DDB0229296

Species: Slime mold
Alias: DDB0229296, DdisK060
External Links: DictyBase Link ,
Annotation:

Classification

Group: CMGC
Family: Dicty1

Sequence

Name Sequence Type Origin Length Description Download
DDB0229296.AA Protein None 460 None Fasta, JSON
DDB0229296.kin_dom Protein Kinase Domain None 300 None Fasta, JSON

Protein domain

Protein domains of DDB0229296.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DDB0229296.AA Dicty1 102-415 62 1.1e-250 839.05 In-house 1-327 (327) Show / Hide
Range on Protein: 102-415
Range on HMM: 1-327/327
Sequence Identity: 62% (206 aa)

INLKSITDCGPDGVMFRAKNEDSKEEVIVKKISVFLMKDDKMARKLLRNLLFQRHFQQHPLVSTFQSVFKRKSSENYL---------ISNKNNRNNVRLP
|    | ||| .|.||||.|.|....||.||||||..|...|....|||..||||||.||.||||||.||||.|.||.         |.|.||.|...|.
IDPNTIVDCGTNGIMFRAFNFDTQRRVIIKKISVFMFKNHLMGHMMLRNCHFQRHFQHHPHVSTFQSIFKRKCSDNYQPPLTSILNSIINSNNNNQQHLI

LLQQKGDDDIYFEYLLPEFTLLQMIHN-KLLTEYNIMIFLYQLLTVVKFMHSAGVIHRDIDP-SAITIDQNQCLKLTEFYFCFPSNCPVDLFFN-DYDTS
|.|||.|||.||||..|.|||.||||| |.|..|....||||||...||||||||||||.|| ..|..|||.|.||||||||||..||.|.||| ||||.
LIQQKDDDDFYFEYIQPQFTLYQMIHNDKMLDQYQCCYFLYQLLMTIKFMHSAGVIHRDLDPENTIFVDQNYCIKLTEFYFCFPTDCPPDFFFNKDYDTN

SFIYRAPETIWRNTTYTTAIDVWNIGVIFGEMILGKRLFKTQDFEDHLISISKLIGNPTAEDLSIVLS-KSIFQYMEKIPKSTLTPSVGIKRRFKGASKD
...||||||||.|..||.|.|||||||||.|||||||||.||.|.||||||.|||||||......|.. ..||.|||...|||..|..||||||||...|
PWPYRAPETIWMNKEYTFACDVWNIGVIFAEMILGKRLFRTQNFQDHLISIYKLIGNPTYDECKYVVNGFAIFFYMEYNRKSTFQPHFGIKRRFKGCNQD

QIELLQGMLCWDPRKRMTIDQLLAHKY
||||||||||||||||..|.|.|.|.|
QIELLQGMLCWDPRKRWPINQILQHPY

Kinase DDB0229296.AA CMGC 114-416 18 1.1e-64 211.13 In-house 13-513 (513) Show / Hide
Range on Protein: 114-416
Range on HMM: 13-513/513
Sequence Identity: 18% (96 aa)

GVMFRAKN--------------EDSKEEVIVKKIS-VFLMK--------DDKMARKLLRNLLFQRHFQ----------------QHPLVSTFQSVFKRKS
|| .....               ...|.| .|||. .| ..         | . .. || . . .|..                .|. . . . .|..| 
GVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKN

SENYL------ISNKNNRNNVRLPLLQQKGDDDIYFEYLLPEFTLLQMIHNKL----------LTEYN------------IMIFL------YQLLTVVK-
|....      ||              |  ....|.   . . .|.|.|.|.           |.|              |  |.      ||.|. .| 
SDGNEYEDKHIIS--------------Q-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKL

-FMHSAG--VIHRDIDPSAITIDQN--------------------QCLKLTEFYFCFPSNCPVDLFF-------------------NDYDTSSFIYRAPE
 ..||..  .||||. |. | |..|                     .||.  | ..   . . | .|                   .  . ..  |||||
KYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPE

TIWRNTTYT---------TAIDVWNIGVIFGEMILG--------KRLFKTQDF-----------EDHLISISKLIGNPT---------------AEDLSI
 . . . ||         |.||.| .| ||.||..|        | ||....             |.|  | |..|.||                |.   
ILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPN

VLS-------------------KSIF--QYMEKIPKSTLTPSVGIKRRFKG-----------------------------------ASKDQIELLQGMLC
...                   .|.|  .| .. ..    |   .|. |..                                   .... |.||..||.
MIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQ

WDPRKRMTIDQLLAHKYF
.|| ||.|..| |.| ||
YDPDKRITAEQALQHPYF

Kinase DDB0229296.AA ERK5 201-416 33 8.1e-32 112.02 In-house 78-295 (295) Show / Hide
Range on Protein: 201-416
Range on HMM: 78-295/295
Sequence Identity: 33% (74 aa)

DIYFEYLLPEFTLLQMIH-NKLLTEYNIMIFLYQLLTVVKFMHSAGVIHRDIDPSAITIDQNQCLKLTEF----YFCFPSNCPVDLFFNDYDTSSFIYRA
|.|  . | |  | |.|| |. .|   |  ||||.|  .|.|||| |||||. || . .  |  ||. .|      |  |     .|  .|    . |||
DVYVVFDLMESDLHQIIHSNQPFTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRW-YRA

PETIWRNTTYTTAIDVWNIGVIFGEMILGKRLFKTQDFEDHLISISKLIGNPTAEDLSIVLSKSIFQYMEK-IPKSTLTPSVGIKRRFKGASKDQIELLQ
|| .     || ||||| .| ||||||  . .|  . . . |  | . .| | .  .  | .  .  |. | .|  .  .   ... . .| .  ..|| 
PELMFSSHDYTQAIDVWSVGCIFGEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKD---WEKVYPKADRQALDLLA

GMLCWDPRKRMTIDQLLAHKYF
 || ..| .|.|. . | | . 
RMLRFEPSERITVNKALQHPFL

Kinase DDB0229296.AA ERK1 201-416 31 3.3e-30 106.68 In-house 76-289 (289) Show / Hide
Range on Protein: 201-416
Range on HMM: 76-289/289
Sequence Identity: 31% (69 aa)

DIYFEYLLPEFTLLQMIHNKLLTEYNIMIFLYQLLTVVKFMHSAGVIHRDIDPSAITIDQNQCLKLTEFYFCFPSNCPVDL--FFNDYDTSSFIYRAPET
|.|    | |  | ...  . |    |  ||||.|  .|..||| |.|||. || . . .   ||. .|     .    |   |  .|    . ||||| 
DVYIVQCLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRW-YRAPEI

IWRNTTYTTAIDVWNIGVIFGEMILGKRLFKTQDFEDHLISISKLIGNPTAEDLSIVLSKSIFQYMEKIPKSTLTPSVGIKRRFKGASKDQIELLQGMLC
.     || .||.| .| |  ||.  . .|  . . | |  |  ..| |  .||  .. .   .|.. .|     | |  .| | .| .  ..||. || 
MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLP---HKPKVPWARLFPKADSKALDLLDKMLT

WDPRKRMTIDQLLAHKYF
. | ||.|... ||| | 
FNPHKRITVEEALAHPYL

Kinase DDB0229296.AA GSK 293-416 29 1.7e-29 86.76 In-house 184-328 (328) Show / Hide
Range on Protein: 293-416
Range on HMM: 184-328/328
Sequence Identity: 29% (43 aa)

YRAPETIWRNTTYTTAIDVWNIGVIFGEMILGKRLFKTQDFEDHLISISKLIGNPTAEDL-SIVLSK--SIFQ-----YMEKIPKST-------------
||||| |   | ||..|||| .| ...||..|. ||. ..  | |. | |..| ||.|.. |.  |.    |.     . ...|...             
YRAPELIFGCTNYTCQIDVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPYWSFQQIKPHPWQKNDTKYEYQTYYHK

-LTPSVGIKRRFKGASKDQIELLQGMLCWDPRKRMTIDQLLAHKYF
  .  | . ....  ..|.|.|.  .|  ||.|| . ....|| .|
KYR-TVYMFKWCHTDMQDWIDLISKCLVYDPKKRLSPLEACAHPFF

Kinase DDB0229296.AA MAPK 293-416 32 3.4e-29 97.94 In-house 197-328 (328) Show / Hide
Range on Protein: 293-416
Range on HMM: 197-328/328
Sequence Identity: 32% (43 aa)

YRAPETIWR--NTTYTTAIDVWNIGVIFGEMIL-GKRLFKTQDFEDHLISISKLIGNPTAEDLSIVL-SKSIFQYMEKIPKSTLTPSVGIKRRFKG----
||||| .     . ||.|.|.| .| ||.||.  .| ||. .|  | .  | ...|.|. |... .  |..  .| .  .  . .| .  .  |..    
YRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFN

ASKDQIELLQGMLCWDPRKRMTIDQLLAHKYF
|. . | ||. || .|| || |... |.| ||
ANPQAIDLLEKMLVFDPDKRITVEEALQHPYF

Kinase DDB0229296.AA ERK7 293-416 31 1.9e-25 83.7 In-house 172-292 (292) Show / Hide
Range on Protein: 293-416
Range on HMM: 172-292/292
Sequence Identity: 31% (39 aa)

YRAPETIWRNTTYTTAIDVWNIGVIFGEMILGKRLFKTQDFEDHLISISKLIGNPTAEDLSIVLSKSIFQYMEKIPKSTLTPSVGIKRRFKGASKDQIEL
|||||     ..|| ..| | || | |||. || .|      . .  | ..|..||.||.  . |.   . .|...    ..   ..  ......| |.|
YRAPEILLGSHRYTKGVDMWSIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMN---QQKRKTLDQMMPQCCDDAIDL

LQGMLCWDPRKRMTIDQLLAHKYF
|. .|.  |.||.|..| |.| | 
LKRLLVFNPKKRLTAEQALQHPYV

Kinase DDB0229296.AA p38 293-416 35 3.8e-25 82.65 In-house 169-289 (289) Show / Hide
Range on Protein: 293-416
Range on HMM: 169-289/289
Sequence Identity: 35% (44 aa)

YRAPETIWRNTTYTTAIDVWNIGVIFGEMILGKRLFKTQDFEDHLISISKLIGNPTAEDLSIVLSKSIFQYMEKIPKSTLTPSVGIKRRFKGASKDQIEL
||||| .     || ..|.| .| |  |.| |. ||. .|. | |  | |..| |..| .. . |..   |.. .|.   .|    .. |.||.   |.|
YRAPEIMLNWMHYTQTVDIWSVGCIMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQ---MPRRDFHHVFMGANPQAIDL

LQGMLCWDPRKRMTIDQLLAHKYF
|  ||  || ||.|  . ..| ||
LEKMLELDPDKRITAEEAMQHPYF

Kinase DDB0229296.AA ERK 293-416 36 1.2e-23 84.86 In-house 182-307 (307) Show / Hide
Range on Protein: 293-416
Range on HMM: 182-307/307
Sequence Identity: 36% (46 aa)

YRAPETIWRNTTYTTAIDVWNIGVIFGEMILGKRLFKTQDFEDHLISISKLIGNP-TAEDLSIVLSKSIFQYMEKIPKSTLTPSVGIKRRFKGAS--KDQ
||||| .  .. ||.|.|.| .|.|| ||. .| ||.  |  ...  | ..|| | . |||.   |.   .|  . |.    | .  . .|. |.  .. 
YRAPEIMLSWQKYTKAMDIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPN-PVRPPKPWENIFPNANCNPQA

IELLQGMLCWDPRKRMTIDQLLAHKYF
|.||. || .|| || |... |.| ||
IDLLEKMLVFDPDKRITVEECLEHPYF

Kinase DDB0229296.AA S_TKc 102-416 16 9.1e-20 72.91 SMART 1-231 (231) Show / Hide
Range on Protein: 102-416
Range on HMM: 1-231/231
Sequence Identity: 16% (55 aa)

INLKSITDCGPDGVMFRAKNEDSKEEVIVKKISVFLMKDDKMARKLLRNLLFQRHFQQHPLVSTFQSVFKRKSSENYLISNKNNRNNVRLPLLQQKGDDD
  .  .   |  |. ..... .....| .|.|.                                    ..  .|  . .. .  | |.|    |   |.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------------------------------EHIRREIQILKK-HHPNIVKLYDVFQD--DH

IYFEYLLPEF---TLLQMIHNKL-------LTEYNIMIFLYQLLTVVKFMHSAGVIHRDIDPSAITIDQNQCLKLTEFYFCFPSNCPVDLFFNDYDTSSF
.|.   . .    .|...|...        ..|  .  ..||..  ....|| |.||||. |. | .|.  ..|.. | ..            .    . 
LYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTP

IYRAPETIWRNTTYTT-AIDVWNIGVIFGEMILGKRLFKTQDFEDHLISISKLIGNPTAEDLSIVLSKSIFQYMEKIPKSTLTPSVGIKRRFKGASKDQI
 |.||| .     |.. ..|.| .|.|. ||. |. .|       ..  . |.||                                        |.. .
WYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG----------------------------------------SPEAK

ELLQGMLCWDPRKRMTIDQLLA-------HKYF
......|..||.||.|. ..|.       | .|
DFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase DDB0229296.AA Pkinase 293-416 26 1.1e-18 67.13 Pfam 177-293 (293) Show / Hide
Range on Protein: 293-416
Range on HMM: 177-293/293
Sequence Identity: 26% (34 aa)

YRAPETIWRNTTYTTAIDVWNIGVIFGEMILGKRLFKTQ----DFEDHLISISKLIGNPTAEDLSIVLSKSIFQYMEKIPKSTLTPSVGIKRRFKGASKD
|.||| |  .. |....|.| .|.|. ||..|. .|. .    .  |..  | .  | |. .| .   |.| |      . .        ... . .|..
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-----F-HWTF-HNWSEE

QIELLQGMLCWDPRKRMTIDQLLAHKYF
 .... ..||.|| || |..|.| |..|
CKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase DDB0229296.AA MAPK-Unclassified 293-416 26 1.1e-17 60.05 In-house 414-575 (575) Show / Hide
Range on Protein: 293-416
Range on HMM: 414-575/575
Sequence Identity: 26% (44 aa)

YRAPETIWRNTTYTTAIDVWNIGVIFGEMILG-----------KRLFKTQD--------------------FEDHLISISKLIGNPTAEDLSIVLSKSIF
||||| .  .  |.|..| | || ||.||..            . ||. ||                      | .  |    | |  ||.. . . |. 
YRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDCNFITCDSAR

QYMEKIPKSTLTPSVGIKRRFKGAS---------KDQIELLQGMLCWDPRKRMTIDQLLAHKYF
.| .   . |. .   .   |  |.          . | ..| ||  .|.|| |.||.| | ||
KYIQSFKCKTPVHFTDL--MFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF

Kinase DDB0229296.AA ERK7 199-269 37 5.6e-11 33.47 In-house 73-144 (292) Show / Hide
Range on Protein: 199-269
Range on HMM: 73-144/292
Sequence Identity: 37% (27 aa)

DDDIYFEYLLPEFTLLQMIH-NKLLTEYNIMIFLYQLLTVVKFMHSAGVIHRDIDPSAITIDQNQCLKLTEF
| |||  .   |  |   |   ..| .      .||||  .|.|||. |||||. || | .| .  .|.  |
DRDIYLVFEFMETDLHAVIRKGNILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDF

Kinase DDB0229296.AA Pkinase 114-251 18 2.4e-10 37.68 Pfam 13-134 (293) Show / Hide
Range on Protein: 114-251
Range on HMM: 13-134/293
Sequence Identity: 18% (28 aa)

GVMFRAKNEDSKEEVIVKKISVFLMKDDKMARKLL-RNLLFQRHFQQHPLVSTFQSVFKRKSSENYLISNKNNRNNVRLPLLQQKGDDDIY--FEYLLPE
|. ..... .. ..| ||.|..   |..|  .... . .   ... .|| . ..  .| .                          .|.||  .||.   
GCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------------------------KDHIYMVMEYCEGG

---FTLLQMIH---NKLL--TEYNIMIFLYQLLTVVKFMHSAGVIHRDI
   . |  .|.   .. .  .|  .  ..||.|  ....|| |.||||.
LYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDL

Kinase DDB0229296.AA MAPK-Unclassified 211-269 36 6.8e-10 31.44 In-house 93-153 (575) Show / Hide
Range on Protein: 211-269
Range on HMM: 93-153/575
Sequence Identity: 36% (22 aa)

FTLLQMIHNKL--LTEYNIMIFLYQLLTVVKFMHSAGVIHRDIDPSAITIDQNQCLKLTEF
| |.| |.  .  . .  | .|.||.|.  | .|||..||||  || . |.|.  ..   |
FDLHQIIKSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDF

Kinase DDB0229296.AA p38 213-256 40 4.9e-09 26.73 In-house 94-137 (289) Show / Hide
Range on Protein: 213-256
Range on HMM: 94-137/289
Sequence Identity: 40% (18 aa)

LLQMIHNKLLTEYNIMIFLYQLLTVVKFMHSAGVIHRDIDPSAI
| ...  . |..  | . .||.|   |. ||||.||||  || |
LNNIMKCQRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNI

Kinase DDB0229296.AA MAPK 210-254 43 5.6e-09 26.95 In-house 99-146 (328) Show / Hide
Range on Protein: 210-254
Range on HMM: 99-146/328
Sequence Identity: 43% (21 aa)

EFTLLQMIH-NKLLTEYNIMIFLYQLLTV--VKFMHSAGVIHRDIDPS
|  | | |. .. |..  |  |.||.|    .|..|||.|||||. ||
ETDLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPS

Kinase DDB0229296.AA ERK 230-254 60 1.6e-08 28.06 In-house 125-149 (307) Show / Hide
Range on Protein: 230-254
Range on HMM: 125-149/307
Sequence Identity: 60% (15 aa)

FLYQLLTVVKFMHSAGVIHRDIDPS
|.||.|  .|..|||.|||||. ||
FMYQILCGLKYIHSANVIHRDLKPS

Kinase DDB0229296.AA GSK 212-266 31 0.001535 6.02 In-house 98-158 (328) Show / Hide
Range on Protein: 212-266
Range on HMM: 98-158/328
Sequence Identity: 31% (19 aa)

TLLQMIH-----NKLLTEYNIMIFLYQLLTVVKFMHSAGVIHRDIDPSAITID-QNQCLKL
|| |.|.     .. .....| .. ||..   .. || |. |||| |. | .| ..  ||.
TLYQVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKI

Kinase DDB0229296.AA ERK1 102-136 37 0.216479 0.99 In-house 2-35 (289) Show / Hide
Range on Protein: 102-136
Range on HMM: 2-35/289
Sequence Identity: 37% (13 aa)

INLKSITDCGPDGVMFRAKNEDSKEEVIVKKISVF
.||. | . |  |..  |  .  |. | .|||| |
TNLQYIGE-GAYGMVCSAYDTVHKQRVAIKKISPF