Gene 2815 (Tetrahymena)

2815

Species: Tetrahymena
Alias: 2815, 390.m00008, 1155, PreTt02815, n.2815, TTHERM_01438780
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C8

Sequence

Name Sequence Type Origin Length Description Download
2815.AA Protein None 820 None Fasta, JSON
2815.kin_dom Protein Kinase Domain None 199 None Fasta, JSON
2815.kin_dom2 Protein Kinase Domain None 200 None Fasta, JSON
2815.NA RNA None 5115 None Fasta, JSON

Protein domain

Protein domains of 2815.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 2815.AA C8 130-363 58 1.1e-119 403.9 In-house 1-226 (226) Show / Hide 
Range on Protein: 130-363
Range on HMM: 1-226/226
Sequence Identity: 58% (143 aa)

FQNFEYLSSGAYALVLKAKNVKNNRMVALKFLTCTNKDGLKGIESLKKEYELLQKFSQSDFLVNVYDCFYLMEQEVEEDKDGNEKSIITQEKSFFVMEME
|.||.|||.|||..||||||||.||...|||..|.||.  ..|||..||||..|.|.|.||.||.|||||.|....||.|..||| ..|.|||.||||||
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME

LCEQNLKQLFDYLRKTQLP-SKQIKEIIAIQMLEGLNTLHIKNIMHRDIKPHNFLVCPSQTYGFNIKICKKFKFLQNLSIQKIIDNQGDLGFASAVTKSK
|||||||||.|..|..|.. ||..||||||||..|.|..|.||||||||||||||||..|.|||.||.|                   |.||||.|.|.|
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLC-------------------DFGFASQVSKNK

SHYLSKK----GTDSYFAPEVEKG------QSRIQSDLFSLGLIL
||..|||    ||. |||||.||.      |.||||||||.||.|
SHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 2815.AA Ciliate-C8 139-363 54 6.2e-117 394.77 In-house 1-238 (238) Show / Hide 
Range on Protein: 139-363
Range on HMM: 1-238/238
Sequence Identity: 54% (136 aa)

GAYALVLKAKNVKNNRMVALKFLTCTNKDGLKGIESLKKEYELLQKFSQSDFLVNVYDCFYLMEQEVEEDKDGNEKSIITQEK---SFFVMEMELCEQN-
||...||||.| |.||.|||||..|.||   ...|...||||....|.|..|.|.|||||||||....||.|||.| . ||||   ||||||||.|.|| 
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

-LKQLFDYLRKTQLP-SKQIKEIIAIQMLEGLNTLHIKNIMHRDIKPHNFLVCPSQTYGFNIKICKKFKFLQNLSIQKIIDNQGDLGFASAVTKSKSHYL
 |||.||..||.|.. |.|.||||||||....|.||..|||||||||||||||..|.|.. ||.|. |     . .|      .|.||||...|.||||.
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCD-F-----K-KQ------CDFGFASQLPKNKSHYH

SKK--GTDSY-----------FAPEVEKGQSRIQSDLFS-------LGLIL
|||  ||| |           |||||||.|||||||.||       .||.|
SKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 2815.AA C2 139-376 37 7.2e-62 210.12 In-house 1-245 (245) Show / Hide 
Range on Protein: 139-376
Range on HMM: 1-245/245
Sequence Identity: 37% (96 aa)

GAYALVLKAKNVKNNRMVALKFLTCTNKDGLKGIESLKKEYELLQKFSQSDFLVNVYDCFYLMEQEVEEDKDGNEKSIITQEK---------SFFVMEME
|| .||||| | | || ||||   |   | ..| ... |||....... . ....||..||| ... | .   |. .. .||.         .|.|.|.|
GAFGLVLKAFNKKQNRHVALKIQECQSND-INGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

LCEQNLKQLFDYLRKTQ-LPSKQIKEIIAIQMLEGLNTLHIKNIMHRDIKPHNFLVCPSQTYGFNIKIC-KKFKFLQNLSIQKIIDNQGDLGFASAVTKS
 |. |||| |. .|| .  |..|.|.|.||||. . | ||...| |||||| |||.  .|     ||.|    .. |.          .|. |||.. ..
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQY-QK-K--------CDFDFASKLKYN

KS-HYLSK-KGTDSY----FAPEVEKGQSRIQSDLFS-LGLILLELDNLNVLYENW
||  . || |.| .|    |||||...  . .||||| .|..|||||| .    . 
KSRIHFSKFKWTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 2815.AA CMGC 130-297 16 2.5e-23 72.7 In-house 1-246 (513) Show / Hide 
Range on Protein: 130-297
Range on HMM: 1-246/513
Sequence Identity: 16% (41 aa)

FQNFEYLSSGAYALVLKAKN--------------VKNNRMVALKFLTCTNKDGLKGI---------ESLKKEYELLQKFS---------------QSDF-
... ... .|.|. | |...               ..|..||.| .     .   .           .   | ..|....               . .  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LVNVYDCFYLMEQEVEEDKDGNEKSIITQEKSFFVMEMELCEQNLKQLFDYLRK-------TQLPSKQ------------IKEII-----AIQMLEGLN-
.|. ||.||  . . .|..| ..  |  |.   . . .|.....|.|. .  ..         |.  .            || ..     . |.|.||. 
IVKLYDIFYHKNSDGNEYEDKHI--I-SQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKL

-TLHIKN--IMHRDIKPHNFLVCPSQTY----------------GFNIKIC
  .| ..  |.|||.|| | |...  ..                 ...|||
KYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKIC
Kinase 2815.AA Pkinase 130-284 22 6.2e-23 82.18 Pfam 1-141 (293) Show / Hide 
Range on Protein: 130-284
Range on HMM: 1-141/293
Sequence Identity: 22% (37 aa)

FQNFEYLSSGAYALVLKAKNVKNNRMVALKFLTCTNKDGLKGIESLK-KEYELLQKFSQSDFLVNVYDCFYLMEQEVEEDKDGNEKSIITQEKSFFVMEM
..  . . ||... | |.........||.| .   ...  | .. ..  | ...... .... |  ||.|.                     |.   | |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------------------KDHIYMVM

ELCEQN--LKQLFDYLR---KTQL--PSKQIKEIIAIQMLEGLNTLHIKNIMHRDIKPHNFLV
|.||    .  ||||..   .. .  . ...| ..  |.|.||. .| ..|.|||.|| |.|.
EYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILI
Kinase 2815.AA Ciliate-E1 136-310 24 5.2e-19 58.82 In-house 1-169 (202) Show / Hide 
Range on Protein: 136-310
Range on HMM: 1-169/202
Sequence Identity: 24% (44 aa)

LSSGAYALVLKAKNVKNN-RMVALKFLTCTNKDGLKGIESLKKEYE-LLQKFSQSDFLVNVYDCFY----LMEQEVEEDKDGNEKSIITQEKSFFVMEME
...| ...|.|||. .|| . ||.|.  |  ..    .....|||  ... | . . .....|...    ... .. |  . . |  ....         
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNH---------

LCEQNLKQLFDYLRKTQLPSKQI-KEIIAIQMLEGLNTLHIKNIMHRDIKPHNFLVCPSQTYGFN-IKICKKFKFLQNLSIQK
   . | .... ....|   ..  |. |..|...||. ||..||.||||||.| |.. .  | .. . |.|..|  || ..|.
---NRL-EYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQY
Kinase 2815.AA CAMK 135-297 13 1.6e-18 55.59 In-house 1-238 (425) Show / Hide 
Range on Protein: 135-297
Range on HMM: 1-238/425
Sequence Identity: 13% (34 aa)

YLSSGAYALVLKAKNVKNN------------RMVALKFLTCTNKDG-------------------------LKGIESLKKEYELLQKFS------QSDFL
 | .|... | .... ...            . || |..  .  ..                          |  .....|.|...| .      .   .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNVYDCFY------------LMEQEVEEDKDGNEKSIITQEKSFFVMEM---ELCEQN--LKQLFDYLRKT----------------QLPSKQIKEIIAI
.. |. .               ..            ..   .....| |   |.|.    .  ||||...                  .. .. . ..  
IKLYEVYEDPHYFKNTNDYET-SKQ-----------VF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFR-

QMLEGLNTLHIKNIMHRDIKPHNFLVCPSQTYG-------------FNIKIC
|...... .| .||.|||.|| | |.. . .               .||||.
QICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKII
Kinase 2815.AA S_TKc 130-429 19 4e-16 59.49 SMART 1-231 (231) Show / Hide 
Range on Protein: 130-429
Range on HMM: 1-231/231
Sequence Identity: 19% (63 aa)

FQNFEYLSSGAYALVLKAKNVKNNRMVALKFLTCTNKDGLKGIESLKKEYELLQKFSQSDFLVNVYDCFYLMEQEVEEDKDGNEKSIITQEKSFFVMEME
..  . . .||.. | |....| .| ||.| .           |....| ..|.|  . ...|. ||.|.                      ... | ||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD---------------------DHLYMVME

LCEQNLKQLFDYLRKTQ-------LPSKQIKEIIAIQMLEGLNTLHIKNIMHRDIKPHNFLVCPSQTYGFNIKIC-----KKFKFLQNLSIQKIIDNQGD
.|...|  ||||..| .       .|  ... ... |....|. .| ..|.|||.|| | |..       .||||     ...                 
YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-----------------

LGFASAVTKSKSHYLSKKGTDSYFAPEVEKGQSRIQSDLFSLGLILLELDNLNVLYENWIDFDIKGEIYQGKGIASKYQIDRNSNIYKIAEICLKPKYLE
               .  ||  | ||||  | ..  .|  |.| || |.     ...         ....  |          .    . . ||.    .
--------------TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG---------SPEAKDFIRKCLQKDPEK

RTTSGNLLS--------ELI
| |   .|         . .
RPTA-EALQDEWDIKCHPWF
Kinase 2815.AA STE 130-297 18 1.3e-15 51.75 In-house 1-189 (359) Show / Hide 
Range on Protein: 130-297
Range on HMM: 1-189/359
Sequence Identity: 18% (39 aa)

FQNFEYLSSGAYALVLKAKNVK---------------NNRMVALKFLTCTNKDG--------------LKGIESLKKEYELLQKFSQ-SDFLVNVYDCFY
... | . .||.  | ||.|.|               .....| | .   |..                . .....|| ....|... ... |. |.|..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LMEQEVEEDKDGNEKSIITQEKSFFVMEMELCE-QNLKQLFDYLRKTQLPSK-----------QIKEIIAIQMLEG-LNTLHIKNIMHRDIKPHNFLVCP
    .             .....   . ||...   | .. .   ... | .           ..  .|. | |.| |. || ..|.|||||| | |.  
KEGHN-------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--

SQTYGFNIKIC
       .|.|
-------VKLC
Kinase 2815.AA Ciliate-E2 228-460 15 2.2e-11 35.34 In-house 113-344 (365) Show / Hide 
Range on Protein: 228-460
Range on HMM: 113-344/365
Sequence Identity: 15% (50 aa)

MELCEQNLKQLFDYLRKTQLPSKQI---------KEI--IAIQMLE---------------GLNTLHIKN-IMHRDIKPHNFLVCPSQTYGFNIKICKKF
||.|..  . ||||... .. ....         |||  |  | |.               .|. || || |.|||||| | |.                
MEYCQG--GDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----------------

KFLQNLSIQKIIDNQGDLGFASAVTKS---------KSHYLSKK-----------------------GTDSYFAPEVEKGQSR----------IQSDLFS
         |||    |.|..  ....            |.  |                       ||  | |||. .|..            ..|..|
--------IKII----DFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWS

LGLILLELDNLNVLYENWIDFDIKGEIYQGKGIASKYQIDRNSNIYKIAEICLKPKYLERTTSGNLLSELIKLHGEPLKFTLASMI-----------LEE
|| || |.   .  .                                                      ... .  ...|  . ..             .
LGVILYEMLFGKPPF------------------------------------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWK

QIPQQAQQIFNR----I
...|........    .
KWSQECKDLIKKFGKRM
Kinase 2815.AA TKL 256-297 28 3.6e-08 25.53 In-house 137-196 (364) Show / Hide 
Range on Protein: 256-297
Range on HMM: 137-196/364
Sequence Identity: 28% (17 aa)

IAIQMLEGLNTLHI--------KNIMHRDIKPHNFLVCPSQT----------YGFNIKIC
.|...  |.| ||         ..| |||.|..| ||    |          .  ..|||
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKIC
Kinase 2815.AA STE20 130-203 18 1.6e-07 23.91 In-house 1-82 (288) Show / Hide 
Range on Protein: 130-203
Range on HMM: 1-82/288
Sequence Identity: 18% (15 aa)

FQNFEYLSSGAYALVLKAKNVKNNRM----VALKFLTCTNKDGL-KGIESLKKEYELLQKFSQSDFLVNVYDCFYLM----EQ
....| . .|.|  | || ......     || | .   ..|   . .|...||.  ....  .   |. |.... .    ..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTCDDE
Kinase 2815.AA Ciliate-E2 130-199 13 1e-06 18.56 In-house 1-102 (365) Show / Hide 
Range on Protein: 130-199
Range on HMM: 1-102/365
Sequence Identity: 13% (14 aa)

FQNFEYLSSGAYALVLKAKNVKNNRMVALKFLTCTN----------------KDGL--KGIESLKKEYELLQ---------------KFSQSDFLVNVYD
.   . . .|... | |.|. |.....|.|. . ..                .  .  ..||..|.|  ...               .. ....... |.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

CFY
||.
CFQ
Kinase 2815.AA TKL 316-366 16 0.00023 11.64 In-house 196-282 (364) Show / Hide 
Range on Protein: 316-366
Range on HMM: 196-282/364
Sequence Identity: 16% (14 aa)

GDLGFASAVTKSKS-------------------HYLSKKGTDSYFAPEV-----------------EKGQSRIQSDLFSLGLILLEL
.|.|..  ...|..                   .  .. ||  . ||||                 ....   ..| .| |..| |.
CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
Kinase 2815.AA STE20 259-281 52 0.00097 9.89 In-house 125-147 (288) Show / Hide 
Range on Protein: 259-281
Range on HMM: 125-147/288
Sequence Identity: 52% (12 aa)

QMLEGLNTLHIKNIMHRDIKPHN
..|.||. || ..|.|||||  |
EVLQGLDYLHSNHIIHRDIKADN
Kinase 2815.AA STE 317-366 20 0.011317 5.41 In-house 190-261 (359) Show / Hide 
Range on Protein: 317-366
Range on HMM: 190-261/359
Sequence Identity: 20% (15 aa)

DLGFASAVTKS----------------KSHYLSKKGTDSYFAPEVEKG-QSR------IQSDLFSLGLILLEL
| |... .|.|                ...  .  ||  . |||| .. ..       ...|  |||. ..|.
DFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase 2815.AA Pkinase 316-366 31 0.072026 7.69 Pfam 154-205 (293) Show / Hide 
Range on Protein: 316-366
Range on HMM: 154-205/293
Sequence Identity: 31% (17 aa)

GDLGFASAV-TKSKSHYLSKKGTDSYFAPEV--EKGQSRIQSDLFSLGLILLEL
.| |.|  . . ..| . .  ||  | ||||  .       .| .|.|.|| |.
CDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase 2815.AA TKL 136-195 14 0.170714 1.16 In-house 1-91 (364) Show / Hide 
Range on Protein: 136-195
Range on HMM: 1-91/364
Sequence Identity: 14% (13 aa)

LSSGAYALVLKAKNVKNN--------RMVALKFLTCTNKDGLKGIES----------------------LKKEYELLQKFSQ-SDFLVNVY
. ||... | |.|   ..        . || | .  .| |    ..                        ..|.|.... .   . .|  .
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFM
Kinase 2815.AA C8 515-713 50 3.9e-103 348.94 In-house 1-226 (226) Show / Hide 
Range on Protein: 515-713
Range on HMM: 1-226/226
Sequence Identity: 50% (113 aa)

VNNFQILNFGSFGMVLSTKKVD--KEIVLKIQKIVDEQEIQNEIRIMQQLKTPLVVQLYDNYVIEKATAPEKYVVFELEKCS-----------CSLQE--
.||||.|.||..||||..|.|.  .|||||.||....|.|||...||.....|.|.|.||.||.|.....|.|.|||.||||           |...|  
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME

---------YLESQGKEGEFSNEEKLNIAIQIIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQL-EIKLCDFGLSAQLEKNCEQIEILEM--VGNWAYMAP
         |.| . |...||.|.|..||||.||.||||||.||.||||||.|||||||.|.. ||||||||...|..||...|.. .|  .|.|||.||
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAP

EILTKEDHQNKIYSKKSDSYSVGLLL
||..|.|.|.|.|...||..||||.|
EIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 2815.AA Ciliate-C8 524-713 42 2.5e-98 332.96 In-house 1-238 (238) Show / Hide 
Range on Protein: 524-713
Range on HMM: 1-238/238
Sequence Identity: 42% (101 aa)

GSFGMVLST------KKVD---KEIVLKIQKIVDEQEIQNEIRIMQQLKTPLVVQLYDNYVIEKATAPEK-----------------YVVFELEKCS--C
|.|||||..      .||    .|.|.||||...|.||.....|||....|.|||.||..........|.                 ..|.|.|||.  |
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

SLQEYLES-QGKEGEFSNEEKLNIAIQIIDSVNYIHCFNIIHRDIKPDNFLVCLD-GNQLEIKLCD------FGLSAQLEKNCE---------QIEILEM
.|..|..  . |....|...|..||||.||||||.|||||.||||||.|||||.| ..|..|||||      ||...||.||..         .....||
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--VGNWAYMAPEILTK-EDHQNKIYSKKSDSYSVGLLL
  .|||.|.|||...| ...|..|.|||||||||||.|
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 2815.AA C2 524-726 29 1.5e-49 167.46 In-house 1-245 (245) Show / Hide 
Range on Protein: 524-726
Range on HMM: 1-245/245
Sequence Identity: 29% (75 aa)

GSFGMVLST--KKVDKEIVLKIQKIVD-----EQEIQNEIRIMQQLK-TPLVVQLYD-NYVIEKATAP------------EK----------YVVFELEK
|.||.|| .  ||  ....||||.. .     ..|.|.|..||.|..  |.....|.  |. ..                |.           ||.|.|.
GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF

CSCSLQEYLESQGKEG-EFSNEEKLNIAIQIIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQL-EIKLCD----------FGLSAQLEKNCEQIEILEMVG
|.. |. |.. . |.  ......|  .|||..||.||.|.|.|.||||||.|||. .| ...  |||||          |  .  |..| ..| . ....
CQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKW

NWAY----MAPEILTKEDHQNKIYSKKSDSYS-VGLLLSLLDNYFILKENT
  .|    .|||.      . .|| |.|| .| ||. |  ||| ..   . 
TQQYYQHIFAPEV------YQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 2815.AA CAMK 520-713 20 9.4e-34 105.6 In-house 1-324 (425) Show / Hide 
Range on Protein: 520-713
Range on HMM: 1-324/425
Sequence Identity: 20% (65 aa)

ILNFGSFGMVLSTKKV-D-------------KEIVLKI---QKIV----------------------------DEQEIQNEIRIMQQ-------LKTPLV
.|  |||| |   .   .             ..   ||   .|.                             |......||.||..       |. | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLYDNYVIEKA--------TAP------EKYVVFEL---EKCSC-----SLQEYLESQGK------------EGEFSNEEKLNIAIQIIDSVNYIHCFN
..||. |  ..         |        .|.... .   | ||       | .|. ..|.            .| |. .|   .  ||.. |.|.|  |
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDIKPDNFLVCLDG--------------NQLEIKLCDFGLSAQLEKNCEQI---------------------EILEMVGNWAYMA-PEILTKEDHQN
|.|||.||.| |.. ..              |.  ||..|||........ ..                         ...|  .||| ||.| .. |.|
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

KI---------YSKKSDSYSVGLLL
.          |..|.|  |.| .|
MQNATDEEKPYYGPKCDMWSCGVIL
Kinase 2815.AA S_TKc 518-783 24 5e-29 103.68 SMART 1-231 (231) Show / Hide 
Range on Protein: 518-783
Range on HMM: 1-231/231
Sequence Identity: 24% (68 aa)

FQILNF---GSFGMVLSTKKVD--KEIVLKIQKIVDEQEIQNEIRIMQQLKTPLVVQLYDNYVIEKATAPEKYVVFELEKCSC---SLQEYLESQGKEGE
..||.    |.|| |   ....  ..  .|| |    . |..||.|... . | .|.||| ..        ... . .| |.    .| .|....|..| 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FSNEEKLNIAIQIIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQLEIKLCDFGLSAQLEKNCEQIEILEMVGNWAYMAPEILTKEDHQNKIYSK-KSD
   |.  .   .. ||.. ..|.|  .|||||.||.| |..      .||.|||||..||           ..|   |||||.|         |.| |.|
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL--------GYGKCKCD

SYSVG-LLLSLLDNYFILKENTGSTFMMMTLNQYDESFKQINIKRNTEIFKFIQLLVVWERVNRASLSIIVE----QNSKKFK
 .|.| .|  .|  |     .   .| ..                  |   ||. . ...  .| .   . .     ..  . 
WWSCGCILYEMLCGYPPFP-QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 2815.AA Pkinase 515-713 27 6e-28 99.9 Pfam 1-202 (293) Show / Hide 
Range on Protein: 515-713
Range on HMM: 1-202/293
Sequence Identity: 27% (59 aa)

VNNFQILNFGSFGMVLSTKKVDKE--IVLKIQKIVDEQEIQN-------EIRIMQQLKTPLVVQLYDNYVIEKATAPEKYVVFELEKCSC-----SLQEY
    ...  |||| |   .... .   ..|| | ..| . ..       ||.||. |. | .|.||| .        .... . .| | .     .| .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDY

LESQGKEGEF--SNEEKLNIAIQIIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQL--EIKLCDFGLSAQLEKNCEQIEILEMVGNWAYMAPEILTKEDHQ
..   ..| |  | .|  ... ||.  ..|.|  .|||||.||.|.|.  . ...   .|.|||||..|.. .  .      .|   |||||.     ..
IST-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEV-----IR

-NKIYSKKSDSYSVGLLL
 .. |..|.| .|.|..|
GGQYYGPKVDMWSCGCIL
Kinase 2815.AA Ciliate-E1 521-707 24 6.9e-27 84.73 In-house 1-202 (202) Show / Hide 
Range on Protein: 521-707
Range on HMM: 1-202/202
Sequence Identity: 24% (53 aa)

LNFGSFGMVLST-------KKVDKEIVLKIQKIV---DEQEIQNEIRIMQQLKTPL-VVQLYDNYVIEKATAPEKYVVFELEKCSCSLQEYLE-------
.  |||..|.         ..| . |.. .....   ...||.... ||. .|.   ..|..| . |...    .  .. .|.|.|||..||.       
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQN----YICIIIFECCCCSLKDYLQNHNRLEY

---SQGKEGEFSNEEKLNIAIQIIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQLEIKLCDFGLSA--QLEKNCEQ---IEILEMVGNWAYMAPEILTKED
    | ....|. ..|..|..|.|| ....| .|||||||||.| |.. . ... .   |||.|   ....| ..    ..  .  .. |. |  .  | 
WQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYC--DFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCP--EQ-EH

HQNKIYSKKSDSY
 .|.....||| |
NKNQKINYKSDIY
Kinase 2815.AA TKL 596-713 24 6.9e-26 90.21 In-house 124-279 (364) Show / Hide 
Range on Protein: 596-713
Range on HMM: 124-279/364
Sequence Identity: 24% (40 aa)

SLQEYLESQGKEGEFSNEEKLNIAIQIIDSVNYIHCFN--------IIHRDIKPDNFLVCLDGN-----------QLEIKLCDFGLSAQLEKNCEQIEIL
|| .||           . ....|..|   .|| |  |        |||||.|..| ||  ...           .  .|.||||||  .... ..  . 
SLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTM

EM-----------------VGNWAYMAPEILTKEDHQNK-----------IYSKKSDSYSVGLLL
 .                 .|. ..||||.| ...  ..            ||.|.| || |..|
TTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL
Kinase 2815.AA STE 516-713 21 1.2e-25 87.56 In-house 1-258 (359) Show / Hide 
Range on Protein: 516-713
Range on HMM: 1-258/359
Sequence Identity: 21% (58 aa)

NNF-QILNFGSFG-MVLSTKK----------------VDKEIVLKIQKIVD--------------------EQEIQNEIRIMQQLK--TPLVVQLYDNYV
  . ...  |.||  ..  ..                  . .  |. .. .                    .|.|..||.||....   | .|. |. |.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

IE---KATAPEKYVVFELEKCSC-SLQEYLE---SQGKEGEFSN-------EEKL-NIAIQIIDS-VNYIHCFNIIHRDIKPDNFLVCLDGNQLEIKLCD
 |   .    | ... |.  ..  || . ..   . ||.  ...       |. .  |. ||.    .|.|  .||||||||.| |.        .||||
KEGHNHKNDDELWICMEY--MDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCD

FGLSAQLEKNCE--------------QIEILEMVGNWAYMAPEILTKEDHQ-NKIYSKKSDSYSVGLLL
||...||....               | .   .||   .||||.......  .| |. |.| .|.|...
FGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI
Kinase 2815.AA CMGC 515-663 15 1.4e-25 80.27 In-house 1-251 (513) Show / Hide 
Range on Protein: 515-663
Range on HMM: 1-251/513
Sequence Identity: 15% (40 aa)

VNNFQILNFGSFGMVLSTKKVD----------------KEIVLKIQKIVDEQEIQ---------------NEIRIMQQLK-----------------TPL
  . . .  |..|.| . .  .                ... .|. | .   |.|                ||.|...|.                  . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVQLYDNYVIEKATAPEK-----------YVVFELEKCSCSLQEYLESQG--KEG----EFSNEE------------KLNIA------IQIIDSVN--YI
.|.||| .. .. . .|.           .. .  | . ..| .|....   . |    ..|  .            . ..        ||. ...  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HCFN--IIHRDIKPDNFLVCLDGNQ-----------------LEIKLCDFGLS
|  .  |||||.|| | |.. ..                    ..|.|||||.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA
Kinase 2815.AA Ciliate-E2 515-713 21 2.5e-24 80.43 In-house 1-286 (365) Show / Hide 
Range on Protein: 515-713
Range on HMM: 1-286/365
Sequence Identity: 21% (65 aa)

VNNFQILNFGSFG-----MVLSTKK-------------------VD-KEIVLKIQKIVDEQEIQNEIRIMQ----------------QLKTPLVVQLYDN
 .  ... .|.||      | ...|                   |. |.. .||.|  . ..| .||.||.                ||. | ....|. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YVIEKATAPEKYVVFELEKCSC-SLQEYLESQGKE--------GEFSNEEKLNIAIQIID---------------SVNYIHCFN-IIHRDIKPDNFLVCL
.  ..    .... . .| |.  .|..|.... |         . |. .| ..|  ||..                ..|.|  | ||||||||.| |.  
FQEKD----DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--

DGNQLEIKLCDFGLSAQL-EKNCEQIEILEM-----------------------------VGNWAYMAPEILTKED----HQNKIYSKKSDSYSVGLLL
      ||..||||| .. ..|..... . .                             .|.  ||||||| ...     . | |..|.| .|.| .|
------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase 2815.AA STE20 627-710 40 1.2e-16 57.57 In-house 131-214 (288) Show / Hide 
Range on Protein: 627-710
Range on HMM: 131-214/288
Sequence Identity: 40% (36 aa)

NYIHCFNIIHRDIKPDNFLVCLDGNQLEIKLCDFGLSAQLEK--NCEQIEI---LEMVGNWAYMAPEILTKEDHQNKIYSKKSDSYSVG
.|.|  .||||||| || |.  ||   |.||.|||..|||.|    .  .      .||   .||||.. ...   | |  |.| .|.|
DYLHSNHIIHRDIKADNILLTEDG---EVKLADFGVCAQLTKHGR-D-TMQFKRNTFVGTPYWMAPEVIQCMEGPDKGYDYKCDIWSLG
Kinase 2815.AA TyrKc 515-778 19 5e-11 -44.33 SMART 1-280 (280) Show / Hide 
Range on Protein: 515-778
Range on HMM: 1-280/280
Sequence Identity: 19% (60 aa)

VNNFQILNFGSFGMVLSTKKVDKEIVL--KIQKIVDEQEIQNEIRIMQQL--KTPLVVQLYDNYVIEKA-----TAPEKYVVFELEKCSCSLQEYLESQG
.   ..|  | || |   .    . |   ....   .... .|.||| .|  . | .|.||   |. .       ..  ..|.|. .   .|..|| . .
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLY--GVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRKHR

KEGEFSNEEKLNIAIQIIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQLEIKLCDFGLSAQLEKN------CEQIEI-----LEMVGNWAYMAPEILTKED
..  ......|....|| .  .|.|  |.||||.   | ||  ..    .| .|||||  ..         . .         ..     |||| .    
PK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----

HQNKIYSKKSDSYSVGLLL-----------SL-----LDNYFILKENTGSTFMMMTLNQYDE-SFKQINIKRNTEIFKFIQLLVVWERVNRASLSIIVEQ
 . .... ||| .| | ..           .      ..|. ...       |.   | | . ||        .|... ..     .  .| . | |.|.
-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSF----VCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

N
 
F
Kinase 2815.AA STE20 548-577 40 0.000136 13.05 In-house 47-76 (288) Show / Hide 
Range on Protein: 548-577
Range on HMM: 47-76/288
Sequence Identity: 40% (12 aa)

DEQEIQNEIRIMQQLKTPLVVQLYDNYVIE
....||.||.||.|.| | .|. |. |. .
EWEDIQKEISIMKQCKHPNIVKYYGSYLKD