Gene PRPK (Human)
PRPK
Sequence
Protein domains of PRPK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | PRPK.AA | Bud32 | 34-251 | 46 | 2.1e-162 | 523.72 | In-house | 1-269 (269) | Show / Hide |
Range on Protein: 34-251 Range on HMM: 1-269/269 Sequence Identity: 46% (125 aa) SGLELVK--------QGAEARVFR--------------GRFQGR------AAVIKHRFPKGYRHPALEARLGRRRTVQEARALLRCRRAGISAPVVFFVD ..|||.| ||||||||. ..|||| ...||.||||.||||.|...|...||.||.||..|||.|||..|.|.|.| MSLELYKDVDIAPISQGAEARVFYTCYLTVSKQKVYTTCNFQGRAKDSHQQCIIKERFPKAYRHPQLDQQLTKHRTKQEVRAMNRCRKAGICVPYVYFCD YASNCLYMEEIEGS------VTVRDYIQSTMETEK---TPQGLSNLAKTIGQVLARMHDEDLIHGDLTTSNMLLKPPLEQL-----NIVLIDFGLSFISA ....|.|||.||.| .||..||....||.| ..| |....|..|.....||....||||||||||.|..|.... ...|||||||.||. NYNHCIYMEYIEESPGGHGFYTVKNYIWQHQETQKEDQHDQCLREFCKKVGRQIGKMHWNHIIHGDLTTSNMMLRHPYADWTKLYGQMHLIDFGLSYISN LP-EDKGVDLYVLEKAFLSTHPNTET-----VFEAFLKSYS---TSSKKARPVLKKLDEVRLRGRKRSM .. |||||||||||.|||||||..|. .||.|...|. |..||...||||..|||||||||.| SVPEDKGVDLYVLERAFLSTHPKCEQKYNAWIFEHFMENYRKQDTKCKKFKAVLKKFNEVRLRGRKRTM |
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| Kinase | PRPK.AA | TKL | 141-187 | 21 | 6.9e-07 | 20.84 | In-house | 136-201 (364) | Show / Hide |
Range on Protein: 141-187 Range on HMM: 136-201/364 Sequence Identity: 21% (14 aa) NLAKTIGQVLARMHDED--------LIHGDLTTSNMLLKPPLE-----------QLNIVLIDFGLS ..|. | . .. .| .. .|| ||...| |.. .. . .. . ||||| RWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLS |
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| Kinase | PRPK.AA | CAMK-Unique | 148-187 | 26 | 1e-06 | 17.44 | In-house | 168-220 (363) | Show / Hide |
Range on Protein: 148-187 Range on HMM: 168-220/363 Sequence Identity: 26% (14 aa) QVLARMHDEDLIHGDLTTSNMLLKPPLE-------------QLNIVLIDFGLS ...| ||. | .|.|| | ... .. ...|.|.||||. SAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLC |
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| S_TKc | PRPK.AA | S_TKc | 33-252 | 14 | 2e-06 | -83.19 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 33-252
Range on HMM: 1-231/231
Sequence Identity: 14% (40 aa)
LSGLELVKQGAEARVFRGRFQG--RAAVIKHRFPKGYRHPALEARLGRRRTVQEARALLRCRRAGISAPVVFFVDYASNCLYMEEIEGS-VTVRDYIQST
|... .|| ..|...| . | || ... .| . | . . | .|.| . .. || ..|. ...|||..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR
ME----TEKTPQGLSNLAKTIGQVLARMHDEDLIHGDLTTSNMLLKPPLEQLNIVLIDFGLS-----------------FISALPEDK-GVDLY------
.. ... | . |. .|. || || .| || .| ..||||. . . .| .| .
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQLTTFCGTPWYMAPEVL----GYGKCKCDWWSCGCIL
---VLEKAFLSTHPNTETVFEAFLKSYSTSSKKARPVLKKLDEVRLR------GRK-------RSMV
. . . . ...|. . |. |. ..|. .. . . .
YEMLCGYPPFP---QMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
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| Kinase | PRPK.AA | TESK | 141-194 | 30 | 8e-06 | 13.9 | In-house | 98-153 (292) | Show / Hide |
Range on Protein: 141-194 Range on HMM: 98-153/292 Sequence Identity: 30% (17 aa) NLAKTIGQVLARMHDEDLIHGDLTTSNMLLK-PPLEQLNIVLIDFGLS-FISALPE .|| | . . .|.. | ||| | | . . .|. |. |||| . .|. HLAYDIARGMSYLHSKGVFHRDLTSKNCLVRQRDNNQYEAVVGDFGLARVLGCMPD |
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| Kinase | PRPK.AA | Ciliate-E2 | 153-187 | 36 | 8e-06 | 15.86 | In-house | 176-203 (365) | Show / Hide |
Range on Protein: 153-187 Range on HMM: 176-203/365 Sequence Identity: 36% (13 aa) MHDED-LIHGDLTTSNMLLKPPLEQLNIVLIDFGLS .| . || |. .| |. | .|||||| LHSKNNIIHRDIKPENILF--------IKIIDFGLS |
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| Kinase | PRPK.AA | RSK | 153-187 | 33 | 2.7e-05 | 15.72 | In-house | 120-154 (278) | Show / Hide |
Range on Protein: 153-187 Range on HMM: 120-154/278 Sequence Identity: 33% (12 aa) MHDEDLIHGDLTTSNMLLKP-PLEQLNIVLIDFGLS .|. . || || .|.|. .. |.|.|||.. LHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFC |
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| Kinase | PRPK.AA | MSK | 153-187 | 37 | 4.4e-05 | 13.12 | In-house | 117-151 (277) | Show / Hide |
Range on Protein: 153-187 Range on HMM: 117-151/277 Sequence Identity: 37% (13 aa) MHDEDLIHGDLTTSNMLLKPPLEQLNIVLIDFGLS ||.. ||.|| | |. .. ..|||||.. MHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFA |
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| Kinase | PRPK.AA | Ciliate-E8 | 154-187 | 35 | 6.3e-05 | 11.35 | In-house | 106-138 (138) | Show / Hide |
Range on Protein: 154-187 Range on HMM: 106-138/138 Sequence Identity: 35% (12 aa) HDEDLIHGDLTTSNMLLKPPLEQLNIVLIDFGLS | || |. | |... ..| .|||| | HNNNIIHCDFKLNNILVQRN-DDTKIKIIDFGFS |
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| Kinase | PRPK.AA | VRK | 153-188 | 30 | 7.6e-05 | 11.94 | In-house | 146-181 (284) | Show / Hide |
Range on Protein: 153-188 Range on HMM: 146-181/284 Sequence Identity: 30% (11 aa) MHDEDLIHGDLTTSNMLLKPPLEQLNIVLIDFGLSF .|. . |||.. .| || . . .|.|.||.. LHENEYVHGDIKAANILLGFEKNPDQVYLVDYGLAY |
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| Kinase | PRPK.AA | TKL-Unique | 141-187 | 33 | 0.000103 | 12.75 | In-house | 114-164 (290) | Show / Hide |
Range on Protein: 141-187 Range on HMM: 114-164/290 Sequence Identity: 33% (18 aa) NLAKTIGQVLARMHDED--LIHGDLTTSNMLLKPPLEQ-----LNIVLIDFGLS ..|. | |.. . | .. ||.||..|| |. . .|| ..||||| KMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVD---NNSNIAEWNIKICDFGLS |
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| Kinase | PRPK.AA | APH | 35-155 | 15 | 0.003346 | 11.8 | Pfam | 1-112 (248) | Show / Hide |
Range on Protein: 35-155
Range on HMM: 1-112/248
Sequence Identity: 15% (21 aa)
GLELVKQGAEARVFRGRFQGR-AAVIKHRFPKGYRHPALEARLG--RRRTVQEARALLRCRRAGI--SAPVVFF---VDYASN--CLYMEEIEGSVTVRD
.. . |.. |... . .| | .. .. . ... .|.|.| . ...|| .| |. |. . . || ..| . |.
WWRPISGGWSNRTYYRTTDDRPRYVLRR------------YPPPWWAEELHREHRWLRHLAAHGIPVPVPRVLWGCTDDEFHGWPWYLMEWLPGEDLWRW
YIQSTMETE-KTPQGLSNLAKTIGQVLARMHD
. ... . .|.. ....|||.|.
--------HALHCAQRPALLEALARFLARLHQ
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| Kinase | PRPK.AA | APH | 158-187 | 25 | 1.089355 | 3.23 | Pfam | 172-202 (248) | Show / Hide |
Range on Protein: 158-187 Range on HMM: 172-202/248 Sequence Identity: 25% (8 aa) LIHGDLTTSNMLLKPPLEQLNIV--LIDFGLS ..|||. |... | .. . | .||.. . WCHGDFHPGNVMWDP-RPDGGRVTGVIDWDDA |
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