Gene Dyrk1 (Slime mold)

Dyrk1

Species: Slime mold
Alias: Dyrk1, DDB0229429, DdisK063
External Links: DictyBase Link ,
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK1

Sequence

Name Sequence Type Origin Length Description Download
Dyrk1.AA Protein None 836 None Fasta, JSON
Dyrk1.kin_dom Protein Kinase Domain None 321 None Fasta, JSON

Protein domain

Protein domains of Dyrk1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
OmpH Dyrk1.AA OmpH 40-278 12 6e-06 22.84 Pfam 36-111 (165) Show / Hide 
Range on Protein: 40-278
Range on HMM: 36-111/165
Sequence Identity: 12% (31 aa)

QQAQQQAQQQAQQLQQQAQQQQHQLQQQQQLLQQQ----QQQQQQQQQQQQQQQQQQQQQQQQQQQYQ-QQHNNNINNNNNNSNINNKNNNNNNTNFNTS
..||.| .....|.|.. |. | .||..|| .|.|     . ..| |. ||. ||.||. ||.||||| |.                             
KDAQKQLEKEFKQWQAELQKMQKELQKEQQKYQKQIRAGTMSEEQRQKKQQEFQQKQQEFQQYQQQYQPQE-----------------------------

NNNNNTNNNSNNNSNNNNSNNNNNNNNINNINNININNKNNNNNNNNNNNINNINNNNNKNNNNNNNNNNNDDNNNINNNNSNNNNNNNNNNNNNNNNNN
                                                                                                    
----------------------------------------------------------------------------------------------------

NNNNNNNSNNNNNNNNLNNNNSNNNYNNNTTTTSSSNNNNNNKQ
                                        ..||
---------------------------------------MQQKQ
Kinase Dyrk1.AA DYRK1 304-624 71 1.6e-230 772.09 In-house 1-321 (321) Show / Hide 
Range on Protein: 304-624
Range on HMM: 1-321/321
Sequence Identity: 71% (231 aa)

FEIISSLGKGSFGQVVKAFDSVLKEYVAIKIIKNKVPFYNQALIEIRLLELMNNKDPEDQYKIIKLKHHFKFRNHLCIVTELLSYNLYDLLRNTHFHGVS
.||.|..|||||||||||.|.. .|||||||||||.||||||.||||||||||..|.|..|.|..||.||.||||||.|.||||||||||||||||.|||
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

LNLIKKFAHQILTALFFMSTPEVDVIHCDLKPENILLRNPKRSAIKIIDFGSSCHSNERMYKYIQSRFYRSPEILLELEYSFSIDMWSLGCILVEMHVGE
|||..|||.|..|||.||||||.|.||||||||||||.||||||||||||||||....|.|.|||||||||||.||..||...||||||||||||||.||
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGE

PLFSGQNEQDQLTKIIEVLDLPPSHMIDSSPKAKKFFTKDPINSTYQLKKNEKLKTNVEFCKKKLSEIIGVETGGPQSRRKNEPGHALVDYLKFLDLIEK
|||||.||.||..||.|||..||.||||..|||.|.|.|||.|..|..|...|.|...|.|..||.||.|||||||..|||.||||...||||| |||..
PLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDPDNTWYCKKTRDKKKHYKEPCTRKLHEILGVETGGPGGRRKGEPGHSVEDYLKFKDLIKR

MLIYDPQKRITPLEALQHSFF
||.|||..||||..|||||||
MLQYDPKQRITPYYALQHSFF
Kinase Dyrk1.AA DYRK 304-624 50 2e-186 625.64 In-house 1-320 (320) Show / Hide 
Range on Protein: 304-624
Range on HMM: 1-320/320
Sequence Identity: 50% (163 aa)

FEIISSLGKGSFGQVVKAFDSVLKEYVAIKIIKNKVPFYNQALIEIRLLELMNNKDPEDQYKIIKLKHHFKFRNHLCIVTELLSYNLYDLLRNTHFHGV-
.||.. .||||||||||..|   .|.||||||.|. .|..||.|||..||..|..||.|.| .......|..|||||||.||||.|||..|.|.||.|. 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

SLNLIKKFAHQILTALFFMSTPEVDVIHCDLKPENILLRNP-KRSAIKIIDFGSSCHSNERMYKYIQSRFYRSPEILLELEYSFSIDMWSLGCILVEMHV
||||..|||.||||.| |....| . ||||||||||.|..| ..|.||.|||||||. ..|.|.||||||||.||..| . |. .||||||||||.|.. 
SLNLVRKFAQQILTCLKFLHKNE-NIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFT

GEPLFSGQNEQDQLTKIIEVLDLPPSHMIDSS--PKAKKFFTKDPINSTYQLKKNEK-LKTNVEFCKKKLSEIIGVETGGPQSRRKNEPGHALVDYLKFL
|.|||.|.||.|||..|.||| .||..|||..  ....|||..      .......|  |.... .  |. .. . ....|..||. .|.|   |...|.
GWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC---FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQFK

DLIEKMLIYDPQKRITPLEALQHSFF
|.|.|.|..||.||||| .||||..|
DFIKKCLQWDPHKRITPSQALQHPWF
Kinase Dyrk1.AA DYRK2 304-624 41 1.9e-129 423.29 In-house 1-318 (318) Show / Hide 
Range on Protein: 304-624
Range on HMM: 1-318/318
Sequence Identity: 41% (137 aa)

FEIISSLGKGSFGQVVKAFDSVLKEYVAIKIIKNKVPFYNQALIEIRLLELMNNKDPEDQYKIIKLKHHFKFRNHLCIVTELLSYNLYDLLRNTHFHGVS
.|| . .||||||||||..|  .|..||||.| ||  | |||..||| |. .  .|.  .. .....  | ||||.||..|||| |||..... ||.| |
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

LNLIKKFAHQILTALFFMSTPEVDVIHCDLKPENILLRNPKRSAIKIIDFGSSCHSNE-RMYKYIQSRFYRSPEILLELEYSFSIDMWSLGCILVEMHVG
|.|. .|||.||..| | .  . ..||||||||||||. . || ||.|||||||  .. |.| ||||||||.||. | . |. .|||||.|||..|.  |
LQLVRRFAHSILQCLRFLH--KNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTG

EPLFSGQNEQDQLTKIIEVLDLPPSHMIDSS-----PKAKKFFTKDPINSTYQLKKNEKLKTNVEFCKKKLSEIIGVETGGPQSRRKNEPGHALVDYLK-
 ||| | ||.||.  ..||| .||....| .      ..| ||..  .        .   .. .....|.    ...    |.|.        ....|| 
YPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFEWYC--TFMTDHSMEIPKHYKNRHGKRRP----PGSKS-------WKSVLKG

-----FLDLIEKMLIYDPQKRITPLEALQHSFF
     |.| | . .  ||..|.|| .||.| ..
CEDENFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase Dyrk1.AA CMGC 304-624 22 1.1e-113 375.18 In-house 1-513 (513) Show / Hide 
Range on Protein: 304-624
Range on HMM: 1-513/513
Sequence Identity: 22% (117 aa)

FEIISSLGKGSFGQVVKAFD--------------SVLKEYVAIKIIKNKVPFYNQAL-------------IEIRLLELMNNK---------DPEDQYK--
.|||. .|.|..|.|.|..|                 .|.||||.|||.  . .||.              ||..|. .|..         ||... .  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IIKLKHHFKFRN-----------------HLCIVTELLSYNLYDLLRNTH--------------------------FHGVSLNLIKKFAHQILTA--LFF
|.||. .|...|                 ||..|.|.. ..||....|..                              .. .|. ...|||..  |..
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

MSTPEVDVIHCDLKPENILLRNPKRS------------------AIKIIDFGSSCHSNER------------------------MYKYIQSRFYRSPEIL
.     ..||.||||||||. . ...                   .||.|||.... ...                        .. |...|.||.||||
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LELE----------YSFSIDMWSLGCILVEMHVG--------EPLFSGQNE-----------QDQLTKIIEVLDLPPSHMIDS-------SPKAKKFFTK
|  .          |. .|||||.|||. ||  |        .||| |..|           .||| ||..||  |. .||..       ... ......
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNM

DP---------INSTYQLKKNEKLKTN--VEFCKKKLSEIIGVETGGPQSRRKNEPGHAL-------------------------------VDYLKFLDL
 .         ... .     .  .||   || .....  .   .  |.. .. .|.|                                  .  ...||
IKLPWYNKFPKKWN-W-----Q-TMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDL

IEKMLIYDPQKRITPLEALQHSFF
..|||.|||.||||. .|||| .|
LKKMLQYDPDKRITAEQALQHPYF
Kinase Dyrk1.AA YAK 304-540 43 2.6e-99 336.25 In-house 246-484 (347) Show / Hide 
Range on Protein: 304-540
Range on HMM: 246-484/347
Sequence Identity: 43% (106 aa)

FEIISSLGKGSFGQVVKAFDSVLKEYVAIKIIKNKVPFYNQALIEIRLLELMNNK-DPEDQY---KIIKLKHHFKFRNHLCIVTELLSYNLYDLLRNTHF
. .  .||.| ||||||      .| .|.|.|||.  .  ||  ||..|.. | . ||..     .|...   | ..||.|.| |.|| |||..| .. |
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

HGVSLNLIKKFAHQILTALFFMSTPEVDVIHCDLKPENILLRNPKRSAIKIIDFGSSCHSNERMYKYIQSRFYRSPEILLELEYSFSIDMWSLGCILVEM
.| | .||. .  ||| ..      .  .||||||||||.|..| . .||||||||||     .|.|||.|.||||||..   |. ||||||||||..| 
CGFSFQLIRQWTKQILDGMCVLE--NKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAEL

HVGEPLFSGQNEQDQLTKIIEVLDLPPSHMIDSSPKAKKFF
  | |.| |  | .|.. ||..|  ||| |||      |.|
FLGLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYF
Kinase Dyrk1.AA HIPK 304-624 35 9.1e-81 254.01 In-house 1-329 (329) Show / Hide 
Range on Protein: 304-624
Range on HMM: 1-329/329
Sequence Identity: 35% (117 aa)

FEIISSLGKGSFGQVVKAFDSVLKEYVAIKIIKNKVPFYNQALIEIRLLELMNNKDPEDQYKIIKLKHHFKFRNHLCIVTELLSYNLYDLLRNTHFHGVS
.|..  ||.| ||||||.     .| |||||.||   .  |  ||...|. . ...... |....    |. .|| |.| |.|  |||| ... .|    
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADE-YHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLP

LNLIKKFAHQILTALFFMSTPEVDVIHCDLKPENILLRNPKRSA--IKIIDFGSSCHSNERMYK-YIQSRFYRSPEILLELEYSFSIDMWSLGCILVEMH
|. |.    |.||||  .   |  .|| |||||||.|  |.|    .|.|||||  |  .   . |.|||.|| |||.| | .  ..|||||||.. | .
LKHIRPILQQVLTALMKLK--ELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELF

VGEPLFSGQNEQDQLTKIIEVLDLPPSHMIDSSPKAKKFF--TKDPINSTYQLKKNEKLKTNVEFCKKKLSEII------GVETGGPQSRRKNEPGHALV
 | ||. | .| ||   |..   ||  |.. .  |...||   |.   . ..||. |   ...    |..   |        |        . .     .
LGWPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRDKQSKFRPWRLKHIEEHEQQTSVKSKEARKYIFNCLDDMPEVNMLVDPERQDYRVEKI

DYLKFLDLIEKMLIYDPQKRITPLEALQHSFF
|.  | ..  ||.  |..|||||.|||.|.| 
DRREFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase Dyrk1.AA S_TKc 304-624 25 2e-77 264.45 SMART 1-231 (231) Show / Hide 
Range on Protein: 304-624
Range on HMM: 1-231/231
Sequence Identity: 25% (86 aa)

FEIISSLGKGSFGQVVKAFDSVLKEYVAIKIIKNKVPFYNQALIEIRLLELMNNKDPEDQYKIIKLKHHFKFRNHLCIVTELLSY---NLYDLLRNTHFH
.||.  .|||.||.| |. .   ...|||||||      .... ||..|.        .   |.||. .|   .||..|.|...    .|.|....   |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

G----VSLNLIKKFAHQILTALFFMSTPEVDVIHCDLKPENILLRNPKRSAIKIIDFGSSCHSNERMYKYIQSRFYRSPEILLELEYSF-SIDMWSLGCI
|     .   ......||. || ..   .  .||.||||||||| .     |||.|||....     . .. ...|..||.|    |.. ..|.||.|||
GLRFPFPE-HARFYMYQICCALEYCH--SHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

LVEMHVGEPLFSGQNEQDQLTKIIEVLDLPPSHMIDSSPKAKKFFTKDPINSTYQLKKNEKLKTNVEFCKKKLSEIIGVETGGPQSRRKNEPGHALVDYL
| || .|.|.|.   ..... |.|                                                                            
LYEMLCGYPPFP---QMQMMFKKIG-------------------------------------------------------------------------SP

KFLDLIEKMLIYDPQKRITPLEALQ-------HSFF
 ..|.|.|.| .||.||.|  ||||       | .|
EAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Dyrk1.AA Pkinase 304-624 24 1.5e-58 205.61 Pfam 1-293 (293) Show / Hide 
Range on Protein: 304-624
Range on HMM: 1-293/293
Sequence Identity: 24% (88 aa)

FEIISSLGKGSFGQVVKAFDSVLKEYVAIKIIKNKVPFYNQ---ALI--EIRLLELMNNKDPEDQYKIIKLKHHFKFRNHLCIVTELLSY-----NLYDL
..|.. .|.||||.| |. .    . ||.|||| .    ..   ..   ||...  .|         |..|.. |  ..|...|.|..        |.|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN------HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

LR---NTHFHGVSLNLIKKFAHQILTALFFM-STPEVDVIHCDLKPENILLRNPKRSAI----KIIDFGSSC---HSNERMYKYIQSRFYRSPEILL-EL
..   .. |   | . .|... ||| .| .. |     .||.||||||||.   ..  |    ||.|||...   ..|. |. .  ...|..||...   
ISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQ

EYSFSIDMWSLGCILVEMHVGEPLFSGQ----NEQDQLTKIIEVLDLPPSHMIDSS---PKAKKFFTKDPINSTYQLKKNEKLKTNVEFCKKKLSEIIGV
.|. ..||||.|||| ||  |.|.|.|.    |  ||. .| .... |..  .. .   .  . |.. .                               
YYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-----------------------------

ETGGPQSRRKNEPGHALVDY---LKFLDLIEKMLIYDPQKRITPLEALQHSFF
            . | .. .     ..|.|...| .||.||.|. ..||| .|
------------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Dyrk1.AA CDK 304-624 25 2.7e-54 172.03 In-house 1-284 (284) Show / Hide 
Range on Protein: 304-624
Range on HMM: 1-284/284
Sequence Identity: 25% (92 aa)

FEIISSLGKGSFGQVVKAFDSV-----LKEYVAIKIIK----------NKVPFYNQALIEIRLLELMNNKDPEDQYKIIKLKHHFKFR-----------N
.|..  .| |..|.| || |        ...||.| |.            .|.   |. || ||  . ..       |.||.  .              |
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPIT--AIREISLLKEL-HPN------IVKLHDVCHTKNMDRNNKDKHEN

HLCIVTELLSYNLYDLLRNTHFHGVSLNLIKKFAHQILTALFFMSTPEVDVIHCDLKPENILLRNPK---RSAIKIIDFGSSCHSNE------RMYKY--
 | .| | . . |. ...           || . .|.| .| ..      ..| |||| |||. |     .  .|| ||| ..  .        . .|  
KLYMVFEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNW--IMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTH

-IQSRFYRSPEILL-ELEYS--FSIDMWSLGCILVEMHV---GEPLFSGQNEQDQLTKIIEVLDLPPSHM---IDSSPKAKKFFTKDPINSTYQLKKNEK
 .  . ||.||.|| . .||   .|||||.|||..||     ..||| |..|.||| ||....  |   .   . . |                      
EVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY--------------------

LKTNVEFCKKKLSEIIGVETGGPQSRRKNEPGHALVDYLKFLDLIEKMLIYDPQKRITPLEALQHSFF
                                          ||..||| |||.|||.  .|||| .|
------------------------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase Dyrk1.AA DyrkP 304-543 35 3.4e-52 169.86 In-house 1-242 (323) Show / Hide 
Range on Protein: 304-543
Range on HMM: 1-242/323
Sequence Identity: 35% (86 aa)

FEIISSLGKGSFGQVVKAFDSVLKEYVAIKIIKNKVPFYNQALIEIRLLELMNNKDPEDQYKIIKLKHHFKFRNHLCIVTELLSYNLYDLLR----NTHF
. |.  ||   | . ..  | .    . .||| |   .. |.. ||.||  .|     |   ...    |  . || |.||||  |||.  .    |   
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQQ

HGVSLNLIKKFAHQILTALFFMSTPEVDVIHCDLKPENILLRNPKRSAIKIIDFGSSCHSNERMYKYIQSRFYRSPEILLELEYSFSIDMWSLGCILVEM
    .  ..|   ||| || ..    . .|||||||||||..   .  .|||||||||   . .  |.||| || ||...   | . |||||||||| |.
RYFTVGRLQKITQQILIALDYIHS--LRLIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAEL

HVGEPLFSGQNEQDQLTKIIEVLDLPPSHMIDSSPKAKKFFTKD
  |  ||   | |  | ..| ..   |  |.      . |||..
WTGNVLFQNDNIQGLLARVIGIIGPFPEWMMQEGRLVQNFFTRK
Kinase Dyrk1.AA PRP4 304-509 34 1.8e-48 167.31 In-house 1-208 (320) Show / Hide 
Range on Protein: 304-509
Range on HMM: 1-208/320
Sequence Identity: 34% (72 aa)

FEIISSLGKGSFGQVVKAFDSVLKE-YVAIKIIKNKVPFYNQALIEIRLLELMNNK--DPEDQYKIIKLKHHFKFRNHLCIVTELLSYNLYDLLRN-THF
.....  |.| |. |... |       |||||| |.   .   | |.  |  .|..  |..| . ..... ||..|.|.|.| | .| || ..|      
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

HGVSLNLIKKFAHQILTALFFMSTPEVDVIHCDLKPENILLRNPKRSAIKIIDFGSSCHSNER-MYKYIQSRFYRSPEILLELEYSFSIDMWSLGCILVE
 | .|. .  .| |.. ||  .     . .| |.|| |||  |  .. .|..||||  | .|  . .| .|||||.|||..  .|  .||||| || | |
VGLHLKAVRSYAQQLFLALKHLK--KCNILHADIKPDNILV-NESKNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYE

MHVGEPLFSGQ
.  |  .|.|.
LYTGKIMFPGK
Kinase Dyrk1.AA CLK 304-440 32 3.2e-43 126.99 In-house 153-299 (350) Show / Hide 
Range on Protein: 304-440
Range on HMM: 153-299/350
Sequence Identity: 32% (49 aa)

FEIISSLGKGSFGQVVKAFDSVL-KEYVAIKIIKNKVPFYNQALIEIR-LLELMNNK-DPEDQYK--IIKLKHHFKF-RNHLCIVTELLSYNLYDLLRNT
.||.. || | || ||.  |.   | |||.|||.|   .  .| .||.  ..  |.| ||. .|   ..|.   |..  .| |||.||.  ..||... .
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

H------FHGVSLNLIKKFAHQILTALFFMSTPEVDVIHCDLKPENILL
.      . .  .. |...|.|...|. |.   ..  .| |||||||..
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLH--DMKLTHTDLKPENICF
Kinase Dyrk1.AA CLK 441-543 30 8.8e-23 64.5 In-house 179-288 (350) Show / Hide 
Range on Protein: 441-543
Range on HMM: 179-288/350
Sequence Identity: 30% (34 aa)

RNPKRSAIKIIDFGSSC---HSNERMYKYIQSRFYRSPEILLELEYSFSIDMWSLGCILVEMHVGEPLFSGQNEQDQLTKIIEVLDLP-PSHMIDSSP--
. .|   |..|||||       .|  .  ...| || ||. |.| .|.  | || ||||.|  .|. || . .. . |  . ... .| |..|| ..   
WHVKNTHICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRF

-KAKKFFTKD
   .|.| ..
KVKQKYFYHN
Kinase Dyrk1.AA CLK 596-624 65 2.7e-16 44.69 In-house 322-350 (350) Show / Hide 
Range on Protein: 596-624
Range on HMM: 322-350/350
Sequence Identity: 65% (19 aa)

KFLDLIEKMLIYDPQKRITPLEALQHSFF
.. |||.|||.||| ||||  .|||| ||
QLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase Dyrk1.AA PRP4 597-624 57 2.2e-12 41.74 In-house 293-320 (320) Show / Hide 
Range on Protein: 597-624
Range on HMM: 293-320/320
Sequence Identity: 57% (16 aa)

FLDLIEKMLIYDPQKRITPLEALQHSFF
| ||..|.|. ||.||||. |||.|.|.
FKDLLDKCLMLDPKKRITCNEALKHPFI
Kinase Dyrk1.AA TyrKc 304-624 16 8.4e-10 -64.14 SMART 1-280 (280) Show / Hide 
Range on Protein: 304-624
Range on HMM: 1-280/280
Sequence Identity: 16% (58 aa)

FEIISSLGKGSFGQVVKAFDSVLKEYVAIKIIKNKVPFYNQALI-EIRLLELM--NNKDPEDQYKIIKLKHHFKFR-------NHLCIVTELLSY-NLYD
 . .  || | ||.|.|.  .   . ||.| .|.      .... |.|..     ...       |..|                |.||.|. .. .| |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHP------NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

LLRNTHFHGVSLNLIKKFAHQILTALFFMSTPEVDVIHCDLKPENILLRNPKRSAIKIIDFGSSCHSNER-------MYKYI----QSR-----FYRSPE
 ||... . ...    .|..||     . .  .  .|| ||   |.|. ...   .|| ||| |    .         |.      ...        .||
YLRKHRPK-LCMKDLLSFCWQIACGMEYLH--SKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

ILLELEYSFSIDMWSLGCILVEM-HVGEPLFSGQ----NEQDQLTKIIEVLDLPPSHMID---SSPKAKKFFTKDPINSTYQLKKNEKLKTNVEFCKKKL
 . . ....  | || |  . |.   |..  .|.     . ... . ..  . .|    |   |                                    
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------------------------

SEIIGVETGGPQSRRKNEPGHALVDYLKFLDLIEKMLIYDPQKRITPLEALQHSFF
                           .  .....   .|| .| |  |   |..|
---------------------FVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase Dyrk1.AA YAK 597-624 39 1.9e-05 14.06 In-house 320-347 (347) Show / Hide 
Range on Protein: 597-624
Range on HMM: 320-347/347
Sequence Identity: 39% (11 aa)

FLDLIEKMLIYDPQKRITPLEALQHSFF
|.|.|  .|  .| .| .|  | || | 
FIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase Dyrk1.AA DyrkP 597-624 42 0.000728 7.85 In-house 296-323 (323) Show / Hide 
Range on Protein: 597-624
Range on HMM: 296-323/323
Sequence Identity: 42% (12 aa)

FLDLIEKMLIYDPQKRITPLEALQHSFF
|.| . ..|  |  .| |  ||||| .|
FIDFVRQCLQIDFTRRPTAKEALQHPWF