Gene 30140 (Tetrahymena)

30140

Species: Tetrahymena
Alias: 254.m00046, 30140, PreTt30140, TTHERM_01148240, 783
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C8

Sequence

Name Sequence Type Origin Length Description Download
30140.AA Protein None 925 None Fasta, JSON
30140.kin_dom2 Protein Kinase Domain None 203 None Fasta, JSON
30140.NA RNA None 2775 None Fasta, JSON
30140.kin_dom Protein Kinase Domain None 179 None Fasta, JSON

Protein domain

Protein domains of 30140.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 30140.AA C8 50-199 48 3.3e-70 239.55 In-house 1-172 (226) Show / Hide 
Range on Protein: 50-199
Range on HMM: 1-172/226
Sequence Identity: 48% (84 aa)

TNNFQILSFGSFGMVLATKKAKLDKKEIVLKIQKIEDEQHIQNEISIMQKLKEPLVVQLYDSYIIENKIGPDRYSVFELEKCS-----------CSLDE-
.||||.||||..||||..|..| |..|||||.||....|.|||..|||.....|.|.|.||.|..|.......|.|||.||||           |...| 
FNNFQYLSFGAYGMVLKAKNVK-DNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEM

----------YLDRQNKDGQFNDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQP-EIKLCNLG
          |..|.||..||....| .||||.||.|||||..||.||||||.||||.||.... ||||| .|
ELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFG
Kinase 30140.AA Ciliate-C8 59-196 41 9.1e-70 238.09 In-house 1-165 (238) Show / Hide 
Range on Protein: 59-196
Range on HMM: 1-165/238
Sequence Identity: 41% (68 aa)

GSFGMVLAT------KKAKLDKKEIVLKIQKIEDEQHIQNEISIMQKLKEPLVVQLYDSYIIENKIGPDR-----------------YSVFELEKCS--C
|.|||||..      .| .|...|.|.||||...|. |.....|||....|.|||.||........ ...                 ..|.|.|||.  |
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

SLDEYLDR-QNKDGQFNDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLD-GKQPEIKLC
.|..|.|| ..|........| .||||.||||||.| |||.||||||.||||..| ..||.||||
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLC
Kinase 30140.AA C2 59-242 27 1.3e-39 132.99 In-house 1-245 (245) Show / Hide 
Range on Protein: 59-242
Range on HMM: 1-245/245
Sequence Identity: 27% (67 aa)

GSFGMVLATKKAKLDKKEIVLKIQKIED-----EQHIQNEISIMQKLK-EPLVVQLYDSYIIENKIGPD-------------R----------YSVFELE
|.||.|| .   | ......||||....     .. .|.|..||....  |.....|...    .   |             .            |.|.|
GAFGLVLKA-FNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

KCSCSLDEYLDRQNKDG-QFNDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQ-PEIKLCN----------------LGYSAPEILNKQ--
.|.. |  |..|. |.  ..... | ..|||..||.||.| |.|.||||||.|||. .| .. | ||||.                | |.  .|  ..  
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK

------------DNELKIYSKKSDSYS-VGLLLAFLDNYQDLKKNA
             .. .|| |.|| .| ||. |  ||| |    . 
WTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 30140.AA Ciliate-E1 56-223 24 8.4e-24 74.59 In-house 1-202 (202) Show / Hide 
Range on Protein: 56-223
Range on HMM: 1-202/202
Sequence Identity: 24% (51 aa)

LSFGSFGMVLATKKAKLDKKEIVLKIQKIEDEQH-------IQNEISIMQKLKEPL-VVQLYDSYIIENKIGPDRYSVFELEKCSCSLDEYLD-------
.. |||..|.  |. .  .... .||..... .        |.....||. .|.   ..|..| ..|.. ..    ... .|.|.||| .||.       
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYI----CIIIFECCCCSLKDYLQNHNRLEY

---RQNKDGQFNDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQPEIK-------------------LCNLGYSAPEILNK---QDNELKI
    |....||... | ||..|.|| ....|..|||||||||.| |.. . ..  .                         |. || .|    . |. ..
WQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQK

YSKKSDSY
...||| |
INYKSDIY
Kinase 30140.AA Ciliate-B2 54-184 30 9.2e-23 50.28 In-house 5-137 (197) Show / Hide 
Range on Protein: 54-184
Range on HMM: 5-137/197
Sequence Identity: 30% (42 aa)

QILSFGSFGMVLATKKAKL--DKKEIVLKIQKI---EDEQHIQNEISIMQKL-KEPLVVQLYDSYIIENKIGPDRYSVFELEKCSCSLDEYLDRQNKDG-
...  | .|..    | .    ......||.      |.. ||.||.||. . ..  ||.. |.  |...|      |. .||| ||| . |.. .|   
KYINKGGCGFICEGYKKHSIREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMFEYNINVVKYIDHIQINETI-----DVLIMEKCECSLKQELQKIQKQQK

QFNDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLV
.||    ||.  | ||    ... ||.| ||||.| |.
CFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILF
Kinase 30140.AA CAMK 55-229 18 5.3e-21 63.78 In-house 1-324 (425) Show / Hide 
Range on Protein: 55-229
Range on HMM: 1-324/425
Sequence Identity: 18% (61 aa)

ILSFGSFGMVLATKKAKLDK-----------KEIVLKI---QKIE----------------------------DEQHIQNEISIMQK-------LKEPLV
.|  |||| |   .  .  .           ..   ||   .|.                             |.. ...||.||.|       |. | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLYDSYI------------IENK--IGP-DRYSVFEL---EKCSC-----SLDEYLDRQNK------------DGQFNDDDKYQIAIQIIDSVNYIHSF
..||. |               .|  .   |.. .. .   | ||       | .|. .. .            .| |. ..  ..  ||.. |.|.|| 
IKLYEVYEDPHYFKNTNDYET-SKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

NIIHRDIKPENFLVYLDGKQPE--------------IKLCNLGYS-------------------------------------------A-PEILNKQ---
||.|||.|||| |.  ...  .              ||..  | .                                           | ||.||..   
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

------DNELKIYSKKSDSYSVGLLL
      |.| . |..|.|  |.| .|
NMQNATDEEKPYYGPKCDMWSCGVIL
Kinase 30140.AA Ciliate-E2 50-229 20 6e-20 65.16 In-house 1-286 (365) Show / Hide 
Range on Protein: 50-229
Range on HMM: 1-286/365
Sequence Identity: 20% (62 aa)

TNNFQILSFGSFG-----MVLATKKA-----------------KLDKKEIVLKIQK------IEDEQHIQNEIS----------IMQKLKEPLVVQLYDS
 .  ... .|.||      |  ..|                  | ..|.. .||.|      |. |.|| .||           |...|. | ....|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YI--IENKIGPDRYSVFELEKCSC-SLDEYLD--RQN-------KDGQFNDDDKYQIAIQIID---------------SVNYIHSFN-IIHRDIKPENFL
..   .|.|       . .| |.  .| .|.   ...       . ..|..    .|  ||..                ..|.|| | |||||||||| |
FQEKDDNNI------YLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENIL

VYLDGKQPEIKLCNLG---------------------------------------------------YSAPEILNKQDNE----LKIYSKKSDSYSVGLL
.        ||.. .|                                                   | ||||||.....     | |..|.| .|.| .
F--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVI

L
|
L
Kinase 30140.AA CMGC 53-199 15 9.9e-20 60.67 In-house 1-249 (513) Show / Hide 
Range on Protein: 53-199
Range on HMM: 1-249/513
Sequence Identity: 15% (38 aa)

FQILS---FGSFGMVLATKKAKLD-------------KKEIVLKIQKIEDEQHIQ---------------NEISIMQKLK-----------------EPL
..|..    |..|.|   .  . .             .... .|. | .   ..|                ||.|...|.                 .. 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVQLYDSYIIEN--KIGP---------DRYSVFELEKCSCSLDEYLDRQN--KDG----QFNDDD------------KYQIA------IQIIDSVN--YI
.|.|||..  .|  . ..         ...  .  | . ..| .|.....  . |     ...              .  .        ||. ...  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSFN--IIHRDIKPENFLVYLDGKQ-----------------PEIKLCNLG
|| .  |||||.|||| |.  ...                   ..|.|  |
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFG
Kinase 30140.AA S_TKc 50-301 24 4.2e-19 70.69 SMART 1-231 (231) Show / Hide 
Range on Protein: 50-301
Range on HMM: 1-231/231
Sequence Identity: 24% (68 aa)

TNNFQILSFGSFGMVLATKKAKLDKKEIVLKIQKIEDEQHIQNEISIMQKLKEPLVVQLYDSYIIENKIGPDRYSVFELEKCSC---SLDEYLDRQNKDG
    ...  |.|| |   .. | ....  .|| |    .||..||.|..| . | .|.|||..          .  . .| |.    .| .|...... |
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHG

Q---FNDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQPEIKLCNLG-------------YSAPEILNKQDNELKIYSK-KSDSYSVGLLL
    |.  .   .. ||.. ..|.|| .|||||.|||| |.       .||.|  |             | |||.|         |.| |.| .|.| .|
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQLTTFCGTPWYMAPEVL--------GYGKCKCDWWSCGCIL

AFLDNYQDLKKNAPFTFLLMTKKQLDKPFEKSKIKINKNSEIYKFINLLVVSDSGQRASLYDIVE-QSD---TKFL
. .     |    ||        |... |.| .      .|   ||. . . |  .| .  .. . ..|     ..
YEM-----LCGYPPFP-------QMQMMFKKIG-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 30140.AA Pkinase 50-184 27 9.5e-16 56.77 Pfam 1-141 (293) Show / Hide 
Range on Protein: 50-184
Range on HMM: 1-141/293
Sequence Identity: 27% (41 aa)

TNNFQILSFGSFGMVLATKKAKLDKKE--IVLKIQKIEDEQHIQN-------EISIMQKLKEPLVVQLYDSYIIENKIGPDRYSVFELEKCSC-----SL
    ...  |||| |   .|..  . .   ..|| | ..| . ..       ||.||..|. | .|.|||..        ...  . .| | .     .|
YHIGRKIGSGSFGCV---YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDL

DEYLDRQNKDGQF--NDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLV
 .|. .  ..| |   ...   .. ||.  ..|.|| .|||||.||||.|.
FDYIST-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILI
Kinase 30140.AA Ciliate-C8 197-229 58 1.6e-15 52.35 In-house 205-238 (238) Show / Hide 
Range on Protein: 197-229
Range on HMM: 205-238/238
Sequence Identity: 58% (20 aa)

NLGYSAPEILNK-QDNELKIYSKKSDSYSVGLLL
|.||.|||...| ......|.|||||||||||.|
NWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 30140.AA CK1 59-184 19 2.1e-15 50.25 In-house 10-165 (339) Show / Hide 
Range on Protein: 59-184
Range on HMM: 10-165/339
Sequence Identity: 19% (32 aa)

GSFG-MVLAT-----KKAKLDK----KEIVLKIQKI-EDEQH--IQNEISIMQKLK---------------------EPLVVQLYDSYIIENKIGPDRYS
|.|| ..        |  | .|    .| ..|. .. .  ||   . |. ...||.                     .| .......   ...     | 
GGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEEDDY-----YN

VFELEKCSCSLDEYLD-RQNKDGQFNDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLV
.  .. .  .|..... ... .. |..   ..||||..... |.|. ..|||||||.||..
YMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCM
Kinase 30140.AA C8 200-229 60 5.6e-15 48.53 In-house 197-226 (226) Show / Hide 
Range on Protein: 200-229
Range on HMM: 197-226/226
Sequence Identity: 60% (18 aa)

YSAPEILNKQDNELKIYSKKSDSYSVGLLL
|.||||..||||..|.|...||..||||.|
YFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 30140.AA STE 156-229 25 2.4e-13 43.59 In-house 156-258 (359) Show / Hide 
Range on Protein: 156-229
Range on HMM: 156-258/359
Sequence Identity: 25% (28 aa)

IAIQIIDS-VNYIHSFNIIHRDIKPENFLVYLDGKQPEIKLCNLGYSA-----------------------------------PEILNKQDNE-LKIYSK
|. ||.    .|.|| .|||||||| | |.        .|||. | ..                                   ||.......   | |. 
ICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTPWMAPEVIQQNGQGRDKGYDT

KSDSYSVGLLL
|.| .|.|...
KCDIWSLGCTI
Kinase 30140.AA TyrKc 50-296 18 3.1e-08 -89.4 SMART 1-280 (280) Show / Hide 
Range on Protein: 50-296
Range on HMM: 1-280/280
Sequence Identity: 18% (54 aa)

TNNFQILSFGSFGMVLATKKAKLDKKEIVLKIQKIEDEQHIQNEISIMQKL--KEPLVVQLYDSYIIENKIG-----PDRYSVFELEKCSCSLDEYL-DR
    ..|  | || |    |....  .   |  | . .. . .|..|| ||  . | .|.||   ..  . .     .  . |.|. .   .|..|| ..
ITLGKKLGEGAFGEVY---KGTWK-IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLY--GVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRKH

QNKDGQFNDDDKYQIAIQIIDSVNYIHSFNIIHRDIKPENFLVYLDGKQPEIKLCNLG-----YSA------PEILNK----QDN-------------EL
..|   .. .|. ....|| .  .|.|| |.||||.   | ||  ..    .| .  |     |.        .   |    . .               
RPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

KIYSKKSDSYSVGLLL----AFLDNYQDL-----KKNAPFTFLLMTKKQLDKPFE----KSKIKINKNSEIYKFINLLVVSDSGQRASLYDIVEQS
.... ||| .| | ..     . .          ..|.    .... . ...| .     .       .|.|. .      |  .| .  .|.|. 
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF---VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 30140.AA STE 50-118 16 2.3e-05 15.04 In-house 1-112 (359) Show / Hide 
Range on Protein: 50-118
Range on HMM: 1-112/359
Sequence Identity: 16% (18 aa)

TNNFQILSFGSFG-MVLATKKAKL-------------DKKEIVLKIQKI--------------------EDEQHIQNEISIMQKLK--EPLVVQLYDSYI
  . ...  |.||  ..| .. .               .. .  |. ..                    |..| |..||.||.|..   | .|. |..|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

IE-------NKI
 |       ...
KEGHNHKNDDEL
Kinase 30140.AA Pkinase 198-230 30 2.073966 2.53 Pfam 175-203 (293) Show / Hide 
Range on Protein: 198-230
Range on HMM: 175-203/293
Sequence Identity: 30% (10 aa)

LGYSAPEILNKQDNELKIYSKKSDSYSVGLLLA
..| |||...    . . |..|.| .|.|..|.
PWYMAPEVIR----GGQYYGPKVDMWSCGCILY