Gene 25504 (Tetrahymena)

25504

Species: Tetrahymena
Alias: 275.m00026, PreTt25504, 767, 25504, TTHERM_01211840
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm, Secondary Subfamily: C2,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C2

Sequence

Name Sequence Type Origin Length Description Download
25504.AA Protein None 1131 None Fasta, JSON
25504.kin_dom Protein Kinase Domain None 218 None Fasta, JSON
25504.kin_dom2 Protein Kinase Domain None 218 None Fasta, JSON
25504.NA RNA None 3396 None Fasta, JSON

Protein domain

Protein domains of 25504.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 25504.AA C2 47-284 52 4.3e-127 428.51 In-house 1-245 (245) Show / Hide 
Range on Protein: 47-284
Range on HMM: 1-245/245
Sequence Identity: 52% (130 aa)

GAFAFVLKANNKKINQIVALKVVECDSNNIPLMEEVQKEYEMLQQLS-SKYIVKVFGSFFLTVEDNSDDDESNNEEEKTVENKIKKEKNERKIFFVIEQE
|||..||||.|||.|..||||..||.||.|..|.||||||....|.. ..||.||...|.|||....|.||.|.||||..|| |||.|||.|||.|.|||
GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQEN-IKKQKNEKKIFVVYEQE

FCQKNLETYIQENRQKNLELSNQEKEIMVIQMLDSVAYLHRFDIIHRDIKPSNFLLLFDQDGIPIIKIYIYHIQYYQS---KQLSDKKQIFKIIRQIQMQ
|||.||..|....|..| ....|.|.||.|||.||..|||||||.||||||||||. |||.|||.||...||||| |.    . ..| .  |.   .. .
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQY-QKKCDFDFASKLKYNKSRIHFSKF

XXTEVY----FAPEIEEGILKKQSDVFS-LGIIFLELDNINTFNICG
  |..|    ||||....|.||.||.|| .|...|||||.....||.
KWTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 25504.AA Ciliate-C8 47-271 40 1.3e-86 294.08 In-house 1-238 (238) Show / Hide 
Range on Protein: 47-271
Range on HMM: 1-238/238
Sequence Identity: 40% (98 aa)

GAFAFVLKANNKKINQIVALKVVEC-DSNNIPLMEEVQKEYEMLQQLS-SKYIVKVFGSFFLTVEDNSDDDESNNEEEKTVENKIKKEKNERKIFFVIEQ
|||..||||.||| |..||||..|| . ...  ||...|||||..| . ....|.|...|.|. |....||..|.....| |. |||      .|||.|.
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEK-IKK------SFFVMEM

EFCQKN--LETYIQENRQKNLELSNQEKEIMVIQMLDSVAYLHRFDIIHRDIKPSNFLLLFDQDGIPIIKIYIYHI--QYYQSKQLSDKKQ---IFKIIR
|.||.|  |..|... |.|....|.|.|||..|||.|||.|||.|.|.||||||.|||. |||...|.||.... .  .  .. ||.. |    . |.  
EKCQQNCNLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKG

QIQMQXX----TEVYFAPEIEEGILKKQSDVFS-------LGIIF
..|..      .  |||||.|... ..|||.||       .|...
TDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 25504.AA C8 38-271 34 1.6e-44 152.46 In-house 1-226 (226) Show / Hide 
Range on Protein: 38-271
Range on HMM: 1-226/226
Sequence Identity: 34% (84 aa)

YTDFTYAGNGAFAFVLKANNKKINQIVALKVVECDSN-NIPLMEEVQKEYEMLQQLSSKYIVKVFGSFFLTVEDNSDDDESNNEEEKTVENKIKKEKNER
  .| |  .||.. ||||.| | |. ..||. .| .. .|  .|...|||||.|      ... .  |.  ..|   ..... ||||  ..||    .| 
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQ------VFQQY-DFYVNEYDCFYEMYEVFEEEKCSNEKIV--QTEE

KIFFVIEQEFCQKNLETYIQENRQKNLELSNQEKEIMVIQMLDSVAYLHRFDIIHRDIKPSNFLLLFDQDGIPIIKIYIYHIQYYQSKQLSDKKQIFKII
| .|| | | |..||. . .| |.|....|...|||. |||.|.| |.| . |.||||||.|||. .||  ...||.         . |.|. |. . ..
KSCFVMEMELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLC----DFGFASQVSKNKSHIQSK

RQIQMQXXTEVYFAPEIEEG------ILKKQSDVFSLGIIF
   .    |  |||||||..      . ..|||.||.|.. 
KMNT--CGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 25504.AA CMGC 38-198 17 4.9e-21 65.02 In-house 1-214 (513) Show / Hide 
Range on Protein: 38-198
Range on HMM: 1-214/513
Sequence Identity: 17% (40 aa)

YTDFTYAGNGAFAFVLKANNKKIN--------------QIVALKVVECDSNNIPLME----------EVQKEYEMLQQLS-----------------SKY
|.   . | |... | |. .|. |              .|||.| .  .  .   .             . | ..|..|.                  ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVKVFGSFFLTVEDNSDDDESNNEEEKTVENKIKKEKNERKIFFVIEQEFCQKNLETYIQENRQ-----KNLELSNQE------------KEIMV-----
||| . .|    .|..... ..          | .  .......|   |.....|  ||..|..     ....||  .            .  ..     
IVKLYDIFYHKNSDGNEYEDKHI---------I-SQ-HFNHLYLV--FEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRY

-IQMLDSVA--YLHRFD--IIHRDIKPSN
  |.| ...  |.|. .  |||||.||.|
MYQILRGLKLKYCHSHWGNIIHRDLKPEN
Kinase 25504.AA STE 38-213 20 2.5e-20 68.58 In-house 1-188 (359) Show / Hide 
Range on Protein: 38-213
Range on HMM: 1-188/359
Sequence Identity: 20% (46 aa)

YTDFTYAGNGAFAFVLKANNKK---------------INQIVALKVVECDSNN---------------IPLMEEVQKEYEMLQQLS--SKYIVKVFGSFF
...    |.|||  | || |.|                ..|.| |... ...|               .  |....|| .......  ...||| .|..|
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LTVEDNSDDDESNNEEEKTVENKIKKEKNERKIFFVIEQEFCQ-KNLETYIQENRQKNLELSNQ--------EKEI--MVIQMLDS-VAYLHRFDIIHRD
   ..                     .||. ... .   |..    |.  |...  .. .|...        |..|  .. | |    .|||.  |||||
KEGHN---------------------HKNDDELWICM--EYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRD

IKPSNFLLLFDQDGIPIIKI
|||.| ||         .|.
IKPANILL---------VKL
Kinase 25504.AA STE20 38-105 27 2.2e-14 49.22 In-house 1-74 (288) Show / Hide 
Range on Protein: 38-105
Range on HMM: 1-74/288
Sequence Identity: 27% (20 aa)

YTDFTYAGNGAFAFVLKANNKKINQI----VALKVVECDSNNI--PLMEEVQKEYEMLQQLSSKYIVKVFGSFF
|...   |.|..  | ||..|. ...    || |... .. .   . .|..|||. ...|. ...||| .||..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYL
Kinase 25504.AA S_TKc 38-336 19 2.9e-14 32.28 SMART 1-231 (231) Show / Hide 
Range on Protein: 38-336
Range on HMM: 1-231/231
Sequence Identity: 19% (63 aa)

YTDFTYAGNGAFAFVLKANNKKINQIVALKVVECDSNNIPLMEEVQKEYEMLQQLSSKYIVKVFGSFFLTVEDNSDDDESNNEEEKTVENKIKKEKNERK
|.     | |||. | |. .|| ..|||.|..          | ...| ..|..   ..||| ...|                                .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-----------------------------DH

IFFVIEQEFCQK---NLETYIQENRQKNLE--LSNQEKEIMVIQMLDSVAYLHRFDIIHRDIKPSNFLLLFDQDGIPIIKI------YIYHIQYYQSKQL
...|   |.|     .| .||.... . |   ..  .   .. |... ..|.|.  |||||.||.| ||         |||       ..          
LYMVM--EYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL----------

SDKKQIFKIIRQIQMQXXTEVYFAPEIEEGILKKQSDVFSLGIIFLEL--------DNINTFNICGTTNKDKLKIKDGNIFSNYQINRLSSIYKIAQQCL
               .  |  | |||.  |  |. .|. |.|.|. |.        .   .|...|                       ..   . ..||
-------------TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG----------------------SPEAKDFIRKCL

NYYVDNRKSAIELLI--------EFI
..  ..| .| |.|         ...
QKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 25504.AA Ciliate-E1 104-265 19 3.5e-14 42.95 In-house 27-202 (202) Show / Hide 
Range on Protein: 104-265
Range on HMM: 27-202/202
Sequence Identity: 19% (36 aa)

FFLTVEDNSDDDESNNEEEKTVENKIKKEKNERKIFFVIE----------QEFCQKNLETYIQ---------ENRQKNLELSNQEKEIMVIQMLDSVAYL
. .   .|.........|.. ... .|||..  .|. .|.          .|.|...|. |.|         . .|.. ... |.|. ...|..| ...|
INCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIEL

HRFDIIHRDIKPSNFLLLFDQDGIPIIK-IYIYHIQYYQSKQLSDKKQIFKIIRQIQMQXXTEVYFAPEIEEGILKKQSDVF
| . ||||||||.|  .|....|. ..  ..| ... ....| ...|.  .  .. ..|  .. .  ..... . ...||..
HQYNIIHRDIKPQN--ILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYP-PEQYNCP-EQ-EHNKNQKINYKSDIY
Kinase 25504.AA Ciliate-E2 145-274 26 5.6e-11 33.9 In-house 114-289 (365) Show / Hide 
Range on Protein: 145-274
Range on HMM: 114-289/365
Sequence Identity: 26% (50 aa)

EFCQK-NLETYIQENRQKNLELSN-----QEKEIMVI--QMLD---------------SVAYLHRFD-IIHRDIKPSNFLLLFDQDGIPIIKIYIYHIQY
|.||  .|. ||..|..| ..  .      ||||  |  | |.                . |||    ||||||||.| |.         |||    |  
EYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKI----IDF

YQSKQLSDK---KQIFKIIRQIQMQXX------------------------TEVYFAPEIEEGILK----------KQSDVFSLGIIFLEL
  ||...|.   ... | .... |.                          |  | |||| .|             ...|..|||.|. |.
GLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM
Kinase 25504.AA CAMK 176-213 33 8e-11 30.37 In-house 187-237 (425) Show / Hide 
Range on Protein: 176-213
Range on HMM: 187-237/425
Sequence Identity: 33% (17 aa)

QMLDSVAYLHRFDIIHRDIKPSNFLLLFDQDGIP-------------IIKI
|... |.|.|  .|.|||.|| | ||  . |. .              |||
QICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKI
Kinase 25504.AA Pkinase 176-201 50 1.3e-08 31.51 Pfam 116-141 (293) Show / Hide 
Range on Protein: 176-201
Range on HMM: 116-141/293
Sequence Identity: 50% (13 aa)

QMLDSVAYLHRFDIIHRDIKPSNFLL
|.|  ..|.|.  |||||.||.|.|.
QILRGLEYCHSMGIIHRDLKPENILI
Kinase 25504.AA Ciliate-E5 260-275 75 2e-08 23.35 In-house 256-271 (271) Show / Hide 
Range on Protein: 260-275
Range on HMM: 256-271/271
Sequence Identity: 75% (12 aa)

KQSDVFSLGIIFLELD
||||..||||.|||| 
KQSDIYSLGIVFLELT
Kinase 25504.AA Ciliate-E5 45-101 28 5.3e-08 21.92 In-house 8-62 (271) Show / Hide 
Range on Protein: 45-101
Range on HMM: 8-62/271
Sequence Identity: 28% (16 aa)

GNGAFAFVLKANNKKINQIVALKVVECDSNNIPLMEEVQKEYEMLQQLSSKYIVKVF
| | ...|.|.  .  .. .| |.. | ..    .|  |.|.. |.|. |..|.||.
GKGGSGMVMKGCSEWNDKPIAIKIMKCKNQKQ--CEDNQREFNILKQFNSPHIIKVY
Kinase 25504.AA Pkinase 38-104 23 1e-06 24.31 Pfam 1-69 (293) Show / Hide 
Range on Protein: 38-104
Range on HMM: 1-69/293
Sequence Identity: 23% (16 aa)

YTDFTYAGNGAFAFVLKANNKKINQIVALKVVECDSNNIPLMEEVQK--EYEMLQQLSSKYIVKVFGSF
|.     | |.|. | |. .|. ..|||.|... ....    ..  .  | .... |....||. ...|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWF
Kinase 25504.AA CAMK 45-104 14 5e-06 14.58 In-house 3-107 (425) Show / Hide 
Range on Protein: 45-104
Range on HMM: 3-107/425
Sequence Identity: 14% (15 aa)

GNGAFAFVLKANNKKIN------------QIVALKVVECDSNN--------------------------IPLMEEVQKEYEMLQQLS-------SKYIVK
| |.|. | .. .|. .            | || |... .                                ...|..|.|....|.        . |.|
GRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIK

VFGSF
 .  .
LYEVY
Kinase 25504.AA Ciliate-E2 38-104 20 3.7e-05 13.62 In-house 1-101 (365) Show / Hide 
Range on Protein: 38-104
Range on HMM: 1-101/365
Sequence Identity: 20% (21 aa)

YTDFTYAGNGAFAFVLKANN-----------------------KKINQIVALKVV-----ECDSNNIPLMEEVQ------KEYEMLQQLSSKYIVKVFGS
|      |.|.|. | |...                       |  ..|.|.|..     |  .. | .| |..      .| ..|.||....|.| . .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

F
|
F
Kinase 25504.AA STE20 182-201 65 8.7e-05 13.77 In-house 131-150 (288) Show / Hide 
Range on Protein: 182-201
Range on HMM: 131-150/288
Sequence Identity: 65% (13 aa)

AYLHRFDIIHRDIKPSNFLL
.|||.  |||||||  | ||
DYLHSNHIIHRDIKADNILL
Kinase 25504.AA Ciliate-E1 44-101 25 0.000146 11.3 In-house 1-61 (202) Show / Hide 
Range on Protein: 44-101
Range on HMM: 1-61/202
Sequence Identity: 25% (16 aa)

AGNGAFAFVLKA-NNKKINQIVALKVVECD--SNNIPLMEEVQKEYEMLQQLS-SKYIVKVF
 ||| |..|.|| ... ... ||.|...|   .| . . .| ...|.... .   .||....
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQII
Kinase 25504.AA Ciliate-E5 183-205 52 0.000683 8.32 In-house 118-140 (271) Show / Hide 
Range on Protein: 183-205
Range on HMM: 118-140/271
Sequence Identity: 52% (12 aa)

YLHRFDIIHRDIKPSNFLLLFDQ
..|   ||| ||||.| ||  |.
DIHQKNIIHLDIKPANILLGYDN
Kinase 25504.AA STE 315-336 32 0.067297 2.64 In-house 335-359 (359) Show / Hide 
Range on Protein: 315-336
Range on HMM: 335-359/359
Sequence Identity: 32% (8 aa)

QQCLNYYVDNRKSAIELLI---EFI
..||..  ..| .| .||    .||
NKCLQKDPNKRPTASQLLKSEHPFI
Kinase 25504.AA STE20 316-332 35 0.359746 0.39 In-house 267-283 (288) Show / Hide 
Range on Protein: 316-332
Range on HMM: 267-283/288
Sequence Identity: 35% (6 aa)

QCLNYYVDNRKSAIELL
.||.. ...| .| .||
KCLQKDPEKRPTASQLL
Kinase 25504.AA Pkinase 262-274 38 9.454475 0.2 Pfam 193-205 (293) Show / Hide 
Range on Protein: 262-274
Range on HMM: 193-205/293
Sequence Identity: 38% (5 aa)

SDVFSLGIIFLEL
.|..|.|.|. |.
VDMWSCGCILYEM
Kinase 25504.AA C2 473-677 37 3.7e-109 368.96 In-house 1-245 (245) Show / Hide 
Range on Protein: 473-677
Range on HMM: 1-245/245
Sequence Identity: 37% (93 aa)

GGKGLVMGAFNKPEGRKVALKIQKFQS-----KHEVIREVGIMRDCQ-MPLVIKFYDFFYMSVNNKDD------------------------FVVFELEK
|..|||..|||| ..|.||||||..||     .|||..|.||||.|| ||..||.|..||..||.|.|                        |||.|.|.
GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF

CTGNLKQFLNKLKEGQILLSESQKMKIAVQIIDVINYLNCNQIVHGDIKLDNILYIDNMINVPTIKLAD----------FDQSRKLPCEFIGLLDKQKFF
|.|||||..|.... .. .....||..|.|..|.||||....|||.|||..|.||.... ..|||||.|          ||...||..... . ...  .
CQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKW

EYTPAQGIVIILNIENILNNNLKKYGTLGYNSPELIDKQQYTLEC
.....|.|... ...||...|.....|.||...||...||||..|
TQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 25504.AA Ciliate-C8 473-686 29 7.8e-80 271.53 In-house 1-238 (238) Show / Hide 
Range on Protein: 473-686
Range on HMM: 1-238/238
Sequence Identity: 29% (74 aa)

GGKGLVMG-------AFNKPEGRKVALKIQKFQSKHEVIREVGIMRDCQMPLVIKFYDFFYMS-VNNKDD-----------------FVVFELEKCT--G
|..|.|..       .... . |....|||| |..||......||..||||.|...||.||.. .|.|.|                 |.|.|.|||   .
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

NLKQFLNKLKEGQILLSESQKMKIAVQIIDVINYLNCNQIVHGDIKLDNILYIDNMINVPTIKLAD------FDQSRKLPCEFIGLLDKQKFFEYTPAQG
||||....... |. .|. .|..||.|.||..|||.|..|.| |||..|.|..... ..|||||.|      |.....||..   ...|... .......
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

IVIILNIENILNNNLKKYGTLGYNSPELIDK------QQYTLECEIFSVGVCL
..               .|..||  ||...|      ..........|||..|
YF---------------CGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 25504.AA C8 465-686 27 2.6e-42 144.68 In-house 2-226 (226) Show / Hide 
Range on Protein: 465-686
Range on HMM: 2-226/226
Sequence Identity: 27% (69 aa)

SNLEFISVGGKGLVMGAFNKPEGRKVALKIQKFQSKHEVIREVGIMRDCQMPLVIKFYDFFYMS-VNNKDDFVVFELEKCT-------------------
.| ...| |..|.|. | |  . |...||.|| |.|..   .  ||. ..||.|.. |||...  .  .....|||.|||                    
NNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMEL

--GNLKQFLNKLKEGQILLSESQKMKIAVQIIDVINYLNCNQIVHGDIKLDNILYIDNMINVPTIKLADFDQSRKLPCEFIGLLDKQKFFEYTPAQGIVI
   ||||.  .... |  .|. .| .||.|.|| .||..| .|.| |||..|.|   .  ....|||.||. . ... .    ..|. .           
CEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNT----------

ILNIENILNNNLKKYGTLGYNSPELIDK-----QQYTLECEIFSVGVCL
               ||..|  || . |     .||. .  .||||. |
--------------CGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 25504.AA CAMK 469-619 17 1.1e-20 62.67 In-house 1-247 (425) Show / Hide 
Range on Protein: 469-619
Range on HMM: 1-247/425
Sequence Identity: 17% (44 aa)

FISVGGKGLVMGAFNKPEG------------RKVALKI-------------------QKFQ------------SKHEVIREVGIMRDCQ-------MPLV
 .  |. | |  ...|  .            .||| ||                    ...            ....| ||. ||. .|        | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKFYDFFYMSVNNK--------------DDFVVFEL---EKCTGN-----LKQFLNKLKEGQ-----------ILLSESQKMKIAVQIIDVINYLNCNQI
||.|...  . ..|              |..... .   | |.|      | ... . . .              ..|..  ..  ||.. ..|.  . |
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHGDIKLDNILYIDNMINVP-------------TIKLADFDQSRKLP
|| |.|..|||. ||. . .             .||..||  ..|..
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFD
Kinase 25504.AA S_TKc 464-762 19 2.1e-20 75.0 SMART 1-231 (231) Show / Hide 
Range on Protein: 464-762
Range on HMM: 1-231/231
Sequence Identity: 19% (61 aa)

DSNLEFISVGGKGLVMGAFNKPEGRKVALKIQKFQSKHEVIREVGIMRDCQMPLVIKFYDFFYMSVNNKDDFVVFELEKCTG---NLKQFLNKLKE--GQ
   |. |  |. | |. . .|  ||.||.|| |      ..||. |..  . | ..|.||.|.       |.. . .| | |   .|.... | .   ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

ILLSESQKMKIAVQIIDVINYLNCNQIVHGDIKLDNILYIDNMINVPTIKLADFDQSRKLPCEFIGLLDKQKFFEYTPAQGIVIILNIENILNNNLKKYG
  ..| .  ... ||.. ..|.  ..|.| |.| .|||  .      .||..||  .|.|                                       |
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-----------------------------------TTFCG

TLGYNSPELIDKQQYTL-ECEIFSVGVCLALLDN----FEKLEPVILKKALDHQNGFKIPFERSINFQDEVINRKGQIYEIIFQTVVFKPQQRKSLSQIL
|. | .||..   .|.  .| . |.|..|. .      |.  . ...|| .                         .  ..| .  .. |..| .  ..|
TPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-----------------------SPEAKDFIRKCLQKDPEKRPTA-EAL

L---NLEQKEYS
       . .. 
QDEWDIKCHPWF
Kinase 25504.AA Ciliate-E1 470-680 18 5.7e-15 45.53 In-house 1-202 (202) Show / Hide 
Range on Protein: 470-680
Range on HMM: 1-202/202
Sequence Identity: 18% (43 aa)

ISVGGKGLVMGAFNKPEG-RKVALKIQKFQ---SK---HEVIREVG-IMRDCQMPL-VIKFYDFFYMSVNNKDDFVVFELEKCTGNLKQ------FLNKL
|. |. ..|  |...    ..||.||.. .   ..   ...|.|   ||   .    .|...|....  |.  .... .....  .  |        ...
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

KEGQILLSESQKMKIAVQIIDVINYLNCNQIVHGDIKLDNILYIDNMINVPTIKLADFDQSRKLPCEFIGLLDKQKFFEYTPAQGIVIILN--IENILNN
.. |. ... |||.|..|.|| ...|  . | |.||| .|||. .. . | .                                    |    ..| ...
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC---------------------------------DFGISKFLKNNQNQQ

NLKKYGTLGYNSPEL--------IDKQQYTLECEIF
  .|. |  | .||         ...|... . .|.
CQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY
Kinase 25504.AA CMGC 465-612 14 1.9e-14 42.95 In-house 2-248 (513) Show / Hide 
Range on Protein: 465-612
Range on HMM: 2-248/513
Sequence Identity: 14% (37 aa)

SNLEFISVGGKGLVMGAFN--------------KPEGRKVALKIQK--FQSKHEVI-------------REVGIMRDCQ-----------------MPLV
 ... |  |  | |  ...              .  ...||.|. |  |  ...               ||. |..  .                  . .
EIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

IKFYDFFYMSVNNKDD------------FVVFELEKCTGNLKQFLNKLKE-----GQILLSESQ------------KMKIA------VQIIDVIN--YLN
.| ||.|| . .....             . .  | .  .|.|.. . .      ... ||| .            . ..        ||.  ..  |. 
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

CNQ--IVHGDIKLDNILYIDNMINV----------------PTIKLADF
 .   |.| |.|  |||  .|  ..                 ..|..||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDF
Kinase 25504.AA STE 467-612 21 2.1e-14 47.41 In-house 1-191 (359) Show / Hide 
Range on Protein: 467-612
Range on HMM: 1-191/359
Sequence Identity: 21% (44 aa)

LEFISVGGK---GLVMGAFNK------PEGRK---------VALKIQKFQS--------------------KHEVIREVGIMRDCQ--MPLVIKFYDFFY
.|.|.. ||   | |  | |.      . |..         .| |. ....                    . ....|. ||..|.   | ..|.|. ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

MS---VNNKDDFVVFELEKCT-GNLKQFLNKLKEGQILLS----------ESQKMKIAVQIIDV-INYLNCNQIVHGDIKLDNILYIDNMINVPTIKLAD
      .|.|.  .. .| .  | | ..... .. .  |.          |||  .|..||.    .||  ..|.| ||| .|||          .||.|
KEGHNHKNDDELWIC-MEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCD

F
|
F
Kinase 25504.AA Ciliate-E2 414-612 18 1.6e-13 42.81 In-house 12-200 (365) Show / Hide 
Range on Protein: 414-612
Range on HMM: 12-200/365
Sequence Identity: 18% (44 aa)

QSQIYELSQYGNNQKHLKKLIKVFNQQKYKPINSDEYEKILKILQNNPKYDSNLEFISVGGKGLVMGAFNKPEGRKVALKIQKFQSKHEVIREVGIMR--
....|. ... ....  .|.|. ..| ..                                    |    |  . ..|.||.| . . .. .|  |||  
FGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQ----------------------------------M--QEKVKIKIYAMKIMKKNQIEQIKQEIHIMREI

--------------DCQMPLVIKFYDFFYMSVNNKDDFVVFELEKCTG-NLKQFLN--KLKEGQILL-----SESQKMKIAVQIID--------------
                . | .||.|..|..   ..|. . . .| | | .|.....  |.|.....      .| .  .|  ||..              
NCFYKKINEKNILEQLNHPNIIKMYECFQE---KDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACII

-VINYLNCNQ-IVHGDIKLDNILYIDNMINVPTIKLADF
  ..||  .  |.| |||..|||.         ||..||
LALEYLHSKNNIIHRDIKPENILF---------IKIIDF
Kinase 25504.AA Pkinase 473-618 24 1e-10 39.0 Pfam 10-162 (293) Show / Hide 
Range on Protein: 473-618
Range on HMM: 10-162/293
Sequence Identity: 24% (39 aa)

GGKGLVMGAFNKPEGRKVALKIQKFQSKHEVIR-------EVGIMRDCQMPLVIKFYDFFYMSVNNKDDFVVFELEKCTG-----NLKQFLNKLKEGQIL
|. | |  . .| .|..||.|| | .....  .       |. ||. .. | ....||.|.      .| . . .| | |      |. ..   ..| ..
GSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY

LSESQKMKIAVQIIDVINYLNCNQIVHGDIKLDNILYIDNMINVPTIKLADFDQSRKL
.|| .  ... ||.  ..|.  . |.| |.|..|||. .|. . ...|..||  ....
FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQF
Kinase 25504.AA Ciliate-E5 473-597 26 2.4e-07 19.77 In-house 10-136 (271) Show / Hide 
Range on Protein: 473-597
Range on HMM: 10-136/271
Sequence Identity: 26% (34 aa)

GGKGLVMGAFNKPEGRKVALKIQKFQSKHEV---IREVGIMRDCQMPLVIKFYDFFYMS-VNNKDDFVVFELEKCTGNLKQFLNKLKEGQILLSESQKMK
|| |.|| .. ...   .| || |...   .    ||  |. ... | .|| |...  .  |..  | .   |.|  .|...|||  . .  ... .  .
GGSGMVMKGCSEWNDKPIAIKIMKCKNQKQCEDNQREFNILKQFNSPHIIKVYQIYQYQYENMNYQFII--MERCKCDLHTYLNKIIYQMKWQKHQDIYQ

IAVQIIDVINYLNCNQIVHGDIKLDNILY
|  | .   ...  . |.| |||  |||.
ICLQLVKGLQDIHQKNIIHLDIKPANILL
Kinase 25504.AA STE20 465-526 27 3.1e-07 22.8 In-house 2-74 (288) Show / Hide 
Range on Protein: 465-526
Range on HMM: 2-74/288
Sequence Identity: 27% (20 aa)

SNLEFISVGGKGLVMGAFNKPEGRK----VALKIQKFQS-------KHEVIREVGIMRDCQMPLVIKFYDFFY
 .|| |  |. | |  | .|| |..    || |. .  .       ..... |. ||..|. | ..|.|. ..
ELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYL
Kinase 25504.AA Ciliate-E2 639-686 16 3.5e-07 20.67 In-house 201-286 (365) Show / Hide 
Range on Protein: 639-686
Range on HMM: 201-286/365
Sequence Identity: 16% (14 aa)

GIVIILNIENI------LNNNLKKYG------------------------TLGYNSPELIDKQQ---------YTLECEIFSVGVCL
|.  .....|.      ......  .                        |.|| .|| . ...         |. .| |.|.||.|
GLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase 25504.AA TyrKc 464-756 17 2e-06 -116.8 SMART 1-280 (280) Show / Hide 
Range on Protein: 464-756
Range on HMM: 1-280/280
Sequence Identity: 17% (57 aa)

DSNLEFISVGGKGLVMGAFNKPEGRKVALKIQKFQSKHEVIREVGIMRDC--QMPLVIKFYDFFYMSVNN----KDDFVVFELEKCTGNLKQFLNKLKEG
 . .. .  |  | |. .  |   ..|| |  |  .. . .||  ||.    . | ....|     .  |    .  ..|.|. .  |.||..| | .. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRKHRPK

QILLSESQKMKIAVQIIDVINYLNCNQIVHGDIKLDNILYIDNMINVPTIKLADFDQSRKLPCE-FIGLLDKQKFFEYTPAQGIVIILNIENILNNN---
   |. ... ....|| .  .||  ....| |.   |.|. .|     |.| .||  ||..  .   |                      .         
---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQG---------------------ESKDYYRKKEH

-LKKY-GTLGYNSPELIDKQQYTLECEIFSVGVCL------ALLDNFE----KLEPVILKKALDHQNGFKIPFE--RSINFQDEVINRKGQIYEIIFQTV
  .|.   .   .|| |..  .| .  ..| |||.            .    ....  . . ... .  ..| .    . |          .|.|. |  
KGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MSF----VCCPDEMYQIMKQCW

VFKPQQRKSLSQILLNL
 ..| .| . |.|   .
HEDPEDRPTFSEIHECF
Kinase 25504.AA CAMK 658-684 23 0.002748 5.65 In-house 281-322 (425) Show / Hide 
Range on Protein: 658-684
Range on HMM: 281-322/425
Sequence Identity: 23% (10 aa)

GTLGYNS-PELIDKQQ--------------YTLECEIFSVGV
||..| . ||.. ...              |. .| . |.||
GTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGV
Kinase 25504.AA STE 658-686 28 0.006676 6.23 In-house 225-258 (359) Show / Hide 
Range on Protein: 658-686
Range on HMM: 225-258/359
Sequence Identity: 28% (10 aa)

GTLGYNSPELIDK------QQYTLECEIFSVGVCL
||  . .|| |..      ..|.  | | |.| ..
GTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI
Kinase 25504.AA STE20 578-596 63 0.013942 5.61 In-house 131-149 (288) Show / Hide 
Range on Protein: 578-596
Range on HMM: 131-149/288
Sequence Identity: 63% (12 aa)

NYLNCNQIVHGDIKLDNIL
.||  |.|.| ||| ||||
DYLHSNHIIHRDIKADNIL
Kinase 25504.AA Pkinase 658-684 35 0.06575 7.83 Pfam 173-200 (293) Show / Hide 
Range on Protein: 658-684
Range on HMM: 173-200/293
Sequence Identity: 35% (10 aa)

GTLGYNSPELID-KQQYTLECEIFSVGV
||..| .||.|   | |. .. ..|.|.
GTPWYMAPEVIRGGQYYGPKVDMWSCGC