Slob

Species: Human
Alias: PXK, MONaKA, FLJ20335, Slob
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 3p12,

Classification

Group: Other
Family: Slob

Sequence

Name Sequence Type Origin Length Description Download
Slob.NA RNA Sugen Kinome 2048 None Fasta, JSON
Slob.AA Protein Sugen Kinome 578 None Fasta, JSON
Slob.kin_dom Protein Kinase Domain Sugen Kinome 248 None Fasta, JSON

Protein domain

Protein domains of Slob.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PX Slob.AA PX 32-122 32 2.6e-19 68.72 Pfam 21-120 (120) Show / Hide
Range on Protein: 32-122
Range on HMM: 21-120/120
Sequence Identity: 32% (32 aa)

SHTEYIIRVQRGIS--VENSWQIVRRYSDFDLLNNSLQ--IAGLSL-PLPPKKLIGN---MDREFIAERQKGLQNYLNVITTNHILSN-CELVKKFLDPN
.|..|......  .   . .|.. ||||||  |   |.  . .. . |||||...|.   .|.||| .|...|..||. . ..  |.| ||....|| |.
MHYYYVYEIHMNTNPFQKKEWHVWRRYSDFHWLHKQLKRHFPMCIIPPLPPKHWFGRYNNFDEEFIEKRRQMLEQYLQRVCQHPELCNHCEVFHDFLHPD





PX Slob.AA PX 17-122 20 2e-17 65.1 SMART 1-142 (142) Show / Hide
Range on Protein: 17-122
Range on HMM: 1-142/142
Sequence Identity: 20% (29 aa)

TVPLTAAIEASQ------SLQSHTEYIIRVQRGISV-ENSWQIVRRYSDFDLLNNSLQIAGLSL-------PLPPKKLIGN------------------M
. .. ...   .      .  .|. |....... .  .  |.. ||||||  | . |.     .       |||||.....                  .
DHIFIITVVEFFTHGKHYHDGKHYYYVYEIHTKTNNHVKMWTVYRRYSDFHWLHHQLKRHFPQEKRMCIIPPLPPKHWFVRYRYWMEHMSMMWWYSFNNF

DREFIAERQKGLQNYLNVITTNHILSN----CELVKKFLDPN
|..|| .|..||..||. .  . ...|    ||.|..|....
DEDFIEKRRRGLERYLQRLCHHPEWINHYMVCEVVYEFFESS

Kinase Slob.AA Slob 152-393 50 4.8e-166 557.93 In-house 1-268 (268) Show / Hide
Range on Protein: 152-393
Range on HMM: 1-268/268
Sequence Identity: 50% (134 aa)

LKDIGWRIRKKYFLMKIKNQPKERLVLSWADLGPD----KYLSDKDFQCLIKLLPSCLHPYIYRVT----FATANESSALLIRMFNEKGTLKDLIYKAKP
|..||||.||....||...||.|..|.||.|.|||    |.|..|..||..|.|.|| |||||.|.    |..........||.||..|.|||.||||||
LDHIGWRHRKNWCMMKNDMQPGEECVQSWIDYGPDCCPWKMLNEKECQCFMKILMSCHHPYIYPVINLVFFINHKHNYCCVIRFFNKRGSLKDFIYKAKP

KDPFLKKYCN----------------PKKIQGLELQQIKTYGRQILEVLKFLHDKGFPYGHLHASNVMLDG--DTCRLLDLENSLLGLPSFYRSYFSQFR
|.|...||||                .||..||...|...|.|||||.|.|||.|||||||||..|||.|.  |.|||.|.||.|||.|.||..|....|
KMPWARKYCNKQPKSSSSSSSSSSSSHKKQNGLPMKQVQKYCRQILEALIFLHSKGFPYGHLHSGNVMIDDSNDCCRLSDIENCLLGMPPFYNDYIMWHR

KINTLESVDVHCFGHLLYEMTYGRPPDSVPVDSFPPAPSMAVVAVLESTLSCEACKNGMPTISRLLQM
||...|.|||.||||.||||..|.|.....|..|||.|..|.....|..||||.||..|||...||||
KIHEIENVDVYCFGHCLYEMCCGYPMQNHSVRNFPPCPFIALFCDKEHILSCEICKHCMPTMRQLLQM

Kinase Slob.AA CLK 254-281 35 2.7e-05 11.04 In-house 105-132 (350) Show / Hide
Range on Protein: 254-281
Range on HMM: 105-132/350
Sequence Identity: 35% (10 aa)

PKKIQGLELQQIKTYGRQILEVLKFLHD
| |........|.  ..|..| .|||||
PNKYIPYPIDHIRHMAYQLCEAVKFLHD

S_TKc Slob.AA S_TKc 146-396 15 3.9e-05 -101.65 SMART 1-231 (231) Show / Hide
Range on Protein: 146-396
Range on HMM: 1-231/231
Sequence Identity: 15% (45 aa)

WEVVEPLKD-------IGWRIR-KKYFLMKIKNQPKERLVLSWADLGPDKYLSDKDFQCLIKLLPSCLHPYIYRVTFATANESSALLIRMFNEK--GTLK
.|.....          .. .. .... .|| .                     ....  |..| .  ||.| .   .  . ..  ..  . .   |.|.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLF

DLIYKAKPKDPFLKKYCNPKKIQGLELQQIKTYGRQILEVLKFLHDKGFPYGHLHASNVMLDGDTCRLLDLENSLLGLPSFYRSYFSQFRKINTL-----
|.|          ||.  ... ...   ... | .||.. |...|..|. .  |  .|..||  .  . |   . .                .|.     
DYI----------KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL---------------TTFCGTPW

----------E-SVDVHCFGHLLYEMTYGRPPDSVPVDSFPPAPSMAVVAVLESTLSCEAC--------KNGM--PTISRLLQ-------MPLF
            ..|.  .| .|||| .|.|| .           ...  ..    | ||.        |.    ||.  .||       .| |
YMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFP---------QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase Slob.AA SRPK 258-282 40 0.000173 5.84 In-house 124-148 (554) Show / Hide
Range on Protein: 258-282
Range on HMM: 124-148/554
Sequence Identity: 40% (10 aa)

QGLELQQIKTYGRQILEVLKFLHDK
||. . ..|.  ||.|. |..||.|
QGMPMHCVKQIARQVLIGLDYLHRK

Kinase Slob.AA STE-Unique 253-302 26 0.00025 10.63 In-house 393-448 (616) Show / Hide
Range on Protein: 253-302
Range on HMM: 393-448/616
Sequence Identity: 26% (15 aa)

NPKKIQGLELQQIKTYGRQILEVLKFLHDKG--FPYGHLHASNVMLDGDT----CR
||  .| ..  ... | .|||| | .|| ..   . . | ..|.... |.    |.
NPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCK

Kinase Slob.AA Delta 261-299 38 0.000476 10.46 In-house 98-136 (259) Show / Hide
Range on Protein: 261-299
Range on HMM: 98-136/259
Sequence Identity: 38% (15 aa)

ELQQIKTYGRQILEVLKFLHDKGFPYGHLHASNVMLDGD
...  . |.  |.  |.||| ||  |  |   ||.|| |
DEKRARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCD

Kinase Slob.AA CMGC 249-284 17 0.000494 8.12 In-house 157-205 (513) Show / Hide
Range on Protein: 249-284
Range on HMM: 157-205/513
Sequence Identity: 17% (9 aa)

KKYCNPKK------------IQGLELQQIKTYGRQILEVLK--FLHDKG--F
... .. .            |. . . .|. | .|||. ||  ..| ..  .
PMPLSE-HENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYCHSHWGNI

Kinase Slob.AA Ciliate-D1 334-352 52 0.000726 13.47 In-house 1-19 (19) Show / Hide
Range on Protein: 334-352
Range on HMM: 1-19/19
Sequence Identity: 52% (10 aa)

DVHCFGHLLYEMTYGRPPD
|. .|| .|||| .|.||.
DIWSFGCILYEMLFGQPPF

Kinase Slob.AA Delta 331-351 52 0.048457 3.08 In-house 179-199 (259) Show / Hide
Range on Protein: 331-351
Range on HMM: 179-199/259
Sequence Identity: 52% (11 aa)

ESVDVHCFGHLLYEMTYGRPP
.|||   || |.|||  |  |
HSVDWWSFGVLMYEMLIGQSP