |.   .|||||. .| . .  . 
WQKGEFIGKGSFGQVYKCMNCNTGEFMAVKQIEIHDYNSQQEDMQKEMIQSIQKEMKVLKQLNHKNIVQYYGCEIHKHEDCINIFMEYMPGGSIWSMLNK

G--LQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLK------------------NNAQTMP---GEVNSTLGTAA---
.  . | ||. | ||| . .  ||.|||.||||||||| . . | .|| ||||. . .                  .. |.     .  .|  ||     
YGCFDEMVIKKYTKQILEGLAYLHSHGIIHRDIKGANILIDFDGICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHINSQQNHCKSMQGTPYQPF

YMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEH--NFQIMYKVG-MGHKPPIPERLS-----------PEGKDFLSHCLESDPKMRWTAS
.||||||..   .||.|..|||||||.|||| |||.||  ..     ....|..  .. |.|||.||           .|.||||..|.. |||.|.||.
WMAPEVIKNSTQTGHCRKSDIWSLGCTVIEMATGKHPWSNCQNDNFMWAIMKIVMSNQIPQIPEHLSPVCDFISCWISQECKDFLRKCFQIDPKKRPTAN

QLLDHSFV
||| |.| 
QLLQHPFI
Kinase MAP3K4.AA Pkinase 1343-1601 28 2.4e-76 264.76 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1343-1601
Range on HMM: 1-293/293
Sequence Identity: 28% (86 aa)

WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETAD--ELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEG----TLE----EVSR
...| |||.| .|.|| |. ..||.. |.|.|. . ....  .. .   |..|   ..||| ||....   . ..|. ||||. |     |       ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

LGL--QEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLI----KLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAA
 ..  .|.... | .||  ... .|..||.|||.| .||.. . | |    |..|||.. ...    . ... ..  ||  |||||||   .|...|...
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNSMTTFCGTPWYMAPEVIR--GGQYYGPKV

DIWSLGCVVIEMVTGKRPWHEY------EHNFQIMYKVGMGHKPPIPERLS-------------------PEGKDFLSHCLESDPKMRWTASQLLDHSFV
|.||.||...||..|. |. .       .... |  . |   . ..|.  |                   .|.|||.. ||. ||| |.|| |.| | ..
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MAP3K4.AA STE20 1343-1601 35 1.7e-69 237.16 In-house 1-288 (288) Show / Hide 
Range on Protein: 1343-1601
Range on HMM: 1-288/288
Sequence Identity: 35% (102 aa)

WQRGNKIGEGQYGKVYTCISVDTGEL----MAMKEIRFQPNDH--KTIKETADELKIFEGIKHPNLVRYFGVELHR----EEMYIFMEYCDEGTLEEVSR
..   |||.| |||||... ..|||.     | | .   . |   . ...   |  |    |||| |.|.|  |      .| .| ||||. |.| .. .
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

----LG-------LQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKN--NAQTMPGEVNSTLGTAAYMAPEVITRAKG
    .|       ..|  |    ...  . . ||...|.|||||..|| ||..| .|| ||| . .| .    .|| .. |.  ||  .|||||| . .|
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGR-DTMQFKRNTFVGTPYWMAPEVIQCMEG

--EGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPI------PERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFV
   |..  .||||||   |||..|. | ... | .. |...  . .||       |.. ||| .||...||. ||. |.|||||| |.|.
PDKGYDYKCDIWSLGITAIEMAEGEPPYFDM-HPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase MAP3K4.AA MEKK2 1343-1601 40 2.4e-68 233.35 In-house 1-262 (262) Show / Hide 
Range on Protein: 1343-1601
Range on HMM: 1-262/262
Sequence Identity: 40% (108 aa)

WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETA---DELKIFEGIKHPNLVRYFGVELHRE--EMYIFMEYCDEGTLEEVSRL--GL
|.||  .| | .|.|| |  ||||  .| | ..|.|..  | ||      |...   ..|. .| |.|    ..   . |||||   | . .  ..   |
WRRGKLLGQGAFGRVYVCYDVDTGRELAVKQVQFDPDNPETRKEVQALECEIQLLKNLQHERIVQYYGCLRDNQEKTLSIFMEYMPGGSVKDQLKAYGAL

QEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVV
 | | | | .||   .  ||.| |||||||||||   ||| .|||||| | .|.       | . |  ||  .|.||||    ||| || ||.||.|| |
TETVTRKYTRQILEGMHYLHDHMIVHRDIKGANILRDSSGNVKLGDFGASKRLQTICMHITG-MKSVTGTPYWMSPEVIN---GEGYGRKADVWSIGCTV

IEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFV
.||.| | || |||    |        .| .|. .| ...|||  |     . |  |  || | ||
VEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPQHVSQHARDFLKRCFVEIKQDRPSAEELLRHHFV
Kinase MAP3K4.AA ASK 1349-1601 39 1.8e-64 213.29 In-house 2-254 (254) Show / Hide 
Range on Protein: 1349-1601
Range on HMM: 2-254/254
Sequence Identity: 39% (102 aa)

IGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEV--SRLG-LQ--EHVIRLY
.| | || ||     .|   .|.|||  .  |..  .   .|... . ..| |.|.| |   . . . ||||    | | ..  |. | ..  |. .. |
LGKGTYGIVYAGRDMHTQVRIAIKEIPER--DSRYVQPLHEEIALHKQLRHRNIVQYLGCCSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNENTMNFY

SKQITIAINVLHEHGIVHRDIKGANIFL-TSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGK
.|||   .. |||. |||||||| |. . | ||..|. ||| . .|   |   |   ..  ||  ||||||| . .  |.|..|||||.|| ..|| |||
TKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTCKRL---AGINP-CTETFTGTLQYMAPEVIDQGQ-RGYGKPADIWSFGCTMVEMATGK

RPWHEYEHNFQIMYKVGM-GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFV
 |.|| ..    |.||||  . |.||| || | |.|. .| | ||. | .|..||   |.
PPFHELGEPQAAMFKVGMYKKHPEIPEELSAECKNFILRCFEPDPCKRASAQDLLQDPFL
Kinase MAP3K4.AA CAMK 1348-1601 19 3.4e-64 205.49 In-house 1-425 (425) Show / Hide 
Range on Protein: 1348-1601
Range on HMM: 1-425/425
Sequence Identity: 19% (85 aa)

KIGEGQYGKVYTCISVDTG------------ELMAMKE-------------------IRFQPNDH-------KTIKETADELKIFEG-------IKHPNL
..|.|..|||. ||   |.            .  |.|                    |... ..|       |. |.   |..|          ..|||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRYFGVELH-------------------REEMYIFM---EYCDEGTL--EEVSRL-------------------GLQEHVIRLYSKQITIAINVLHEHGI
.. . |                      ...||..|   |||. | |  .  ...                    ..|.  | | .||  |.. .|.|.|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDIKGANIFLTSS-----------------GLIKLGDFGCSVKL-----------KNNAQTMPGE----------VNSTLGTAAYMA-PEVITRAK--
||||.|  || |...                 . ||. ||| . |.           ..... |  .           .   || .||| |||. . .  
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

---------GEGHGRAADIWSLGCVVIEMVTGKRPWH-EYEH----------NFQIMY-KVGMGHKPPIPERLSP-----------------------EG
          ...|...|.||.|..   |..|. |.  ...           | . .. |.  |    .|. .||                       | 
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

KDFLSHCLESDPKMRWTASQLLDHSFV
||.....|. ||. |.|..| |.| ..
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MAP3K4.AA MEKK15 1343-1601 38 1e-62 214.68 In-house 1-264 (264) Show / Hide 
Range on Protein: 1343-1601
Range on HMM: 1-264/264
Sequence Identity: 38% (104 aa)

WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKET----ADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEE-VSRLG-LQ
|..|| .| | || || |   .|| |.|.| .  .  | .  |.      .| ..   .|| |.| | || |.   . |||..   | .   . | | |.
WKKGNILGKGAYGTVY-CGLTNTGQLIAVKQVELDEIDKEKAKQQYRKLQEEVDLLKTLKHKNIVAYLGVCLEDNVVNIFMQFVPGGSISSIINRFGPLD

EHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNN--AQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCV
| |   | |||   .  |||  .|||||||.|. | . |.||| ||||  .|      .|    . |  ||  .||||||  .   |.|| .||||.|| 
EMVFCKYTKQILQGVQYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLCWQGINRTHSDMLKSMRGTPYWMAPEVIMET---GYGRKSDIWSIGCT

VIEMVTGKRPWHEYEHNFQIMYKVGMG--HKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFV
| || |.| || . .     |. .| .    |..|.. | . ..|   ||  | . | |||||| |.|.
VFEMATRKPPWADMDR-MAAMFYIGAHRDPMPQLPVKFSEDARMFVRMCLTRDQHERPTASQLLKHPFI
Kinase MAP3K4.AA Ciliate-E2 1343-1601 22 1.7e-57 195.91 In-house 1-365 (365) Show / Hide 
Range on Protein: 1343-1601
Range on HMM: 1-365/365
Sequence Identity: 22% (85 aa)

WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQP-------------------NDHKTIKETADELKIF----------------EGIKHPNLVRYFG
    .|||.|..|.|| |    .... |.| |. |                    . .. |...  |..|.                | ..|||..... 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

VEL--HREEMYIFMEYCDEGTLEEVSR-------------LGLQEHVIRLYSKQIT---------------IAINVLHEHG-IVHRDIKGANIFLTSSGL
.     .. .|. ||||. |.|..  .             . . |  |. ..|||.                |.. ||. . |.|||||  ||..     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

IKLGDFGCSVKLKNN---------AQTMPGEV-------------------NSTLGTAAYMAPEVITRAK------GEGHGRAADIWSLGCVVIEMVTGK
||. ||| | |....         .. ..                      |...||. |||||.. . |      ..|.. ..||||||..  ||..||
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

RPWHEYEHNFQIMYKVGMGHKPPI---------------PERLSPEGKDFLSH----CLESDPKMRWT-ASQLLDHSFV
.|.       |.  | .    |.                .. .|.|.||...     .|. ||. | | ..|.|.| . 
PPF-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MAP3K4.AA TyrKc 1343-1601 23 1.5e-16 45.01 SMART 1-280 (280) Show / Hide 
Range on Protein: 1343-1601
Range on HMM: 1-280/280
Sequence Identity: 23% (69 aa)

WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGI--KHPNLVRYFGVELHR-------EEMYIFMEYCDEGTLEE---V
 . | |.|||..|.|| ..     .  | | ..        ...  .|..|   .  .|||.|| .|| ..        | ..| |||.. | | .    
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

SRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNN-------AQTMPGE-VNST-LGTAAYMAPEVITRAKGEG
.|  |.      .. ||    . ||.....|||.   |. ... . .| .||| | ....           .. |  ..  .     ||||.|   |   
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK---

HGRAADIWSLGCVVIEMVT-GKRPWHEY----EHNFQIMYKVGMGHKPPIPER--------LSPEGKDFLSHCLESDPKMRWTASQLLDHSFV
   . |.|| | .  |. | |. |. .       |.... .|  |. .|.|.          ..|  .  . | . ||..| | |..  |.. 
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase MAP3K4.AA Pkinase_Tyr 1343-1483 27 9.9e-13 43.74 Pfam 1-156 (270) Show / Hide 
Range on Protein: 1343-1483
Range on HMM: 1-156/270
Sequence Identity: 27% (43 aa)

WQRGNKIGEGQYGKVYTCISV----DTGELMAMKEIRFQPNDHKT--IKETADELKIFEGI-KHPNLVRYFGVEL-HREE--MYIFMEYCDEGTLEE---
 . | |.|||..|.|| ..      .|.   | | .. .  .|.   ...   |.||   . .|||.||. || . ..|   .|| |||.  | | .   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

VS---RLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFG
     .  |  . .  .. ||  . . |......|||.   |. .|... .| .|||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase MAP3K4.AA Pkinase_Tyr 1509-1601 29 0.00012 16.36 Pfam 181-270 (270) Show / Hide 
Range on Protein: 1509-1601
Range on HMM: 181-270/270
Sequence Identity: 29% (28 aa)

MAPEVITRAKGEGHGRAADIWSLGCVVIEMVT-GKRP-WHEYEHNFQIMYKV-GMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFV
||||.|   |      . |.|| | .  |..| |. | . .   |.... ..   |.  |.||  ..|  | . .| . ||..| | |..  |.. 
MAPECINYGK---FTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEI--HEQL