Gene YakA (Slime mold)

YakA

Species: Slime mold
Alias: DdisK066, YakA, DDB0191191, dagB
External Links: DictyBase Link ,
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: YAK

Sequence

Name Sequence Type Origin Length Description Download
YakA.AA Protein None 1458 None Fasta, JSON
YakA.kin_dom Protein Kinase Domain None 344 None Fasta, JSON

Protein domain

Protein domains of YakA.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase YakA.AA YAK 205-548 63 5.5e-293 979.61 In-house 1-347 (347) Show / Hide 
Range on Protein: 205-548
Range on HMM: 1-347/347
Sequence Identity: 63% (222 aa)

YKVLDSLGQGTFGQVVKCKNCDTDELVAIKILKNKQAYFQQGRLEIQTLKSLNDQHDPEDKN---HILRLLDSFIHKMHLCIVFELLSVNLFELIKQNNF
|.|||.||||||||||||.||||.||.|.|..||.||||||...|||.|..||.||||..||   ||||..|.|.||.|.|.|||.||.||.|..|||.|
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

RGLSTNLIKVFLIQILDALIVLANANIIHCDLKPENILLQNVNSPAIKIIDFGSACYEKSTLYTYIQSRHYRSPEVLVGTVYCASIDMWSLGCISAELFL
.|.|..||.....||||...||.|..|||||||||||.|...|.|.||||||||.|.||...|||||.|||||||..|...||.||||||||||.|||||
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFL

GLPLFPGNSEYNQISRIVEMRGIFPSDLLDKGKSSTRYFHRHLGSNSDDNNNNNNNNNGKPYYYTLKSEEDYQRDSKTTLLPSKKYFNYKTLPEIIQNYG
|||.||||||||||.||..|.|..||...|.|.....|||.|.|||||||||||||||||||||..|...|||.|.|..|..||.||.||.|..|.....
GLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYFHCHDGSNSDDNNNNNNNNNGKPYYYIFKTKQDYQIDEKIQLKESKTYFQYKCLNDIKNYMY

FKKSMSPQDIEKEKQHRIVFTDFINGLLQLDPNERWSPMQAKEHPFI
||..|..||..|...||..|.||||.||||.|.|||.||||..||||
FKQFMRNQDDTKNNRHRDCFIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase YakA.AA DYRK 205-548 41 1.3e-173 583.09 In-house 1-320 (320) Show / Hide 
Range on Protein: 205-548
Range on HMM: 1-320/320
Sequence Identity: 41% (146 aa)

YKVLDSLGQGTFGQVVKCKNCDTDELVAIKILKNKQAYFQQGRLEIQTLKSLNDQHDPEDKNHILRLLDSFIHKMHLCIVFELLSVNLFELIKQNNFRGL
|..|. .|.|.|||||||... |.|.|||||..|......|.  ||. |. ||.| ||.|| |.....|.|.|..|||||||||| ||.|..|.|.|.|.
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQ-DPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGF

-STNLIKVFLIQILDALIVLANA-NIIHCDLKPENILLQNV-NSPAIKIIDFGSACYEKSTLYTYIQSRHYRSPEVLVGTVYCASIDMWSLGCISAELFL
 | ||...|. |||..| .|..  ||||||||||||.|..  | ..||.|||||.|.|. ..|||||||.||.|||..|. || .||||||||| ||||.
FSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFT

GLPLFPGNSEYNQISRIVEMRGIFPSDLLDKG--KSSTRYFHRHLGSNSDDNNNNNNNNNGKPYYYTLKSEEDYQRDSKTTLLPSKKYFNYKTLPEIIQN
| |||||..||.|. .|.|..|..|....|||  .  ...| .                           . .........  ....|...|. |. . .
GWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC--------------------------FMYCECDEWTKQNKITDHYMTPKCHPTKR-G

YGFKKSMSPQDIEKEKQHRIVFTDFINGLLQLDPNERWSPMQAKEHPFI
..  ......| ... .... |.|||...||.||..|..|.|| .||..
QRRPPGRRNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase YakA.AA CMGC 205-548 21 4.7e-110 362.98 In-house 1-513 (513) Show / Hide 
Range on Protein: 205-548
Range on HMM: 1-513/513
Sequence Identity: 21% (118 aa)

YKVLDSLGQGTFGQVVKCKN--------------CDTDELVAIKILKNKQAYFQQGR-------------LEIQTLKSLNDQHDPED-----------KN
|.... .|.||.|.|.||..              ..|.|.||||..||.. |  |..              ||. || ||..||| .           .|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

HILRLLDSFIHKM-----------------HLCIVFELLSVNLFELIKQNN--------------------------FRGLSTNLIKVFLIQILDALI--
.|..|.|.| ||                  ||..|||..  .|...||.|.                           . ..  .|. .  ||| .|   
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

VLANAN--IIHCDLKPENILLQNVNS------------------PAIKIIDFGSACYEKST------------------------LYTYIQSRHYRSPEV
 .  ..  |||.||||||||. . .                     .||.|||.|... .                         ...|...|.||.||.
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

LVG----------TVYCASIDMWSLGCISAELFLG--------LPLFPGNSE-----------YNQISRIVEMRGIFPSDLLDKGKSS------TRYFHR
|.|          . |. .|||||.||| ||...|         |||||.||           ..|. .|... | ..  ...|||..      .. .  
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPN

HLG--------------------SNSDDNNNNNNNNNGKPYYYTLKSEEDYQRDSKT-------------TLLPSKKYFNYKTLPEIIQNYGFKKSMSPQ
...                    | .  |  ..||. ..... ..|. .  ...  .                .|  .||                   .
MIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSH-KFN-------------------H

DIEKEKQHRIVFTDFINGLLQLDPNERWSPMQAKEHPFI
 ..|.|.    . |.....||.||..|... || .||..
-QFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase YakA.AA DYRK2 205-440 46 1.1e-100 328.2 In-house 1-240 (318) Show / Hide 
Range on Protein: 205-440
Range on HMM: 1-240/318
Sequence Identity: 46% (112 aa)

YKVLDSLGQGTFGQVVKCKNCDTDELVAIKILKNKQAYFQQGRLEIQTLKSLNDQHDPEDKNHILRLLDSFIHKMHLCIVFELLSVNLFELIKQNNFRGL
| .|  .|.| |||||||    |...||||.. ||. . .|   ||. |. .  ..|.     . ..||.|.   |.||.|||||.|| |.||.|.| |.
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIR-RQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGF

STNLIKVFLIQILDALIVLANANIIHCDLKPENILLQNVNSPAIKIIDFGSACYEKS-TLYTYIQSRHYRSPEVLVGTVYCASIDMWSLGCISAELFLGL
| .|.  |  .|| .|  |   ||||||||||||||   |   ||.||||| |.|.   .||||||| ||.||| .|. |  .|||||.||| |||. | 
SLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGY

PLFPGNSEYNQISRIVEMRGIFPSDLLDKG----KSSTRYF
|||||  |  |.  . |  |. |....|.     .. ..||
PLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYF
Kinase YakA.AA HIPK 205-548 38 5.2e-96 302.86 In-house 1-329 (329) Show / Hide 
Range on Protein: 205-548
Range on HMM: 1-329/329
Sequence Identity: 38% (133 aa)

YKVLDSLGQGTFGQVVKCKNCDTDELVAIKILKNKQAYFQQGRLEIQTLKSLNDQHDPEDKNHILRLLDSFIHKMHLCIVFELLSVNLFELIKQNNFRGL
| ||. ||.|||||||||    |.|.||||||||   |  ||. |.. |. | ..    |  |..| .. | || | |.|||.|  ||..  |||.|  |
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQEN--ADEYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPL

STNLIKVFLIQILDALIVLANANIIHCDLKPENILL-QNVNSP-AIKIIDFGSACYE-KSTLYTYIQSRHYRSPEVLVGTVYCASIDMWSLGCISAELFL
  . |.  | |.| ||. | .  .|| |||||||.|   .  |  .|.|||||| .  |    ||.|||.|| ||...|  .| ..|||||||. |||||
PLKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFL

GLPLFPGNSEYNQISRIVEMRGIFPSDLLDKGKSSTRYFHRHLGSNSDDNNNNNNNNNGKPYYYTLKSEEDYQRDSKTTLLPSKKYFNYKTLPEIIQNYG
| ||.||..||.||  | .  .     || ..  ..|.|.|                . |  .. ||  |..  ..   ..  .||  .  | .. ..  
GWPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRD--------------KQSKFRPWRLKHIEEHEQQTSVKSKEARKYI-FNCLDDMPEVN-

FKKSMSPQDIEKEKQHRIVFTDFINGLLQLDPNERWSPMQAKEHPFI
      .||   ||  |  | .    .. .|...| .|..| .|||.
MLVDPERQDYRVEKIDRREFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase YakA.AA DYRK1 205-442 48 3.2e-94 319.31 In-house 1-239 (321) Show / Hide 
Range on Protein: 205-442
Range on HMM: 1-239/321
Sequence Identity: 48% (116 aa)

YKVLDSLGQGTFGQVVKCKNCDTDELVAIKILKNKQAYFQQGRLEIQTLKSLNDQHDPEDKNHILRLLDSFIHKMHLCIVFELLSVNLFELIKQNNFRGL
|..  ..|.| ||||||     . |.|||||.|||.....| ..||. |  .| .||.|.| .|..|   |... |||.|||||| ||..|..  .||| 
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMN-KHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGV

STNLIKVFLIQILDALIVLA--NANIIHCDLKPENILLQNVNSPAIKIIDFGSACYEKSTLYTYIQSRHYRSPEVLVGTVYCASIDMWSLGCISAELFLG
| ||.. |  |.. ||. ..    .||||||||||||| |    |||||||||.|     .| ||||| |||||||.|. |  .|||||||||  |.  |
SLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTG

LPLFPGNSEYNQISRIVEMRGIFPSDLLDKGKSSTRYFHR
 ||| | .|  |...|||. |. |....|..  . .||..
EPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEK
Kinase YakA.AA S_TKc 205-548 24 4.3e-82 279.96 SMART 1-231 (231) Show / Hide 
Range on Protein: 205-548
Range on HMM: 1-231/231
Sequence Identity: 24% (87 aa)

YKVLDSLGQGTFGQVVKCKNCDTDELVAIKILKNKQAYFQQGRLEIQTLKSLNDQHDPEDKNHILRLLDSFIHKMHLCIVFELLSV---NLFELIKQNNF
|..|. .|.|.||.| ||.. .|...|||||.|      .. | ||| ||.        .  .| .|.|.| .  ||..|.|...    .||..||... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK--------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

RG----LSTNLIKVFLIQILDALIVLANANIIHCDLKPENILLQNVNSPAIKIIDFGSACYEKSTLYTYIQSRHYRSPEVLVGTVYCA-SIDMWSLGCIS
.|    ..   .. .. ||..||  . . .|||.||||||||| .     |||.|||.|.      .|.. ...|..||||    |   ..|.||.||| 
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

AELFLGLPLFPGNSEYNQISRIVEMRGIFPSDLLDKGKSSTRYFHRHLGSNSDDNNNNNNNNNGKPYYYTLKSEEDYQRDSKTTLLPSKKYFNYKTLPEI
.|.. | |.||   ..... ...                                                                             
YEMLCGYPPFP---QMQMMFKKIG----------------------------------------------------------------------------

IQNYGFKKSMSPQDIEKEKQHRIVFTDFINGLLQLDPNERWSPMQAKE-------HPFI
                        . |||...|| ||..|..  .| .       ||..
---------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase YakA.AA Pkinase 205-548 25 2.8e-64 224.65 Pfam 1-293 (293) Show / Hide 
Range on Protein: 205-548
Range on HMM: 1-293/293
Sequence Identity: 25% (96 aa)

YKVLDSLGQGTFGQVVKCKNCDTDELVAIKILKNKQAYFQQGRL-----EIQTLKSLNDQHDPEDKNHILRLLDSFIHKMHLCIVFELLSV-----NLFE
|...  .|.|.||.| ||.. .| ..||.||.| . .  .. .      ||| .|.||  |.     .|.||.|.|  | |...|.|..        ||.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN--HP-----NIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD

LIK---QNNFRGLSTNLIKVFLIQILDALIVLANANIIHCDLKPENILLQNVNSP--AIKIIDFGSAC---YEKSTLYTYIQSRHYRSPEVLV-GTVYCA
.|.   ...|  .| . .| .. ||| .|  . . .|||.||||||||. | . .   .||.|||.|.   | .....|.  ...|..|||.  |. |  
YISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGP

SIDMWSLGCISAELFLGLPLFPGN----SEYNQISRIVEMRG---IFPSDLLDKGK--SSTRYFHRHLGSNSDDNNNNNNNNNGKPYYYTLKSEEDYQRD
..||||.||| .|...| |.|||     . ..|. .|.. .|    |... .. .   . .|.   |                                 
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---------------------------------

SKTTLLPSKKYFNYKTLPEIIQNYGFKKSMSPQDIEKEKQHR--IVFTDFINGLLQLDPNERWSPMQAKEHPFI
                                 . .... |.    . |||...|..||..|....|...||..
---------------------------------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase YakA.AA PRP4 205-440 36 2.4e-63 216.75 In-house 1-239 (320) Show / Hide 
Range on Protein: 205-440
Range on HMM: 1-239/320
Sequence Identity: 36% (87 aa)

YKVLDSLGQGTFGQVVKCK-NCDTDELVAIKILKNKQAYFQQGRLEIQTLKSLNDQ-HDPEDKNHILRLLDSFIHKMHLCIVFELLSVNLFELIKQN-NF
|.|    ||| |. |..|. .  . | |||||. |.    . |  |.  |. |||.  |..|| |..|. ..| |. |.|.||| .| || |..|.    
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

RGLSTNLIKVFLIQILDALIVLANANIIHCDLKPENILLQNVNSPAIKIIDFGSACY-EKSTLYTYIQSRHYRSPEVLVGTVYCASIDMWSLGCISAELF
 ||. . . ..  |.. ||  | . ||.| |.|| |||  | .   .|..|||||   . . .  | .|| ||.||...|  | ..||||| ||  .||.
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNILV-NESKNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELY

LGLPLFPGNSEYNQISRIVEMRGIFPSDLLDKGKSSTRYF
 |  .||| .    .  . ...| .|  .. ||.    .|
TGKIMFPGKTNNHMLKLFMDYKGKMPNKMIRKGQFKDNHF
Kinase YakA.AA CDK 205-548 23 1.2e-59 189.42 In-house 1-284 (284) Show / Hide 
Range on Protein: 205-548
Range on HMM: 1-284/284
Sequence Identity: 23% (91 aa)

YKVLDSLGQGTFGQVVKCKNCDTD-----ELVAIKILKNKQ---AYFQQGRL-----EIQTLKSLNDQHDPEDKNHILRLLDSFIHK-----------MH
|. |. .|.||.|.| |... .|.     ..||.| ..  .        |       || .|| |   |.     .| .|.| ...|             
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL---HP-----NIVKLHDVCHTKNMDRNNKDKHENK

LCIVFELLSVNLFELIKQNNFRGLSTNLIKVFLIQILDALIVLANANIIHCDLKPENILLQNVNSPA---IKIIDFGSACYE--------KSTLYT-YIQ
| .||| .   | ....           || .. |.|..|  .   .|.| |||| |||. |  ..    .|| ||| |.          ..  ||  . 
LYMVFEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVV

SRHYRSPEVLV-GTVYC--ASIDMWSLGCISAELFL---GLPLFPGNSEYNQISRIVEMRGIFPSDLLDKGKSSTRYFHRHLGSNSDDNNNNNNNNNGKP
 . ||.||.|   . |    .|||||.||| ||.|.   . |||||.|| .|. .| .. |    |     ..   |                       
TLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-----------------------

YYYTLKSEEDYQRDSKTTLLPSKKYFNYKTLPEIIQNYGFKKSMSPQDIEKEKQHRIVFTDFINGLLQLDPNERWSPMQAKEHPFI
                                                            |..|..|..||. |.|  || .||. 
------------------------------------------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase YakA.AA DyrkP 205-443 39 4e-54 176.34 In-house 1-242 (323) Show / Hide 
Range on Protein: 205-443
Range on HMM: 1-242/323
Sequence Identity: 39% (95 aa)

YKVLDSLGQGTFGQVVKCKNCDTDELVAIKILKNKQAYFQQGRLEIQTLKSLNDQHDPEDKNHILRLLDSFIHKMHLCIVFELLSVNLFELIKQN----N
|.... ||   | . ..|.   |. .. .||. | . || |   ||. |. .|   | ..|| .||  | | || || |. |||  ||.|  | |     
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKN-VLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQ

FRGLSTNLIKVFLIQILDALIVLANANIIHCDLKPENILLQNVNSPAIKIIDFGSACYEKSTLYTYIQSRHYRSPEVLVGTVYCASIDMWSLGCISAELF
 |      ..    ||| ||  .    .|||||||||||..      .|||||||.|.    |  |.||| || |||..|  |   ||||||||| |||.
QRYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELW

LGLPLFPGNSEYNQISRIVEMRGIFPSDLLDKGKSSTRYFHRH
 |  ||        . |.. . | ||  ..  |.    .| |.
TGNVLFQNDNIQGLLARVIGIIGPFPEWMMQEGRLVQNFFTRK
Kinase YakA.AA CLK 205-340 32 2.7e-48 142.47 In-house 1-147 (350) Show / Hide 
Range on Protein: 205-340
Range on HMM: 1-147/350
Sequence Identity: 32% (48 aa)

YKVLDSLGQGTFGQVVKCKNCDT-DELVAIKILKNKQAYFQQGRLEIQ-TLKSLNDQHDPEDKNH--ILRLLDSFIH-KMHLCIVFELLSVNLFELIKQN
|.... ||.|||| ||.|.     . .||.|| .|   |  . ..||.  .|..|  |||. |.   .....|.| . . | ||||||.  ......| |
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

N------FRGLSTNLIKVFLIQILDALIVLANANIIHCDLKPENILL
|      ....  . |...  |.. |.  |    ..| |||||||..
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICF
Kinase YakA.AA CLK 341-411 37 2.5e-21 60.04 In-house 179-252 (350) Show / Hide 
Range on Protein: 341-411
Range on HMM: 179-252/350
Sequence Identity: 37% (28 aa)

QNVNSPAIKIIDFGSAC---YEKSTLYTYIQSRHYRSPEVLVGTVYCASIDMWSLGCISAELFLGLPLFPGNSE
. | .. |..||||||    ...   .| ...|||| |||  |  .    | || |||  || .|  ||.....
WHVKNTHICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDN
Kinase YakA.AA TyrKc 205-528 15 2.4e-08 -87.74 SMART 1-280 (280) Show / Hide 
Range on Protein: 205-528
Range on HMM: 1-280/280
Sequence Identity: 15% (57 aa)

YKVLDSLGQGTFGQVVKCKNCDTDELVAIKILKNKQAYFQQGRLEIQTLKSL--NDQHDPEDKNHILRLLDSFIHK-------MHLCIVFELLSV-NLFE
 . .. || | ||.|.|..     . ||.| ||.     .  . |.. ...|  . .       .|.||.   ...         |.||.|. .  .| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHP-------NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

LIKQNNFRGLSTNLIKVFLIQILDALIVLANANIIHCDLKPENILLQNVNSPAIKIIDFGSACYEKST-------LYTYI----QSR-----HYRSPEVL
 .. .  . |..     | .|| .    |.  |.|| ||   |.|. . .   .|| ||| . . ..         |       ...        .||..
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

VGTVYCASIDMWSLGCISAELF-LGLPLFPG-----NSEYNQISRIVEMRGIFPSDL----LDKGKSSTRYFHRHLGSNSDDNNNNNNNNNGKPYYYTLK
   ..    | || |    |.| .| .  ||      | .  | .. . .   . .                                            
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------------------

SEEDYQRDSKTTLLPSKKYFNYKTLPEIIQNYGFKKSMSPQDI--------EKEKQHRIVFTDFINGL
                                 |     |...        . .   |  |.. .  .
---------------------------------F--VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase YakA.AA PRP4 509-548 34 4.6e-08 25.68 In-house 280-320 (320) Show / Hide 
Range on Protein: 509-548
Range on HMM: 280-320/320
Sequence Identity: 34% (14 aa)

QDIEKEKQHRIV-FTDFINGLLQLDPNERWSPMQAKEHPFI
| | .. . ..  | |.. ..|.|||  | .. .| .||||
QRIPEDQMKKVHQFKDLLDKCLMLDPKKRITCNEALKHPFI
Kinase YakA.AA DYRK2 521-548 50 8.9e-07 17.71 In-house 291-318 (318) Show / Hide 
Range on Protein: 521-548
Range on HMM: 291-318/318
Sequence Identity: 50% (14 aa)

FTDFINGLLQLDPNERWSPMQAKEHPFI
|.|||   .. || || .| || .||.|
FIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase YakA.AA DYRK1 521-548 42 1.7e-05 14.7 In-house 294-321 (321) Show / Hide 
Range on Protein: 521-548
Range on HMM: 294-321/321
Sequence Identity: 42% (12 aa)

FTDFINGLLQLDPNERWSPMQAKEHPFI
| | |  .|| ||..| .|..| .|.|.
FKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase YakA.AA DyrkP 520-548 34 0.000561 8.23 In-house 295-323 (323) Show / Hide 
Range on Protein: 520-548
Range on HMM: 295-323/323
Sequence Identity: 34% (10 aa)

VFTDFINGLLQLDPNERWSPMQAKEHPFI
.| ||.  .||.|   | .   | .||..
MFIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase YakA.AA Pkinase_Tyr 205-239 33 0.000796 13.58 Pfam 1-39 (270) Show / Hide 
Range on Protein: 205-239
Range on HMM: 1-39/270
Sequence Identity: 33% (13 aa)

YKVLDSLGQGTFGQVVKCKNC----DTDELVAIKILKNK
 . .  ||.| ||.|.|..      .|.  ||.|.||..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEG
Kinase YakA.AA CLK 501-548 35 0.002684 4.94 In-house 308-350 (350) Show / Hide 
Range on Protein: 501-548
Range on HMM: 308-350/350
Sequence Identity: 35% (17 aa)

GFKKSMSPQDIEKEKQHRIVFTDFINGLLQLDPNERWSPMQAKEHPFI
..|..|...| |    ||. | | |  .|  ||. | .  .|  ||| 
PLKQYMDCKDPE----HRQLF-DLIRKMLEYDPSKRITCKDALQHPFF