Gene TLK2 (Human)

TLK2

Species: Human
Alias: Hs.57553, MGC44450, PKU-ALPHA, TLK2
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 17q23,

Classification

Group: Other
Family: TLK

Sequence

Name Sequence Type Origin Length Description Download
TLK2.NA RNA Sugen Kinome 5874 None Fasta, JSON
TLK2.AA Protein Sugen Kinome 772 None Fasta, JSON
TLK2.kin_dom Protein Kinase Domain Sugen Kinome 269 None Fasta, JSON

Protein domain

Protein domains of TLK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase TLK2.AA TLK 462-741 79 2.5e-250 837.88 In-house 1-285 (285) Show / Hide 
Range on Protein: 462-741
Range on HMM: 1-285/285
Sequence Identity: 79% (227 aa)

YLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKL
|.||||||.||||||||||||.|.||||.|||||||||..|||.||.|||||||.|||||||.|||||||||..|..||||||||||||||||||||||.
YQLLHLLGKGGFSEVYKAFDLHEFRYVACKIHQLNKNWKEEKKANYIKHACREYKIHKELDHCRIVKLYDYFEIDNNSFCTVLEYCEGNDLDFYLKQHKT

MSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGK-----EPP
|.|||||.||||||..||||||||||||||||||.||....|..|||||||||||||||||..|....||||||||||||||||||||||||     .||
MPEKEARCIIMQIVCCLKYLNEIKPPIIHYDLKPQNIIFHKGNTCGEIKITDFGLSKIMDDEQYRHDHGMELTSQGAGTYWYLPPECFVVGKCEEFENPP

KISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL
|||.|||||||||||||||||.||||||.|||.||..||||||||||||.||.|. |.|.||||||.||.|||.|||||...||.
KISCKVDVWSVGVIFYQCLYGQKPFGHNMSQQQILEQNTILKATEVQFPSKPQVSNECKDFIRRCLQYRQEDRWDVQQLWNHPYM
Kinase TLK2.AA S_TKc 462-741 31 1e-80 275.42 SMART 1-231 (231) Show / Hide 
Range on Protein: 462-741
Range on HMM: 1-231/231
Sequence Identity: 31% (94 aa)

YLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEG--NDLDFYLKQH
| .| ..|.|.|..|||. .   .|.||.||                .|..|| .|.|. .|| ||||||.|    |... |.|||.|   ||  |.|..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKR

KL------MSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGK
.       ..| .||... ||..||.|. .    ||| |||| |||| .     .|||.||||....              .   || ||..|| .    
GRHGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE-----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL----

EPPKISN-KVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLAC-------DPYL
   . .  |.|.||.|.|.| .|.|. ||          |.....|            .|||| |||.|| .  |.|. . ..         .|..
---GYGKCKCDWWSCGCILYEMLCGYPPFP---------QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TLK2.AA Pkinase 462-741 30 1.8e-67 235.29 Pfam 1-293 (293) Show / Hide 
Range on Protein: 462-741
Range on HMM: 1-293/293
Sequence Identity: 30% (96 aa)

YLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGN----DLDFYLK
| ..  .|.|.|..|||. .  ... |||||  ..|  ....|. .| .. .| .|.|.|.|| ||.|||.|    |. . |.|||||     ||  |..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKI--IKKRHEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIS

--QHKLM--SEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLV-NGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVG
  .|. .  ||.|..... ||. .|.|. .    ||| |||| |||.. ||. .  .||.||||.| .|          . ..  .||.||..||     
TWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIR--

KEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQ----SQQDILQENTILKATEVQFPPKPVVT-------------------PEAKAFIRRCLAYRKEDR
 . .... |||.||.|.|.|. | || ||  ..    .  | .|     . ... |.     .                   .|.| ||..||..  ..|
-GGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKR

IDVQQLACDPYL
.  .|. ..|..
PTAEQILQHPWF
Kinase TLK2.AA Ciliate-E2 462-741 24 2.8e-63 216.05 In-house 1-365 (365) Show / Hide 
Range on Protein: 462-741
Range on HMM: 1-365/365
Sequence Identity: 24% (96 aa)

YLLLHLLGRGGFSEVYKAFDLTEQR------------------YVAVKIHQLNKNWRDEKKENYH-KHACREYR----------IHKELDHPRIVKLYDY
| .. ..|.|.|. |||. .  .|.                  .|..||  .. .  .....    .| .|| .          | ..|.|| |.|.|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FSL-DTDSFCTVLEYCEGNDLDFYLKQHKLMS-----------EKEARSIIMQIVN---------------ALKYLNEIKPPIIHYDLKPGNILLVNGTA
|   |....  |.|||.|.||  |.|..|. .           |||.. |. ||..               ||.|| . .. ||| |.|| |||.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF-----

CGEIKITDFGLSKIMDDD-----------SYNSVDGMELTSQG--------------AGTYWYLPPECFVVGK-----EPPKISNKVDVWSVGVIFYQCL
   |||.||||||. |||            |    ... ...|              .||. |..|| .  .|     .    . |.|.||.|||.|..|
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

YGRKPFGHNQSQQDILQENTILKATEVQFPPK----------------PVVTPEAKAFIRR----CLAYRKEDRID-VQQLACDPYL
.|. ||              . |  ...||..                  ...|.| .|..    .| .  | ||.  .|.   |..
FGKPPF------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase TLK2.AA ULK 462-741 30 6.2e-63 215.39 In-house 1-329 (329) Show / Hide 
Range on Protein: 462-741
Range on HMM: 1-329/329
Sequence Identity: 30% (103 aa)

YLLLHLLGRGGFSEVYKAFDLTE----QRYVAVKIHQLNKNWRDEKK---ENYHKHACREYRIHKELD--------HPRIVKLYDYFSLDTD-SFCTVLE
| | | || | |  |||...       . .||.|. ...|  ....    .   .  ..| .| |.|.        || ||||||.|  ...  .  ..|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCEGNDLDFYLKQHKL----------MSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTAC---------GEIKITDFGLSKIMDDDSYN
||.| ||. |.|..|            ||.||.....||.|..|.|.. .  ||| |.|| |||. ||..          | .||.|||..| .|.|. .
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHN--IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNME

SVDGMELTSQGA---GTYWYLPPECFVVG--KEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDI------LQENTILKA-----TEVQFP---PK
  . |  . .     ||  |  |. .     ..|.  . |.|.||.|.|||..|||. ||  .  ....      | .|.   .     .  |||   ..
QQMMMTCVNE-KRLCGTPLYMAPQILQGQGEQKPYYDY-KCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGND

PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL
|.. || | .|||.| |  .|||. ..|   | .
PQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase TLK2.AA ULK 462-741 30 2.4e-62 213.44 In-house 1-324 (324) Show / Hide 
Range on Protein: 462-741
Range on HMM: 1-324/324
Sequence Identity: 30% (102 aa)

YLLLHLLGRGGFS-EVYKAFDLTE---QRYVAVKIHQ---LNKNWRD--EKKENYHKHACREYRIHKELD---HPR--IVKLYDYFSLDTD-SFCTVLEY
| | | || | |   |||...      . |||.|. .   .||.  .  .  .   .  ..| .| |.|.   ||   ||||||.|  ...  .. ..||
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEG--QYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEY

CEGNDLDFYLKQHKL---------MSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTAC---------GEIKITDFGLSKIMDDDSYNSV
|.| ||. |.|..|           ||.||.....||.|..|.|.. .  ||| |.|| |||. ||..          | .||.|||..|. |... .  
CNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHN--IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQ

DGMELTSQGA---GTYWYLPPECFVVG--KEPPKISNKVDVWSVGVIFYQCLYGRKPFGHN-QSQQ----DILQE----NTILKATEVQFP---PKPVVT
. ...  .     ||  |  |. .     ..|.  . |.|.||.|.|||..|||. ||  . ..|.    . ..      .. | . .|||   . |.. 
MCQTCVNE-KRIKGTPLYMAPQILQGQGEQKPYYDY-KCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKIS

PEAKAFIRRCLAYRKEDRIDVQQLACDPYL
|| | .|||.| |  .|||. ...   | .
PECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase TLK2.AA CAMK 467-741 22 1.1e-60 194.0 In-house 1-425 (425) Show / Hide 
Range on Protein: 467-741
Range on HMM: 1-425/425
Sequence Identity: 22% (95 aa)

LLGRGGFSEVYKAFDL-TEQ-----------RYVAVKI-----HQLNKNWRDEKK------------------ENYHKHACREYRIHKE-------LDHP
 ||||.|..|.....  | .           . ||.||     .. ..|  |.                    ..  |   ||..|.|        ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQN-QDY-SNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHP

RIVKLYDYFS------------LDTD-------SFCTVL---EYCEGN----DLDFYLKQHKL---------------MSEKEARSIIMQIVNALKYLNE
 |.|||...               ..        .. |.   |||.|     ||  |...|.                ..|.||| .. ||. |..|. .
NIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHS

IKPPIIHYDLKPGNILLV--NGTAC------------GEIKITDFGLSKIMDDDS----YNSVDGMELTSQ-------------GAGTYWYLP-PECFVV
 .  |.| |||| ||||.  |.  .            . |||.|||.....|...     ....|.|. ..               ||  | . || .  
HN--IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEM-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNG

----------GKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDI-------LQENTILKATEVQFP-PKPVVTP---------------------
            | | .. |.|.||.||| | .| |. || .   ....        ....  | .. ..  | | ..|                     
KGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFV

--EAKAFIRRCLAYRKEDRIDVQQLACDPYL
  |.| .||..| .  |.|. ..|   .| .
SQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase TLK2.AA Ciliate-E2-Unclassified 462-741 25 2.2e-56 193.65 In-house 1-352 (352) Show / Hide 
Range on Protein: 462-741
Range on HMM: 1-352/352
Sequence Identity: 25% (92 aa)

YLLLHLLGRGGFSEVYKAFDLTEQRYV-----AVKIHQLNKNWR-------------DEKKENYHKHACREYRIHKE--LDHPRIVKLYDYFSL-DTDSF
| ... .|.|||..|||. .  .. ..     . ||.. ...                .||. ||       .| ..  |.|| ........   |.. .
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQR-KY-NKIMQQILLNHPHPFIVKMFYCFQDKQNI

CTVLEYCEGNDLDFYLKQ------------HKLMS-----EKEAR-----SIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSK
. |.|||||.|| .|.|.            |....     |..|.      .. ||...|.|| . .  |||.|.|| |||. |.   ..|||.|||.||
YIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISK

IMDDDSYNSVD---------GMELTSQGAGTYWYL----PPECFVV-GKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQ------------DILQ
  ......  .           ..... .||. |.    .||..   . . .|   |.|.||.|||.|..|.|. ||. |.. |            ...|
KYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA-YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQ

ENTILKATEVQFPPKP------VVTPEAKAFIR----RCLAYRKEDRIDVQQLACDPYL
   . |. ..|||. |       . |||| ||.    ..| .. . ||. .|. . |..
LYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase TLK2.AA CAMKL 462-741 28 1.2e-44 140.31 In-house 1-297 (297) Show / Hide 
Range on Protein: 462-741
Range on HMM: 1-297/297
Sequence Identity: 28% (89 aa)

YLLLHLLGRGGFSEVYKAFD-LTEQRYVAVKIHQLNKNWRDEKKEN-------YHKHAC--REYRIHKELD---HPRIVKLYDYF-SLDT----DSFCTV
| ..  ||.|.|..|  | . .| .. ||.||   .| | |.....         .  .  ||..|.| |.   || |.|||. .   ..    . .. |
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

LEYCEGND--LDFYLKQH----KLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLV-NGTACGEIKITDFGLSKIMDD--DSYNSVDGMELT
.|||.| .  |  |...|    . |.|.||| .  ||| |..|. . .  |.| |.|| ||||  ||     |||.|||.| ....  . ..     .. 
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG--IVHRDIKPENILLDENGNN--NIKIIDFGFSNMYRPCIFGPG-----QKL

SQGAGTYWYLPPECFVVGK-EPPKISNKVDVWSVGVIFYQCLYGRKPFG--HNQ--SQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDR
.   |.. | .||  .. . . | .  |||.|| ||| |  ..|. ||   ...   . .|  .  . . .  ..|. . |  ... .||. |    |.|
KTFCGSPPYMAPE--IFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKR

IDVQQLACDPYL
. ..|.  .| .
PTIHQIMNHPWM
Kinase TLK2.AA TKL 468-729 20 3.2e-44 153.21 In-house 1-354 (364) Show / Hide 
Range on Protein: 468-729
Range on HMM: 1-354/364
Sequence Identity: 20% (75 aa)

LGRGGFSEVYKAFDLTEQ--------RYVAVKIHQLNK-NWRDEKKEN-------------------YHKHACREYRIHKELDHPRIVKLYDYFSLDTD-
.|.|||.||||.    .         . ||||.   .  . .... ..                   . ..  .| .... |.|| ||... |    .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------SFCTVLEYCEGND-LDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIK------PPIIHYDLKPGNILLV-NGT----------ACGEI
            .| | |||.| . |....            .....|  .. ||   .      ||||| |||. |||.  |.|          | . .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KITDFGLSKIMD---DDSYNSVDGME---------LTSQGAGTYWYLPPECFVVGKEPP------------KISNKVDVWSVGVIFYQCLYGRKPFG-HN
||.|||||. |.   ... .. ..||          |.   ||. ...||..    . .            . | |.||.| |.... .| ...|.  ..
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

QSQQD------ILQENTILKATEVQFP----------PKPVVTPEAKAFIRRCLAYRKEDR
 ....      . ..  ..|      |          | | . |. |  . .| ..  |.|
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKR
Kinase TLK2.AA CMGC 462-681 20 4.3e-43 138.86 In-house 1-342 (513) Show / Hide 
Range on Protein: 462-681
Range on HMM: 1-342/513
Sequence Identity: 20% (71 aa)

YLLLHLLGRGGFSEVYKAFD--------------LTEQRYVAVKIHQLNKNWRDEK----KENYHKHACREYRIHKEL-----------------DHPRI
|  .  .|.| ...|||..|                 ...||.|.  .... ...|    |..  . |.|| .| |.|                 .|. |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VKLYDYFS-LDTD---------------SFCTVLEYCEGNDLDFYLKQHK--------LMSEKE------------ARSII------MQIVNALK--YLN
|||||.|   ..|               ... | ||.. . ...  ....         .|| .             ....       || ..||  |. 
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

EIKPPIIHYDLKPGNILLVNGTAC-----------------GEIKITDFGLSKIMDDDSYN---------------SVDGMELTSQGAGTYWYLPPECFV
  .  ||| |||| |||. . . .                 |..|| ||||... .. | .               . . ..  ..   | || .||  .
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDD-KPNRPYTHYVVTRWYRAPEILL

VGKEP------PKISNKVDVWSVGVIFYQCLYG-------RKPF
  |.        . . ..|.|||| ||.  . |       .||.
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPL
Kinase TLK2.AA STE 462-741 20 7e-41 142.1 In-house 1-359 (359) Show / Hide 
Range on Protein: 462-741
Range on HMM: 1-359/359
Sequence Identity: 20% (76 aa)

YLLLHLLGRGGFSEVYKAFDLT---------------EQRYVAVKIHQLNK---------NWRDE---KKENYHKHACREYRIHKELD--HPRIVKLYDY
. ..  .|.|.| .|||| .                  ....|.|.  |..         | . |   | .. ..   .| .|.|...  || ||| |..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQEN-Q-ELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGC

FSLD------TDSFCTVLEYCEGNDLDFYLKQH--------------KLMSEKEARSIIMQIVNA-LKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKI
.  .       |. . ..||..|  ||  .|.               . ..|.. . |. ||. . |.|| . .  ||| |.||.||||        .|.
YFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL--------VKL

TDFGLSKIMDDDSY-----------NSVDGMELTSQGAGTYWYLPPECFVVGKEP--PKISNKVDVWSVGVIFYQCLYGRKPF---GHNQSQQDILQEN-
.|||......|..            .. ...  |  |     .  ||    ....  .. . |.|.||.|      . |. |.    . .    |.... 
CDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP---WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYH

--------TILKATEVQFPP-----------------KPVVTPEAKAFIRRCLAYRKEDRIDVQQLAC--DPYL
         |.. .  ..|.                 .  ..|| | ||..|| .  ..| ...||     | .
MQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase TLK2.AA TyrKc 462-739 25 2.6e-14 8.77 SMART 1-280 (280) Show / Hide 
Range on Protein: 462-739
Range on HMM: 1-280/280
Sequence Identity: 25% (79 aa)

YLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL--DHPRIVKLYDYFSLDT-------DSFCTVLEYCEGNDL
  |.. ||.| | ||||.      . ||||  . ..          ..  .|| || ..|  .|| ||.||    ..        .  . |.||... ||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----------REDFMREARIMCKLGGHHPNIVRLY-GVCTQQGRNFMYIEPLMIVMEYMPHGDL

DFYLKQHKL-MSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDD-------SYNSVDGMELTSQGA--GTYW
. ||. |.   . |.  |.  || .   || .   ..|| ||   |.|. ..     .||.|||||.  .||       .| .. .   ...|     . 
KDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKE---HKGGKTMLPIR

YLPPECFVVGKEPPKISNKVDVWSVGVIFY-QCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVV---------TPEAKAFIRRCLAYRKEDRIDV
 ..|||.  |    | . | |||| ||  .  . || .|      | ..  .  | .  .   .|.|           ..|    ...| ..  |||   
WMAPECINYG----KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTF

QQLACDP
...  . 
SEIHECF
Kinase TLK2.AA Pkinase_Tyr 462-625 28 2.5e-10 35.59 Pfam 1-167 (270) Show / Hide 
Range on Protein: 462-625
Range on HMM: 1-167/270
Sequence Identity: 28% (52 aa)

YLLLHLLGRGGFSEVYKAFDL----TEQRYVAVKIHQLNKNWRDEKKENYHKHA------CREYRIHKEL-DHPRIVKLYDYFSLDTDS--FCTVLEYCE
  ... ||.| | ||||.        ..  ||||.            |......       || .| |.| .|| ||.||   . . ..   . |.||..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK----------EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMP

GNDLDFYLKQH----KLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIM-DDDSY
. ||. ||..|    .  . |.  .. .|| ... || ...  .|| ||   |.|. .    . .||.||||.. . .|| |
HGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTE---NNVVKICDFGLARDIYNDDYY
Kinase TLK2.AA CMGC 703-741 16 0.000245 9.14 In-house 443-513 (513) Show / Hide 
Range on Protein: 703-741
Range on HMM: 443-513/513
Sequence Identity: 16% (12 aa)

QFPPKPV--------------------------------VTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL
.||..|                                  .|.|  .. ..| |  ..|| ..|    ||.
LFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF