SRPK1

Species: Human
Alias: SFRSK1, SRPK1
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 6p21,

Classification

Group: CMGC
Family: SRPK

Sequence

Name Sequence Type Origin Length Description Download
SRPK1.NA RNA Sugen Kinome 4361 None Fasta, JSON
SRPK1.AA Protein Sugen Kinome 655 None Fasta, JSON
SRPK1.kin_dom Protein Kinase Domain Sugen Kinome 574 None Fasta, JSON

Protein domain

Protein domains of SRPK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SRPK1.AA SRPK 80-653 53 0.0 1183.33 In-house 1-554 (554) Show / Hide
Range on Protein: 80-653
Range on HMM: 1-554/554
Sequence Identity: 53% (321 aa)

YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPN---------------------DPNREMVVQLLDDFKISGVNG
|||||||||||||||||.||.|....||||.||||.||||||.|||.||..||..|||                     ||||..||||||.||..|.||
YHVIRKLGWGHFSTVWLCWDMQYDRYVAMKIVKSAPHYTETAVDEIKLLQCVRKHDPNPQWMHFLKEYYEDYKRDCKEFDPNRCHVVQLLDHFKHRGPNG

THICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQ--
.|.|||||||||.|||||...||||.|..|||.|..|||.||||||.||.||||||||||.||.||..||.|.|||.||||..|...||.|.|.||||  
NHYCMVFEVLGHNLLKWIKHYNYQGMPMHCVKQIARQVLIGLDYLHRKCGIIHTDIKPENVLLCVNQDYIKRMAAEWTEWQKMGMQMPSSSMVQTAPQHQ

-PKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQKRPNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQTLMERDTEGGAAEIN
 .....|||||||||.|||||.|.|..||..|....||......  ..|.||............|..|.|..|..|...|..|..............|..
TQCQQQKMSKNKKKKMKKKQKQQQEQQEKNQQQKQQMEDDQNDN--EDNNQEDNDNEQDNKNNQNQENNMENEQEEKENTNKQKKNQKKKEQHKDKKEQE

CNGVIEVINYTQNSNNETLRHKEDLHNANDCDVQNLNQESSFLSSQNGDSSTSQETDSCTPITSEVSDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPC
|..|....|.                             ..|. ||| ||...|||.||.........||.||.|..  ..  .|.. . ..|...|...
CQNVQKQNND-----------------------------PNFE-SQN-DSQMEQETNSCNNQEHKQEKTMQCQDSTKQQNKQ-DQQKEGQKQSEESECES

EDEQEQEHNGPLDNKGKSTAGNFLVNPLEPKNAE---KLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFE
||.|||             ||.|||....|.||.   |.|.||||||||||||.|||||||||||||.||.||.||||||||||||||||||||||||||
EDMQEQ-------------AGKFLVWWKNPRNADLDHKIKIKIADLGNACWVHHHFTEDIQTRQYRSPEVIIGAGYNTPADIWSTACMAFELATGDYLFE

PHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPW
|||||.|.||.||||.||||.||.|......||||.|||.|||.|.||.|||||.|..||.||||||.|||. |.|||.|||...|||||||.|||.|||
PHSGEDYSRDDDHIAHIIELCGKIPWHFALSGKYSREFFNKKGELRHIPKLKPWPLMNVLIEKYEWSHEEAKQFEDFLMPMLHYNPEKRATAKECLQHPW

L
|
L

Kinase SRPK1.AA CMGC 80-653 14 1e-123 408.73 In-house 1-513 (513) Show / Hide
Range on Protein: 80-653
Range on HMM: 1-513/513
Sequence Identity: 14% (113 aa)

YHVIRKLGWGHFSTVWLSWD--------------IQGKKFVAMKVVKSAEHYTE-------------TALDEIRLLKSVR----------NSDPNDPNRE
|..|.|.|.|....|.  .|              ......||.| .|... |.|             .||.||..|| ..          . ||......
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRD-DPDNKHHN

MVVQLLDDFKISGVNGT-------------HICMVFEVLGHHLLKWIIKSN--YQG------------------------LPLPCVKKIIQQVLQGLD--
 .|.|.| |. .. .|.             |...||| ..| |.. | . .  |||                        ... ... ...|.|.||.  
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

YLHTKC-RIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQ
|.| .. .|||.|.||||||.. | ..|.|. .    | .|     .                                                     
YCHSHWGNIIHRDLKPENILINHNCELITRM-M----W-KS-----E-----------------------------------------------------

KRPNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQTLMERDTEGGAAEINCNGVIEVINYTQNSNNETLRHKEDLHNANDCDVQNLNQESSFLSS
                                                                                                    
----------------------------------------------------------------------------------------------------

QNGDSSTSQETDSCTPITSEVSDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPCEDEQEQEHNGPLDNKGKSTAGNFLVNPLEPKNAEKLKVKIADLGN
                                                                            . . ||.    ... ..||.| |.
----------------------------------------------------------------------------D-W-NPC----QKNGRLKICDFGL

ACWVHKH------------------------FTEDIQTRQYRSLEVLIGSG----------YNTPADIWSTACMAFELATG--------DYLFEPHSGE-
|.|.|.|                        .|....|| ||. |.|.|..          |.|| |.|| .|. .|. ||        ..|| .||.. 
ARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYP

----EYTRDEDHIALIIELLGKVPRKLIVAGK-------YSKEFFTKKGDLKHITKLK-------------------------PWGLFEVLVEKYEWSQE
     .... |....|...||. . ..| .||       ...|...... . .....|                         ||  .  . ... |...
NDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPN

--------------------------------EAAGFTDFLLPMLELIPEKRATAAECLRHPWL
                                .   . |.|  ||.. |.|| ||...|.||..
WDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF

Kinase SRPK1.AA CLK 80-653 15 9.2e-62 183.65 In-house 1-350 (350) Show / Hide
Range on Protein: 80-653
Range on HMM: 1-350/350
Sequence Identity: 15% (95 aa)

YHVIRKLGWGHFSTVWLSWDIQG-KKFVAMKVVKSAEHYTETALDEIR-LLKSVRNS-DPNDPNREMVVQLLDDFKISGVN-GTHICMVFEVLGHHLLKW
| .. .|| | |..|   || .  ||.|| |.....| |.| |  ||.  .|.. .  |||  ..| .....| |.    . . |||.||| .|  .   
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFD----YGHGHICIVFELYGLSIYDF

IIKSN------YQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNE--QYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKPADKMSKNK
. . |      |...|.  ....  | .. .  || . ...||| |||||.. |..  ....      ..   .                          
MKSNNSKMPNKYIPYPIDHIRHMAYQLCEAVKFLH-DMKLTHTDLKPENICF-VDSRFTHFDCTFKYNHKKKIN--------------------------

KKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQKRPNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQTLMERDTEGGAAEINCNGVIEVINYTQ
                                                                                                    
----------------------------------------------------------------------------------------------------

NSNNETLRHKEDLHNANDCDVQNLNQESSFLSSQNGDSSTSQETDSCTPITSEVSDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPCEDEQEQEHNGPL
                                                                                                    
----------------------------------------------------------------------------------------------------

DNKGKSTAGNFLVNPLEPKNAEKLKVKIADLGNAC---WVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDED
       .     .  . .  . . ... | |.|      | | .. ..||.||  ||  | |...| |.|| .|  ||| ||. ||  |.        .
-------KKS-NNCVCHYWHVKNTHICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHD------NRE

HIALIIELLG-KVPRKLIVAG---KYSKEFF---TKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWL
| |.. ...|  .|   | .    | ....|      .| .  .  .     . | .  .  ..|.  . | .  |||  | || |... | ||. 
HLAMMERIMGMPIPQWMIQRTRRFKVKQKYFYHNRLDWDWHNSDGRYVMENCKPLKQYMDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF

Kinase SRPK1.AA S_TKc 80-653 13 3.3e-46 160.75 SMART 1-231 (231) Show / Hide
Range on Protein: 80-653
Range on HMM: 1-231/231
Sequence Identity: 13% (78 aa)

YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGH---HLLKWI
|...||.| | |..|.. ...  .. ||.|..|      |... ||..||.      . ||   .|.|.| |       .|..||.| ...    |.. |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK------HHPN---IVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYI

IKSNYQG----LPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRR-------LAAEATEWQRSGAPPPSGSAVSTAPQPKPADKMSK
 | ...|    .|   ......|....|.|.| . .||| |.|||||||.       .       ||..                               
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE------HIKICDFGLARQL------------------------------

NKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQKRPNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQTLMERDTEGGAAEINCNGVIEVINY
                                                                                                    
----------------------------------------------------------------------------------------------------

TQNSNNETLRHKEDLHNANDCDVQNLNQESSFLSSQNGDSSTSQETDSCTPITSEVSDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPCEDEQEQEHNG
                                                                                                    
----------------------------------------------------------------------------------------------------

PLDNKGKSTAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNT-PADIWSTACMAFELATGDYLFEPHSGEEYTRDED
                                           |  . |. |.. |||   ||.. ..|.||  |. .|...|  .|.            
-------------------------------------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP------------

HIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLR-------HPWL
.........|                                                   . ||.  .|.  |||| || |.|.       |||.
QMQMMFKKIG------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase SRPK1.AA DYRK 80-221 31 1.6e-31 111.03 In-house 1-137 (320) Show / Hide
Range on Protein: 80-221
Range on HMM: 1-137/320
Sequence Identity: 31% (45 aa)

YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKS
| ..  .| | |. |   || .... ||.|.... . .  .|..||..|.  ..   .. ..  .|...| |.  .    | |.||| |   |   . . 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQ--DPDDKYHCVHMYDYFYHRN----HLCIVFELLSMNLYEFLKNN

NYQGL-PLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILL
. ||. .|  |.|..||.|..|..||.. .||| |.|||||.|
HFQGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIML

Kinase SRPK1.AA DYRK 486-653 28 2.2e-28 100.64 In-house 138-320 (320) Show / Hide
Range on Protein: 486-653
Range on HMM: 138-320/320
Sequence Identity: 28% (55 aa)

KNA-EKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAG
|..  |  .|..| | .| .|....  || | ||. ||..|  |... |.||  |   || ||  ||   .|| .    | .|.|.|.||. |...| .|
KQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLF---PGENE---YDQLACIMEVLGMPPKWMIDKG

--KYSKEFFTK---------KGDLK----------HITKLKPWGLFEVLVE-KYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWL
  .. ..||..         ..  |          |.||    ..       ...    .   |.||.. .|.. |.|| |... |.|||.
RCRRKHKFFDCFMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF

Kinase SRPK1.AA DYRK2 80-221 35 1.5e-27 86.37 In-house 1-135 (318) Show / Hide
Range on Protein: 80-221
Range on HMM: 1-135/318
Sequence Identity: 35% (51 aa)

YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKS
| .   .| | |  |    |   |..|| |..     . ..|. ||| |.  |  |..  |   .| .|| |   .    |.|..|| |.  | . | | 
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKD--NTMNCVHMLDYFYFRN----HHCITFELLSMNLYEYIKKN

NYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILL
..||. |  | . ....||.|. || | .||| | |||||||
HFQGFSLQLVRRFAHSILQCLRFLH-KNNIIHCDLKPENILL

Kinase SRPK1.AA DYRK1 80-221 32 2.5e-22 74.82 In-house 1-137 (321) Show / Hide
Range on Protein: 80-221
Range on HMM: 1-137/321
Sequence Identity: 32% (46 aa)

YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKS
| ..  .| | |  |   .| | ...||.|..|    . . |. |||||  . . |..  ..  .|.|   |.       |.|.|||.|   |   .   
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKE--MKYYIVHLKRHFMFR----NHLCLVFELLSYNLYDLLRNT

NYQGLPLPCVKKIIQQVLQGLDYLHT-KCRIIHTDIKPENILL
...|  |  ..|. ||... | .. |    ||| |.|||||||
HFRGVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILL

Kinase SRPK1.AA CDC2 80-222 31 7.3e-22 63.5 In-house 1-137 (301) Show / Hide
Range on Protein: 80-222
Range on HMM: 1-137/301
Sequence Identity: 31% (47 aa)

YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTE-----TALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLK
|  |.|.| | .  |    | | .. ||.| ..      .     ||. || .||  .    ..||   .|.| | ...       . |||| | ..| |
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELK----DHPN---IVKLHDVIHQ-----NKLYMVFEYLDMDLKK

WIIKSNY--QGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLS
   .|.   . .|.  ||... | |||....|.. ||.| |.|| |||..
YMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQR-RIMHRDLKPQNILID

Kinase SRPK1.AA Pkinase 80-222 28 2.5e-21 76.52 Pfam 1-142 (293) Show / Hide
Range on Protein: 80-222
Range on HMM: 1-142/293
Sequence Identity: 28% (45 aa)

YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALD------EIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGH---
||..||.| | |..|..  ..   | ||.|..|   |  .  .       ||...|...         . .|.|.| |      ..||.||.| ...   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLN--------HPNIVRLYDWFED----KDHIYMVMEYCEGGLY

--HLLKWIIKSNYQGL--PLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLS
   |  .|  ... ..  .   .|... |.|.||.|.|  ..||| |.||||||..
VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILID

Kinase SRPK1.AA DYRK2 486-595 31 1.7e-18 56.46 In-house 136-245 (318) Show / Hide
Range on Protein: 486-595
Range on HMM: 136-245/318
Sequence Identity: 31% (37 aa)

KNAEKLKVKIADLGNACWVHK-HFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAG
| . .  .|..| |  | .|  ..  .||.| ||. || .|  |... |.||  | . || ||  ||    || .    | .|...|.||. |.|..   
KQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLF---PGENE---NDQFACMMEVLGMPPKKFFDTW

-----KYSKEFFTKKG
     .. | ||....
FYIHCFRRKYFFNSHC

Kinase SRPK1.AA DyrkP 486-594 34 9.9e-17 50.98 In-house 140-242 (323) Show / Hide
Range on Protein: 486-594
Range on HMM: 140-242/323
Sequence Identity: 34% (38 aa)

KNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGK
|   | .||| | | .|..| |    .| | ||  ||.||  |    |.||  |.  || ||  ||              .| .| ..| .|  ..  |.
KSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWTGNVLFQNDNIQGL------LARVIGIIGPFPEWMMQEGR

YSKEFFTKK
  . |||.|
LVQNFFTRK

Kinase SRPK1.AA YAK 80-221 31 6.1e-16 50.28 In-house 1-139 (347) Show / Hide
Range on Protein: 80-221
Range on HMM: 1-139/347
Sequence Identity: 31% (46 aa)

YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSV-RNSDPNDPN-REMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWII
| |   || | |  |        .  .| ||.|.   |   |  ||..|..     |||. |    .. ..| |    |   | |.||| |   |   . 
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFF----VHKNHFCLVFEMLSNNLYEYLK

KSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILL
  .. |.    ..    |.| |.  |  | .||| | |||||.|
QNKFCGFSFQLIRQWTKQILDGMCVLENK-QIIHCDLKPENIML

Kinase SRPK1.AA Pkinase 492-653 23 6.4e-16 57.37 Pfam 150-293 (293) Show / Hide
Range on Protein: 492-653
Range on HMM: 150-293/293
Sequence Identity: 23% (40 aa)

KVKIADLGNAC---WVHKHFTEDIQ-TRQYRSLEVLI-GSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLG---KVPRKLIVA
.|||.| | |.   . ... . ..  |. |.. ||.  |..| ...|.||  |. .|...|  .|  ...    .  |....| . .|   . ..     
CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCS

GKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWL
. |.. |.. .              |   .  ..||.|    . ||.  .|.. |.|| ||...| |||.
ISYFF-FRH-W-H------------F-HWTF-HNWSEE----CKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase SRPK1.AA DYRK1 487-602 33 6.7e-16 51.87 In-house 139-248 (321) Show / Hide
Range on Protein: 487-602
Range on HMM: 139-248/321
Sequence Identity: 33% (39 aa)

NAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKY
|. . ..|| | | .| . .   . || | ||| |||.|  |..  |.||  |.  |. ||. ||   || .   . | .  |.| ||  |...|  .  
NPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGEPLF---SGSN---EVDQMNKIVEVLGMPPKHMIDQAPK

SKEFFTKKGDLKHITK
.. .|.|. |  .  |
AHKYFEKDPDNTWYCK

Kinase SRPK1.AA CDK4 80-226 27 1.7e-15 49.47 In-house 1-148 (290) Show / Hide
Range on Protein: 80-226
Range on HMM: 1-148/290
Sequence Identity: 27% (43 aa)

YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYT-----ETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNG--THICMVFEVLGHHL
|  .  .| | . ||.   |..  .||| | |.              . || ...    .  . ||   .|.|.| .. . . .  . | ||||     |
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQF--EHPN---IVKLMDVCHVMDTDRAEMKITMVFEHCDWDL

LKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQ
  .. |    |.| . .|..  | | |.|.||. . ||| | ||.|||.. . .
HTYLDKCPPPGMPPCTIKHMMHQLLRGVDFLHSHR-IIHRDLKPQNILVTSDGH

Kinase SRPK1.AA YAK 486-591 33 7.8e-10 29.19 In-house 140-239 (347) Show / Hide
Range on Protein: 486-591
Range on HMM: 140-239/347
Sequence Identity: 33% (36 aa)

KNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGK
.. .|  .|| | | .|   |  .  || | ||| |....  | |  | ||  |   ||  |  .|   |  ||    . |  ||. ||. |  .|  |.
CKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFLGLPIFPGNS--EY----NQIKRIIDMLGYPPSWMIDQGR

YSKEFF
..  .|
FKNKYF

Kinase SRPK1.AA DyrkP 189-221 57 6.8e-09 24.71 In-house 108-139 (323) Show / Hide
Range on Protein: 189-221
Range on HMM: 108-139/323
Sequence Identity: 57% (19 aa)

VKKIIQQVLQGLDYLHTKCRIIHTDIKPENILL
..|| ||.| .|||.|   |.|| |.||||||.
LQKITQQILIALDYIHS-LRLIHCDLKPENILM

Kinase SRPK1.AA CDK4 517-544 53 2.9e-08 24.21 In-house 175-202 (290) Show / Hide
Range on Protein: 517-544
Range on HMM: 175-202/290
Sequence Identity: 53% (15 aa)

YRSLEVLIGSGYNTPADIWSTACMAFEL
||. |||  | |||| |.|| .|  .|.
YRAPEVLLQSYYNTPVDMWSVGCIFAEM

Kinase SRPK1.AA DYRK2 626-653 39 4.6e-07 18.67 In-house 291-318 (318) Show / Hide
Range on Protein: 626-653
Range on HMM: 291-318/318
Sequence Identity: 39% (11 aa)

FTDFLLPMLELIPEKRATAAECLRHPWL
|.||..  .|  |..| |... |.|||.
FIDFIKRCFEWDPSERMTPSQALKHPWI

Kinase SRPK1.AA CDC2 628-653 46 5.5e-07 16.96 In-house 276-301 (301) Show / Hide
Range on Protein: 628-653
Range on HMM: 276-301/301
Sequence Identity: 46% (12 aa)

DFLLPMLELIPEKRATAAECLRHPWL
| |  || . |.|| .| | |.||..
DLLMQMLQYDPQKRISAKEALQHPYF

Kinase SRPK1.AA TyrKc 80-312 16 3e-06 -122.49 SMART 1-280 (280) Show / Hide
Range on Protein: 80-312
Range on HMM: 1-280/280
Sequence Identity: 16% (50 aa)

YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSV--RNSDPNDPNREMVVQLLDDFKISGVNG---THICMVFEVLGHHLLK
 . ..||| |.| .|..   .     || |..|.     |  ..|.|.....  ..        . .|.|.     .| |      ...|.|   |  ||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHH--------PNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

WIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNE-----------------------QYI-------RR-------LAAEATE
  ....   |...   ..  |. .| .||| | ..|| |.   |.|.. |                        .|.       ..       .| |.  
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-

WQRS---------------------GAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQ----------AELLEKRMQEIEEMEKESGPGQKRPNKQ
 . .                     |..|..| .      ..... . .. |.    .|             .|. .  |..  . . |     .||. .
-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ----MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPE-----DRPTFS

EESESP
|  |  
EIHECF

Kinase SRPK1.AA CDC2 505-551 33 4e-06 14.38 In-house 157-209 (301) Show / Hide
Range on Protein: 505-551
Range on HMM: 157-209/301
Sequence Identity: 33% (18 aa)

HKHFT--EDIQTRQYRSLEVLIGSG-YNTPADIWSTACMAFEL---ATGDYLF
..  |   .. |. ||. |.| |.  |.|| |.||  |   |.   .|  .||
IRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEMFMDVTKKPLF

Kinase SRPK1.AA DyrkP 80-129 30 5e-06 15.0 In-house 1-50 (323) Show / Hide
Range on Protein: 80-129
Range on HMM: 1-50/323
Sequence Identity: 30% (15 aa)

YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLK
| ..  ||   ||      | |  . . ||..     | . ..|||.||.
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLR

Kinase SRPK1.AA CDK4 628-653 42 5e-06 16.55 In-house 265-290 (290) Show / Hide
Range on Protein: 628-653
Range on HMM: 265-290/290
Sequence Identity: 42% (11 aa)

DFLLPMLELIPEKRATAAECLRHPWL
|.|. ||   ..|| .| .|| ||..
DLLQKMLCYNHHKRMSAYQCLQHPYF

Kinase SRPK1.AA DyrkP 626-653 42 3.6e-05 12.21 In-house 296-323 (323) Show / Hide
Range on Protein: 626-653
Range on HMM: 296-323/323
Sequence Identity: 42% (12 aa)

FTDFLLPMLELIPEKRATAAECLRHPWL
| ||   .| .   .| || | |.|||.
FIDFVRQCLQIDFTRRPTAKEALQHPWF

Kinase SRPK1.AA YAK 626-653 32 0.000123 11.24 In-house 320-347 (347) Show / Hide
Range on Protein: 626-653
Range on HMM: 320-347/347
Sequence Identity: 32% (9 aa)

FTDFLLPMLELIPEKRATAAECLRHPWL
|.||.  .|.| | .| ..     || .
FIDFINQLLQLNPRERWKPMQAMQHPFI

Kinase SRPK1.AA DYRK1 626-653 32 0.001026 8.36 In-house 294-321 (321) Show / Hide
Range on Protein: 626-653
Range on HMM: 294-321/321
Sequence Identity: 32% (9 aa)

FTDFLLPMLELIPEKRATAAECLRHPWL
| | .. ||.  |..| |  . |.|...
FKDLIKRMLQYDPKQRITPYYALQHSFF