Gene Cdc2 (Slime mold)

Cdc2

Species: Slime mold
Alias: DdisK045, mo15, Cdc2, cdcB, DDB0185028
External Links: DictyBase Link ,
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDK2

Sequence

Name Sequence Type Origin Length Description Download
Cdc2.AA Protein None 296 None Fasta, JSON
Cdc2.kin_dom Protein Kinase Domain None 279 None Fasta, JSON

Protein domain

Protein domains of Cdc2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Cdc2.AA CDC2 10-288 62 7.2e-222 689.44 In-house 1-301 (301) Show / Hide 
Range on Protein: 10-288
Range on HMM: 1-301/301
Sequence Identity: 62% (189 aa)

YQKLEKLGEGTYGKVYKAKEKATGRMVALKKIRLE--DDG--VPSTALREISLLKEVP-HPNVVSLFDVLHCQNRLYLVFEYLDQDLKKYMD-SVP---A
|||.||.||||||.|||.|.. |...|||||||||  |.|  |||||.||||.|||   |||.|.|.||.|. |.||.||||||.||||||| | |    
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

LCPQLIKSYLYQLLKGLAYSHGHRILHRDLKPQNLLIDRQGALKLADFGLARAVSIPVRVYT--HEIVTLWYRAPEVLLGSKSYSVPVDMWSVGCIFGEM
..|||.|||.||.|.|... | .||.||||||||.|||..|..|.||||||||..||.|.||  ||.|||||||||.|||.| ||.||||||.|||| ||
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---LNKKPLFSGDCEIDQIFRIFRVLGTPDDSIWPGVTKLPEYVSTFPNWPGQPYNKIFPR---------CEPLALDLIAKMLQYEPSKRISAKEALLHP
    .|||||.||.||||.|.|||.||||....|||||.||.| .|||.|. |   ||.|.         ..| ..||. .||||.|.||||||||| ||
FMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHP

YF
||
YF
Kinase Cdc2.AA CDK 10-288 54 1e-187 605.84 In-house 1-284 (284) Show / Hide 
Range on Protein: 10-288
Range on HMM: 1-284/284
Sequence Identity: 54% (172 aa)

YQKLEKLGEGTYGKVYKAKEKATG-----RMVALKKIRLE-------DDGVPSTALREISLLKEVPHPNVVSLFDVLHCQ-----------NRLYLVFEY
|.||||.||||||.||||. | ||     ..|||||||.|       ..|.|.||.||||||||  |||.|.|.|| |             |.||.||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

LDQDLKKYMDSVPALCPQLIKSYLYQLLKGLAYSHGHRILHRDLKPQNLLIDRQGA-----LKLADFGLARAVSI------PVRVYTHEIVTLWYRAPEV
.|.|||||||         ||.|..|||.||.| | ..|.||||||||.||...|      ||.|||||||| .|      |.|.||||.|||||||||.
MDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPEL

LLGSKSYS--VPVDMWSVGCIFGEMLN---KKPLFSGDCEIDQIFRIFRVLGTPDDSIWPGVTKLPEYVSTFPNWPGQPYNKIFPRCEPLALDLIAKMLQ
||||| ||   |.|||||||||.||..   .|||| ||.||||.|.|||..|||....||||||||.|                        ||. |||.
LLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------DLLNKMLC

YEPSKRISAKEALLHPYF
|.|.|||||..|| ||||
YDPKKRISAEQALQHPYF
Kinase Cdc2.AA CDK5 10-288 57 7.29999999999e-175 557.41 In-house 1-287 (287) Show / Hide 
Range on Protein: 10-288
Range on HMM: 1-287/287
Sequence Identity: 57% (166 aa)

YQKLEKLGEGTYGKVYKAKEKATGRMVALKKIRLEDD--GVPSTALREISLLKEVPHPNVVSLFDVLHCQNRLYLVFEYLDQDLKKYMDSVPA-LCPQLI
|.|.||.|||||| ||||..| |. .||||..||...  ||||||.|||.||||  |.|.| |.||.|  ..| ||||..||||||||||.   . ...|
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

KSYLYQLLKGLAYSHGHRILHRDLKPQNLLIDRQGALKLADFGLARAVSIPVRVYTHEIVTLWYRAPEVLLGSKSYSVPVDMWSVGCIFGEML-NKKPLF
||..||||||||. | |..|||||||||||| ..| |||||||||||  |||| |.||.||||||.| ||.||| || ..||||.|||| ||  . .|||
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

SGDCEIDQIFRIFRVLGTPDDSIWPGVTKLPEYV---STFPNWPGQP-YNKIFPRCEPLALDLIAKMLQYEPSKRISAKEALLHPYF
 |  . || .|||...|||  . ||..||||.|      .| .|... . .| |. .   .||  ||||..| .|||||.|| ||||
PGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase Cdc2.AA CMGC 10-288 30 2e-154 511.49 In-house 1-513 (513) Show / Hide 
Range on Protein: 10-288
Range on HMM: 1-513/513
Sequence Identity: 30% (156 aa)

YQKLEKLGEGTYGKVYKAKE--------------KATGRMVALKKIR-----------LEDDGVPSTALREISLLKEVP-----------------HPNV
|....|.||||||.|||..               . |...||.|||.           .| ||.|..|||||..||..                  |.|.
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VSLFDVLHCQN-----------------RLYLVFEYLDQDLKKYMDSVP---------ALCPQL------------IKSYL------YQLLKGLA--YSH
|.|.|...  |                  |||||||.|.||..|... .          | .              ||...      ||.|.||.  | |
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

GHR--ILHRDLKPQNLLIDRQ--------------------GALKLADFGLARAVSIP---------------------VRVYTHEIVTLWYRAPEVLLG
 |.  |.||||||.|.||. .                    | ||..||||||.....                     .| |||..||.||||||.|||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

SKSYS---------VPVDMWSVGCIFGEMLNK--------KPLFSGDCE-----------IDQIFRIFRVLGTPD---------------DSIWPGVTKL
.| |.          |.|||||||||.||...        |||| |. |           |||.|.||.|||||.               . .||...||
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

PEY---------------VST-----------FPNWPGQPYNKIFPR-----------------------------------CEPLALDLIAKMLQYEPS
|.|                |            ||.||..| ...||.                                   | |.|.||. |||||.|.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

KRISAKEALLHPYF
|||.|..|| ||||
KRITAEQALQHPYF
Kinase Cdc2.AA CDK7 10-288 44 1.2e-153 412.78 In-house 1-288 (288) Show / Hide 
Range on Protein: 10-288
Range on HMM: 1-288/288
Sequence Identity: 44% (128 aa)

YQKLEKLGEGTYGKVYKAKEKATGRMVALKKIR------LEDDGVPSTALREISLLKEVPHPNVVSLFDVLHCQNRLYLVFEYLDQDLKKYM-DSVPALC
|.|....|||... |||| ...||. || |||.        .||.  ||.||| .|.|  |.||. | |..  .  ..|||...| ||     |.   | 
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

PQLIKSYLYQLLKGLAYSHGHRILHRDLKPQNLLIDRQGALKLADFGLARAVSIPVRVYTHEIVTLWYRAPEVLLGSKSYSVPVDMWSVGCIFGEMLNKK
|  ||.|  ..|.|| | | . |||||||| |||..  | ||.|||||||.   | |.||| .|| |||||| | | ..| . |||||||||| | .   
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

PLFSGDCEIDQIFRIFRVLGTPDDSIWPGVTKLPEYVSTFPNWPG---QPYNKIFPRCEPLALDLIAKMLQYEPSKRISAKEALLHPYF
| . || .|||. |||. |||| .. ||.......|. .| ..||    | ..||      .|||...|.  .|.||... ..| .|||
PYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYI-KFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase Cdc2.AA PFTAIRE 10-288 52 3.3e-133 448.85 In-house 1-287 (287) Show / Hide 
Range on Protein: 10-288
Range on HMM: 1-287/287
Sequence Identity: 52% (150 aa)

YQKLEKLGEGTYGKVYKAKEKATGRMVALKKIRLEDD-GVPSTALREISLLKEVPHPNVVSLFDVLHCQNRLYLVFEYLDQDLKKYMDSVP-ALCPQLIK
|.||||||||.| .|||.. . ....|||| |||... |.| || || ||||.  | |.| | |. | .  | .||||.. ||..|||. | .. |. ..
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQQEEGTPFTAIREASLLKNLKHANIVCLHDIIHTKETLTFVFEYVHTDLCQYMDKHPGGMHPNNVR

SYLYQLLKGLAYSHGHRILHRDLKPQNLLIDRQGALKLADFGLARAVSIPVRVYTHEIVTLWYRAPEVLLGSKSYSVPVDMWSVGCIFGEMLNKKPLFSG
 .|.||| ||.| |  |.||||||||||||   | ||||||||||| |.| . | ||.|||||| | |||||  ||  .||| ||||| ||.  .|.| |
LFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMWGQPAFPG

D-CEIDQIFRIFRVLGTPDDSIWPGVTKLPEYVSTFPN---WPGQPYNKIFPRCE--PLALDLIAKMLQYEPSKRISAKEALLHPYF
     ||  .||.||||| .  ||||..||.|            ..  ...|| .  | | ||. ||||.|| .|.||.||. ||||
MKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase Cdc2.AA PCTAIRE 10-288 52 5.5e-131 441.47 In-house 1-291 (291) Show / Hide 
Range on Protein: 10-288
Range on HMM: 1-291/291
Sequence Identity: 52% (154 aa)

YQKLEKLGEGTYGKVYKAKEKATGRMVALKKIRLE-DDGVPSTALREISLLKEVPHPNVVSLFDVLHCQNRLYLVFEYLDQDLKKYMDS-VPALCPQLIK
| ||.|||||||  ||| . | |. .|||| |||| . | | || ||.||||.  | |.|.| |..| .  | |||||.|.|||.|||  .  .    .|
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTHHQLTLVFEYMDMDLKQYMDDCGNIMNMHNVK

SYLYQLLKGLAYSHGHRILHRDLKPQNLLIDRQGALKLADFGLARAVSIPVRVYTHEIVTLWYRAPEVLLGSKSYSVPVDMWSVGCIFGEMLNKKPLFSG
 .|.||| |||| |  .|||||||||||||. .| ||||||||||| |.| ..| ||.|||||| |.||.||  || ..||| ||||| ||   .||| |
LFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMCTGRPLFPG

DC------EIDQIFRIFRVLGTPDDSIWPGVTKLPEYVS-TFPNWPGQPYNKIFPRCE---PLALDLIAKMLQYEPSKRISAKEALLHPYF
          ||   |||.|||||.  ||||. ..|...  || .. ||     || .       ||. ..||||. .|.|| .|..||||
STDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYNFPRYREQPLINHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKHPYF
Kinase Cdc2.AA PITSLRE 10-288 46 3.4e-120 405.62 In-house 1-295 (295) Show / Hide 
Range on Protein: 10-288
Range on HMM: 1-295/295
Sequence Identity: 46% (138 aa)

YQKLEKLGEGTYGKVYKAKEKATGRMVALKKIRLE-D---DGVPSTALREIS-LLKEVPHPNVVSLFDVL--HCQNRLYLVFEYLDQDLKKYMDSVP---
.|.| . .||||| ||.||.| |.. ||||.. .|     .| | |.||||. .|... |||.|..  ..     .  |.|.||.. |||  |.      
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

-ALCPQLIKSYLYQLLKGLAYSHGHRILHRDLKPQNLLIDRQGALKLADFGLARAVSIPVRVYTHEIVTLWYRAPEVLLGSKSYSVPVDMWSVGCIFGEM
    |  ||. . |||.| .. | . |.|||||  |||.  .| ||..||||||    |.. ||  .|||||||||.|||.| || |||||||||||.|.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

LNKKPLFSGDCEIDQIFRIFRVLGTPDDSIWPGVTKLPEYVSTFPNWPGQPYN---KIFP---RCEPLALDLIAKMLQYEPSKRISAKEALLHPYF
. .|||| |. ||||| .||  .|||  .||||.|.||  .  . | | .|||   |.||   .    ..||  .|| | | .||.| .|| ||.|
ITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPH-WKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase Cdc2.AA CDK4 10-288 45 2.4e-110 372.9 In-house 1-290 (290) Show / Hide 
Range on Protein: 10-288
Range on HMM: 1-290/290
Sequence Identity: 45% (135 aa)

YQKLEKLGEGTYGKVYKAKEKATGRMVALKKIR--LEDD--GVPSTALREISLLK---EVPHPNVVSLFDVLHC--QNR----LYLVFEYLDQDLKKYMD
||..  .||| ||.||.|    ||. ||||..|  ....  |.|   .||||...      |||.|.|.|| |     |    . .|||  |.||. |.|
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

SVPA--LCPQLIKSYLYQLLKGLAYSHGHRILHRDLKPQNLLIDRQGALKLADFGLARAVSIPVRVYTHEIVTLWYRAPEVLLGSKSYSVPVDMWSVGCI
 .|   . |. ||    ||| |. . | ||| ||||||||.|. ..| .|||||||||  |      |  .|||||||||||| | .|  ||||||||||
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMAL-TPVVVTLWYRAPEVLLQS-YYNTPVDMWSVGCI

FGEMLNKKPLFSGDCEIDQIFRIFRVLGTPDDSIWPGVTKLPEYVSTFPNWPGQPYNKIFPRCEPLALDLIAKMLQYEPSKRISAKEALLHPYF
| || . .||| |  | ||  .|| | |.|    ||    ||   . ||    .|  .. |  . ...||. ||| |...||.|| ..| ||||
FAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLP--WDHFPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase Cdc2.AA S_TKc 10-288 35 7.4e-110 372.18 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-288
Range on HMM: 1-231/231
Sequence Identity: 35% (104 aa)

YQKLEKLGEGTYGKVYKAKEKATGRMVALKKIRLEDDGVPSTALREISLLKEVPHPNVVSLFDVLHCQNRLYLVFEYLDQ---DLKKYMDSVPA------
|..|.|.|.|..|||||...| ||| ||.|.|.        ...|||..||.  |||.| |.|| .  ..||.|.||.|.   ||..|... .       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LCPQLIKSYLYQLLKGLAYSHGHRILHRDLKPQNLLIDRQGALKLADFGLARAVSIPVRVYTHEIVTLWYRAPEVLLGSKSYSV-PVDMWSVGCIFGEML
. .  ...|.||....|.| | |.|.||||||.|.|.|.   .|..|||||| .       |. ..|.||.|||||    .|.  ..|.||.|||. |||
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEML

NKKPLFSGDCEIDQIFRIFRVLGTPDDSIWPGVTKLPEYVSTFPNWPGQPYNKIFPRCEPLALDLIAKMLQYEPSKRISAKEALL-------HPYF
  .|.|.      |....|...|                                    | |.|.| |.||..|.||..| |||        ||.|
CGYPPFP------QMQMMFKKIG-----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Cdc2.AA MAPK 10-288 36 2.1e-106 359.78 In-house 1-328 (328) Show / Hide 
Range on Protein: 10-288
Range on HMM: 1-328/328
Sequence Identity: 36% (119 aa)

YQKLEKLGEGTYGKVYKAKEKA------TGRMVALKKIR--LEDDGVPSTALREISLLKEV-PHPNVVSLFDVLHCQ-----------NRLYLVFEYLDQ
|| |...|.| || | .|. |       .|. ||.|||    ..      ..||| ||..   |.|...|.|...             | .|.|.|. . 
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLKKYMDSVPALCPQLIKSYLYQLLKG--LAYSHGHRILHRDLKPQNLLIDRQGALKLADFGLARAVSI-PVRVY-------------THEIVTLWYRAP
|| . . | . |. . |.. .||.|.|  | | |  ...|||||| |.|..  . ||..|||||| .       .             |  ..| |||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EVLLG--SKSYSVPVDMWSVGCIFGEMLN-KKPLFSGDCEIDQIFRIFRVLGTPDDSIWPGVT--KLP-EYVSTF---PNWPGQPYNKIFPR----CEPL
|..|.  .. |.  ||||||||||.|||.  |||| |.  |||...|. |||||..  .  ..  . . .|.. .   |. |..|  |.||     . |.
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

ALDLIAKMLQYEPSKRISAKEALLHPYF
|.||. |||.  |.|||...||| ||||
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase Cdc2.AA Pkinase 10-288 34 5.5e-99 339.95 Pfam 1-293 (293) Show / Hide 
Range on Protein: 10-288
Range on HMM: 1-293/293
Sequence Identity: 34% (104 aa)

YQKLEKLGEGTYGKVYKAKEKATGRMVALKKIRLEDDGV--PSTALR--EISLLKEVPHPNVVSLFDVLHCQNRLYLVFEYLDQ-----DLKKYMD--SV
|....|.|.|..|.|||...| ||..||.|.|.....    . |..|  ||...|.. |||.| |.|. .  ...|.|.||..      ||. |.   . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

PAL--CPQLIKSYLYQLLKGLAYSHGHRILHRDLKPQNLLIDRQGAL----KLADFGLARAV-SIPVRVYTHEIVTLWYRAPEVLLGSKSYSVPVDMWSV
 ..   .. .|.|.||.|.||.| | ..|.||||||.|.|||..| .    |..|||||. .   . . .|.  .|.||.||||..|.. |. .|||||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCIFGEMLNKKPLFSGD----CEIDQIFRIFRVLGTPDDSIWPGVTKLPEYVSTFPNWPGQPYNKIFPRCEPLALDLIAKMLQYEPSKRISAKEALLHPY
|||. |||...|.|.|.      .||...|.|..|.| .. ||     . .  ... |  .   .  .. .. ..|.| ..|.. |.||..|...| ||.
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

F
|
F
Kinase Cdc2.AA Pkinase_Tyr 10-154 31 3.8e-21 72.26 Pfam 1-161 (270) Show / Hide 
Range on Protein: 10-154
Range on HMM: 1-161/270
Sequence Identity: 31% (51 aa)

YQKLEKLGEGTYGKVYKAKEK----ATGRMVALKKIRLEDDGVPSTA------LREISLLKEV-PHPNVVSLFDVLHCQ---NRLYLVFEYLDQ-DLKKY
 ....||||| .|.|||.. |     |.  || |...   .|  . .      .||....|.   |||.|.|  |  .|   |..|.|.||    ||..|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK---EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

MDS----VPALCPQLIKSYLYQLLKGLAYSHGHRILHRDLKPQNLLIDRQGALKLADFGLARAV
  .     ..|... . .. .|  ||..| . ... ||||   | |.....  | .||||||..
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI
Kinase Cdc2.AA TyrKc 10-288 21 2.6e-15 24.78 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-288
Range on HMM: 1-280/280
Sequence Identity: 21% (68 aa)

YQKLEKLGEGTYGKVYKAKEKATGRMVALKKIRLEDDGVPSTALREISLLKEV--PHPNVVSLFDVLHCQ-------NRLYLVFEYLDQ-DLKKYM-DSV
 ....||||| .|.|||.. |   ..|| |... .        .||.......   |||.| |. |   |         |..|.|| .  |||.|  .. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

PALCPQLIKSYLYQLLKGLAYSHGHRILHRDLKPQNLLIDRQGALKLADFGLARAVSIP------VRVYT-----HEI--VTLWYRAPEVLLGSKSYSVP
| ||..   |. .|  .| .| | ... ||||   | |.....  | .||||.|..           .|.     ..   . .   |||..   . ..  
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTTK

VDMWSVGCI------FGEMLNKKPLFSGDCEIDQIFRI---FRVLGTPDD----SIWPGVTKLPEYVSTFPNWPGQPYNKIFPRCEPLALDLIAKMLQYE
 | || |        .|..    . .  ... .....     . .  |..    |                          |..| .   ... .  ...
SDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------FVCCPDEMYQIMKQCWHED

PSKRISAKEALLHPYF
|..| . .|   | .|
PEDRPTFSEI--HECF