Gene DDB0216376 (Slime mold)

DDB0216376

Species: Slime mold
Alias: DdisK053, DDB0216376
External Links: DictyBase Link ,
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: PITSLRE

Sequence

Name Sequence Type Origin Length Description Download
DDB0216376.AA Protein None 358 None Fasta, JSON
DDB0216376.kin_dom Protein Kinase Domain None 285 None Fasta, JSON

Protein domain

Protein domains of DDB0216376.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DDB0216376.AA PITSLRE 52-336 60 1.3e-223 749.11 In-house 1-295 (295) Show / Hide 
Range on Protein: 52-336
Range on HMM: 1-295/295
Sequence Identity: 60% (179 aa)

FKKLYTINEGAFGVVYCAQDKETEEIVALKKIKME--REREGIPITSVREIK-VLMELKHDNIVQIKEIVLGKNINSIFMAMEFIDHDLRGLMEVIK---
|..|..|.||..||||.|.||.|.||||||..|||  .|.||.||||.|||. .||.|.|.|||..||||.|.|...|.|.||...|||..|||..|   
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

KPFLPSEIKTLIQQLLNGVSYMHDNWVIHRDLKTANLLYTNKGVLKIADFGLAREYGSPLKPLSKGVVTLWYRAPELLLDTEIYTPAIDIWSVGCIFAEI
.||.|.|||.|.||||.||..|||||..||||||.||||..||.|||.|||||||||||.||....|||||||||||||....|....|.|||||||||.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

ISKEVLLQGSSEIDQMDKIFKLFGTPTEKSWPAFFKLPLAKYFN-LTDQPYNNLKSKFP---HITDNAFDLLNKLLELNPEARISASDALKHPYF
|....|.||.|||||...|||..||||||.||....||..|..| ....|||||...||   ||.|..|||||..|..||..||.||||||||.|
ITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase DDB0216376.AA CDK 52-336 44 5.3e-166 535.25 In-house 1-284 (284) Show / Hide 
Range on Protein: 52-336
Range on HMM: 1-284/284
Sequence Identity: 44% (141 aa)

FKKLYTINEGAFGVVYCAQDKETE-----EIVALKKIKMER-----EREGIPITSVREIKVLMELKHDNIVQIKEIVLGKN---------INSIFMAMEF
..||  | ||..|||| |.||.|      .|||||||.||      |.||.|||..|||. |.|| |.|||........||         .|...| .|.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

IDHDLRGLMEVIKKPFLPSEIKTLIQQLLNGVSYMHDNWVIHRDLKTANLLYTNKGV-----LKIADFGLAREYGS------PLKPLSKGVVTLWYRAPE
.|||| ..|.          ||....|||.|..|.|.||..|||||..|.|..|.|.     ||||||||||..|.      |...... ||||||||||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

LLLDTEIYT--PAIDIWSVGCIFAEIIS---KEVLLQGSSEIDQMDKIFKLFGTPTEKSWPAFFKLPLAKYFNLTDQPYNNLKSKFPHITDNAFDLLNKL
||| ...|.  ..||.|||||||||..    .. |..|.|||||..|||...|||||..|| . |||.                          |||||.
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------DLLNKM

LELNPEARISASDALKHPYF
| ..|. ||||..||.||||
LCYDPKKRISAEQALQHPYF
Kinase DDB0216376.AA CMGC 52-336 26 5.9e-134 443.0 In-house 1-513 (513) Show / Hide 
Range on Protein: 52-336
Range on HMM: 1-513/513
Sequence Identity: 26% (137 aa)

FKKLYTINEGAFGVVYCAQD--------------KETEEIVALKKIK---MER------EREGIPITSVREIKVLMELK-----------------HDNI
....  | ||..|||| ..|              .||.||||.||||   .|.      |..|.||.. |||| |..|.                 | ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VQIKEIVLGKN---------------INSIFMAMEFIDHDLRGLMEVIKK--------PFLPSE------------IKTLI------QQLLNGVS--YMH
|....|.  ||                |.... .|..|||| ....  ..        |. . .            || ..      .|.|.|.   |.|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

DNW--VIHRDLKTANLLYTNK--------------------GVLKIADFGLAREYGSP---------------------LKPLSKGVVTLWYRAPELLLD
 .|  .|||||| .|.| ...                    |.|||.|||||| |...                     ..|..  |||.||||||.|| 
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

TEIYT---------PAIDIWSVGCIFAEIISK--------EVLLQGSSE-----------IDQMDKIFKLFGTPT---------------EKSWPAFFKL
 . ||         ..||.|||||||||.. .        . | .|.||           |||..||||..||||               |. || . ||
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

PLAKYFN-------------------------LTDQPYNNLKSKFPH-----------------------------------ITDNAFDLLNKLLELNPE
|  . |                          .  .|....|..||                                    ... |.|||.|.|...|.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

ARISASDALKHPYF
 ||.|..||.||||
KRITAEQALQHPYF
Kinase DDB0216376.AA CDC2 52-336 42 5e-133 411.42 In-house 1-301 (301) Show / Hide 
Range on Protein: 52-336
Range on HMM: 1-301/301
Sequence Identity: 42% (129 aa)

FKKLYTINEGAFGVVYCAQDKETEEIVALKKIKMEREREG--IPITSVREIKVLMELK-HDNIVQIKEIVLGKNINSIFMAMEFIDHDLRGLME-VIK--
..|.  |.|| .|||| ..|..| .|||||||. |.| ||  .| |..|||  | ||| |.|||......     |...|  |..|.||. .|.  |.  
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKN

KPFLPSEIKTLIQQLLNGVSYMHDNWVIHRDLKTANLLYTNKGVLKIADFGLAREYGSPLKPLS--KGVVTLWYRAPELLLDTEIYTPAIDIWSVGCIFA
|.. |. .| .. |.|.||.. | . ..|||||  |.|  .||..|||||||||  | |....   . ||||||||||.||  . |. ..|.||.|||||
KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFA

EI---ISKEVLLQGSSEIDQMDKIFKLFGTPTEKSWPAFFKLP--LAKYFNLTDQPYNNLKSKFPH---------ITDNAFDLLNKLLELNPEARISASD
|.   ..|. | .| |||||  |||. .|||.|..||   .||   ... ... |   .|.. .|          ......|||...| ..|. |||| .
EMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQ---DLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKE

ALKHPYF
||.||||
ALQHPYF
Kinase DDB0216376.AA CDK7 52-336 41 3.2e-131 351.85 In-house 1-288 (288) Show / Hide 
Range on Protein: 52-336
Range on HMM: 1-288/288
Sequence Identity: 41% (121 aa)

FKKLYTINEGAFGVVYCAQDKETEEIVALKKIK----MEREREGIPITSVREIKVLMELKHDNIVQIKEIVLGKNINSIFMAMEFIDHDLRGLMEVIKKP
..|.  | || |..|| |.|..|..||| ||||     .  . ||  | .||||.| |..|||..    |   |   .| . ..|.| ||    .  .  
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHK--SNIQLVFDFMDWDLEVVIKDKSII

FLPSEIKTLIQQLLNGVSYMHDNWVIHRDLKTANLLYTNKGVLKIADFGLAREYGSPLKPLSKGVVTLWYRAPELLLDTEIYTPAIDIWSVGCIFAEIIS
. |..||    ..| |. |.| ||. |||||  |||    |.|||||||||| |||| . ..  ||| ||||||||    .|....|.||||||||| . 
LTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELML

KEVLLQGSSEIDQMDKIFKLFGTPTEKSWPAFFKLPLAKYFNLTDQPY---NNLKSKFPHITDNAFDLLNKLLELNPEARISASDALKHPYF
    | | |.|||. .||.  |||||. ||   ...   |  ..|.|      |.  |   .| . ||. ... .|| .|......||.|||
RVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMM--DYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase DDB0216376.AA CDK10 52-336 48 7.79999999999e-127 427.67 In-house 1-285 (285) Show / Hide 
Range on Protein: 52-336
Range on HMM: 1-285/285
Sequence Identity: 48% (137 aa)

FKKLYTINEGAFGVVYCAQDKETEEIVALKKIKMEREREGIPITSVREIKVLMELKHDNIVQIKEIVLGKNINSIFMAMEFIDHDLRGLMEVIKKPFLPS
| ||  . ||..|.|| | |  ..|||||||..|..|..|.|| ..|||..|....|.|||...|.| |. ..|||. |.. . ||  |.. . .||  .
FEKLNRVGEGTYGIVYRARDMRSDEIVALKKVRMDKEKDGLPISGLREIMLLIQCRHENIVELHEVVVGQHLDSIFLVMQYCEQDLASLLDNMPQPFTET

EIKTLIQQLLNGVSYMHDNWVIHRDLKTANLLYTNKGVLKIADFGLAREYGSPLKPLSKGVVTLWYRAPELLLDTEIYTPAIDIWSVGCIFAEIISKEVL
..| .. |.| |. |.|||..|||||| .||| | || .|.||||||| || | ||.   .|||||||||||| .   | |||.| |||| .|.. .  |
QVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVADFGLARMYGVPVKPMTPKMVTLWYRAPELLLGCRTQTTAIDMWAVGCILGELLVHKPL

LQGSSEIDQMDKIFKLFGTPTEKSWPAFFKLPLAKYFNLTDQPYNNLKSKFPHITDNAFDLLNKLLELNPEARISASDALKHPYF
. |.||| |.| | .| ||| |. || | .||... | |  ||||||| ||. . .    ||| |.  ||  |  | ..|.  ||
MPGNSEIHQIDMIIDLLGTPSENIWPGFSDLPMVQNFTLKKQPYNNLKHKFHWLSQSGRRLLNFLFMYNPKKRATAEECLESSYF
Kinase DDB0216376.AA CRK7 52-336 37 5.9e-117 394.85 In-house 1-343 (343) Show / Hide 
Range on Protein: 52-336
Range on HMM: 1-343/343
Sequence Identity: 37% (127 aa)

FKKLYTINEGAFGVVYCAQDKETEEIVALKKIKMERE---REGIPITSVREIKVLMELKHDNIVQIKEIVLGK-------NIN-SIFMAMEFIDHDLRGL
....  | || .| || |..|.|.|.|||||..|. |   .|| |||..||||.| .|.|.|||..||||. |       .   |..|  | .|||| ||
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

MEVI-KKPFLPSEIKTLIQQLLNGVSYMHDNWVIHRDLKTANLLYTNKGVLKIADFGLAREYGSPL--KPLSKGVVTLWYRAPELLLDTEIY--------
.|    . | ....| .  ||| |. |.|.. ..|||.| .|.|. |.| .||||||||| | |    .|.   |.|||||.||||| .| |        
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKE

------------------------------TPAIDIWSVGCIFAEIISKEVLLQGSSEIDQMDKIFKLFGTPTEKSWPAFFKLPLAKYFNLTDQPYNNLK
                              .|.||.||.|||..|  .|. ..||. |..|..||.|. |.|.  .||   |||. . .    |    | 
LIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNRRLR

SKFP------HITDNAFDLLNKLLELNPEARISASDALKHPYF
  |        ..  ..||| |.| |.|. |..|...| |..|
EEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase DDB0216376.AA CDK5 52-336 42 7e-110 348.46 In-house 1-287 (287) Show / Hide 
Range on Protein: 52-336
Range on HMM: 1-287/287
Sequence Identity: 42% (124 aa)

FKKLYTINEGAFGVVYCAQDKETEEIVALKKIKMEREREGIPITSVREIKVLMELKHDNIVQIKEIVLGKNINSIFMAMEFIDHDLRGLMEVIKKPFLPS
..|.  | || .|.|| |..|||.||||||..... | ||.| | .||| .| |||| ||| .  ..   .   . .  ||.| ||.  |. ..    . 
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKK--LTLVFEFCDQDLKKYMDSCNGEMDMH

EIKTLIQQLLNGVSYMHDNWVIHRDLKTANLLYTNKGVLKIADFGLAREYGSPLKPLSKGVVTLWYRAPELLLDTEIYTPAIDIWSVGCIFAEII-SKEV
 || .. ||| |... |.. | |||||  |||   .| || ||||||| .| | .  |  |||||||.|  |.    |.  ||.||.||||||.. .   
IIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRP

LLQGSSEIDQMDKIFKLFGTPTEKSWPAFFKLPLAK--YFNLTDQPYNN-LKSKFPHITDNAFDLLNKLLELNPEARISASDALKHPYF
|  |... ||. .|||. |||.| .||.  |||  |    ..   | .  ...  |.   .  |||.|.|..||. |||| .||.||||
LFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase DDB0216376.AA CDK8 56-336 34 5.1e-92 288.81 In-house 1-329 (329) Show / Hide 
Range on Protein: 56-336
Range on HMM: 1-329/329
Sequence Identity: 34% (114 aa)

YTINEGAFGVVYCAQDKET----EEIVALKKIKMER------EREGIPITSVREIKVLMELKHDNIVQIKEIVLGKNINSIFMAMEFIDHDLRGLME---
. |  | .| || |..|..    .  .|||... |.      | .||  .  |||  . ||.| |..   .. | ..   ..| ...  ||| .      
KYIGRGTYGHVYKAKRKKQKKKPNKEYALKQFRTEKDGVEQLEGTGISMSACREIALCRELHHPNVICLQRVFLNHKDKCVWMLFDYAEHDLWHIIKFHR

VIKKPFLPSE------IKTLIQQLLNGVSYMHDNWVIHRDLKTANLLYTNKG------VLKIADFGLAREYGSPLKPLSKG---VVTLWYRAPELLLDTE
  |. . .        .| .. |.|.|..| | |||.||||| || . .  |        ||||.|.|| . .|||||  .   |||.|||||||||   
HNKAHMKDPTMVPRNMVKSIMWQILDGIHYLHSNWVLHRDLKPANIMVMGDGPEDMCGCVKIADMGFARIFHNPLKPLYDLDPVVVTFWYRAPELLLGAR

IYTPAIDIWSVGCIFAEIISKEVLLQGSSE-----------IDQMDKIFKLFGTPTEKSWPAFFKLPLAKYFNLTD-----QPYNN-LKSKFPH---ITD
 ||.|||||..|||||| |  | . ..  |            ||.|.||.. |.|..| ||   |.|   . .|.      | | | .  ..     |  
HYTKAIDIWAIGCIFAELITSEPIFHCKEEKLDIKTQNPYHHDQLDRIFHVMGFPQDKMWPDIKKMP--EHQRLMKDFRRMQTYPNCSLHWYMEKHKIKR

N--AFDLLNKLLELNPEARISASDALKHPYF
.  |..|| |.|   |  ||....|. ||||
DSHAYHLLYKMLTMDPTKRITCEQAMEHPYF
Kinase DDB0216376.AA S_TKc 52-336 27 5.5e-92 312.81 SMART 1-231 (231) Show / Hide 
Range on Protein: 52-336
Range on HMM: 1-231/231
Sequence Identity: 27% (83 aa)

FKKLYTINEGAFGVVYCAQDKETEEIVALKKIKMEREREGIPITSVREIKVLMELKHDNIVQIKEIVLGKNINSIFMAMEFIDH---DLRGLMEVIKKP-
...| .| .||||.||....|.| .|||.|.||         ..  |||..|.. .|.|||.....      ....| ||..|.   ||. ...  ... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FLPSEIKTLIQQLLNGVSYMHDNWVIHRDLKTANLLYTNKGVLKIADFGLAREYGSPLKPLSKGVVTLWYRAPELLLDTEIYTP-AIDIWSVGCIF
    | . ... ...|..... |.|....|||||| .|.| ..  ..||.||||||..       .  ..|.||.|||.|     |.. ..|.||.|||.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCIL

AEIISKEVLLQGSSEIDQMDKIFKLFGTPTEKSWPAFFKLPLAKYFNLTDQPYNNLKSKFPHITDNAFDLLNKLLELNPEARISASDALK-------HPY
.| .. . . .      ||...||. |                                    .. | |...|.|. .|| |..| .||.       ||.
YEMLCGYPPFP------QMQMMFKKIG------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

F
|
F
Kinase DDB0216376.AA CDK4 52-336 40 3.4e-86 292.66 In-house 1-290 (290) Show / Hide 
Range on Protein: 52-336
Range on HMM: 1-290/290
Sequence Identity: 40% (118 aa)

FKKLYTINEGAFGVVYCAQDKETEEIVALKKIKMERERE--GIPITSVREIKVLMELK---HDNIVQIKEIVLGKNINS----IFMAMEFIDHDLRGLME
....  | |||.| || | | .|  .||||...   . |  |.|.  .||| |.  |.   | |||. ...            | | .| .| ||. ...
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

VIKKPFLPSE-IKTLIQQLLNGVSYMHDNWVIHRDLKTANLLYTNKGVLKIADFGLAREYGSPLKPLSKGVVTLWYRAPELLLDTEIYTPAIDIWSVGCI
 . .| .| . || .  ||| || . | . .||||||  |.| |  | .|.|||||||.|..  . |   |||||||||| ||    |   .|.||||||
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMA-LTPVVVTLWYRAPEVLLQ-SYYNTPVDMWSVGCI

FAEIISKEVLLQGSSEIDQMDKIFKLFGTPTEKSWPAFFKLPLAKYFNLTDQPYNNLKSKFPHITDNAFDLLNKLLELNPEARISASDALKHPYF
|||.     |  |.|| || .|||.. |.|.|. ||    ||.  .     .|   .    ||.   . |||.| |  |.. |.||  .|.||||
FAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLPWDHFPQRHPRPFKDF---CPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase DDB0216376.AA Pkinase 52-336 29 6.4e-86 296.55 Pfam 1-293 (293) Show / Hide 
Range on Protein: 52-336
Range on HMM: 1-293/293
Sequence Identity: 29% (89 aa)

FKKLYTINEGAFGVVYCAQDKETEEIVALKKIKMEREREGIPITSVR--EIKVLMELKHDNIVQIKEIVL-GKNINSIFMAMEFIDHDLRGLMEVI----
.... .| .|.||.|| ...| |..|||.|.|| ..|... ..| .|  ||... .|.|.|||......  ...|    | ||. ...|  .|.      
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIY---MVMEYCEGGLY-VMDLFDYIS

---KKPF--LPSEIKTLIQQLLNGVSYMHDNWVIHRDLKTANLLYTNKGVL----KIADFGLAREY-GSPLKPLSKGVVTLWYRAPELLLDTEIYTPAID
   ...|   . |.|  . |.| |. |.|....|||||| .|.|. |.|..    ||.|||||. .   .   ..  ..|.||.|||.... . |.|..|
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

IWSVGCIFAEIISKEVLLQGS----SEIDQMDKIFKLFGTPTEKSWPAFFKLPLAKYFNLTDQPYNNLKSKFPHITDNAFDLLNKLLELNPEARISASDA
.||.|||..| .... . .|.    . .||| .|..  |.|.. .||     .. . |.  . .   .. . . ..... |.....|...|. |..| ..
MWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQI

LKHPYF
|.||.|
LQHPWF
Kinase DDB0216376.AA Pkinase_Tyr 52-199 31 1.5e-15 53.29 Pfam 1-159 (270) Show / Hide 
Range on Protein: 52-199
Range on HMM: 1-159/270
Sequence Identity: 31% (52 aa)

FKKLYTINEGAFGVVYCAQDK----ETEEIVALKKIKMEREREGIPITS------VREIKVLMEL-KHDNIVQIKEIVL--GKNINSIFMAMEFIDH-DL
 ... .. |||||.|| .  |    .|.  || |..|     ||            ||.|....| .|.|||.   ...  |. . .|.. ||.  | ||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDL

RGLMEVI---KKPFLPSEIKTLIQQLLNGVSYMHDNWVIHRDLKTANLLYTNKGVLKIADFGLAR
.         |.|. ....    .|  .| .| ...  ||||| . | | |...| ||.||||||
LDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase DDB0216376.AA TyrKc 52-336 19 9.2e-15 15.97 SMART 1-280 (280) Show / Hide 
Range on Protein: 52-336
Range on HMM: 1-280/280
Sequence Identity: 19% (62 aa)

FKKLYTINEGAFGVVYCAQDKETEEIVALKKIKMEREREGIPITSVREIKVLMEL--KHDNIVQIKEIVLGK-----NINSIFMAMEFIDH-DLRGLMEV
 ... .. |||||.|| .. |   . || |..| .           ||......|  .|.|||..  ... .      |  ... ||. .| ||.     
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

IKKPFLPSEIKTLIQQLLNGVSYMHDNWVIHRDLKTANLLYTNKGVLKIADFGLAREYGSP--------LKP-----LSKGVVTLWYRAPELLLDTEIYT
 .. . ...      |  .| .| |.. .||||| . | |...... ||.||||.|. ..          .       .|... .   ||| . .. ..|
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFT

PAIDIWSVGCI-----------FAEI----ISKEVLLQGSSEIDQMDKIFK----LFGTPTEKSWPAFFKLPLAKYFNLTDQPYNNLKSKFPHITDNAFD
.. |.|| |               ..    .| . ...   . . |..                                          |.. .|  ..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------------------FVCCPDEMYQ

LLNKLLELNPEARISASDALKHPYF
.  .  . .|| | . |.   | .|
IMKQCWHEDPEDRPTFSEI--HECF