Gene Cdk5 (Slime mold)

Cdk5

Species: Slime mold
Alias: DDB0191155, CRP, DdisK046, Cdk5, crpA
External Links: DictyBase Link ,
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDK5

Sequence

Name Sequence Type Origin Length Description Download
Cdk5.AA Protein None 292 None Fasta, JSON
Cdk5.kin_dom Protein Kinase Domain None 282 None Fasta, JSON

Protein domain

Protein domains of Cdk5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Cdk5.AA CDK5 4-285 75 5.8e-241 769.97 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-285
Range on HMM: 1-287/287
Sequence Identity: 75% (217 aa)

YSKIEKLGEGTYGIVYKAKNRETGEIVALKRIRLDSEDEGVPCTAIREISLLKELKHPNIVRLHDVIHTERKLTLVFEYLDQDLKKYLDECGGEISKPTI
|.|.||.||||||.||||.|.||.|||||||.||||||||||.||||||.|||||||.||||||||||.|.|||||||..|||||||.|.|.||.....|
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

KSFMYQLLKGVAFCHDHRVLHRDLKPQNLLINRKGELKLADFGLARAFGIPVRTYSHEVVTLWYRAPDVLMGSRKYSTPIDIWSAGCIFAEMA-SGRPLF
||||||||||.||||.|.||||||||||||||..|||||||||||||||||||.|||||||||||.|||||||..|||.||.||.|||||||| .|||||
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

PGSGTSDQLFRIFKILGTPNEESWPSITELPEYK---TDFPVHPAHQ-LSSIVHGLDEKGLNLLSKMLQYDPNQRITAAAALKHPYF
||....|||.|||||.|||.|..|||||.||.||   ...|..|||| ...||..|||||..||.||||..|||||.|.|||.||||
PGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase Cdk5.AA CDC2 4-285 60 4.1e-204 633.89 In-house 1-301 (301) Show / Hide 
Range on Protein: 4-285
Range on HMM: 1-301/301
Sequence Identity: 60% (183 aa)

YSKIEKLGEGTYGIVYKAKNRETGEIVALKRIRLDSEDEG--VPCTAIREISLLKELK-HPNIVRLHDVIHTERKLTLVFEYLDQDLKKYLD-ECGG--E
| ||||.||||||.|||.|...|..|||||.|||..||||  || |||||||.||||| |||||.||||||  .|| .||||||.|||||.| . .   .
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

ISKPTIKSFMYQLLKGVAFCHDHRVLHRDLKPQNLLINRKGELKLADFGLARAFGIPVRTYS--HEVVTLWYRAPDVLMGSRKYSTPIDIWSAGCIFAEM
..  ..||.|||.|.||.||| .|..||||||||.||..||..|.||||||||||||.|||   ||||||||||| .|.|...||||.|.|| |||||||
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---ASGRPLFPGSGTSDQLFRIFKILGTPNEESWPSITELPEYKTDFPVHPAHQLSSIVHG---------LDEKGLNLLSKMLQYDPNQRITAAAALKHP
   .. .|||.|    ||||.||.|||||||..||..|.||.||..||  .. .||.|.           ||..|. ||..||||||..||.| .||.||
FMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHP

YF
||
YF
Kinase Cdk5.AA CDK 4-285 53 3.9e-198 639.7 In-house 1-284 (284) Show / Hide 
Range on Protein: 4-285
Range on HMM: 1-284/284
Sequence Identity: 53% (170 aa)

YSKIEKLGEGTYGIVYKAKNRETG-----EIVALKRIRLDS-----EDEGVPCTAIREISLLKELKHPNIVRLHDVIHTE-----------RKLTLVFEY
| |.||.||||||.||||....||     .|||||.||...     |.||.|.|||||||||||| |||||.||||.||.           .||..||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

LDQDLKKYLDECGGEISKPTIKSFMYQLLKGVAFCHDHRVLHRDLKPQNLLINRKGE-----LKLADFGLARAFGI------PVRTYSHEVVTLWYRAPD
.|.|||||.|          ||..|.|||.|...||.....||||||||.|||..||     ||.|||||||||||      |.|||.|||||||||||.
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

VLMGSRKYS--TPIDIWSAGCIFAEMAS---GRPLFPGSGTSDQLFRIFKILGTPNEESWPSITELPEYKTDFPVHPAHQLSSIVHGLDEKGLNLLSKML
.|.||..||  ||||.||.|||||||.    ..|||||.   ||||.||.|.|||.|..||..|.||.|                        .||.|||
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------DLLNKML

QYDPNQRITAAAALKHPYF
.|||..||.| .||.||||
CYDPKKRISAEQALQHPYF
Kinase Cdk5.AA PCTAIRE 4-285 57 1.1e-165 556.69 In-house 1-291 (291) Show / Hide 
Range on Protein: 4-285
Range on HMM: 1-291/291
Sequence Identity: 57% (169 aa)

YSKIEKLGEGTYGIVYKAKNRETGEIVALKRIRLDSEDEGVPCTAIREISLLKELKHPNIVRLHDVIHTERKLTLVFEYLDQDLKKYLDECGGEISKPTI
| |..|||||||  ||| . . |. .|||| |||. | || |||||||.||||.||| ||| |||.|||.. |||||||.|.|||.|.|.||  ..   .
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKHANIVTLHDIIHTHHQLTLVFEYMDMDLKQYMDDCGNIMNMHNV

KSFMYQLLKGVAFCHDHRVLHRDLKPQNLLINRKGELKLADFGLARAFGIPVRTYSHEVVTLWYRAPDVLMGSRKYSTPIDIWSAGCIFAEMASGRPLFP
| |..||| | |.||  ..||||||||||||| .|||||||||||||  .| .|||||||||||| |||||||  |||.||.|  ||||.||..||||||
KLFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMCTGRPLFP

GSG------TSDQLFRIFKILGTPNEESWPSITELPEYKTD-FPVHPAHQLSSIVHGLD---EKGLNLLSKMLQYDPNQRITAAAALKHPYF
||       . |||  ||.||||| |..|| .. ..|..|  ||  ..  | .    ||   ... .||...||| . .|. |..|.|||||
GSTDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYNFPRYREQPLINHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKHPYF
Kinase Cdk5.AA PFTAIRE 4-285 53 7.6e-160 537.32 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-285
Range on HMM: 1-287/287
Sequence Identity: 53% (155 aa)

YSKIEKLGEGTYGIVYKAKNRETGEIVALKRIRLDSEDEGVPCTAIREISLLKELKHPNIVRLHDVIHTERKLTLVFEYLDQDLKKYLDECGGEISKPTI
| |.||||||.|  |||.. . .. .|||| |||. ..||.|.||||| ||||.||| ||| |||.|||.. ||.||||.. ||..|.|.. | .    .
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQ-QEEGTPFTAIREASLLKNLKHANIVCLHDIIHTKETLTFVFEYVHTDLCQYMDKHPGGMHPNNV

KSFMYQLLKGVAFCHDHRVLHRDLKPQNLLINRKGELKLADFGLARAFGIPVRTYSHEVVTLWYRAPDVLMGSRKYSTPIDIWSAGCIFAEMASGRPLFP
. |..||| | ..||  ||||||||||||||  .|||||||||||||  .| .|||||||||||| ||||.||  ||| .|.| .|||| ||  |.|.||
RLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMWGQPAFP

GS-GTSDQLFRIFKILGTPNEESWPSITELPEYK-TDFP--VHPAHQLSSIVHGLD--EKGLNLLSKMLQYDPNQRITAAAALKHPYF
|   . ||| .|||.||||.|. || ...||.||   |.  ..  ..|  ..  ..   .. .|..||||. | .|. |..|..||||
GMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase Cdk5.AA CMGC 4-285 29 2.2e-159 528.08 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-285
Range on HMM: 1-513/513
Sequence Identity: 29% (151 aa)

YSKIEKLGEGTYGIVYKAKN--------------RETGEIVALKRIRLDS---------EDEGVPCTAIREISLLKELK-----------------HPNI
| .|.|.||||||.|||...              .||.||||.|.|...          | .|.|..|.|||..||.|.                 |.||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VRLHDVIHTER-----------------KLTLVFEYLDQDLKKYLDECGG--------EISKPT------------IKSFM------YQLLKGVA--FCH
|.|.|.....                  .| |||||.|.||..|.... .        . |               ||.||      ||.|.|..  .||
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

DHR--VLHRDLKPQNLLINRKGEL--------------------KLADFGLARAFGIP---------------------VRTYSHEVVTLWYRAPDVLMG
 |.  ..||||||.|.||| ..||                    |..||||||.....                     .|.|.|.|||.||||| .|.|
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

SRKYS---------TPIDIWSAGCIFAEMASG--------RPLFP-----------GSGTSDQLFRIFKILGTPN---------------EESWPSITEL
...|.         ||||.||.|||||||  |        .||||           |. . ||||.|||.||||.               || ||....|
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

PEY---------------KTD-----------FPVHPAHQLSSIVHG-----------------------------------LDEKGLNLLSKMLQYDPN
|.|               ...           || .| . ..... .                                   .|.....||.|||||||.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

QRITAAAALKHPYF
.||||. ||.||||
KRITAEQALQHPYF
Kinase Cdk5.AA CDK7 4-285 43 5.3e-148 397.47 In-house 1-288 (288) Show / Hide 
Range on Protein: 4-285
Range on HMM: 1-288/288
Sequence Identity: 43% (126 aa)

YSKIEKLGEGTYGIVYKAKNRETGEIVALKRIR-LDSEDE---GVPCTAIREISLLKELKHPNIVRLHDVIHTERKLTLVFEYLDQDLKKYLDECGGEIS
| ||...|||... ||||   .||.||| |.|. | . .|   |.  |||||| .|.|..|.|.. | |..     . |||...| ||            
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

KPTIKSFMYQLLKGVAFCHDHRVLHRDLKPQNLLINRKGELKLADFGLARAFGIPVRTYSHEVVTLWYRAPDVLMGSRKYSTPIDIWSAGCIFAEMASGR
   ||..| ..|.|. .|| . .||||||| |||.|  |.||.|||||||..| | | |.| ||| |||||  | | | | | .|.|| ||||||     
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

PLFPGSGTSDQLFRIFKILGTPNEESWPSITELPEYKTDFPVHPA---HQLSSIVHGLDEKGLNLLSKMLQYDPNQRITAAAALKHPYF
| .|| .  ||| |||..||||.|| || ......|   |  .|.     |  |     .  | |...|.  .| .|.|.. .||.|||
PYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDY-IKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase Cdk5.AA PITSLRE 4-285 46 1.5e-135 456.63 In-house 1-295 (295) Show / Hide 
Range on Protein: 4-285
Range on HMM: 1-295/295
Sequence Identity: 46% (136 aa)

YSKIEKLGEGTYGIVYKAKNRETGEIVALKRIRLD--SEDEGVPCTAIREIS-LLKELKHPNIVRLHDVI--HTERKLTLVFEYLDQDLKKYLDECG---
. .. . .|||||.||.||...|.|||||||. ..   | || | |..|||. .|..|.||||| .  ..   .  |  .|.||.. |||  ..      
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

GEISKPTIKSFMYQLLKGVAFCHDHRVLHRDLKPQNLLINRKGELKLADFGLARAFGIPVRTYSHEVVTLWYRAPDVLMGSRKYSTPIDIWSAGCIFAEM
 . . . ||..| |||.||.. ||. ..|||||  |||.. || ||..|||||| .| |.. |.  ||||||||| .| |..|||||.|.|| ||||||.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

ASGRPLFPGSGTSDQLFRIFKILGTPNEESWPSITELPEYK-TD-FPVHPAHQLSSIVH---GLDEKGLNLLSKMLQYDPNQRITAAAALKHPYF
 ...|||.|..  ||. .||| .|||.| .|| .||||  | .  || .|  .| ...     . . |. || .|| |.| .|||| .|||||.|
ITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase Cdk5.AA CDK4 4-285 46 6.7e-121 407.95 In-house 1-290 (290) Show / Hide 
Range on Protein: 4-285
Range on HMM: 1-290/290
Sequence Identity: 46% (138 aa)

YSKIEKLGEGTYGIVYKAKNRETGEIVALKRIRLDSEDE--GVPCTAIREISLLKELK---HPNIVRLHDVIH---TER---KLTLVFEYLDQDLKKYLD
| ..  .||| ||.||.|   .|| .||||..|  ...|  |.|   |||||... |.   |||||.| || |   | |   |.|.|||  |.||. |||
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

ECGG-EISKPTIKSFMYQLLKGVAFCHDHRVLHRDLKPQNLLINRKGELKLADFGLARAFGIPVRTYSHEVVTLWYRAPDVLMGSRKYSTPIDIWSAGCI
 |    ....|||  | ||| || | | ||. ||||||||.|... |..||||||||| ..      .  ||||||||| ||  |  | ||.|.||.|||
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMALTPV-VVTLWYRAPEVLLQS-YYNTPVDMWSVGCI

FAEMASGRPLFPGSGTSDQLFRIFKILGTPNEESWPSITELPEYKTDFPVHPAHQLSSIVHGLDEKGLNLLSKMLQYDPNQRITAAAALKHPYF
||||   ||||.|.   ||| .||.. |.| |. ||.   ||     ||   . .. ...  ... |. || ||| |..  |..| ..|.||||
FAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLP--WDHFPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase Cdk5.AA S_TKc 4-285 31 6.1e-115 389.07 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-285
Range on HMM: 1-231/231
Sequence Identity: 31% (95 aa)

YSKIEKLGEGTYGIVYKAKNRETGEIVALKRIRLDSEDEGVPCTAIREISLLKELKHPNIVRLHDVIHTERKLTLVFEYLDQ---DLKKYLDECGGE---
| ...|.|.|..| |||.....||.|||.|.|.         ....|||..||. .|||||.|.||...  .| .|.||.|.   ||..|....|..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--ISKPTIKSFMYQLLKGVAFCHDHRVLHRDLKPQNLLINRKGELKLADFGLARAFGIPVRTYSHEVVTLWYRAPDVLMGSRKYST-PIDIWSAGCIFAE
  ..  .....|||.......||.|...||||||.|.|...  ..|..|||||| .       .. ..|.||.|| ||    .|.. ..|.|| |||..|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

MASGRPLFPGSGTSDQLFRIFKILGTPNEESWPSITELPEYKTDFPVHPAHQLSSIVHGLDEKGLNLLSKMLQYDPNQRITAAAALK-------HPYF
|..|.|.||      |....||..|                                   .. ......|.||.||..|.||  ||.       ||.|
MLCGYPPFP------QMQMMFKKIG-----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Cdk5.AA Pkinase 4-285 34 1.5e-113 388.38 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-285
Range on HMM: 1-293/293
Sequence Identity: 34% (105 aa)

YSKIEKLGEGTYGIVYKAKNRETGEIVALKRIRLDSEDEGVPCTAIR--EISLLKELKHPNIVRLHDVIHTERKLTLVFEYLDQ-----DLKKYLD-ECG
| ...|.|.|..| |||.... ||.|||.|.|....|..... |..|  ||...|.|.|||||||.|. ...... .|.||..      ||. |.  . .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GEI--SKPTIKSFMYQLLKGVAFCHDHRVLHRDLKPQNLLINRKGEL----KLADFGLARAF-GIPVRTYSHEVVTLWYRAPDVLMGSRKYSTPIDIWSA
| .  |  ..|..|||.|.|...||.....||||||.|.||...|..    |..|||||. |   . . ... ..|.||.|| |..|...|....|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCIFAEMASGRPLFPGS----GTSDQLFRIFKILGTPNEESWPSITELPEYKTDFPVHPAHQLSSIVHGLDEKGLNLLSKMLQYDPNQRITAAAALKHPY
|||..||..|||.|||.    .  ||...|..|.|.|....||   . . .. ...   .  ..   | ..| .. .....|..||..|.||. .|.||.
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

F
|
F
Kinase Cdk5.AA CRK7 4-285 37 1.5e-109 370.22 In-house 1-343 (343) Show / Hide 
Range on Protein: 4-285
Range on HMM: 1-343/343
Sequence Identity: 37% (129 aa)

YSKIEKLGEGTYGIVYKAKNRETGEIVALKRIRLDSE---DEGVPCTAIREISLLKELKHPNIVRLHDVIHT--------ERK--LTLVFEYLDQDLKKY
| .|.  |||||| |||||| .|||.||||..|.| |    || | |||||| .|..|.|.|||.|....          . |    .|||| | ||   
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

LDEC-GGEISKPTIKSFMYQLLKGVAFCHDHRVLHRDLKPQNLLINRKGELKLADFGLARAFGIPV--RTYSHEVVTLWYRAPDVLMGSRKY--------
|.     ..|.  .|.|| ||| |.. ||.  .||||.|  |.|.| .||.|.||||||| .      | |   |.|||||.|  | |  .|        
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKE

------------------------------STPIDIWSAGCIFAEMASGRPLFPGSGTSDQLFRIFKILGTPNEESWPSITELPEYKTDFPVH--PAHQL
                               . ||.|| |||..| ....|.|.|.   .||  |.|| |.|| ..|| ...|| ..|  |        .
LIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNRRLR

SSIVH-----GLDEKGLNLLSKMLQYDPNQRITAAAALKHPYF
   .|      .... |.|| ||| .||  |.||  .| |..|
EEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase Cdk5.AA Pkinase_Tyr 4-150 30 5.5e-24 81.87 Pfam 1-160 (270) Show / Hide 
Range on Protein: 4-150
Range on HMM: 1-160/270
Sequence Identity: 30% (50 aa)

YSKIEKLGEGTYGIVYKAKNR----ETGEIVALKRIRLDSEDEGVPCTA------IREISLLKEL-KHPNIVRLHDVIH-TERK--LTLVFEYLDQ-DLK
 ....||||| .| |||.. .    .|.  || | ..     ||    .      .||....|.| .|||||||. |.   ..   . .|.||    ||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

KYLDEC---GGEISKPTIKSFMYQLLKGVAFCHDHRVLHRDLKPQNLLINRKGELKLADFGLARA
.|| .    .. .. ... .. .|  || .. ....  ||||   | |.....  | .||||||.
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase Cdk5.AA TyrKc 4-285 23 2.5e-15 25.17 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-285
Range on HMM: 1-280/280
Sequence Identity: 23% (74 aa)

YSKIEKLGEGTYGIVYKAKNRETGEIVALKRIRLDSEDEGVPCTAI-REISLLKEL--KHPNIVRLHDVIHTE-------RKLTLVFEYLDQ-DLKKYLD
 ....||||| .|.|||.. .   . || | .. |.        .. ||......|  .|||||||. |. ..         | .|.|| .  |||.|| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

ECGGEISKPTIKSFMYQLLKGVAFCHDHRVLHRDLKPQNLLINRKGELKLADFGLARAFGIPVR--------TYS-----HEV--VTLWYRAPDVLMGSR
....... ..  ||..|  .| .. |.... ||||   | |.....  | .||||.|.  |           .|.     ..   . .   || ..   .
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRD--IYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYG

KYSTPIDIWSAGCIFAEMAS-GRPLFPG---SGTSDQLFRIFKILGTPNEESWPSI----TELPEYKTDFPVHPAHQLSSIVHGLDEKGLNLLSKMLQYD
|..|  |.|| |    |. . | .  ||          ..... . . .    |                         . |.  ||    . ..  ..|
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMS------------------F-VCCPDEMYQ-IMKQCWHED

PNQRITAAAALKHPYF
|..| | ..   | .|
PEDRPTFSEI--HECF