Gene DDB0216336 (Slime mold)
DDB0216336
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| DDB0216336.AA | Protein | None | 495 | None | Fasta, JSON |
| DDB0216336.kin_dom | Protein Kinase Domain | None | 253 | None | Fasta, JSON |
Protein domains of DDB0216336.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | DDB0216336.AA | TTBK | 16-271 | 62 | 5.2e-202 | 677.4 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 16-271 Range on HMM: 1-257/257 Sequence Identity: 62% (161 aa) WTVVKKIGQGAFGEIFSGKNIINN-EQIAIKVEKVDTKKQVLRLEVAVLKKLQLCPYVCRFITCGRHNDYNYMVMELLGENLSELRRKQLDGKFSLGSTL |.||||||.|.||||...|..||. ||.|||||.....||||..|||||||||.|..|||||.|||....|||||.|.|.||..|||||..|.|||..|| WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL KLGVQMIQSLQAVHDLGYLHRDVKPSNFAIGLNPSKRNITYLIDFGLARRFVLASGEVRPARESTGFRGTARYASINSHLSKDLGRRDDLWSIFYVLIEF .||||..||....|..|.||||.||||||.|.|||.....|..||||||....|.|||||.||..|||||.||||||.|.....||.|||||.||.|.|| RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEF AEGQLPWRKLKDKDQIGEMKQKYNTPDLVKDLPPQFSQFMKHLKSLNYEDRPNYVFL ..|||||||.|||||.||||.||....|.|..|..|.|||.|.|||||||||.|... VQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI |
|||||||||
| Kinase | DDB0216336.AA | CK1 | 16-271 | 34 | 4e-126 | 425.31 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 16-271 Range on HMM: 1-339/339 Sequence Identity: 34% (118 aa) WTVVKKIGQGAFG-EIFSG-----KNIINN-----EQIAIKVEKVDTKKQ-VLRLEVAVLKKLQL---------------------CPYVCRFITCGRHN |.||||||.|.|| .|. . |.. || |. |.|||......| ...|.....|. ||..|... .|. . WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED D-YNYMVMELLGENLSELRR-KQL-DGKFSLGSTLKLGVQMIQSLQAVHDLGYLHRDVKPSNFAIGLNPS------------KRNITYLIDFGLAR-RFV | ||||||.|||.||..||. ... ..|||....|....||...|. .|| |..|||.||.||..|.|.| .... |.||||.|| ... DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR LASGEV------------RPARE---STGFRG-TARYASINSHLSKDLGRRDDLWSIFYVLIEFAEGQ--LPWRKLKDKDQ-----IGEMKQKYNTPDLV .|.. ||.|| .|||| ||||.|||.|| |..|||||||| ||.|||. |. |||...||... ...||... . .. DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM KD------------LPPQFSQFMKHLKSLNYEDRPNYVFL .. .|..| ..||...||.|.|||.| .. STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
|||||||||
| Kinase | DDB0216336.AA | TTBKL | 16-275 | 37 | 4.3e-116 | 392.0 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 16-275 Range on HMM: 1-288/288 Sequence Identity: 37% (108 aa) WTVVKKIGQGAFGEIFSGKNIINNEQIAIKVEKVDT-KK--QVLRLEVAVLKKLQ--LCPYVCRFITCGRHNDYNYMVMELLGENLSELRRKQLDGK-FS |..||.||.|.||... .... . .. |...| ... . ... .|| ||.||| .|...... .|. |||.|||.|.|.||. ||.. .| || WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS LGSTLKLGVQMIQSLQAVHDLGYLHRDVKPSNFAIGLN---PSKRNITYLIDFGLARRFVLASGEV-----------RPARE---STGFRGTARYASINS |... .|.| . .|. .|| |..||||||.|...|.. ... . ||||||.||... .|| |..|. ...|||| ||.|.| DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM HLSKDLGRRDDLWSIFYVLIEFAEGQLPWRKLKDKDQIGEMKQKYNTPDLVKD------LPPQFSQFMKHLKSLNYEDRPNYVFLQTLL |. |..|| ||||| .|..||...| |||. ..||..|..||.. .. || || .|..| |||||.||.| |||.| .. .. HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
|||||||||
| Kinase | DDB0216336.AA | Worm6 | 16-271 | 34 | 2.7e-101 | 342.84 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 16-271 Range on HMM: 1-279/279 Sequence Identity: 34% (97 aa) WTVVKKIGQGAFGEIFSGKNIINNE--QIAIKVEK--VDTKKQVLRLEVAVLKKL--QLCPYVCRFITCGRHND--YNYMVMELLGENLSELRRKQLDGK |.|.||||.|.|| ... .. ... |.|.|.|| |.|.|..|..|||.. . |...|... .|. . .||.||.|.|.||..||. . |.| WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK FSLGSTLKLGVQMIQSLQAVHDLGYLHRDVKPSNFAIGL-----NPSKRNITYLIDFGLAR--RFVLASGEVRPAR-ESTGFRGTARYASINSHLSKDLG ||.| .||.. |...... .| |..||||||.||.|| . ..| |..|||..| .. .|.|. | . ||||| |||....| .... FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTI-YMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQC RRDDLWSIFYVLIEFAEGQLPWRKLKDKDQIG-EMKQKYNTPD------LVKDLPP-QFSQFMKHLKSLNYEDRPNYVFL |.||. | ||...|. |.||||..||.|. . . |..... . . . |. .|. |. . ...|.|||.| |. RKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
|||||||||
| Kinase | DDB0216336.AA | CK1 | 16-269 | 38 | 3e-87 | 296.18 | In-house | 1-271 (271) | Show / Hide |
Range on Protein: 16-269 Range on HMM: 1-271/271 Sequence Identity: 38% (105 aa) WTVVKKIGQGAFGEIFSGKNIINNEQ--IAIKVEKVDTKKQVLRLEVAVLKKLQL------CPYVCRFITCGRH--NDYNYMVMELLGENLSELRRKQLD |..|||||.||.|. |.|. |.| .|||.|| ..| . | |. ..| || |... . ..||. .|||.|||.|||..| .| . . YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDL-FNFCN GKFSLGSTLKLGVQMIQSLQAVHDLGYLHRDVKPSNFAIGLNPSKRNITYLIDFGLARRFV-LASGEVRPARESTGFRGTARYASINSHLSKDLGRRDDL .|||| .| .. |||| .. || ...|||.|| || .|. . .. |.|||||| |.. ... | || .. |||||||||.|| . .||||. RKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDM WSIFYVLIEFAEGQLPW-----RKLKDK-DQIGEMKQKYNTPDLVKD-LPPQFSQFMKHLKSLNYEDRPNYV |. |||. |. |.||| . |.| ..|.|.|.... .| |. .| .| ..... ..|..|..|.| ESLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM |
|||||||||
| Kinase | DDB0216336.AA | CK1-Unclassified | 16-221 | 41 | 2.7e-80 | 236.68 | In-house | 1-216 (244) | Show / Hide |
Range on Protein: 16-221 Range on HMM: 1-216/244 Sequence Identity: 41% (91 aa) WTVVKKIGQGAFGEIFSGKNIINNEQIAIKVEKVDTKKQVLRLEVAVLKKLQLCP-------YVCRFITCGRH--NDYNYMVMELLGENLSELRRKQLDG |..|||||.||||. ..|. .|| |||.|| ..| | |. ... || . .. . ..||. |||.|||.|||..| .| . . YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDL-FNMCNR KFSLGSTLKLGVQMIQSLQAVHDLGYLHRDVKPSNFAIGLNPSKRNITYLIDFGLARRFVLA--SGEVRPARESTGFRGTARYASINSHLSKDLGRRDDL |||| .| .. |||| .. .| ...||| || || .| .... |.|||||. |.. . |. | || .. |||||||||.|| . .||||| KFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDL WSIFYVLIEFAEGQLPW |. |||| |. |.||| ESLGYVLIYFLKGSLPW |
|||||||||
| Kinase | DDB0216336.AA | CK1-D | 16-271 | 40 | 1.5e-65 | 224.12 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 16-271 Range on HMM: 1-261/261 Sequence Identity: 40% (107 aa) WTVVKKIGQGAFGEIFSGKNIINNEQIAIKVEKVDTKKQVLRLEVAVLKKLQLCPYVCRFITCGRHNDYNYMVMELLGENLSELRRKQLDGKFSLGSTLK . . .||| |.||.|. |.||..|| .|||.| . || | .| . | .| . . ||. ||| |||.||| | .| . |||| | YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDL-FNYCHRKFSLKTVLM LGVQMIQSLQAVHDLGYLHRDVKPSNFAIGLNPSKRNITYLIDFGLARRFVLAS-GEVRPARESTGFRGTARYASINSHLSKDLGRRDDLWSIFYVLIEF |. |||. .. .| ..|||.|| || .|| . |. |.||||||.|. | . | || ||||||||| |. . ||||| |. |||. | LADQMICRIEYIHCRNFIHRDIKPDNFLMGLG-KRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYF AEGQLPWRKLKDK------DQIGEMKQKYNTPDLVKDLPPQFSQFMKHLKSLNYEDRPNYVFL . | ||| || ..| | | . . .| | .| .|.|.| . ..| ..|.|.|..| NRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL |
|||||||||
| Kinase | DDB0216336.AA | CK1-G | 16-271 | 37 | 7e-60 | 201.62 | In-house | 1-266 (266) | Show / Hide |
Range on Protein: 16-271 Range on HMM: 1-266/266 Sequence Identity: 37% (102 aa) WTVVKKIGQGAFGEIFSGKNIINNEQIAIKVEKVDTKKQVLRLEVAVLKKLQLC----PYVCRFITCGRHNDYNYMVMELLGENLSELRRKQLDGKFSLG . | |||| | |||.| |||..||| .||| | . .. |..| | | | |.| | || || |||.||| | | | |||. YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGK---YNIMVMDLLGPSLEDL-FDWCDRKFSVK STLKLGVQMIQSLQAVHDLGYLHRDVKPSNFAIGLNPSKR-NITYLIDFGLARRFV-LASGEVRPARESTGFRGTARYASINSHLSKDLGRRDDLWSIFY ... . .|||. ...||. . ||||| || || .|. .. ..||||.|. .. . . | || ||||| ||| || . ||||. .. TVCMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGH VLIEFAEGQLPWRKLKDK------DQIGEMKQKYNTPDLVKD--LPPQFSQFMKHLKSLNYEDRPNYVFL . . | |.||| || . ||. |.| | ||.. .| || .... .|.... | | .| MFMYFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL |
|||||||||
| Kinase | DDB0216336.AA | CK1-A | 16-271 | 38 | 8.8e-59 | 201.6 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 16-271 Range on HMM: 1-261/261 Sequence Identity: 38% (101 aa) WTVVKKIGQGAFGEIFSGKNIINNEQIAIKVEKVDTKKQVLRLEVAVLKKLQLCPYVCRFITCGRHNDYNYMVMELLGENLSELRRKQLDGKFSLGSTLK . .|.||| |.||.|. | || | |..|||.|. . . | | | . || |. . . |. ||| |||.||| | .| . .|.. | YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDL-FNFCKRRFTMKTVLM LGVQMIQSLQAVHDLGYLHRDVKPSNFAIGLNPSKRNITYLIDFGLARRFVLASGEVR-PARESTGFRGTARYASINSHLSKDLGRRDDLWSIFYVLIEF | ||| . || ...|||.|| || .|.. | .|||||||... . . | || ||||||||| || . ||||. |. ||.. | LADQMIMRIEYVHEKNFIHRDIKPDNFLMGIG-RHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYF AEGQLPWRKLK--DKDQ----IGEMKQKYNTPDLVKDLPPQFSQFMKHLKSLNYEDRPNYVFL |.||| .| | | | | | | | | .|. .|.. ..| .|. |.|..| NRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL |
|||||||||
| Kinase | DDB0216336.AA | Dual | 85-260 | 30 | 1e-35 | 117.53 | In-house | 87-260 (282) | Show / Hide |
Range on Protein: 85-260 Range on HMM: 87-260/282 Sequence Identity: 30% (55 aa) NYMVMELLGENLSELRRKQLDGKFSLGSTLKLGVQMIQSLQAVHDLGYLHRDVKPSNFAIGLNPSKRNITYLIDFGLARRFVL-ASGEVRPARESTGFRG .|.|| . | | | ||| . | .| . ||....| | .|||||..||.||..||. . |. ||...| .. ...|.|| . | KYWVMSPYGPSLQEIRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGMDETTV-YMQDFRIVRKYIDPENKKHRTARKKVKMYG TARYASINSHLSKDLGRRDDLWSIFYVLIE-FAEGQ-LPWRKLKDKDQIGEMKQKYNTPDLVKDLPPQFSQFMKHLKSL ..|||.. ..|| || ||| . | . . .. ..|||. | . . |. . ... |.|. . || | CGRYACRACMMQKDQGRKDDLECWIYMVFDLMDPEHGMSWRKECDCNMMIKQKDNFMY----HFDKHQYSHIPRRLKPL |
|||||||||
| Kinase | DDB0216336.AA | Pkinase | 16-230 | 24 | 9.9e-32 | 113.27 | Pfam | 1-224 (293) | Show / Hide |
Range on Protein: 16-230 Range on HMM: 1-224/293 Sequence Identity: 24% (58 aa) WTVVKKIGQGAFGEIFSGKNIINNEQIAIKVEKVDTKKQVL----RL--EVAVLKKLQLCPYVCRFITCGRHNDYNYMVMELLGEN--LSELR----RKQ .....|||.|.||. . .... .... |.|. |....| |. |....|.|. .|...|.. . . .|. |||||... . .| . . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-W LDGKF--SLGSTLKLGVQMIQSLQAVHDLGYLHRDVKPSNFAIGLNPSKRNIT----YLIDFGLARRFVLASGEVRPARESTGFRGTARYASINSHL-SK .|.| | . |... |. |. | .|||.||.|. | .... . ..|||||. | . . |.| || .|.. .. .. RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILI----DNNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMAPEVIRGGQ DLGRRDDLWSIFYVLIEFAEGQLPWRKL----KDKDQI . |.. | ||. .|.|.. |..|.. . ||. YYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQM |
|||||||||
| Kinase | DDB0216336.AA | S_TKc | 16-280 | 21 | 4.3e-30 | 107.23 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 16-280 Range on HMM: 1-231/231 Sequence Identity: 21% (60 aa) WTVVKKIGQGAFGEIFSGKNIINNEQIAIKVEKVDTKKQVLRLEVAVLKKLQLCPYVCRFITCGRHNDYNYMVMELLGE---NLSELRRKQLDGK----F .....|||.||||. . .... ... |||. | . .| |...||| .|...... . .. |. |||||... .| .. .|. .. | YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF SLGSTLKLGVQMIQSLQAVHDLGYLHRDVKPSNFAIGLNPSKRNITYLIDFGLARRFVLASGEVRPARESTGFRGTARYASINSHLSKDLGR-RDDLWSI . . .. |... |. |..| .|||.||.| . ..||||||.. | | || | . |. . | ||. PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC FYVLIEFAEGQLPWRKLKDKDQIGEMKQKYNTPDLVKDLPPQFSQFMKHLKSLNYEDRPNYVFLQT----LLNDCYT .|.|.. |. |.. . ... .. .|.. .|.... . |.|| . . .. . GCILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
| Kinase | DDB0216336.AA | TyrKc | 16-275 | 20 | 4.3e-09 | -75.68 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 16-275 Range on HMM: 1-280/280 Sequence Identity: 20% (62 aa) WTVVKKIGQGAFGEIFSGKNIINNEQIAIKVEKVDTKKQVLRLEVAVLKKL-QLCPYVCRFITCGRHN-------DYNYMVMELL-GENLSELRRKQLDG | ||.| |||||.. |. . .| |.|. | |. .. .. | ...|| | . |.. . .. . ..|||. . .| . || . ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK KFSLGSTLKLGVQMIQSLQAVHDLGYLHRDVKPSNFAIGLNPSKRNITYLIDFGLARRFVLA-----SGEVRPARESTGFR--GTARYASINSHLSKDLG ... |. .| . . |. .. ||| | .| | . ||||.| |... ..|. | . | .. . -LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI------ RRD------DLWSIFYVLI--EFAEGQLPWRKL----KDKDQIGEMKQKYNTPDLVKD--------LPPQFSQFMKHLKSLNYEDRPNYVFLQTLL . | || | |.. | || |. .. ... | .. . .. .. |. | || . ||||. . .. NYGKFTTKSDVWS-FGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
|||||||||