DDB0219793e

Species: Slime mold
Alias: DDB0219793e, DdisK120, FLIPPER
External Links: DictyBase Link ,
Annotation:

Classification

Group: Other
Family: PEK
Subfamily: PEK

Sequence

Name Sequence Type Origin Length Description Download
DDB0219793e.AA Protein None 962 None Fasta, JSON
DDB0219793e.kin_dom Protein Kinase Domain None 755 None Fasta, JSON

Protein domain

Protein domains of DDB0219793e.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DDB0219793e.AA PEK 83-837 53 0.0 1635.42 In-house 1-758 (758) Show / Hide
Range on Protein: 83-837
Range on HMM: 1-758/758
Sequence Identity: 53% (410 aa)

FCEIEKVGKGGYGSVFKVKNKLDGEYYALKKIPFKN-------TTKTFLEKVLREVKTLASLNHRNIVRYHSAWLETEELLPPSSSMASTSLSTSNGKQI
|..|...|.||.|.||..|||.|...||.|.|.|.|       ......|||.|||.|||.|.|.|||||..|||||.|||||...|.|||.||.|||||
FEHIQCLGHGGFGVVFRAKNKVDMNNYAIKRITFPNSNNQSPTNRESAREKVMREVRTLAMLDHHNIVRYFNAWLETPELLPPNNKMRSTSFSTVNGKQI

DSDIKNIIYNNHLLFDGNWGTTSEEASYLNESDNPCNRRVNKAKKKVSPQKKKNVNNNNNNSKKKALDQSGAGDDNDDDISSSSSSSSSSSSDDSLYKLQ
||...|.|||||..||||||....|..|.||.||||||.|||..||......|..|||..|..||.|.|.......|||||...........|.|.||.|
DSNNDNDIYNNHFFFDGNWGQDEDEDEYENEDDNPCNRFVNKIPKKWQEKMDKCWNNNISNNWKKKLHQLKYPFKMDDDISFIRNMDQTMQNDQSRYKMQ

FPHDEDFKQFNKQTSIRESMINSSRFKKSYDDSDDSNDVSSNGVGFFKTPKKHYTSFSLDDGSDEESDEDDSQGFDDTNRSTMTNIQNDTDTESFNHSRH
..||..||.||||..|||.|.|||..|.||.|.|||||..||.|.||.||||.|.|.|....|......|..|...|.|..||.|.|....|..|.|..|
YSHDPFFKKFNKQIIIREPMRNSSFSKESYCDQDDSNDIYSNEVDFFFTPKKCYFSESQFMPSEFSGTDDEEQSWMDSNNDTMYNAQQKCMTKCFGHHKH

RRSFSSSEGEEETDDDSLSESDSDYSGVFENNDDLIPNPSSIPTSTTPPISMPPKQYQQQQQQQQQKSQPPSLRSSLTQNNSLLKPSINNNNNNNNNNNN
...||....||.|..|..||....|||.|.||...|...||.........||..||.||||.|.||..|..|...|...||.||....||||||||||||
MMDFSKDNKEEHTFFDCPSEASDYYSGSFSNNSSIIFEDSSCEDNKPKEYSMSTKQHQQQQCQNQQTNQKCSSSKSCMENNWLLTSHHNNNNNNNNNNNN

KNNIVSPKINRITTLFIVMQLYSQTLSQWLENR-PPDQVNEEENLNIFKQICIGLRYIHSKGIIHRDLKPGNVFLVREEDHHQQSSFSNISSSFEENSDG
||....|..|.|............||..|..|| ..........|..|.|||.|..||||||.|||||||.|.|......||||||||||||||||||||
KNWKMHPTGNCIYMYIQMQLCRKETLKDWMRNRCTMESRPWMHMLHWFHQICEGVNYIHSKGMIHRDLKPSNIFFSMDSQHHQQSSFSNISSSFEENSDG

GGLLVSLGDFGLAVQHTIVSSTPSPTPTSTPSLTPVNSHISPIDQIININQQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQXXXXXXXXXXTVSLSSS
|......|||||...||||..||.|||..|||.||.|.||.|||||||||||.||||||||||||||||||||||||||||||          |.|.|.|
GHQIIKIGDFGLVTDHTIVTPTPTPTPNNTPSTTPINTHITPIDQIININQQPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ----T-TIT-TISVSPS

SSSSILTPPISSMQQQHQQQPPPLQTTSPTGQSQQSIPSTPSSLSSSSTTPSVSTGTSLSRSLEHCKHTSAVGTLTYSSPEQKKGLYNEKTDIYSLGIIL
..|||.||||||||.||||||.|.||||||...||....||.....|.....|..||.|..|.|.|.|.|..||.||..|||||..||.|.||||||.|.
KPSSISTPPISSMQHQHQQQPCPIQTTSPTAIDQQMEWCTPQMSMPSCHRHTVQVGTHLYMSPEQCHHQSVFGTGTYTNPEQKKTWYNHKVDIYSLGLIF

FELYFP-ISTRMEKARVLTDLRNGVLPKSFLQKYPKVSELILLMMKTNPDERPSASDILKSDLF
|||..| .||.||..|...|||||..||.|.||||...|.|..||..||||||.|..|...|.|
FELIHPGFSTQMERIRTMCDLRNGQWPKWFTQKYPQEYEFIQQMMSMNPDERPTADQISMHDFF

Kinase DDB0219793e.AA PEK 83-837 25 2.3e-249 834.68 In-house 1-655 (655) Show / Hide
Range on Protein: 83-837
Range on HMM: 1-655/655
Sequence Identity: 25% (212 aa)

FCEIEKVGKGGY-GSVFKVKNKLDGEYYALKKIPFKNTT---------------KTFLEKVLREVKTLASLNHRNIVRYHSAWLETEELLPPSSSMASTS
|.||...||||. |.|.||.|||||.|||.|.|......               |. .|||||||||||.|||.||||||.||.|..|  ..........
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEKWQQQQDEMWQ

LSTSNGKQIDSDIKNIIYNNHLLFDGNWGTTSEEASYLNESDNPCNRRVNKAKKKVSP----QKKKNVNNNNNNSKKKALDQSG--------------AG
|..|........ |...||.| .|...| .. |||...|.... |..|..|.|||...    ...||...............|               ..
LDSSTDWPNGKH-KSKDYNFH-PFEKEW-DD-EEAQESNVMSE-CEDREQKGKKKCWSESNSHSSKNNYEESMEWSCSEHSDSSSFPNIENQFSINFGTE

DDNDDDISSSSSSSSSSSSDDSLYKLQFPHDEDFKQFNKQTSIRESMINSSR-FKKSYDDSDDSNDVSSNGVGFFKTPKKHYTSFSLDDGSDEESDEDDS
..|...||..|||...|||.|. .. .|....|...|||..........|.. .....|||.||......|....................|..|...||
NENESHISYWSSSVYMSSSWDNPFDSSFSNSCDSTNFNKDEDHSFFSCSSYSSCSTDCDDSKDSSPFNWDGGCDNWEQYEYSDQDDEHEQNDCQSKQCDS

QGFDDTNRSTMTNIQNDTDTESFNHSRHRRSFSSSEGEEETDDDSLSESDSDYSGVFENNDDLIPNPSSIPTSTTPPISMPPKQYQQQQQQQQQKSQPPS
..........||.||...|... |.|.|..|.|.|..|.|............. ....                          ||... . |.   . .
KNQSHKKCMEMTWIQDQEDNKN-NCSHHIGSSSQSQEEMENNTNNNKNKFKQMHNTKQ--------------------------YQCHYLYIQMEYCEKK

LRSSLTQNNSLLKPSINNNNNNNNNNNNKNNIVSPKINRITTLFIVMQLYSQTLSQWLENRPPDQVNEEENLNIFKQICIGLRYIHSKGIIHRDLKPGNV
.......||. . | ...|.. . .|..||..... |.... .|...... .. .|| ............ ..||.||. || ||||.|.|||||||.|.
TLRDWIDNNG-C-P-VQFNYW-R-RNSCKNHYNNY-IMNQC-CFQSTWSM-NM-RQW-DENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKPSNI

FLVREEDHHQQSSFSNISSSFEENSDGGGLLVSLGDFGLAVQHT--------------------IVSSTPSPTPTSTPSLTPVNSHISPIDQIININQQL
|| ....|||                   ..|  |||||| .|.                    . .......  ...| |....|.. ... ..| |. 
FLDCDGQHHQ-------------------MQVKIGDFGLATNHEMLSQSQKNYNQQDQSYWKYVANDNCQWWNTNQQNSPTGQDTHMW-SNN-YHI-QP-

QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQXXXXXXXXXXTVSLSSSSSSSILTPPISSMQQQHQQQPPPLQTTSPTGQSQQSIPSTPSSLSSSSTTPSV
                                                                                                    
----------------------------------------------------------------------------------------------------

STGTSLSRSLEHCKHTSAVGTLTYSSPEQKKG------LYNEKTDIYSLGIILFELYFPISTRM-EKARVLTDLRN------GVLP-KSFLQKYPKVSEL
   || ....|||.||..|||..|.|||| .|       ||.|.|.||||||.||...|..| | |....|||||.      | .| |.| .|||| ...
---TS-MFYCEHCHHTGGVGTCLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMERVKTLTDLRDESIQFPGDFPPKWFDNKYPKQADF

ILLMMKTNPDERPSASDILKSDLF
|..|.. .|..||||..||....|
IQWMLSHDPQQRPSAQQILQHEFF

Kinase DDB0219793e.AA STE 83-837 9 1.4e-43 151.06 In-house 1-359 (359) Show / Hide
Range on Protein: 83-837
Range on HMM: 1-359/359
Sequence Identity: 9% (80 aa)

FCEIEKVGKGGYGSVFKVKNKL---------------DGEYYALKKIPFKNTTK---------------TFLEKVLREVKTLASLN--HRNIVRYHSAWL
.  |||.|||..|.|.| .|.                 ||..| |.....| ..               . ....|.|.|..  .|  | |||.|. . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

-ETEELLPPSSSMASTSLSTSNGKQIDSDIKNIIYNNHLLFDGNWGTTSEEASYLNESDNPCNRRVNKAKKKVSPQKKKNVNNNNNNSKKKALDQSGAGD
 | ..                                                                                               
KEGHN-----------------------------------------------------------------------------------------------

DNDDDISSSSSSSSSSSSDDSLYKLQFPHDEDFKQFNKQTSIRESMINSSRFKKSYDDSDDSNDVSSNGVGFFKTPKKHYTSFSLDDGSDEESDEDDSQG
                                                                                                    
----------------------------------------------------------------------------------------------------

FDDTNRSTMTNIQNDTDTESFNHSRHRRSFSSSEGEEETDDDSLSESDSDYSGVFENNDDLIPNPSSIPTSTTPPISMPPKQYQQQQQQQQQKSQPPSLR
                                                                                                    
----------------------------------------------------------------------------------------------------

SSLTQNNSLLKPSINNNNNNNNNNNNKNNIVSPKINRI-TTLFIVMQLYS-QTLSQWLE-NRPPDQ-----------VNEEENLNIFKQICIG-LRYIHS
                                   .   ..|.|.| . .  .|.. .. .  . .           ..|..   | .||. | | |.||
-----------------------------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHS

KGIIHRDLKPGNVFLVREEDHHQQSSFSNISSSFEENSDGGGLLVSLGDFGLAVQHT-----------IVSSTPSPTPTSTPSLTPVNSHISPIDQIINI
..|||||.||.|..|                             | | |||.. | |           |                               
HHIIHRDIKPANILL-----------------------------VKLCDFGVCGQLTDSMANIQSNNII-------------------------------

NQQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQXXXXXXXXXXTVSLSSSSSSSILTPPISSMQQQHQQQPPPLQTTSPTGQSQQSIPSTPSSLSSSST
                                                                                                    
----------------------------------------------------------------------------------------------------

TPSVSTGTSLSRSLEHC------KHTSAVGTLTYSSPEQKKGL-------YNEKTDIYSLGIIL---FELYFPIST-RMEKARVLTDLRNGVLP------
                |      | .. |||  . .||  ..        |..| ||.|||. .    .   | ..    .|  ..   ... .      
---------------DCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----KSFLQKY----------------------PKVSELILLMMKTNPDERPSASDILK--SDLF
    ..   .                       |.  . | .  . .|..||.||. ||     .
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI

Kinase DDB0219793e.AA HRI 83-158 53 4.5e-37 128.19 In-house 1-76 (613) Show / Hide
Range on Protein: 83-158
Range on HMM: 1-76/613
Sequence Identity: 53% (41 aa)

FCEIEKVGKGGYGSVFKVKNKLDGEYYALKKIPFKNTTKTFLEKVLREVKTLASLNHRNIVRYHSAWLETEELLPP
| . | .|||||| |.||..|||...|| |||  |  ||. . |..||||.|| |.| |||||| ||.| .  . |
FEQKEIIGKGGYGRVYKVRHKLDKQHYAIKKIKIKKRTKCSCMKMQREVKVLACLQHHNIVRYHQAWIEHVHQIQP

Kinase DDB0219793e.AA CMGC 83-778 8 5.1e-34 108.49 In-house 1-329 (513) Show / Hide
Range on Protein: 83-778
Range on HMM: 1-329/513
Sequence Identity: 8% (72 aa)

FCEIEKVGKGGYGSVFKVKNKLDG--------------EYYALKKIP---FKNTTK------TFLEKVLREVKTLASLN-----------------HRNI
.  |.|.|.| || |.| ..|. .              |..|.|||    .... |       |  . |||.| |  ||                 | ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VRYHSAWLETE---------ELLPPSSSMASTSLSTSNGKQIDSDIKNIIYNNHLLFDGNWGTTSEEASYLNESDNPCNRRVNKAKKKVSPQKKKNVNNN
|. .      .         ..                                                                              
VKLYDIFYHKNSDGNEYEDKHI------------------------------------------------------------------------------

NNNSKKKALDQSGAGDDNDDDISSSSSSSSSSSSDDSLYKLQFPHDEDFKQFNKQTSIRESMINSSRFKKSYDDSDDSNDVSSNGVGFFKTPKKHYTSFS
                                                                                                    
----------------------------------------------------------------------------------------------------

LDDGSDEESDEDDSQGFDDTNRSTMTNIQNDTDTESFNHSRHRRSFSSSEGEEETDDDSLSESDSDYSGVFENNDDLIPNPSSIPTSTTPPISMPPKQYQ
                                                                                                    
----------------------------------------------------------------------------------------------------

QQQQQQQQKSQPPSLRSSLTQNNSLLKPSINNNNNNNNNNNNKNNIVSPKINRITTLFIVMQLYSQTLSQWLENRPPD-------QVNEEE---------
                                             | |  .     |..|. .  ..| | ..| ..|         .| .         
---------------------------------------------I-S--Q-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRP

---NLNIF------KQICIGLR--YIHSKG--IIHRDLKPGNVFLVRE----------EDHHQQSSFSNISSSFEENSDGGGLL----------VSLGDF
     ...      .||. ||   |.||..  |||||||| |. .  .          .                                   . ..||
PHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKS------------------------EDWNPCQKNGRLKICDF

GLAVQHTI---------------VSSTPSPTPTSTPSLTPVNSHISPIDQIININQQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQXXXXXXXXXXTV
||| .  .               |                                                                            
GLARWYHPHSDHHFQQQPQSFKNVN---------------------------------------------------------------------------

SLSSSSSSSILTPPISSMQQQHQQQPPPLQTTSPTGQSQQSIPSTPSSLSSSSTTPSVSTGTSLSRSLEHCKHTSAVGTLTYSSPEQKKGL---------
                                                                .   .   .|. | |. | .||   |          
---------------------------------------------------------------KDD-KPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYS

--YNEKTDIYSLGIILFELY
  |... |. |.| |..|.|
MHYTTPIDMWSVGCIFAEMY

Kinase DDB0219793e.AA GCN2 742-837 37 1.6e-31 107.38 In-house 410-511 (511) Show / Hide
Range on Protein: 742-837
Range on HMM: 410-511/511
Sequence Identity: 37% (38 aa)

HTSAVGTLTYSSPEQKKGLYNEKTDIYSL-GIILFELYFP-ISTRMEKARVLTDLRNGVLPKSFLQ----KYPKVSELILLMMKTNPDERPSASDILKSD
||..|||  | .||| |. ||.| |.||| |||.||. .|  .| ||.. .|..||.  .|. |      ....  ..|  . . .|..||||...|...
HTGKVGTPFYMCPEQQKSHYNQKVDMYSLGGIIFFEMWYPPFCTQMERVQILKQLRSCEFPQDFDKKVDNHHKDQQDMIRWCLNHDPQKRPSAQQLLQHE

LF
. 
FL

Kinase DDB0219793e.AA HRI 742-837 48 1.1e-29 101.61 In-house 517-613 (613) Show / Hide
Range on Protein: 742-837
Range on HMM: 517-613/613
Sequence Identity: 48% (47 aa)

HTSAVGTLTYSSPEQKKG-LYNEKTDIYSLGIILFELYFPISTRMEKARVLTDLRNGVLPKSFLQKYPKVSELILLMMKTNPDERPSASDILKSDLF
||| ||| || ||||  |  |  | | ||.|.|||||. |  | ||.| ||| .| | .| |   . |     | .. . |   ||||  .|.|.||
HTSRVGTCTYASPEQLDGSQYDNKSDMYSMGVILFELFQPFGTEMERAEVLTGVRTGQIPESLRKRCPVQAKYIQHLTRRNASQRPSAIQLLQSELF

Kinase DDB0219793e.AA GCN2 83-151 48 5.7e-26 87.66 In-house 1-72 (511) Show / Hide
Range on Protein: 83-151
Range on HMM: 1-72/511
Sequence Identity: 48% (35 aa)

FCEIEKVGKGGYGSVFK-VKNKLDGEYYALKKIPF--KNTTKTFLEKVLREVKTLASLNHRNIVRYHSAWLE
| ||. .|||| |.| | |.|..|| |||.||.|   |.   ... | .||||.|..|.|...|||. ||.|
FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQRKLPCKHKIMREVKLLCRLHHQHVVRYYQAWIE

Kinase DDB0219793e.AA PEK-Unclassified 743-835 36 1.3e-23 78.99 In-house 731-835 (835) Show / Hide
Range on Protein: 743-835
Range on HMM: 731-835/835
Sequence Identity: 36% (38 aa)

TSAVGTLTYSSPEQK------------KGLYNEKTDIYSLGIILFELYFPISTRMEKARVLTDLRNGVLPKSFLQKYPKVSELILLMMKTNPDERPSASD
|| .|| ||||.||                || .|||||.|||.|..  .. | ||. . .  .. | ||| |  |.|.. |.|   .   |  ||  | 
TSTCGTYTYSSNEQESQKKVRIKAHFQADFYNHRTDIYSVGIIFFQMFHQMNTTMERVKTIQNCKKGELPKHFCAKFPRLAEIIKDSLSNDPQKRPLLSK

ILKSD
| .  
IEQTL

Kinase DDB0219793e.AA WEE 83-156 36 2.1e-22 72.02 In-house 1-81 (297) Show / Hide
Range on Protein: 83-156
Range on HMM: 1-81/297
Sequence Identity: 36% (30 aa)

FCEIEKVGKGGYGSVFKVKNKLDGEYYALKK--IPFKNTTKTFLEKVLREVKTLASLN-------HRNIVRYHSAWLETEELL
| |..|.|.| .|.|.|.....||  || ||   ||. .   . .  ||||. ...|        | .||||.||| |.  ..
FQEVQKIGEGSFGEVYKCRCRIDGCIYAIKKSKQPFRGYS--ERKRALREVYAHMVLGQIMDCDHHPHIVRYYSAWEEDDHMY

Kinase DDB0219793e.AA PEK-Unclassified 83-154 33 1.4e-21 71.63 In-house 1-77 (835) Show / Hide
Range on Protein: 83-154
Range on HMM: 1-77/835
Sequence Identity: 33% (26 aa)

FCEIEKVGKGGYGSVFKVKNKLDGEYYALKKIPFK-----NTTKTFLEKVLREVKTLASLNHRNIVRYHSAWLETEE
| .. |.|.||...|... .|.|   || |.|  .            || ..||  .| .|| ||.||   | | |.
FNQVQKIGQGGFAIVYQCCHKFDQMEYAVKQIHVNIKDIKEDLQKHYEKEIMEVRYMAQVNHPNIIRYYHSWIEVEI

Kinase DDB0219793e.AA PKR 83-149 46 5.6e-20 68.12 In-house 1-61 (272) Show / Hide
Range on Protein: 83-149
Range on HMM: 1-61/272
Sequence Identity: 46% (31 aa)

FCEIEKVGKGGYGSVFKVKNKLDGEYYALKKIPFKNTTKTFLEKVLREVKTLASLNHRNIVRYHSAW
| .||..| ||.| ||| | ..||  |..|.. . |      ||  .||. || |.| |||.||| |
FKDIEEIGSGGFGQVFKAKHRIDGKRYVIKRVKYNN------EKAEHEVQALAKLDHVNIVHYHSCW

Kinase DDB0219793e.AA NEK 83-155 33 2.4e-19 65.09 In-house 1-81 (286) Show / Hide
Range on Protein: 83-155
Range on HMM: 1-81/286
Sequence Identity: 33% (27 aa)

FCEIEKVGKGGYGSVFKVKNKLDGEY-----YALKKIPFKNTTKTFLEKVL-REVKTLASLNHRNIVRYHSAWLETE--EL
. .|.|.|.| .|.|.||. | ||       |..||| ..| .    .. .  ||. |..|.| |||.|. ...| .   |
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCL

Kinase DDB0219793e.AA PKR 490-552 50 4.6e-18 61.17 In-house 96-159 (272) Show / Hide
Range on Protein: 490-552
Range on HMM: 96-159/272
Sequence Identity: 50% (32 aa)

LFIVMQLYSQ-TLSQWLENRPPDQVNEEENLNIFKQICIGLRYIHSKGIIHRDLKPGNVFLVRE
||| |    . || ||..||  ..|     |... ||  |  |||||..|||||||.|.||| |
LFIQMEFCDKGTLEQWMRNRRQEKVDKVLILDLYEQIVKGVDYIHSKKLIHRDLKPSNIFLVDE

Kinase DDB0219793e.AA NEK 519-587 27 9.1e-18 59.48 In-house 117-170 (286) Show / Hide
Range on Protein: 519-587
Range on HMM: 117-170/286
Sequence Identity: 27% (20 aa)

LNIFKQICIGLRYIHSK-----GIIHRDLKPGNVFLVREEDHHQQSSFSNISSSFEENSDGGGLLVSLGDFGLA
...| |.|..|.|.|..      |.|||.|| |.|| ..                         .| .||||..
WDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDY--------------------HNVKIGDFGIS

Kinase DDB0219793e.AA Pkinase 83-155 26 2.4e-17 62.44 Pfam 1-75 (293) Show / Hide
Range on Protein: 83-155
Range on HMM: 1-75/293
Sequence Identity: 26% (20 aa)

FCEIEKVGKGGYGSVFKVKNKLDGEYYALKKIPFKNTTKTFLEKVLR--EVKTLASLNHRNIVRYHSAWLETEEL
.. ..|.|.|..|.|.| ..| .|. .|.|.|. ... . ...  .|  |.. ...||| ||||.. .. .  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHI

Kinase DDB0219793e.AA S_TKc 83-837 8 8e-17 63.14 SMART 1-231 (231) Show / Hide
Range on Protein: 83-837
Range on HMM: 1-231/231
Sequence Identity: 8% (67 aa)

FCEIEKVGKGGYGSVFKVKNKLDGEYYALKKIPFKNTTKTFLEKVLREVKTLASLNHRNIVRYHSAWLETEELLPPSSSMASTSLSTSNGKQIDSDIKNI
.  ..|.|||..|.|.|...| .|...|.|.|.                                                                   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

IYNNHLLFDGNWGTTSEEASYLNESDNPCNRRVNKAKKKVSPQKKKNVNNNNNNSKKKALDQSGAGDDNDDDISSSSSSSSSSSSDDSLYKLQFPHDEDF
                                                                                                    
----------------------------------------------------------------------------------------------------

KQFNKQTSIRESMINSSRFKKSYDDSDDSNDVSSNGVGFFKTPKKHYTSFSLDDGSDEESDEDDSQGFDDTNRSTMTNIQNDTDTESFNHSRHRRSFSSS
                                                                                                    
----------------------------------------------------------------------------------------------------

EGEEETDDDSLSESDSDYSGVFENNDDLIPNPSSIPTSTTPPISMPPKQYQQQQQQQQQKSQPPSLRSSLTQNNSLLKPSINNNNNNNNNNNNKNNIVSP
                                                                            ..  |.   .  .  |  . . . 
--------------------------------------------------------------------------EHIRREIQILKK--HHPNIVKLYDVF

KINRITTLFIVMQLYSQ---TLSQWLENRPP----DQVNEEENLNIFKQICIGLRYIHSKGIIHRDLKPGNVFLVREEDHHQQSSFSNISSSFEENSDGG
     . |..|| . ..   .| . ...|..     . .| .   ...||| .| |.||.||||||||| |..| .                        
QD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------------------------

GLLVSLGDFGLAVQHTIVSSTPSPTPTSTPSLTPVNSHISPIDQIININQQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQXXXXXXXXXXTVSLSSSS
   . ..||||| |                                                                                      
--HIKICDFGLARQL-------------------------------------------------------------------------------------

SSSILTPPISSMQQQHQQQPPPLQTTSPTGQSQQSIPSTPSSLSSSSTTPSVSTGTSLSRSLEHCKHTSAVGTLTYSSPEQKKGLYNE-KTDIYSLGIIL
                                                                   |. .||. | .||     |.  | |..|.|.||
-------------------------------------------------------------------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCIL

FELYF---PISTRMEKARVLTDLRNGVLPKSFLQKYPKVSELILLMMKTNPDERPSASDILK-------SDLF
.|..    | .        .  . . ..        | . ..|  ... .|..||.| ..|.          |
YEMLCGYPPFP-------QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase DDB0219793e.AA Pkinase 515-605 32 1.3e-14 52.71 Pfam 107-175 (293) Show / Hide
Range on Protein: 515-605
Range on HMM: 107-175/293
Sequence Identity: 32% (30 aa)

EEENLNIFKQICIGLRYIHSKGIIHRDLKPGNVFLVREEDHHQQSSFSNISSSFEENSDGGGLLVSLGDFGLAVQHTIVSSTPSPTPTSTP
|.|  ....||. || |.||.||||||||| |.... ...|                       | ..||||| |. . ...   |.. ||
EWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDA-------------------CVKICDFGLAKQFDY-NNS-MTTFCGTP

Kinase DDB0219793e.AA PKR 741-835 36 8e-13 42.12 In-house 178-272 (272) Show / Hide
Range on Protein: 741-835
Range on HMM: 178-272/272
Sequence Identity: 36% (35 aa)

K-HTSAVGTLTYSSPEQ-KKGLYNEKTDIYSLGIILFELYFPISTRMEKARVLTDLRNGVLPKSFLQKYPKVSELILLMMKTNPDERPSASDILKSD
|  |   ||| | ||||     |    ||| ||.|| ||     | .|| .  .|||.|..      .  |   |.  ..   |..||  |.||.  
KSRTRRKGTLQYMSPEQIFSQHYGKEVDIYALGLILAELLHVCFTEFEKIKFFEDLRDGDFSNDIFDN--KEKTLLQKLLSKKPKDRPNTSEILRTL

Kinase DDB0219793e.AA HRI 490-558 36 7.7e-12 37.23 In-house 394-475 (613) Show / Hide
Range on Protein: 490-558
Range on HMM: 394-475/613
Sequence Identity: 36% (30 aa)

LFIVMQLYSQTLSQWLENR-------------PPDQVNEEENLNIFKQICIGLRYIHSKGIIHRDLKPGNVFLVREEDHHQQ
|.| ||| . .|  |.  |             | .  || .  .|| ||  |. ||| ..|.|||.|| |.||    . | |
LHIQMQLCELSLWDWISERNKRSREYVDETECPYVMANEKVIQKIFQQIVEGMFYIHNMFIVHRDVKPRNIFLHDPDQGHPQ

Kinase DDB0219793e.AA GCN2 430-549 27 2.4e-11 35.56 In-house 212-341 (511) Show / Hide
Range on Protein: 430-549
Range on HMM: 212-341/511
Sequence Identity: 27% (40 aa)

KQYQQQQQQQQQKSQPPSLRSSLTQNNSLLKPSINNNNNNN----------------NNNNNKNNIVSPKIN------RITTLFIVMQLYS-QTLSQWLE
.|.||. | .|.|... .            . .. .   ||                ...| ..|.|. | .       . .|.|.|   .  ||.| ..
EQEQQNNQSFQPKQEDHQ------------NQYYDQEDLNNAESEDQNKKKSQQQDKMCQNQHKNKVHYKCMNCKKPKEVHYLYIQMEYCEGKTLRQYID

NRPPDQVNEEENLNIFKQICIGLRYIHSKGIIHRDLKPGNVFL
|  . .  . |   .| ||  || ||||.|.||||||| |.||
NHGWCMDHD-ELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFL

Kinase DDB0219793e.AA PEK-Unclassified 521-549 43 3.3e-10 30.8 In-house 618-647 (835) Show / Hide
Range on Protein: 521-549
Range on HMM: 618-647/835
Sequence Identity: 43% (13 aa)

IFKQICIGLRYIHSKG-IIHRDLKPGNVFL
| .||  .|..||. . ..|||.|| |.|.
ITRQIIKALYHIHHQCKMVHRDIKPHNIFV

Kinase DDB0219793e.AA WEE 515-758 7 7.8e-10 29.25 In-house 110-162 (297) Show / Hide
Range on Protein: 515-758
Range on HMM: 110-162/297
Sequence Identity: 7% (18 aa)

EEENLNIFKQICIGLRYIHSK-GIIHRDLKPGNVFLVREEDHHQQSSFSNISSSFEENSDGGGLLVSLGDFGLAVQHTIVSSTPSPTPTSTPSLTPVNSH
|..  .|. .|| ||..|||. |..| |.||.|.|. ..   .|                                                        
EWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIV-NN---------------------------------------------------

ISPIDQIININQQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQXXXXXXXXXXTVSLSSSSSSSILTPPISSMQQQHQQQPPPLQTTSPTGQSQQSIPS
                                                                                                    
----------------------------------------------------------------------------------------------------

TPSSLSSSSTTPSVSTGTSLSRSLEHCKHTSAVGTLTYSSPEQKK
                                        ..| .
----------------------------------------DQQNN

Kinase DDB0219793e.AA WEE 793-837 22 2.7e-08 24.03 In-house 244-297 (297) Show / Hide
Range on Protein: 793-837
Range on HMM: 244-297/297
Sequence Identity: 22% (12 aa)

DLRNG-------VLP-KSFLQKYPK-VSELILLMMKTNPDERPSASDILKSDLF
..|.|        .|   |...... . .|| .||. .|. ||.....|.... 
QIRQGDLSFDKNQIPFPEFDNIISQELKQLIKWMMHPDPEQRPTCQQLLQHPVL

Kinase DDB0219793e.AA Pkinase 743-837 19 6.6e-08 29.04 Pfam 169-293 (293) Show / Hide
Range on Protein: 743-837
Range on HMM: 169-293/293
Sequence Identity: 19% (24 aa)

TSAVGTLTYSSPEQ--KKGLYNEKTDIYSLGIILFELYF--PISTRM----EKARVLTDLRNGVLPKSFLQKY-----------------------PKVS
|. .||. | .||   .   |  | |..|.|.||.|...  |.        . .. .  ...   |.   . .                       .   
TTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECK

ELILLMMKTNPDERPSASDILKSDLF
..|  . . .| .||.| .||... |
DFIKWCLCKDPKKRPTAEQILQHPWF

Kinase DDB0219793e.AA NEK 808-837 30 3e-06 18.7 In-house 257-286 (286) Show / Hide
Range on Protein: 808-837
Range on HMM: 257-286/286
Sequence Identity: 30% (9 aa)

PKVSELILLMMKTNPDERPSASDILKSDLF
.. ..|| .| . .|..|||...||.  . 
QDLQNLISQMLQKDPEQRPSCNQILEMPFI

Kinase DDB0219793e.AA NEK 733-777 40 7e-06 17.19 In-house 169-217 (286) Show / Hide
Range on Protein: 733-777
Range on HMM: 169-217/286
Sequence Identity: 40% (20 aa)

LSRSLEHC--KHTS-AVGTLTYSSPEQKKGL-YNEKTDIYSLGIILFEL
.|. |.|   . ..  |||  | |||. ..  ||.| || ||| .|.|.
ISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKPYNNKSDIWSLGCVLYEM

Kinase DDB0219793e.AA TyrKc 83-636 6 1.2e-05 -131.16 SMART 1-280 (280) Show / Hide
Range on Protein: 83-636
Range on HMM: 1-280/280
Sequence Identity: 6% (45 aa)

FCEIEKVGKGGYGSVFKVKNKLDGEYYALKKIP-----FKNTTKTFLEKVLREVKTLASL--NHRNIVRYHSAWLET-------EELLPPSSSMASTSLS
   ..| | | .| |.| . |          |.      |. .   .|  .|| . . .|  .| |||| . . ..        | |.     |.  .| 
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

TSNGKQIDSDIKNIIYNNHLLFDGNWGTTSEEASYLNESDNPCNRRVNKAKKKVSPQKKKNVNNNNNNSKKKALDQSGAGDDNDDDISSSSSSSSSSSSD
    |  .                                                                                            
DYLRKHRPK-------------------------------------------------------------------------------------------

DSLYKLQFPHDEDFKQFNKQTSIRESMINSSRFKKSYDDSDDSNDVSSNGVGFFKTPKKHYTSFSLDDGSDEESDEDDSQGFDDTNRSTMTNIQNDTDTE
                                                                                                    
----------------------------------------------------------------------------------------------------

SFNHSRHRRSFSSSEGEEETDDDSLSESDSDYSGVFENNDDLIPNPSSIPTSTTPPISMPPKQYQQQQQQQQQKSQPPSLRSSLTQNNSLLKPSINNNNN
                                                                                                    
----------------------------------------------------------------------------------------------------

NNNNNNNKNNIVSPKINRITTLFIVMQLYSQTLSQWLENRPPDQVNEEENLNIFKQICIGLRYIHSKGIIHRDLKPGNVFLVREEDHHQQSSFSNISSSF
                                            .. .. |..  ||. | .|.|||..|||||   |. . ..                
--------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---------------

EENSDGGGLLVSLGDFGLAVQHTIV-------SSTPS----PTP-------------------------------------TSTPSLT-----PVNSHIS
          |  .||||.  ..         .   .     .                                        .|          |... 
---------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVI

PIDQIININQQLQQ-------------------------------QQQQQQQ
   .  .   | .                                ..  .. 
EYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase DDB0219793e.AA CMGC 800-837 14 4.4e-05 11.65 In-house 437-513 (513) Show / Hide
Range on Protein: 800-837
Range on HMM: 437-513/513
Sequence Identity: 14% (11 aa)

PKSFLQKYPKVSE---------------------------------------LILLMMKTNPDERPSASDILKSDLF
||.. ...|. ..                                       |.  |.. .||.|..|...|. . |
PKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF

Kinase DDB0219793e.AA Pkinase_Tyr 83-146 25 0.009648 9.91 Pfam 1-70 (270) Show / Hide
Range on Protein: 83-146
Range on HMM: 1-70/270
Sequence Identity: 25% (19 aa)

FCEIEKVGKGGYGSVFKVKNKLDGEYY----------ALKKIPFKNTTKT-FLEKVLREVKTLASL-NHRNIVRYH
   ..| |.| .|.|.|      |...          | |... . . .  ..|. .||.|.. .| .| ||||..
ITFGKKLGEGAFGEVYK------GTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY

Kinase DDB0219793e.AA GCN2 582-657 30 0.022835 3.6 In-house 350-400 (511) Show / Hide
Range on Protein: 582-657
Range on HMM: 350-400/511
Sequence Identity: 30% (23 aa)

GDFGLAVQHTIVSSTPSPTPTSTPSLTPVNSHISPIDQIININQQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ
||||||     .|                          ||  ||.|||| . ... |.  .|..|..|||.|..|
GDFGLATNNKMESQ-------------------------INRKQQKQQQQASSHWAIQNEICQDDQFNQQQSQFSQ

Kinase DDB0219793e.AA Pkinase_Tyr 214-542 3 0.127782 6.11 Pfam 99-137 (270) Show / Hide
Range on Protein: 214-542
Range on HMM: 99-137/270
Sequence Identity: 3% (13 aa)

RVNKAKKKVSPQKKKNVNNNNNNSKKKALDQSGAGDDNDDDISSSSSSSSSSSSDDSLYKLQFPHDEDFKQFNKQTSIRESMINSSRFKKSYDDSDDSND
| ..                                                                                                
RKHR------------------------------------------------------------------------------------------------

VSSNGVGFFKTPKKHYTSFSLDDGSDEESDEDDSQGFDDTNRSTMTNIQNDTDTESFNHSRHRRSFSSSEGEEETDDDSLSESDSDYSGVFENNDDLIPN
                                                                                                    
----------------------------------------------------------------------------------------------------

PSSIPTSTTPPISMPPKQYQQQQQQQQQKSQPPSLRSSLTQNNSLLKPSINNNNNNNNNNNNKNNIVSPKINRITTLFIVMQLYSQTLSQWLENRPPDQV
                                                                                               .....
----------------------------------------------------------------------------------------------EDKQPL

NEEENLNIFKQICIGLRYIHSKGIIHRDL
. .. |..  ||. |. | .||..|||||
TMKDLLQMCWQIAKGMEYLESKNCIHRDL

Kinase DDB0219793e.AA WEE 764-777 64 0.289996 0.08 In-house 216-229 (297) Show / Hide
Range on Protein: 764-777
Range on HMM: 216-229/297
Sequence Identity: 64% (9 aa)

KTDIYSLGIILFEL
| ||.|||| ..||
KADIFSLGITIYEL

Kinase DDB0219793e.AA Pkinase_Tyr 757-778 27 2.377264 1.81 Pfam 187-208 (270) Show / Hide
Range on Protein: 757-778
Range on HMM: 187-208/270
Sequence Identity: 27% (6 aa)

KKGLYNEKTDIYSLGIILFELY
. | ...|.|..| |. ..|..
NYGKFTTKSDVWSFGVLMWEIF