Gene 13310 (Tetrahymena)

13310

Species: Tetrahymena
Alias: 263.m00024, 1158, 13310, n.13310, TTHERM_01170560, PreTt13310
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C8

Sequence

Name Sequence Type Origin Length Description Download
13310.AA Protein None 750 None Fasta, JSON
13310.kin_dom Protein Kinase Domain None 218 None Fasta, JSON
13310.kin_dom2 Protein Kinase Domain None 203 None Fasta, JSON
13310.NA RNA None 5178 None Fasta, JSON

Protein domain

Protein domains of 13310.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 13310.AA Ciliate-C8 51-256 57 3e-121 409.11 In-house 1-238 (238) Show / Hide 
Range on Protein: 51-256
Range on HMM: 1-238/238
Sequence Identity: 57% (138 aa)

GAYALVLKAQNSQQNRQVALKFLGCSNKDDKDGIESLKKEYEMLQKFSQSEFLVKVYDCFYLMEEKEDEDDDGNDIIVQTQNK---SYFVMEMELCEKN-
||...||||||..|||.|||||. |.|| .|...|...|||||...|.|..|.|.||||||||||...|||||||.|||||.|   |.||||||.|..| 
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

-LKQLFDFLRKQQVPPSNVIKEVIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSQEYGFSIKLCD------LGFASAVSKSKS-FLSKK--GTDAY---
 |||.||..||.|..||. .||.||||||...|.||..|||||||||.|||||..|.|...|||||      .||||...|.|| ..|||  |||.|   
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--------FAPEVEKGQSRIQSDLFS-------LGLVL
        |||||||.|||||||.||       .||||
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 13310.AA C8 42-256 61 1.2e-120 407.08 In-house 1-226 (226) Show / Hide 
Range on Protein: 42-256
Range on HMM: 1-226/226
Sequence Identity: 61% (138 aa)

FKNYEYLSSGAYALVLKAQNSQQNRQVALKFLGCSNKDDKDGIESLKKEYEMLQKFSQSEFLVKVYDCFYLMEEKEDEDDDGNDIIVQTQNKSYFVMEME
|.|..|||.|||..||||.|...||...|||. |.||.|...|||..|||||.|.|.|..|.| .|||||.|.|...|....|..||||..||.||||||
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME

LCEKNLKQLFDFLRKQQVPPSNVIKEVIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSQEYGFSIKLCDLGFASAVSKSKS-FLSKK----GTDAYFAP
|||.|||||.|..|..|...|. .|| ||||||.|.|..|.||||||||||.|||||..|.|||.|||||.||||.|||.|| ..|||    ||.|||||
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAP

EVEKG------QSRIQSDLFSLGLVL
|.||.      |.||||||||.||||
EIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 13310.AA C2 51-269 39 1.6e-69 236.6 In-house 1-245 (245) Show / Hide 
Range on Protein: 51-269
Range on HMM: 1-245/245
Sequence Identity: 39% (98 aa)

GAYALVLKAQNSQQNRQVALKFLGCSNKDDKDGIESLKKEYEMLQKFSQSEFLVKVYDCFYLMEE-KEDEDDDGNDIIVQTQN--------KSYFVMEME
|| .||||| | .|||.||||   | .  |  | ... |||....... . ...|||..||| .. ||||| | ...... .|        |. .|.|.|
GAFGLVLKAFNKKQNRHVALKIQEC-QSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

LCEKNLKQLFDFLRKQQVPPSNVIKEVIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSQEYGFSIKLCD----------LGFASAVSKSKSFLSK---K
 |..|||| |. .|||.  |.. .|...||||. . | || ..| ||||||.|||.  .|.    |||||          . |||.....|| ..    |
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK

GTDAY----FAPEVEKGQSRIQSDLFS-LGLVLLELDNLKTLNENW
.| .|    |||||...  . .||||| .|.||||||| .. . . 
WTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 13310.AA CMGC 42-220 16 2.3e-27 86.22 In-house 1-256 (513) Show / Hide 
Range on Protein: 42-220
Range on HMM: 1-256/513
Sequence Identity: 16% (42 aa)

FKNYEYLSSGAYALVLKAQN--------------SQQNRQVALKFLGCSNKDDKDGI---------ESLKKEYEMLQKFS---------------QSEF-
... ... .|.|. | |...               . |..||.| .     .. ..           .   | ..|....               . .  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LVKVYDCFYLMEEKEDEDDDGNDIIVQTQNKSYFVMEMELCEKNLKQLFDFLR------KQQVPPSNV------------IKEVI-----AIQMIEGLN-
.|| ||.||  ... .|..| . |  .  .  .. . .|.....|.|. .  .      ...  .  .            ||  .     . |...||. 
IVKLYDIFYHKNSDGNEYEDKHII--SQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKL

-NLHVKN--IMHRDIKPQNFLVCPSQEY----------------GFSIKLCDLGFASAVSK
  .| ..  |.|||.||.| |...  |.                 . .|.|| |.| ....
KYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHP
Kinase 13310.AA Pkinase 42-259 22 2.5e-27 97.69 Pfam 1-205 (293) Show / Hide 
Range on Protein: 42-259
Range on HMM: 1-205/293
Sequence Identity: 22% (51 aa)

FKNYEYLSSGAYALVLKAQNSQQNRQVALKFLGCSNKDDKDGIESLK-KEYEMLQKFSQSEFLVKVYDCFYLMEEKEDEDDDGNDIIVQTQNKSYFVMEM
..  . . ||... | |...   ...||.| .  ......  .. ..  | ...... .... |. ||.|.                     |..  | |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------------------KDHIYMVM

ELCEKN--LKQLFDFLR--KQQVP--PSNVIKEVIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSQEYGFSIKLCDLGFASA--VSKSKSFLSKKGTDA
|.||.   .  |||...  .. .   . ...| ..  |...||. .| ..|.|||.||.|.|.    . . ..|.|| |.|      ..  . .  ||  
EYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW

YFAPEV--EKGQSRIQSDLFSLGLVLLEL
| ||||  .       .| .|.|..| |.
YMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase 13310.AA STE 42-259 18 2.6e-26 90.0 In-house 1-261 (359) Show / Hide 
Range on Protein: 42-259
Range on HMM: 1-261/359
Sequence Identity: 18% (53 aa)

FKNYEYLSSGAYALVLKAQNS------QQNRQ---------VALKFLGCSNKD--------------DKDGIESLKKEYEMLQKFSQ-SEFLVKVYDCFY
... | . .||.  | || |       . ...         .| | .  .|..              ... .....|| ....|... ... || |.|..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LMEEKEDEDDDGNDIIVQTQNKSYFVMEMELCE-KNLKQLFDFLRKQQVPPS----------NVIKEVIAIQMIEG-LNNLHVKNIMHRDIKPQNFLVCP
   ..             ..|...  . ||...   | .. .   . . | .            .  .|. | ..| |. || ..|.||||||.| |.  
KEGHN-------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--

SQEYGFSIKLCDLGFASAVSK-----------------SKSFLSKKGTDAYFAPEVEKG-QSR------IQSDLFSLGLVLLEL
       .|||| |... ...                 ..   .  ||  . |||| .. ..       ...|  |||....|.
-------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase 13310.AA CAMK 47-238 16 5.4e-24 73.59 In-house 1-291 (425) Show / Hide 
Range on Protein: 47-238
Range on HMM: 1-291/425
Sequence Identity: 16% (50 aa)

YLSSGAYALVLKAQNSQQN------------RQVALKFLGCSNKDDKD-------------------------GIESLKKEYEMLQKFS------QSEFL
 | .|... | .... . .            ..|| |..  .  .||                            .....|.|...| .      . . .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKVYDCFYL-----------MEEKEDEDDDGNDIIVQTQNKSYFVM-EMELCEKN--LKQLFDFLRKQ-----------QVPPSNVIKEVIAI----QMI
.| |. .               .|         ..  .... |.||  ||.|.    .  |||.....            |  .  ..|  |     |..
IKLYEVYEDPHYFKNTNDYET-SKQ--------VF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQIC

EGLNNLHVKNIMHRDIKPQNFLVCPSQEYG-------------FSIKLCDLGFASAVSKSK------------------------SFLSKKGTDAYFA-P
.... .| .||.|||.|| | |.. . .               . ||..| |||  . ...                         .    || .| | |
SAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAP

EV
||
EV
Kinase 13310.AA Ciliate-E2 167-259 25 1.5e-22 74.22 In-house 163-289 (365) Show / Hide 
Range on Protein: 167-259
Range on HMM: 163-289/365
Sequence Identity: 25% (35 aa)

EVIAIQMIEGLNNLHVKN-IMHRDIKPQNFLVCPSQEYGFSIKLCDLGFASAVSKS----------KSFLSKK-----------------------GTDA
| .. ..|..|. || || |.||||||.| |.         ||..|.|..  ....          | ..  |                       ||  
EFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPG

YFAPEVEKGQSR----------IQSDLFSLGLVLLEL
| |||. .|..            ..|..||| .| |.
YMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM
Kinase 13310.AA S_TKc 42-323 21 2.4e-22 81.49 SMART 1-231 (231) Show / Hide 
Range on Protein: 42-323
Range on HMM: 1-231/231
Sequence Identity: 21% (63 aa)

FKNYEYLSSGAYALVLKAQNSQQNRQVALKFLGCSNKDDKDGIESLKKEYEMLQKFSQSEFLVKVYDCFYLMEEKEDEDDDGNDIIVQTQNKSYFVMEME
..  . . .||.. | |...   .|.||.| .           |....| ..|.|  . ...|| ||.|.                      ... | ||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD---------------------DHLYMVME

LCEKNLKQLFDFLRKQQ-------VPPSNVIKEVIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSQEYGFSIKLCDLGFASAVSKSKSFLSKKGTDAYF
.|. .|  |||...|..        |.  . .  .. |....|. .| ..|.|||.||.| |..        ||.|| |.|  .       .  ||  | 
YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARF--YMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYM

APEVEKGQSRIQSDLFSLGLVLLELDNLKTLNENWIDVEIKNNLFKGQEIPNDIYQIDKKSNIYKIAQICLKPSYLDRTSAGELLS--------KLI
||||  | ..  .|  |.| .| |.   ... .   . .. ...                .    . . ||.    .| .| |.|           .
APEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 13310.AA Ciliate-A1 129-259 26 1.9e-19 62.82 In-house 69-221 (301) Show / Hide 
Range on Protein: 129-259
Range on HMM: 69-221/301
Sequence Identity: 26% (43 aa)

QTQNKSYFVMEMELCEKNLKQLFDFLRKQQVPPSNVIKEVIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSQEYGFSIKLCDLGFASAVSKSK------
.|.||  . . || |....  ||..           | | |  |.|||.  .| .||.|||.|||| |.     .    |.||||       ..      
NTNNKECMFIIMEYCQYGN--LFNYCYQNDYMKKEEIYE-ICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKW----KICDLGMSKQLEQNQDCCDDV

-------------SFLSKKGTDAYFAPEV----------EKGQSRIQSDLFSLGLVLLEL
                .| |.  | .||            ..    |||..|||.....|
NGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQMHYRDQMFIENKIYKQSDMYSLGCIICFL
Kinase 13310.AA TKL 169-259 21 1.6e-18 63.28 In-house 137-282 (364) Show / Hide 
Range on Protein: 169-259
Range on HMM: 137-282/364
Sequence Identity: 21% (31 aa)

IAIQMIEGLNNLHV--------KNIMHRDIKPQNFLVCPSQE----------YGFSIKLCDLGFASAVSKSKS--------------------FLSKKGT
.|...  |.| ||         ..| |||.|..| ||    .          .   .|.||.|..  .|.|..                      .. ||
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT

DAYFAPEV-----------------EKGQSRIQSDLFSLGLVLLEL
 .. ||||                 ....   ..| .| |.|| |.
PRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
Kinase 13310.AA Ciliate-E1 140-250 25 3.5e-15 46.22 In-house 76-202 (202) Show / Hide 
Range on Protein: 140-250
Range on HMM: 76-202/202
Sequence Identity: 25% (34 aa)

MELCEKNLKQLFD---------FLRKQQVPPSNVIKEVIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSQEYGFSIKLCDLGFAS--AVSKSKSFLSKK
.|.|...||. ..          ....|   .   |. |..|.|.||. || .||.|||||||| |.. . .| ..    |.| ..    .. ..   | 
FECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC----DFGISKFLKNNQNQQCQYKG

GTDAYFAPEVEK------GQS---RIQSDLF
 |. |  ||. .       ..    ..||..
YTHYYYPPEQYNCPEQEHNKNQKINYKSDIY
Kinase 13310.AA TyrKc 42-322 18 3.3e-10 -57.65 SMART 1-280 (280) Show / Hide 
Range on Protein: 42-322
Range on HMM: 1-280/280
Sequence Identity: 18% (58 aa)

FKNYEYLSSGAYALVLKAQNSQQNRQVALKFLGCSNKDDKDGIESLKKEYEMLQKF-SQSEFLVKVYDCFYLMEEKEDEDDDGNDIIVQTQNKSYFVMEM
 .  . | .||.  | |.. .   .||| | |  .       .| . .| ... |.  . . .|. | .    ...                     . |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-------------FMYIEPLMIVM

ELCEKNLKQLFDFLRKQQVPPSNVIKEVIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCPSQEYGFSIKLCDLGFASAVSKS-------KSFLSKK--GTD
|....    | |.||| .   ..  .  ...|  .| . || ||. |||.   | ||   .     .| .| | . ..          .   .|.  |..
EYMPH--GDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK

-----AYFAPEVE-KGQSRIQSDLFSLGLVLLELDNL-KTLNEN-----WIDVEIKNNLFKG--QEIPNDIYQID-----KKSNIYKIAQICLKPSYLDR
        |||.  .|   ..|| .| | .. |.  . ..  ..       . |. ... .|   ..| ..|          . .|.| . | .    ||
TMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--PMSFVCCPDEMYQIMKQCWHEDPEDR

TSAGELLSKL
 .  |. ...
PTFSEIHECF
Kinase 13310.AA Ciliate-E1 48-136 19 1.7e-08 24.26 In-house 1-108 (202) Show / Hide 
Range on Protein: 48-136
Range on HMM: 1-108/202
Sequence Identity: 19% (21 aa)

LSSGAYALVLKA-QNSQQNRQVALKFLGCSNKDDKDGIESLKKEYE-MLQKFSQSEFLVKVYDCFY---------LMEEKEDEDDDGND---------II
...| ...|.|| |......|||.|.  |  ..... .....|||  ... | . . .....|...         ..|. .... | ..         ..
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

VQTQNKSYF
 |.||. .|
QQNQNQFTF
Kinase 13310.AA Ciliate-E2 42-116 15 1.4e-07 22.04 In-house 1-107 (365) Show / Hide 
Range on Protein: 42-116
Range on HMM: 1-107/365
Sequence Identity: 15% (17 aa)

FKNYEYLSSGAYALVLKAQNSQQNRQVALKFLGCSN--------KDD----------KDGIESLKKEYEMLQ---------------KFSQSEFLVKVYD
.|  . . .|... | |... ....|.|.|.    .        |..          |..||..|.|  ...               .. .. ...| |.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

CFYLMEEK
||. . ..
CFQEKDDN
Kinase 13310.AA Ciliate-A1 42-79 17 0.000393 9.89 In-house 1-39 (301) Show / Hide 
Range on Protein: 42-79
Range on HMM: 1-39/301
Sequence Identity: 17% (7 aa)

FKNYEYLSSGAYALVLKAQNSQQNR-QVALKFLGCSNKD
.     . .| .  |..| ..| ..  ...| . |.|..
YHVVQLIDKGSFGVVMRAYDIQNQKKYLCCKIIICTNFE
Kinase 13310.AA TKL 48-107 13 0.023115 4.33 In-house 1-91 (364) Show / Hide 
Range on Protein: 48-107
Range on HMM: 1-91/364
Sequence Identity: 13% (12 aa)

LSSGAYALVLKAQNSQQN--------RQVALKFLGCSNKDDKDGIES----------------------LKKEYEMLQKFSQ-SEFLVKVY
. ||... | |..  ...        . || | .   | | .. ..                        ..|.|.... .   . .|. .
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFM
Kinase 13310.AA Ciliate-E1 260-298 19 0.216423 0.87 In-house 157-202 (202) Show / Hide 
Range on Protein: 260-298
Range on HMM: 157-202/202
Sequence Identity: 19% (9 aa)

DNLKTLNENWIDVEIKNNLFKGQEIPN-------DIYQIDKKSNIY
..||  ... ....   . .. .|  |       . ..|..||.||
KFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY
Kinase 13310.AA C8 410-611 47 1.1e-99 337.52 In-house 1-226 (226) Show / Hide 
Range on Protein: 410-611
Range on HMM: 1-226/226
Sequence Identity: 47% (108 aa)

TNNFQILSFGSFGIVLSTKKVKLDNKEIVLKIQKIVDEQEIQNEISIMQKLKEPLVVQIYDSYIIENKLGPDRYSVFELEKCS-----------CSLDE-
.||||.||||..|.||..|.|| ||.|||||.||....|.|||..|||.....|.|.| ||.|..|.......|.|||.||||           |...| 
FNNFQYLSFGAYGMVLKAKNVK-DNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEM

----------YLERSNIDGQFNEDDKFQIAIQIIDSVNYIHSFNILHRDIKPENFLVYLEGKQP-EIKLCDFGLSAQIPDNEDSIQTIEH--IGNLGYSA
          |.|| | ..||....|..||||.||.|||||..||.||||||.||||.|..... ||||||||...|...|...||....  .|...|.|
ELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFA

PEILNKKDNELKFYTKKSDSYSVGLLL
|||..|.||..|.|...||..||||.|
PEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 13310.AA Ciliate-C8 419-611 39 5.1e-96 325.3 In-house 1-238 (238) Show / Hide 
Range on Protein: 419-611
Range on HMM: 1-238/238
Sequence Identity: 39% (94 aa)

GSFGIVLST------KKVKLDNKEIVLKIQKIVDEQEIQNEISIMQKLKEPLVVQIYDSYIIENKLGPDR-----------------YSVFELEKCS--C
|.||.||..      .||.|...|.|.||||...|.||.....|||....|.||| ||.......  ...                 ..|.|.|||.  |
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

SLDEYLER-SNIDGQFNEDDKFQIAIQIIDSVNYIHSFNILHRDIKPENFLVYLE-GKQPEIKLCD------FGLSAQIPDNED---------SIQTIEH
.|..|..|  . ........|..||||.||||||.| |||.||||||.||||... ..||.|||||      ||...|.|.|..         ..|.||.
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--IGNLGYSAPEILNK-KDNELKFYTKKSDSYSVGLLL
  .||.||.|||...| .........||||||||||.|
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 13310.AA C2 419-624 28 3.2e-42 142.07 In-house 1-245 (245) Show / Hide 
Range on Protein: 419-624
Range on HMM: 1-245/245
Sequence Identity: 28% (71 aa)

GSFGIVLSTKKVKLDNKEIVLKIQKIVD-----EQEIQNEISIMQKLK-EPLVVQIYDSYIIENKLGPD-------------R----------YSVFELE
|.||.|| .   | .|....||||.. .     ..|.|.|..||....  |.....|...    .   |             .            |.|.|
GAFGLVLKAFN-KKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

KCSCSLDEYLERSNIDG-QFNEDDKFQIAIQIIDSVNYIHSFNILHRDIKPENFLVYLEGKQ-PEIKLCD----------FGLSAQIPDNEDSIQTIEHI
.|.. |  |..|   .  ..... | ..|||..||.||.| |.|.||||||.|||. .  .. | |||||          |  .  .. |.  | . .  
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK

GNLGY----SAPEILNKKDNELKFYTKKSDSYS-VGLLLALLDNYQDLKTNT
.   |    .|||.      . . | |.|| .| ||. |  ||| |    . 
WTQQYYQHIFAPEV------YQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 13310.AA CAMK 415-611 20 2e-34 107.78 In-house 1-324 (425) Show / Hide 
Range on Protein: 415-611
Range on HMM: 1-324/425
Sequence Identity: 20% (66 aa)

ILSFGSFGIVLSTKKVKLDN-----------KEIVLKI---QKIV----------------------------DEQEIQNEISIMQK-------LKEPLV
.|  ||||.|   .  .  .           ..   ||   .|.                             |......||.||.|       |. | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQIYDSYIIEN--------------KLGPDRYSVFEL---EKCSCS------LDEYLERSNI-----------DGQFNEDDKFQIAIQIIDSVNYIHSFN
...|. |  ..                 .|.. .. .   | ||        .|   |...            .| |.|..  ..  ||.. |.|.|| |
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

ILHRDIKPENFLVYLEGKQPE--------------IKLCDFGLSAQIPDNEDSI---------------------QTIEHIGNLGYSA-PEILNKK----
| |||.|||| |.   ..  .              ||..|||........|..                         .  | ..| | ||.||.|    
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----DNELKFYTKKSDSYSVGLLL
     |.| . |..|.|  |.| .|
MQNATDEEKPYYGPKCDMWSCGVIL
Kinase 13310.AA S_TKc 410-683 22 1.3e-29 105.57 SMART 1-231 (231) Show / Hide 
Range on Protein: 410-683
Range on HMM: 1-231/231
Sequence Identity: 22% (66 aa)

TNNFQILSFGSFGIVLSTKKVKLDNKEIVLKIQKIVDEQEIQNEISIMQKLKEPLVVQIYDSYIIENKLGPDRYSVFELEKCSC---SLDEYLERSNIDG
    ...  |.|| |   ...| ....  .|| |    . |..||.|..| . | .|..||..          .  . .| |.    .| .|... .  |
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHG

Q---FNEDDKFQIAIQIIDSVNYIHSFNILHRDIKPENFLVYLEGKQPEIKLCDFGLSAQIPDNEDSIQTIEHIGNLGYSAPEILNKKDNELKFYTK-KS
    |.| .   .. ||.. ..|.|| .|.|||.|||| |.       .||.|||||..|.            .| . | |||.|         |.| |.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL--------GYGKCKC

DSYSVGLLLALLDN----YQDLKTNTTSNFALMTLKQLDKPFEKSNIQINKNSQIYKFINLLVVSDSSQRASLYDIVE-QSD---IKFL
| .|.| .|. .      ..        . ..|  | .              ..   ||. . . | ..| .  .. . ..|     ..
DWWSCGCILYEMLCGYPPFP--------QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 13310.AA Ciliate-E2 410-611 22 2.2e-27 91.08 In-house 1-286 (365) Show / Hide 
Range on Protein: 410-611
Range on HMM: 1-286/365
Sequence Identity: 22% (68 aa)

TNNFQILSFGSFG-----IVLSTKKV-----------------KLDNKEIVLKIQKIVDEQEIQNEISIMQ----------------KLKEPLVVQIYDS
 .  ... .|.||      | ...|                  | ..|.. .||.|  . ..| .||.||.                .|. | ....|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YI--IENKLGPDRYSVFELEKCSC-SLDEYLE------RSNID--GQFNEDDKFQIAIQIID---------------SVNYIHSFN-ILHRDIKPENFLV
..   .|..       . .| |.  .| .|..       ..|.  ..|.|    .|  ||..                ..|.|| | |.|||||||| |.
FQEKDDNNI------YLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF

YLEGKQPEIKLCDFGLSAQIPDNED--------SIQTIEH----------------------IGNLGYSAPEILNKKDNE----LKFYTKKSDSYSVGLL
        ||..||||| .. |...         . .  .                      .|..|| ||||||.|...     | |..|.| .|.| .
--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVI

L
|
L
Kinase 13310.AA Ciliate-E1 416-605 26 2.7e-27 86.1 In-house 1-202 (202) Show / Hide 
Range on Protein: 416-605
Range on HMM: 1-202/202
Sequence Identity: 26% (57 aa)

LSFGSFGIVLSTKKVKLDNKEIVLKIQKIVDEQE-------IQNEISIMQKLKEPL-VVQIYDSYIIENKLGPDRYSVFELEKCSCSLDEYLE-------
.. |||.||.  |. .  .... .||... . ..       |.....||. .|.   ..||.| ..|.. ..    ... .|.|.||| .||.       
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYI----CIIIFECCCCSLKDYLQNHNRLEY

---RSNIDGQFNEDDKFQIAIQIIDSVNYIHSFNILHRDIKPENFLVYLEGKQPEIKLCDFGLSA-QIPDNEDSIQTIEHIGNLGYSAPEILNK---KDN
    .. ..||... | ||..|.|| ....|..||.||||||.| |.. . ..   ..||||.|  ..  .....|   .. .  |. || .|    . |
WQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GN--YVYCDFGISKFLKNNQNQQCQYKGYTHY--YYPPEQYNCPEQEHN

ELKFYTKKSDSY
. . ...||| |
KNQKINYKSDIY
Kinase 13310.AA Pkinase 410-612 26 3.1e-25 90.32 Pfam 1-203 (293) Show / Hide 
Range on Protein: 410-612
Range on HMM: 1-203/293
Sequence Identity: 26% (59 aa)

TNNFQILSFGSFGIVLSTKKVKLDNKEIVLKIQKIVDEQEIQN-------EISIMQKLKEPLVVQIYDSYIIENKLGPDRYSVFELEKCSC-----SLDE
    ...  |||| |   .... ..|. ..|| | ..| . ..       ||.||..|. | .|..||..        ...  . .| | .     .| .
YHIGRKIGSGSFGCVYKCHHKG-TGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFD

YLERSNIDGQF--NEDDKFQIAIQIIDSVNYIHSFNILHRDIKPENFLVYLEGKQPEI----KLCDFGLSAQIPDNEDSIQTIEHIGNLGYSAPEILNKK
|...   .| |   |..   .. ||.  ..|.|| .|.|||.||||.|  .  ....|    |.|||||..|.  .  .  .    | ..| |||...  
YIST-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENIL--ID-NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR--

DNELKFYTKKSDSYSVGLLLA
  . . |..|.| .|.|..|.
--GGQYYGPKVDMWSCGCILY
Kinase 13310.AA STE 410-611 21 1.9e-24 83.35 In-house 1-258 (359) Show / Hide 
Range on Protein: 410-611
Range on HMM: 1-258/359
Sequence Identity: 21% (57 aa)

TNNFQILSFGSFG-IVLSTKKVKL-------------DNKEIVLKIQKIVD--------------------EQEIQNEISIMQKLK--EPLVVQIYDSYI
  . ...  |.||  ..  .. .               .. .  |. .. .                    .|.|..||.||.|..   | .|. |..|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

IEN--KLGPDRYSVFELEKCSC-SLDEYLERSNIDGQ-----------FNEDDKFQIAIQIIDS-VNYIHSFNILHRDIKPENFLVYLEGKQPEIKLCDF
 |.  .   |   .. .| ..  |||. ...  . |.           |.|.    |. ||.    .|.|| .| |||||| | |.        .|||||
KEGHNHKNDDELWIC-MEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDF

GLSAQIPDN--------------EDSIQTIEHIGNLGYSAPEILNKKDNE-LKFYTKKSDSYSVGLLL
|...|. |.                . ..   .|   . |||.... ..   | |. |.| .|.|...
GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI
Kinase 13310.AA CMGC 413-561 16 5.8e-24 74.82 In-house 1-251 (513) Show / Hide 
Range on Protein: 413-561
Range on HMM: 1-251/513
Sequence Identity: 16% (43 aa)

FQILS---FGSFGIVLSTKK-------------VKLDNKEIVLKIQKIVDEQEIQ---------------NEISIMQKLK-----------------EPL
..|..    |..|.| . .               . .|... .|. | .   |.|                ||.|...|.                 .. 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVQIYDSYIIENKLGP-----------DRYSVFELEKCSCSLDEYLERSN--IDG----QFNEDD------------KFQIA------IQIIDSVN--YI
.|..||..  .|  |.           ...  .  | . ..| .|... .    |     ..|              .  .        ||. ...  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSFN--ILHRDIKPENFLVYLEGKQ-----------------PEIKLCDFGLS
|| .  |.|||.|||| |.  ...                   ..|.|||||.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA
Kinase 13310.AA TKL 494-611 23 7e-21 71.92 In-house 124-279 (364) Show / Hide 
Range on Protein: 494-611
Range on HMM: 124-279/364
Sequence Identity: 23% (39 aa)

S-LDEYLERSNIDGQFNEDDKFQIAIQIIDSVNYIHSFN--------ILHRDIKPENFLVYLEGKQPE-----------IKLCDFGLSA------QIPDN
| |. ..           . ....|..|   .|| || |        |.|||.|..| ||   ..              .|.||||||       .  |.
SLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDT

EDSIQ-----------TIEHIGNLGYSAPEILNKKDNELKF-----------YTKKSDSYSVGLLL
. ...           |.  .|.... |||.|....|  .            |..|.| || |..|
MTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL
Kinase 13310.AA Ciliate-A1 516-619 33 4.9e-17 54.5 In-house 106-226 (301) Show / Hide 
Range on Protein: 516-619
Range on HMM: 106-226/301
Sequence Identity: 33% (42 aa)

IAIQIIDSVNYIHSFNILHRDIKPENFLVYLEGKQPEIKLCDFGLSAQIPDNE----------------DSIQTIEHIGNLGYSAPEI----L-NKKDNE
|  |||  .  ||. ||||||.||.| |.  . |   .|.||.|.| | . |                    .|..  ||| | .||     .  ..  |
ICYQIIEGYADIHDHNILHRDLKPQNILIHFDDK---WKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQMHYRDQMFIE

LKFYTKKSDSYSVGLLLALLDNYQD
 | | |.|| ||.|. .  | .  |
NKIY-KQSDMYSLGCIICFLCYKED