Gene TTK (Human)

TTK

Species: Human
Alias: TTK, MPS1L1, PYT, ESK, FLJ38280
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 6q14.1,

Classification

Group: Other
Family: TTK

Sequence

Name Sequence Type Origin Length Description Download
TTK.NA RNA Sugen Kinome 3010 None Fasta, JSON
TTK.AA Protein Sugen Kinome 857 None Fasta, JSON
TTK.kin_dom Protein Kinase Domain Sugen Kinome 267 None Fasta, JSON

Protein domain

Protein domains of TTK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase TTK.AA TTK 525-791 52 1e-212 710.59 In-house 1-344 (344) Show / Hide 
Range on Protein: 525-791
Range on HMM: 1-344/344
Sequence Identity: 52% (182 aa)

YSILKQIGSGGSSKVFQVLNE-KKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEIT--DQYIYMVMECGNIDLNSWLKKKK---S
|||.||||.||||||||||.| .|.|||.|||.|..||.||...|.|||..||||||..|.||.|||||.|  .||||||||||..|||.||.|.|   .
YSIIKQIGCGGSSKVFQVLSEDSKKIYALKYVCLDFADPQTIQGYMNEIEMLNKLQQQKDCIIQLYDYEMTMEEQYIYMVMECGDCDLNKWLQKYKTPMN

IDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMQP-DTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKS----------
..||....||..||..||.||||||||||||||||..|.||||||||||||..|. |||..||.||.||.|||.||||.|||...||...          
LNPWFMWCYWQQMLQCVHVIHQHGIVHSDLKPANFVMVQGMLKLIDFGIANAIQNDDTTNIVKESQIGTFNYMSPEAIQDMSYGNENMCMHHKKPRLKIN

------------------KS------------------------------------KISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHE
                  ..                                    |||.||||||.|||||||.|||||||.|.||.||.|||..|.|.
CKSDVWSLGCILYSMVYGRTKFQHIVHRLLKMQAICNPDHFIDFQPIENELLLDVWKISCKSDVWSCGCILYYMIYGKTPFQHIQNQYSKMHAICNPHHK

IEFPDIP------EKDLQDVLKCCLKRDPKQRISIPELLAHPYV
||||..|      .|.|..|.||||.|.||.|.||||||.||..
IEFPEHPPYYEKINKMLIHVMKCCLYRNPKKRWSIPELLNHPFH
Kinase TTK.AA Pkinase 525-791 27 8.2e-94 322.77 Pfam 1-293 (293) Show / Hide 
Range on Protein: 525-791
Range on HMM: 1-293/293
Sequence Identity: 27% (85 aa)

YSILKQIGSGGSSKVFQVLNEKKQI-YAIKYVNLEEADNQTLDSYRN--EIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNI-----DLNSWLK--
| |...||||....|..  . . .. .|.| ....... . . . |.  ||.....|.  .. |.||||.  ....||||||. .      || ....  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN--HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

KKKSI--DPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIV-DGML----KLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKS
.....  ..|| |.|.. .|...  .|..||.| ||||.|.||. .| .    |..|||.| |..    ..  .. .|| .||.|| |.          .
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR----------G

KSKISPKSDVWSLGCILYYMTYGKTPFQQI-----INQISKLHAIIDPNHEIEFPDIPE-------------------KDLQDVLKCCLKRDPKQRISIP
 ....||.|.||.|||||.|  |..||..      ..|. ..  | .|  . ..|   .                   ....|..|.||..|||.|....
GQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE

ELLAHPYV
..| ||..
QILQHPWF
Kinase TTK.AA S_TKc 525-791 28 4.8e-82 279.81 SMART 1-231 (231) Show / Hide 
Range on Protein: 525-791
Range on HMM: 1-231/231
Sequence Identity: 28% (82 aa)

YSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNI---DLNSWLKKKKS--
| ||..||.|. .||... . | ..|.||| ..         .. |.||. | |   | . |..|||.  . ...|||||. .    || . .||...  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK---HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----IDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISP-
    ... . ..| . ...|.  .|.|||.| ||||.| |. .  .|..|||.| |.         ....|| .||.|| .              . .. 
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL---------TTFCGTPWYMAPEVL--------------GYGKC

KSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLA-------HPYV
|.|.||.||||| | .|..||.    |. ..  .|             ... | .. ||..||..|... |.|.       ||..
KCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TTK.AA CAMK 530-791 19 9.1e-61 194.23 In-house 1-425 (425) Show / Hide 
Range on Protein: 530-791
Range on HMM: 1-425/425
Sequence Identity: 19% (85 aa)

QIGSGGSSKVFQVLNE-KK------------QIYAIKYVNLEEADNQ--------------------------TLDSYRNEIAYLNKLQQ-----HSDKI
..|.|. .||. . .   .            | .||| .. . ....                          .... |.||. ..|||.     .   |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IRLYDYEIT-------------------DQYIYMVM------ECGNI--DLNSWLKKKKS---------------IDPWERKSYWKNMLEAVHTIHQHGI
|.||..  .                   |...||||      . |    || ........               .. .| . | . ...||| .|.|.|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHSDLKPANFLIVD------------------GMLKLIDFGIANQMQPDTTSV---------------------VKDSQVGTVNYMP-PEAIKD--MSSS
|| |||| | |..|                  . .|.|||| ||...|.  .                          ..||  ||. || ..   ....
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

RENGKS---KSKISPKSDVWSLGCILYYMTYGKTPFQ-----QII-------NQISKLHAIIDPNHEIEFPDIPE----------------------KDL
  |. .   |  ..||.|.||.|.||| |  |. ||.     .|.       |.   .. |.  . . . | ...                      .. 
Q-NA-TDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

QDVLKCCLKRDPKQRISIPELLAHPYV
.| ....|..||..|..| . |.|| .
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase TTK.AA ULK 525-791 26 4.1e-57 196.05 In-house 1-324 (324) Show / Hide 
Range on Protein: 525-791
Range on HMM: 1-324/324
Sequence Identity: 26% (87 aa)

YSILKQIGSGGSS-KVFQVLNEKK----QIYAIKYVNLEEADNQTLD--------SYRNEIAYLNKL----QQHSDKIIRLYDYEITD--QYIYMVMECG
|.. ...|.|    ||..  |.|.    |..|.| ... .  .. ..        . .|||  . ||     ..   |..|||.  |.   .||..||  
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNH-HIVKLYDWFETSNHNNIYIIMEYC

NI-DLNSWLKKKKS---------IDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDG-------------MLKLIDFGIANQMQPD-TTSVVKD
|  || . .||.|          .   | ... |  ...   .|.|.|.| |.||.| || .|              ||. ||| | . . .     .  
NGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

SQV------GTVNYMPPEAIKDMSSSRENGKSKSKIS-PKSDVWSLGCILYYMTYGKTPF--QQIINQI----SKLH-----AIIDPNHEIEFP---DIP
..|      ||  || |. ....         . . .  |.|.||||||.|.| |||.||  . . .|.    . ..      |.  |  |.||   ..|
TCVNEKRIKGTPLYMAPQILQGQG-------EQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDP

E--KDLQDVLKCCLKRDPKQRISIPELLAHPYV
   ....| ....|..|.|.|||..|...|| .
KISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase TTK.AA ULK 525-791 25 8.4e-57 195.02 In-house 1-329 (329) Show / Hide 
Range on Protein: 525-791
Range on HMM: 1-329/329
Sequence Identity: 25% (86 aa)

YSILKQIGSGGSSKVFQVLNEKK-----QIYAIKYVNLEEADNQTLD--------SYRNEIAYLNKLQQH--SDK----IIRLYDYEITD--QYIYMVME
|.. ...|.|   ||..  |.|.     ...|.| . ... ...  .        . .|||  . || .   .      |..|||.  |.   .||..||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

CGNI-DLNSWLKKKKS----------IDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDG-------------MLKLIDFGIANQMQPD-TTSV
  |  || . .||.|           .   | ... |  |..   .|.|.|.| |.||.| || .|              ||. ||| | ... |     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

VKDSQV------GTVNYMPPEAIKDMSSSRENGKSKSKIS-PKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDP------------NHEIEFP--
.  ..|      ||  || |. ....         . . .  |.|.||||||.|.| |||.||.   ..  .|  |..             .. ..||  
MMMTCVNEKRLCGTPLYMAPQILQGQG-------EQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKD

---DIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYV
   ..  ....| ....|..|.|.|||..||..|| .
GNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase TTK.AA AGC 525-791 19 3.5e-53 134.76 In-house 1-395 (395) Show / Hide 
Range on Protein: 525-791
Range on HMM: 1-395/395
Sequence Identity: 19% (80 aa)

YSILKQIGSGGSSKVFQVLN-------EKKQIYAIKYVNLEE--------ADNQTLDS--------YRNEIAYLNKLQQH--------SDKIIR-LYDYE
. .|| || |. .||..|           ...||.| .. ..           .|.           ..|   | |....        .. |.. |.   
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ITDQY--IYMVME-----------CGNIDLNSWLK---KKKSIDPWERKSYWKN-------MLEAVHTIHQ-HGIVHSD-LKPANFLIVD-GMLKLIDFG
 ....  .|.|||           .|  .| . |.   |... |  . . |          .. |.. .|. .||.| | ||| | |. . | .|| |||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

IANQMQPDTTSVVKDSQ-------------------------------------------------VG--TVNYMPPEAIKDMSSSRENGKSKSKISPKS
 . ..  | . ... ||                                                 .|  | .||.|| .                ..  
LCKEGMNDGEKGQQ-SQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL---------------YGKAC

DVWS--LGCILYYMTYGKTPFQQII---------NQISKLHAIIDP----NHEIEFP-----DIPE-----KDLQDVLKCCLKRDPKQRIS---------
| ||  |||..| | .|..||.            |.  . . |...    |....||     ..||     ....| .| .|..||..|.          
DWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDK

-IPELLAHPYV
 . |. .||. 
GAEEIKNHPWF
Kinase TTK.AA CAMKL 525-791 25 4.6e-50 157.88 In-house 1-297 (297) Show / Hide 
Range on Protein: 525-791
Range on HMM: 1-297/297
Sequence Identity: 25% (79 aa)

YSILKQIGSGGSSKVFQVLN-EK-KQIYAIKYVNLEEADN--QTLDSYRN-----------EIAYLNKLQ----QHSDKIIRLYDYEITDQY------IY
| |.|..| |. .||   ..    .. .||| .. . . |  ....  ..           ||. . .|.    ..   ||.||.   |...      ||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPN---IIKLYEVIETPEHDIETKKIY

MVMECGN---IDLNSWLKKK----KSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIV-DG--MLKLIDFGIANQMQP--DTTSVVKDSQVGTV
.|||      .||  ...|.    ......| . | . ...||. .|.||||| |.|| | |.  .|   .|.|||| .|...|  ...    . . |. 
LVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSP

NYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQII-------NQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRI
.||.|| ...          |. . || |.||.| ||| | .|. || .         |.  ... |.   ...  .  .  |..| ..  |...|..|.
PYMAPEIFQGN--------NKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRP

SIPELLAHPYV
.| ... || .
TIHQIMNHPWM
Kinase TTK.AA Ciliate-E2 525-791 21 2.4e-49 167.57 In-house 1-365 (365) Show / Hide 
Range on Protein: 525-791
Range on HMM: 1-365/365
Sequence Identity: 21% (81 aa)

YSILKQIGSGGSSKVFQV--LNEKKQI-----------------YAIKYVNLEEADNQTLDSYRNEIAYLNKLQ--QHSDK---------------IIRL
| ..|.||.|. ..|...   ...||.                 ..||.....   .. . .  .||  .....  .   |               ||..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFY---KKINEKNILEQLNHPNIIKM

YDYEI--TDQYIYMVME-CGNIDLNSWLKKK-----------KSIDPWERKSYWKNMLE---------------AVHTIHQHG-IVHSDLKPANFLIVDG
|.. .  .|..||.||| |   || ...|..           |...  |.| . |  |.               |.. .|. . |.| |.|| | |.   
YECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---

MLKLIDFGIANQMQPD-----------TTSVVK-------------------DSQVGTVNYMPPEAIKDMSSSRENGKSKSK-ISPKSDVWSLGCILYYM
 .|.||||.. . ..|                |                   ....|| .||.|| ..  . . .   .|.|  . |.|.||||.|||.|
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ---QKQKGYDYKCDIWSLGVILYEM

TYGKTPFQQIINQISKLHAIIDPNHEIEFP----------------DIPEKDLQDVLKC----CLKRDPKQRIS-IPELLAHPYV
 .||.||         .  |.. . .. .|                .  ... .| .|     .|..||..||. . ..| ||. 
LFGKPPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase TTK.AA STE 525-791 19 3.5e-45 156.43 In-house 1-359 (359) Show / Hide 
Range on Protein: 525-791
Range on HMM: 1-359/359
Sequence Identity: 19% (74 aa)

YSILKQIGSGGSSKVFQVLNEK----------------KQIYAIKYVNLEEADN---------------QTLDSYRNEIAYLNKLQ-QHSDKIIRLYDYE
. ....||.|.. .|.. .| |                ..|.||| .|||. .|               . .... .||  ..|..   .. |.. |...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHM-HPNIVKYYGCY

ITD-------QYIYMVMECGN-IDLNSWLKKKKSIDP--------------WERKSYWKNMLEA-VHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIAN
. .       ......||  .   | . .|.|...                 . . . .  |..  . .|.|.|.| |.|||| |.     ||.|||.. 
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCG

QMQPD--------------TTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEI-
|....              |..   .. |||  .| || |. ....      ... . |.|.||||| .  |  || |.    .  . . .|.. .|   
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-R----DKGYDTKCDIWSLGCTIIEMATGKPPWHD-MHPMRAMFMIPFNYHMQQ

----------EFPDIPE----------------------KDLQDVLKCCLKRDPKQRISIPELLA--HPYV
          . | .|.                      ....| .. ||..||..| .  .||   || .
QFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase TTK.AA CMGC 525-791 16 5.8e-45 145.13 In-house 1-513 (513) Show / Hide 
Range on Protein: 525-791
Range on HMM: 1-513/513
Sequence Identity: 16% (83 aa)

YSILKQIGSGGSSKVFQVLN---------------EKKQIYAIKYVNLEEADNQTL----------DSYRNEIAYLNKLQ---------------QHSDK
| |.|.||.|  ..|..  .               | ..|.||| . ... ..| .           ..| || .| .|.               .|   
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALR-EIKILKHLNKNHDPNWQRRDDPDNKHHNN

IIRLYDYEITDQ-----------------YIYMVMECGNIDLNSWLKKKK---------SIDPWE------------RKSYW------KNMLEAVH--TI
|..|||.  ...                 ..|.|.|.   ||   .|...           .. .             |..       . .|....   .
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HQHG--IVHSDLKPANFLIVD---------------------GMLKLIDFGIANQMQPD-------------------TTSVVKDSQVGTVNYMPPEAIK
|.|.  |.| ||||.| || .                     | ||..||| | .  |                     ..    ..| |  | .|| . 
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

DMSSSRENGKSKSKISPKSDVWSLGCILYYMTYG--------KTPFQ----------------QIINQISKLHAIID---------------PN------
 ..   ..   . . ... |.||.|||.. |  |        |. |.                  ...| |.   ..               ..      
GWKHYTNH-NYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

--------------------HEIE----------FPDIPEKDLQ----------------------------------------------DVLKCCLKRD
                    . .           || .| |...                                              | || .|. |
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PKQRISIPELLAHPYV
|..||.. . |.||| 
PDKRITAEQALQHPYF
Kinase TTK.AA Ciliate-E2-Unclassified 525-791 22 3.8e-43 147.49 In-house 1-352 (352) Show / Hide 
Range on Protein: 525-791
Range on HMM: 1-352/352
Sequence Identity: 22% (83 aa)

YSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYR-------NEIAYLNKLQQHSDK----------------IIRLYDYEITDQYIYM
| |.||||.|| .||... ..| ||.||.|| .    ..| .  .        .|.  ..|  ... |                |....... ..|.||.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQR-KYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VME-CGNIDLNSWLKKKKS-----------------IDPWERK-----SYWKNMLEAV-HTIHQHGIVHSDLKPANFLIVDGM----LKLIDFGIANQMQ
||| | . ||  ..||.|.                 ..  . |      | .  |..  . .|...|.| |.|| | |. ...    .|.|||||. . |
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

PDTTSVVKD--------------SQVGTVNYM----PPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ---QII-------------
 .  .  ..              ...|| |||    .|| ..    . .          |.|.||||.|||.| .|. ||.   ...             
QNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA-------YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAY

--NQISKLHA-IIDPNHEIE--FPDIPEKDLQDVLK----CCLKRDPKQRISIPELLAHPYV
  ..... .. .|. ... .  .|..  .  .| ..    ..|| .|..||.....| ||. 
RKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase TTK.AA TyrKc 525-793 19 8.6e-13 -15.85 SMART 1-280 (280) Show / Hide 
Range on Protein: 525-793
Range on HMM: 1-280/280
Sequence Identity: 19% (58 aa)

YSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKL-QQHSDKIIRLYDYEITD-------QYIYMVME-CGNIDLNSWLKK
 . .|..|.|   .|..      .  |.| .. .      .   ..|.  . ||  .| . |.||| . ...       . ...||| . . ||.. |.|
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-----REDFMREARIMCKLGGHH-PNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

KKS-IDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGM-LKLIDFGIANQMQPD------TTSVVK----DSQ-VGTVNYMPPEAIKDMSSSR
..  . . .  |.     .    .|.....| ||   | |. ..   |  ||| .     |      .   .|    ..  .  .  |.||.|       
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-------

ENGKSKSKISPKSDVWSLGCILY-YMTYGKTPFQQII---NQISKLHAIIDPNHEIEFPDI--------PEKDLQDVLKCCLKRDPKQRISIPELLAHPY
     ..| ..|||||| |  ..  .|||..|   .|      . ... ..  .  . |.           ... .. |.| ..||..| .  |.    .
----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI----H

VQI
 ..
ECF
Kinase TTK.AA Pkinase_Tyr 664-740 26 3e-06 21.86 Pfam 154-222 (270) Show / Hide 
Range on Protein: 664-740
Range on HMM: 154-222/270
Sequence Identity: 26% (21 aa)

DFGIANQMQPDTTS-VVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILY-YMTYGKTP-FQQIINQ
||| |  ...| .  .....    .  |.||.|...             . |||||| |  ..  .|||..| .. . |.
DFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK-----------FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNE