Gene RSK4 (Human)

RSK4

Species: Human
Alias: RSK4, RPS6KA6
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: Xq21.31, Secondary Group: CAMK, Secondary Family: RSKb, Secondary Subfamily: RSKb,

Classification

Group: AGC
Family: RSK
Subfamily: RSKp90

Sequence

Name Sequence Type Origin Length Description Download
RSK4.NA RNA Sugen Kinome 8239 None Fasta, JSON
RSK4.AA Protein Sugen Kinome 745 None Fasta, JSON
RSK4.kin_dom Protein Kinase Domain Sugen Kinome 258 None Fasta, JSON
RSK4.kin_dom2 Protein Kinase Domain Sugen Kinome 258 None Fasta, JSON

Protein domain

Protein domains of RSK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase RSK4.AA AGC 73-330 34 7.4e-186 485.76 In-house 1-395 (395) Show / Hide 
Range on Protein: 73-330
Range on HMM: 1-395/395
Sequence Identity: 34% (137 aa)

FELLKVLGQGSFGKVFLVRKKTGP---DAGQLYAMKVLKKAS---LKVR-DRVRTKME------------RDILVEVN----------HPFIVK-LHYAF
||.|||.|.||||||.|||||.|.   | |..||||||||.    .| . .  .|. |            |.||...|          |||||| |||.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTEGK--LYLILDFLR---------GG-DVFTRLS---KEVLFTEEDVKFYLAE-------LALALDHLHQ-LGIVYRD-LKPENILLDEIGHIKLTDFG
|.. .  ||......          || . |..|    ||  |.|| ..||.||       ..|||..||. .||..|| |||||||||| |||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKESVD--------------------------------------------------QEKKAYSFCG--TVEYMAPEVVNRRGHSQSADWWS--YGVLMF
|.|| ..                                                  .......|||  | ||||||..    .....||||  .|.||.
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLTGTLPFQGK----------DRNETMNMIL------KAKLGMP----------QFLSAEAQSLLRMLFKRNPANRLGSE-------GVEEIKRHLFF
|||||  ||.|.          ...|... |.      . |. .|          ...| ||..|...|....|..|||.        |.||||.| .|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase RSK4.AA RSK 73-330 54 5.9e-184 617.42 In-house 1-271 (271) Show / Hide 
Range on Protein: 73-330
Range on HMM: 1-271/271
Sequence Identity: 54% (147 aa)

FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTE
.||....|||||.||....|....|..|.||||..|||...|.|||....||.|| ...|||||||||.||.|||.|.|.||.|||| |.||.|.. |.|
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSE

EDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEI----GHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLT
..||||.||.|||...||..|||.|||||||||.|.     ||||..|||..|.. |.......||.|..||||||..|.||.|..||||.||||.||||
REVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLT

GTLPFQGKDRNETMNMILKAKLGM-------PQFLSAEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFF
|..|||.|.|...||.|...||||       ..|.|.||..||||...|.|.||||.  .|||.||.| .|
GCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase RSK4.AA RSK 76-330 54 1.1e-166 560.03 In-house 1-278 (278) Show / Hide 
Range on Protein: 76-330
Range on HMM: 1-278/278
Sequence Identity: 54% (151 aa)

LKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDR-VRTKM-ERDILVEVN-HPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVL---
|||||||..|||||.||.|. |.||.||||||||| ...|.. .|..| ||.|| ... |||||.||||||||||||||....|||. ||.|.||.    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDE---IGHIKLTDFGLSKE-SVDQEKKAYSFCGTVEYMAPEVVN----RRGHSQSADWWSYGV
|.|....||.||..||..||||.||..|||||||||.|.    |||||||||..|. . |.......||.|.||||||...    ..||....|||| ||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LMFEMLTGTLPFQG---KDRNETMNMILKAK--LGMP--QFLSAEAQSLLRMLFKRNPANRLG--SEGVEEIKRHLFF
||.||||| .||||   ..|.|.|. |.|.|  |.||  |.||.||..|.|....|.|..|||   ...||||.| .|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase RSK4.AA Akt 73-330 47 2.8e-142 457.69 In-house 1-264 (264) Show / Hide 
Range on Protein: 73-330
Range on HMM: 1-264/264
Sequence Identity: 47% (127 aa)

FELLKVLGQGSFGKVFLVRKKTGPDAGQLY-AMKVLKKASLKVRDRVR-TKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLF
|..|||||.|||||||||.||   | ...| |||||||  .  .. |. || || ||. .||||||.|||.|||. |||...|.  ||. |. |...  |
FDFLKVLGKGSFGKVFLVKKK---DTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRF

TEEDVKFYLAELALALDHLHQLGIVYRD-LKPENILLDEIGHIKLTDFGLSKES-VDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWS-YGVLMFEML
.|.  .|| ||. ||..|||. .|.||| |||||||.|. |||.||||||.||  . .  |...|||| ||.|||. |  ||....|||.  |..|.||.
SEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMM

TGTLPFQGKDRNETMNMILKAKLGMP--QFLSAEAQSLLRMLFKRNPANRLG--SEGVEEIKRHLFF
.| .||  .|. . .  |. ... .|   ..| |...|.. | ...| .|||  .....||||| .|
CGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase RSK4.AA p70 73-330 47 3.8e-138 465.25 In-house 1-299 (299) Show / Hide 
Range on Protein: 73-330
Range on HMM: 1-299/299
Sequence Identity: 47% (141 aa)

FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASL--KVRDRVRTK-------------------------MERDILVEVNHPFIVKLHYAFQTE
||||||||.| .||||.||| || |.|..||||||.||.     .|   |.                          || || ||.||||..|||||||.
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

GKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKK----------AYSFCG
|||||||..| ||  |. | ..  . |. ..|||.|  .|| ||||.||.||||||||..|.. ||..||||||.|||.   ..           ..|||
GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCG

TVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAK--LGMPQFLSAEAQSLLRMLFKRNPANRLG--SEGVEEIKRHLFF
| ||||||.. | ||..  |||| |.||. ||||  || |  | .|.. |||.|  | .|  |..|.  |.. | ||.|. |.|   | ...|..| ||
TIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase RSK4.AA S_TKc 73-330 34 2.2e-106 360.66 SMART 1-231 (231) Show / Hide 
Range on Protein: 73-330
Range on HMM: 1-231/231
Sequence Identity: 34% (93 aa)

FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRG--GDVFTRLSKEVL-
.|.|...|.|.||||...|.|     |...|.|..|          ... |..|| . .||.||||...||. ..||...... |  ||.|... |    
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----FTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQ-SADWWSYGVLM
     |.| ...||......||...|..||..||||||||||||  |||..||||...        ..|||| .||||||.   |..  ..|||| |...
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

FEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGSEGVEE----IKRHLFF
.|||.|  ||.  . ......|.          | || ...| .....|..|..   . .    || | .|
YEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RSK4.AA MSK 76-325 40 1.5e-105 356.94 In-house 1-277 (277) Show / Hide 
Range on Protein: 76-325
Range on HMM: 1-277/277
Sequence Identity: 40% (111 aa)

LKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTK--MERDILVEV-NHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTE
|||||.|. ||.|..|| .. |.|.|||||.|.|| .  . ..      || .|  . .||.||.||||||.. ..||......||  ||...|   |.|
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

EDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEI---GHIKLTDFGLSKESVDQ-EKKAYSFCGTVEYMAPEVVNR-----RGHSQSADWWSYGVLM
. . ....|| .|.||.||.||..|||||||||.|..   ||.||.|||.... . . |....|.|.| .|||||...|      |.... |||| ||..
SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVIL

FEMLTGTLPFQ--GKDRN-------ETMNMILKAKLGMP----QFLSAEAQSLLRMLFKRNPANRLGSE--GVEEIK
..||||  |||  ..||        | |  |.|..   |    |  |..|. |.. |  ..|. ||| .  ...|.|
YTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase RSK4.AA Pkinase 73-330 28 2.3e-94 324.6 Pfam 1-293 (293) Show / Hide 
Range on Protein: 73-330
Range on HMM: 1-293/293
Sequence Identity: 28% (86 aa)

FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKM--ERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGG----DVFTRLS-
.......|.||||.|.. ..|  ..   ..|.|..|| . |   ...     |  |. ..|||.||.|...|......|.......||    | |...| 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

-KEVLF--TEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHI----KLTDFGLSKE--SVDQEKKAYSFCGTVEYMAPEVVN-RRGHSQSAD
 ..  |  .|...|||. ... .|...|. ||..|||||||||.|. |||    |..||||.|      ..  ...|||| .||||||.. ........|
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVD

WWSYGVLMFEMLTGTLPFQGK------DRNETMNMILKAKLGMPQFLS---------------------AEAQSLLRMLFKRNPANRLGSEGVEEIKRHL
.||.|....|||.| .||.|.      | .. ...|....|  . . .                      |...... .....|. |..    |.|. | 
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQHP

FF
.|
WF
Kinase RSK4.AA Ciliate-E2 73-330 24 5.8e-89 301.87 In-house 1-365 (365) Show / Hide 
Range on Protein: 73-330
Range on HMM: 1-365/365
Sequence Identity: 24% (92 aa)

FELLKVLGQGSFGKVFLVRK-KTGP-------------------DAGQLYAMKVLKKASLKVRDRVRTKM-----------ERDILVEVNHPFIVKLHYA
....|..|||.||.|..... |..                    .....||||..||  ..   ..   |           |. || ..|||.|.|....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--TEGKLYLILDFLRGGDVFTRLS------------------KEVL-FTEEDVK-------FYLAELALALDHLHQLG-IVYRDLKPENILLDEIGHI
||  .. ..||..... ||| | ..                   ||.. .... ..       ||.|.. ||| .||. . |..||.||||||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLTDFGLSKESVDQEK-------------------------------KAYSFCGTVEYMAPEVVNRRG---------HSQSADWWSYGVLMFEMLTGTLP
|..||||||.  |...                                ....||| .|||||..|. .         .. ..|.|| ||...|||.| .|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FQGKDRNETMNMILKAKLGMPQF------------------LSAEAQSLLRM----LFKRNPANRLGSEGVEEIKRHLFF
|        .. |.. |.  |..                  .| |.. |..     .....| .|..  | |.|. | .|
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT--GWEQILNHPWF
Kinase RSK4.AA Ciliate-E2-Unclassified 73-330 26 2.1e-85 290.04 In-house 1-352 (352) Show / Hide 
Range on Protein: 73-330
Range on HMM: 1-352/352
Sequence Identity: 26% (93 aa)

FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTK----------MERD-------------ILVEVNHPFIVKLHYAFQTEGKLY
....|..|||.||||.....|   .  |.|||| .||.  . .  ...|          ...              ||.  .||||||..|.||.. ..|
YKIIKQIGQGGFGKVYKCQHKK--QK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIY

LILDFLRGGDVFTRLSKE-----------------VLFTEEDVK-----FYLAELALALDHLHQLG-IVYRDLKPENILLDEIG---HIKLTDFGLSKES
.......||| .  ..|                    |||. .|     ||.|.. ..|..||. . |..||.||||||.|. |   .||..|||.||..
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

VDQ---------------EKKAYSFCGTVEYM----APEVVNRRGHSQS----ADWWSYGVLMFEMLTGTLPFQGKDRNE----------------TMNM
 ..               ......|||| .||    ||||  . ....|    .|.|| ||...|||.|..||.......                  . 
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQN

ILKAKLG--------MPQFLSAEAQSLLRMLFKRNPANRLGSE-GVEEIKRHLFF
|.. ..          |. .| ||. ... |..... .....  . |.|. | .|
IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase RSK4.AA CAMK 78-330 22 6.8e-85 273.38 In-house 1-425 (425) Show / Hide 
Range on Protein: 78-330
Range on HMM: 1-425/425
Sequence Identity: 22% (97 aa)

VLGQGSFGKVFLVRKK-TG---------PDAGQLYAMKVLKKASLK--------------------------VRDRVRTKMERDILVE-------VNHPF
.||.||||||.|.. | |.          . || .|.|...|  ||                           .|| . . | .|.         ..|| 
TLGRGSFGKVKLCIHKNTTGKERVHHIYTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN

IVKLHYAFQ------------TEGK--------LYLIL---DFLRGG----DVFTRLSKE---------------VLFTEEDVKFYLAELALALDHLHQL
|.||. ...            |  |        .|...   ..  ||    |.| .. .                  |||.....|   .. |....|..
IIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

GIVYRDLKPENILLDEI-----------------GHIKLTDFGLSKESVDQE-----------------------KKAYSFCGTVEYMA-PEVVNR----
.|| |||||||||||.                  . ||..|||....  . |                       .| . |||| |||| |||.|.    
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

----------RGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMN-------------MILKAKLG-MPQF-----------------------LSAEA
          .......| || ||... ||.|..||.|...||...             .|.|.|    | .                       .|.|.
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

QSLLRMLFKRNPANRLGSEGVEEIKRHLFF
..|.| . ...| .|.    .|....| ..
KDLIRKMLQVDPEKRM---TIEQCLNHPWM
Kinase RSK4.AA CAMK1 73-316 29 1.3e-66 192.62 In-house 1-265 (276) Show / Hide 
Range on Protein: 73-316
Range on HMM: 1-265/276
Sequence Identity: 29% (79 aa)

FELLKVLGQGSFGKVFLVRKKTG-PDAGQLYAMKVLK-KASLKVRDR---VRTKMERDILVEV---NHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRL
.|. |..| |.|..|.|. .|      |. ||.|... | ..|  |.    . ..| .|.  |   .||.|.|..  .... ..||... . ||. | | 
YEFGKEIGRGAFSEVYLCTHKETQT-NGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRI

SKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEI-GH--IK--LTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNR---RGHSQSADW
 .   .||.|      ... |. ..|..||| |||||||.|.  .  .  ||  . ||||||   ..| . .  ||| .|.||||...    ..... | 
VEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDM

WSYGVLMFEMLTGTLPFQGKD-RNETMNMILKAKLGMPQF----LSAE-AQSLLRMLFKRNPANRL
|| ||  . .|.|  ||....  || . .|.|.....| .     | . |  ... . . .| .|.
WSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRY
Kinase RSK4.AA S_TK_X 331-392 39 2.1e-21 78.37 SMART 1-79 (79) Show / Hide 
Range on Protein: 331-392
Range on HMM: 1-79/79
Sequence Identity: 39% (31 aa)

ANIDWDKLYK--REVQPPFKPASG----KPDDTFCFDPEFTAKTPKDSPGLPASANAHQL-----------FKGFSFVA
..|||||||.  .|..|||||        | ||  |||||| .||...|  |.. |...            | ||..|.
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase RSK4.AA Pkinase_Tyr 73-294 26 1.2e-19 67.18 Pfam 1-237 (270) Show / Hide 
Range on Protein: 73-294
Range on HMM: 1-237/270
Sequence Identity: 26% (63 aa)

FELLKVLGQGSFGKVFLVRKK-TGPDAGQLYAMKVLKKASLKVRD--RVRTKMERDILVEV-NHPFIVKLHYAFQ-TEGK--LYLILDFLRGGDVFTRLS
 ...|.||.|.||.|.. . |  . . ..  | |.| | .   ..  |     |  |. .  .|| ||.|. .    ..   .|... .  .||  . | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

K----EVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAY-SFCG----TVEYMAPEVVNRRGHSQSADW
|    .  .| .|   . .. | ....|.. ... |||   |.|..| ...| .||||..    ...  |    |     .  ||||. | .  .   | 
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI--YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

WSYGVLMFEMLT-GTLP-FQGKDRNETMNMILKAKLGMPQ
||.||||.|..| |  | ..| . .| ...| .    ||.
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPC
Kinase RSK4.AA TyrKc 73-329 22 2.8e-17 56.67 SMART 1-280 (280) Show / Hide 
Range on Protein: 73-329
Range on HMM: 1-280/280
Sequence Identity: 22% (67 aa)

FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEV--NHPFIVKLHYAFQTE-------GKLYLILDFLRGGDVFTR
 .|.|.|| | ||.|.. . |      .  | |.||. .     |     |  |. ..  .|| ||.|. .  ..       . |.... .  .||   .
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LSKEVL-FTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQ-----EKKAYSF----CGT----VEYMAPEVVNRRG
| |    .. .|   .    |   ..||. ... |||   |.|..| ...| .|||||..  |      .|. |.     .|     .  ||||. | . 
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

HSQSADWWSYGVLMFEMLT-GTLPFQG-----KDRNETMNMILKAKLGMPQFL---------SAEAQSLLRMLFKRNPANRLGSEGVEEIKRHLF
 .   | ||.||.|.|..| |  |  |     ..  | .. . . .  ..            ..|  .. ..  ...|..|   . .    ...|
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI----HECF
Kinase RSK4.AA Pkinase_C 354-394 39 3.5e-11 42.61 Pfam 5-46 (46) Show / Hide 
Range on Protein: 354-394
Range on HMM: 5-46/46
Sequence Identity: 39% (17 aa)

PDDTFCFDPEFTAKTPKDSP--GLPASANAHQLFKGFSFVATS
|.||  ||||||  .|.|.|  .   |.... .| ||..|. .
PTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase RSK4.AA RSK 426-683 57 1.4e-190 639.45 In-house 1-271 (271) Show / Hide 
Range on Protein: 426-683
Range on HMM: 1-271/271
Sequence Identity: 57% (155 aa)

YELKEDIGVGSYS---VCKRCIHATTNMEFAVKIIDKSKRDPS-----EEIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSE
|||.|.||.||.|   |||.|.|  ||...|.|||.|..||..     ||..|..|||.||.|..|..||.|...||...|.|.||.|.||.||||.|||
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSE

REASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTMLA
||.......| ....|||.||.|||||||.||||.|||.....|.|||||||||||.|||.|.|.|||||..|||||..||.|.|||.||.|||.|.||.
REVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLT

GYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRYTA-----EQILKHSWI
|.|||.|.|.|||..|..||..|.||...||||.||| |||||..|||.|||.|..|     |||..|.|.
GCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase RSK4.AA RSK 428-683 43 3e-156 525.37 In-house 1-278 (278) Show / Hide 
Range on Protein: 428-683
Range on HMM: 1-278/278
Sequence Identity: 43% (121 aa)

LKED--IGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPS--------EEIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKC---
||..  .|.|....|..|.|  |....|.|...|.|....        .|..||.|..|||.|.||...|... ..||......||||.....|.|.   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGE-NGLLLTPCYTANFVAPEVLM----QQGYDAACDIWSLG
|||.||..... |...|..|| ||..||||||.||||.||| .  .|...||||.||.| . |... |.|||....|||.|.    | |.|.|||.||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

VLFYTMLAGYTPFANGPND-TPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRYT-----AEQILKHSWI
|| |.||.|..||.. ||| ...||. ||..|||||...||...|. ||||...|||.|||.|..     ||.|..|.|.
VLMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase RSK4.AA CAMK1 426-683 39 6e-114 332.64 In-house 1-276 (276) Show / Hide 
Range on Protein: 426-683
Range on HMM: 1-276/276
Sequence Identity: 39% (110 aa)

YELKEDIGVGSYSVCKRCIHATT---NMEFAVKIIDKSKRDPSE-----------EIEILMRYG--QHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRI
||... || |. |. ..|.|  |   . ..|.|.||| |.  ..           ||||. . .  .||||| ....... ...|||..|..||||.|||
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDK-KKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRI

LKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIR--ICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQ---QGYDAACD
.. ....|..|..|   | . | |.| .|.||||||| |.|| |..  .. |.  |.||| .|.. ....|. |.| |  .|||||| .   ..|| |||
VEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSK-IKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACD

IWSLGVLFYTMLAGYTPFANGPNDT-PEEILLRIGNGKFSLSGGNWDNISDG-AKDLLSHMLHMDPHQRYTAEQILKHSWI
.|| || .|..| || ||     ..  .|..  | ....      ||||||. |||...|||  || .|||.||.|.| ||
MWSIGVITYILLCGYPPFY---DENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase RSK4.AA Pkinase 426-683 33 8.10000000001e-105 359.32 Pfam 1-293 (293) Show / Hide 
Range on Protein: 426-683
Range on HMM: 1-293/293
Sequence Identity: 33% (99 aa)

YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSE--------EIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGG----ELLDRIL--K
|.... || ||......|.|  |. ..|||||.|.......        ||.|. |  .||||..|.|.| |....|.|.... ||    .| |.|   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

QKCF--SEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQL-RGENGLLLTPCYTANFVAPEVLM-QQGYDAACDIWS
..||  ||.|. ...| | . ..|.| .|..||||||.|||. ..   .....|||||.|||.    |. . |.| | ...||||.. .|.|. ..|.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGVLFYTMLAGYTPFANG----PNDTPEEILLRIGNGKFSLSGGNWDNIS-----------------DGAKDLLSHMLHMDPHQRYTAEQILKHSWI
.|...| || |..|| .     . ... ... ||. .... .  .|..||                 . .||... .|..||..|.||||||.| |.
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase RSK4.AA AGC 426-683 22 2.2e-102 264.94 In-house 1-395 (395) Show / Hide 
Range on Protein: 426-683
Range on HMM: 1-395/395
Sequence Identity: 22% (92 aa)

YELKEDIGVGSYSVCKRCIHA------TTNMEFAVKIIDKSK---------RDPS-------------EEIEILMRYGQ---------HPNIIT-LKDVF
.|..  || ||.. .  . .       .|.  .|.|...|..          .               || .||... .         ||.|.  |.  |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

DDGRY--VYLVTDLMK---------GG-ELLDRIL---KQKCFSEREASDILYV--------ISKTVDYLHC-QGVVHRD-LKPSNILYMDESASADSIR
 | ..  .|.| ..|.         || ||. ..    |...|.| |.. .           |   ..|||  .|..||| ||| |||  ..      |.
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDE-ERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED----GHIK

ICDFGFAKQLRGE-----------------------------------------------------NGLLLTPCYTANFVAPEVLMQQGYDAACDIWS--
..|||..|.....                                                     .  .  || |....|||.|    |. |||.||  
LTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPC-TPEYMAPEIL----YGKACDWWSFG

LGVLFYTMLAGYTPFANGPND-------TPEEILLRIGNGK-FSLSGGNW-----------DNISDGAKDLLSHMLHMDPHQRYT----------AEQIL
||.|.| ||.||.|| . ...       .|.|.  .| ||. |.  .  .           ...|. ||||....|. || .| .          ||.| 
LGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIK

KHSWI
.| | 
NHPWF
Kinase RSK4.AA CAMK 431-683 25 5.8e-101 326.11 In-house 1-425 (425) Show / Hide 
Range on Protein: 431-683
Range on HMM: 1-425/425
Sequence Identity: 25% (110 aa)

DIGVGSYSVCKRCIHATTN------------MEFAVKIIDKS--------------------------------KRDPSEEIEILMRYG------QHPNI
 .| ||... |.|||  |.             ..|.|||||.                                ..    ||||...        .||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ITLKDVFDDGRY-------------------VYLVT---DLMKGGEL----LDRILKQKC---------------FSEREASDILYVISKTVDYLHCQGV
| | .|..|..|                   .|.|.   ... ||||    .|.| ...|               |.||||. .   |   |.|.| ...
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKPSNILYMDESASAD-------------SIRICDFGFAKQLRG-----------------------ENGLLLTPCYTANFVA-PEVLMQ------
||||||| |||. | . . |              | |.|||||.....                       |. .. |.| |  ..| |||| .      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------QGYDAACDIWSLGVLFYTMLAGYTPFANGPND----------TPEEILLRIGNGKFSLSGGN------------WDNISDG--------AKD
        ..|. .||.||.||. |.|| || ||    ..          ...|.. .| .||..                 ||.|||         .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LLSHMLHMDPHQRYTAEQILKHSWI
|...||  || .|.|.||.|.| |.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase RSK4.AA S_TKc 426-683 35 1.1e-100 341.68 SMART 1-231 (231) Show / Hide 
Range on Protein: 426-683
Range on HMM: 1-231/231
Sequence Identity: 35% (96 aa)

YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKG--GELLDRILKQKC------FSE
||. . || |.......|.|  |. ..|.|||.   ..   ||.||..  .||||..|.|||.|  ..|.|.... |  |.|.|.| |...      |.|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE

REASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDA-ACDIWSLGVLFYTML
 .|  ..| | . ..|.| .|..||||||.|||  .       | |||||.|.||        | | | ...|||||   ||.  .||.||.|...| ||
-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

AGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILK-------HSWI
.||.||      ...... .||              |. |||.....|..|| .|.|| ..|.       | |.
CGYPPFP-----QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RSK4.AA MSK 428-683 36 2e-86 292.19 In-house 1-277 (277) Show / Hide 
Range on Protein: 428-683
Range on HMM: 1-277/277
Sequence Identity: 36% (101 aa)

LKED--IGVGSYSVCKRCIHATTNMEFAVKIID-----KSKRDPSE---EIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSE
||.   .| |....|..| |  |. ..|.||.       ... ...   |. .| .  ||||| .|...| |    ||| .. .||||. .| | . |.|
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

REASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGE-NGLLLTPCYTANFVAPEVLM----QQG-YDAACDIWSLGVL
 |...|.  .   ||..|  |..|||||| |||. ||. ..  ... |||||. .  . .  . .||.|  . |||.|     |.| ||.|||.|||||.
SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGH-VKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVI

FYTMLAGYTPFA---NGPN---DTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILKHSWI
 |||| |  ||.    .      .  ||  ||  |.||. |  | |.|  ||||.. .|  ||  | ... ...|.|.
LYTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase RSK4.AA Ciliate-E2 426-683 24 1.2e-76 260.97 In-house 1-365 (365) Show / Hide 
Range on Protein: 426-683
Range on HMM: 1-365/365
Sequence Identity: 24% (94 aa)

YELKEDIGVGSYSVCKRCIH-----------------------ATTNMEFAVKIIDKSKRDPSEEIEILMR----------------YGQHPNIITLKDV
|.. . || |.... ..| .                        ......|.||. |..    . .. .||                  .||||| ....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FD--DGRYVYLVTDLMKGGELLDRILKQ-----------KCFSEREASDILYVISK---------------TVDYLHCQG-VVHRDLKPSNILYMDESAS
|   |  ..|||... .||.|.|.| ..           |.|.|.|...| . | .                . ||| .. ..|||.||.|||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

ADSIRICDFGFAKQLRGENG-------------------------------LLLTPCYTANFVAPEVLM---------QQGYDAACDIWSLGVLFYTMLA
   | |.|||..|..  .|                                .  | |.|....|||.|.         |.||| .||||||||..| || 
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GYTPFANGPNDTPEEILLRIGNGKFSLSGG--------------NWDNISDGAKDLLSH----MLHMDPHQRYT-AEQILKHSWI
|..||           .  | ..|....                .|...|. .|||..     ||  || .|.| .||||.| |.
GKPPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase RSK4.AA Ciliate-E2-Unclassified 426-683 25 5.3e-64 218.93 In-house 1-352 (352) Show / Hide 
Range on Protein: 426-683
Range on HMM: 1-352/352
Sequence Identity: 25% (90 aa)

YELKEDIGVGSYSVCKRCIHATTNMEF------AVKIIDKSKRDPS--------EEIEILM---------------RYGQHPNIITLKDVFDDGRYVYLV
|.. . || |.... ..|.|  .. ..       ...|.|.|   .        .|.....               .  .||.|. . ..| |  ..|.|
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

TDLMKGGELLDRILKQ-----------------KCFSEREAS-----DILYVISKTVDYLHCQG-VVHRDLKPSNILYMDESASADSIRICDFGFAK---
.....||.|.. | |.                 |.|.|..|.     .... | .  .||| .. ..|||.||.|||. ..      |.|.|||..|   
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-NYYIKIIDFGISKKYQ

QLRGE------------NGLLLTPCYTANFV----APEVLMQQGYD----AACDIWSLGVLFYTMLAGYTPF-ANGPND------------TPEEILLRI
| ...            . .. | | | |.     |||||..|.||     .||||||||..| || || || .|  ..            . ....  |
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

GNGKFSLSGGNW----DNISDGAKDLLS----HMLHMDPHQRYTAEQILKHSWI
 ..... .  .|    ...|. |||...     ||  .| .|.|.||||.| |.
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase RSK4.AA p70 476-683 28 4.4e-27 95.15 In-house 86-299 (299) Show / Hide 
Range on Protein: 476-683
Range on HMM: 86-299/299
Sequence Identity: 28% (63 aa)

QHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGE
.||.|. |   | ..   ||. . . ||||     ..  . |  |.  |  |.    .|| .|.. ||||| |..      ..  .   |||  |.   .
KHPFICDLHYAFQTNGKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCML----NQQGHVVLTDFGLCKESIHD

NGL----------LLTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGK--FSLSGGNWDNISDGAKDLLSHM
             ..| | |  . |||.||  |.. |.| ||||.| | || |  ||     ... ..   |  ||   .|        . ...||.  .
GAVDEEDPENVNATHTFCGTIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFT---GENRKKTIDKILKGKQGLKL----PPYLTHEMRDLIKKL

LHMDPHQRYT-----AEQILKHSWI
|  .| || .     |..| .| . 
LKRHPTQRWGAGPEDAADIQEHPFF
Kinase RSK4.AA Akt 561-622 35 7.5e-15 43.82 In-house 140-203 (264) Show / Hide 
Range on Protein: 561-622
Range on HMM: 140-203/264
Sequence Identity: 35% (23 aa)

IRICDFGFAKQL-RGENGLLLTPCYTANFVAPEVLMQQGYDAACDIWS-LGVLFYTMLAGYTPF
|...||| .|.    ..    | | |.   |||.| ..|.. |.|.|. ||...| |. |  ||
ICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPF
Kinase RSK4.AA TyrKc 426-683 18 1.3e-14 13.8 SMART 1-280 (280) Show / Hide 
Range on Protein: 426-683
Range on HMM: 1-280/280
Sequence Identity: 18% (56 aa)

YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSE---EIEILMRYG-QHPNIITLKDVFDDG-------RYVYLVTDLMKGGELLDRILKQKC
 .|.. .| | . .  ...     .. ||| . ...    .   |..|....| .||||. |  |  ..         ...|. .|..| |.|.. | . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

-FSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGE-----NGLLLTPCY--TANFV------APEVLMQQGYD
 .. ..  .. . |..  .||| ....||||   |.|. ..      ..|.||| .. .  .     ..   ..     ....      |||...   . 
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

AACDIWSLGVLFYTMLA-GYTPFAN---GPNDTPEEILLRIGNGKFSLSGGNWDN--------ISDGAKDLLSHMLHMDPHQRYTAEQILKHSWI
 . |.|| ||. . ..  | .|  .       ...|.. .. .|.        .|         .|   .. .   | ||..| | ..|  |. .
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQP---PNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase RSK4.AA Pkinase_Tyr 426-611 25 1e-13 47.07 Pfam 1-203 (270) Show / Hide 
Range on Protein: 426-611
Range on HMM: 1-203/270
Sequence Identity: 25% (53 aa)

YELKEDIGVGSYSVCKRCIHA----TTNMEFAVKIIDKSKRDPSE--------EIEILMRYGQHPNIITLKDVFD-DGRY--VYLVTDLMKGGELLDRIL
 .. . .| |.. . ....       |... |||.. | . ....        |..|.. .|.||||. |  |   .|.   .|.|. .|..| |||   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

K----QKCFSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQL-------RGENGLLLTPCYTANFVAPEVLMQQGY
|    .. ..  .  .. . |.|  .||. .. .||||   |.|  .       ..||||| |. .       |   |  |    .    |||...   .
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE----NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM----APECINYGKF

DAACDIWSLGVL
  . |.|| |||
TTKSDVWSFGVL
Kinase RSK4.AA Akt 476-550 35 9.4e-08 20.78 In-house 58-133 (264) Show / Hide 
Range on Protein: 476-550
Range on HMM: 58-133/264
Sequence Identity: 35% (27 aa)

QHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRD-LKPSNIL
.|| |. |.  | .  . |.|.| ..||||   . ... ||| .|      |.   ..|| .... || ||| |||
NHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENIL
Kinase RSK4.AA Akt 650-683 38 8.7e-05 11.14 In-house 226-264 (264) Show / Hide 
Range on Protein: 650-683
Range on HMM: 226-264/264
Sequence Identity: 38% (15 aa)

DNISDGAKDLLSHMLHMDPHQRY-----TAEQILKHSWI
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DWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF