Gene 19409 (Tetrahymena)

19409

Species: Tetrahymena
Alias: 594.m00002, PreTt19409, TTHERM_01725470, 19409, 38
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C8

Sequence

Name Sequence Type Origin Length Description Download
19409.AA Protein None 652 None Fasta, JSON
19409.kin_dom Protein Kinase Domain None 202 None Fasta, JSON
19409.kin_dom2 Protein Kinase Domain None 203 None Fasta, JSON
19409.NA RNA None 1959 None Fasta, JSON

Protein domain

Protein domains of 19409.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 19409.AA C8 27-54 64 5.9e-15 48.43 In-house 193-226 (226) Show / Hide 
Range on Protein: 27-54
Range on HMM: 193-226/226
Sequence Identity: 64% (22 aa)

GTDAYFAPEVEKG------QSRIQSDIFSLGLVL
||.||||||.||.      |.|||||.||.||||
GTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 19409.AA Ciliate-C8 27-54 65 2.1e-13 44.66 In-house 204-238 (238) Show / Hide 
Range on Protein: 27-54
Range on HMM: 204-238/238
Sequence Identity: 65% (23 aa)

GTDAYFAPEVEKGQSRIQSDIFS-------LGLVL
|. .||||||||.||||||||||       .||||
GNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 19409.AA C2 23-67 42 6.3e-09 26.76 In-house 196-245 (245) Show / Hide 
Range on Protein: 23-67
Range on HMM: 196-245/245
Sequence Identity: 42% (21 aa)

SSSKGTDAY----FAPEVEKGQSRIQSDIFS-LGLVLLELDNLNVLNDNW
|  |.| .|    |||||...  . .||.|| .|.||||||| .  . . 
SKFKWTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 19409.AA TKL 23-57 23 1.2e-05 16.36 In-house 231-282 (364) Show / Hide 
Range on Protein: 23-57
Range on HMM: 231-282/364
Sequence Identity: 23% (12 aa)

SSSKGTDAYFAPEV-----------------EKGQSRIQSDIFSLGLVLLEL
..  || .. ||||                 ....   ..|..| |.|| |.
MTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
Kinase 19409.AA Ciliate-E2 27-57 34 6.5e-05 12.79 In-house 249-289 (365) Show / Hide 
Range on Protein: 27-57
Range on HMM: 249-289/365
Sequence Identity: 34% (14 aa)

GTDAYFAPEVEKGQSR----------IQSDIFSLGLVLLEL
||  | |||. .|..            ..||.||| .| |.
GTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM
Kinase 19409.AA STE 24-57 29 0.002446 7.79 In-house 222-261 (359) Show / Hide 
Range on Protein: 24-57
Range on HMM: 222-261/359
Sequence Identity: 29% (12 aa)

SSKGTDAYFAPEVEKG-QSR------IQSDIFSLGLVLLEL
.  ||  . |||| .. ..       ...|| |||....|.
TFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase 19409.AA Pkinase 27-57 36 1.161739 3.42 Pfam 173-205 (293) Show / Hide 
Range on Protein: 27-57
Range on HMM: 173-205/293
Sequence Identity: 36% (12 aa)

GTDAYFAPEV--EKGQSRIQSDIFSLGLVLLEL
||  | ||||  .       .|..|.|..| |.
GTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase 19409.AA C8 188-389 48 2.8e-103 349.43 In-house 1-226 (226) Show / Hide 
Range on Protein: 188-389
Range on HMM: 1-226/226
Sequence Identity: 48% (110 aa)

VNNFQILNFGSFGMVLSTKKVNLNNKEIALKIQKIVNDQEIQNEIRIMQQLKTPLVVQLYDHYVIEKATAPEKYVVFELEKCS-----------CSLQD-
.||||.|.||..||||..|.|. .|.||.||.||..|.|.|||...||.....|.|.|.||.||.|.....|.|.|||.||||           |.... 
FNNFQYLSFGAYGMVLKAKNVK-DNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEM

----------YLERQTKEGEFSDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLDGNQL-EIKLCDFGLSVQLGKDCEQIEVQCM--VGNMTYSA
          |.||..|...||.|.|..||.|.||.||||||.||.||||||.|||||||.|.. ||||||||.. |..|....|. . |  .|...|.|
ELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFA

PEIIAKEDDQNKIYSKKSDSYSVGLLL
|||..|.|.|.|.|...||..||||.|
PEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 19409.AA Ciliate-C8 197-389 40 1e-98 334.25 In-house 1-238 (238) Show / Hide 
Range on Protein: 197-389
Range on HMM: 1-238/238
Sequence Identity: 40% (97 aa)

GSFGMVLST------KKVNLNNKEIALKIQKIVNDQEIQNEIRIMQQLKTPLVVQLYDHYVIEKATAPEK-----------------YVVFELEKCS--C
|.|||||..      .||.|...|...||||.....||.....|||....|.|||.||..........|.                 ..|.|.|||.  |
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

SLQDYLER-QTKEGEFSDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLD-GNQLEIKLCD------FGLSVQLGKDCE---------QIEVQCM
.|..|..| . |....|...|..|| |.||||||.|||||.||||||.|||||.| ..|..|||||      ||.. || |...         ......|
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--VGNMTYSAPEIIAK-EDDQNKIYSKKSDSYSVGLLL
  .||..|.|||...| ...|..|.|||||||||||.|
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 19409.AA C2 197-389 30 1.5e-48 163.94 In-house 1-232 (245) Show / Hide 
Range on Protein: 197-389
Range on HMM: 1-232/245
Sequence Identity: 30% (73 aa)

GSFGMVLSTKKVNLN-NKEIALKIQKIVN-----DQEIQNEIRIMQQLK-TPLVVQLYD-HYVIEKATAP------------EK----------YVVFEL
|.||.||  |  | . |...|||||..        .|.|.|..||.|..  |.....|.  |. ..                |.           ||.|.
GAFGLVL--KAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQ

EKCSCSLQDYLERQTKEG-EFSDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLDGNQL-EIKLCD----------FGLSVQLGKDCEQIEVQCM
|.|.. |. |..|..|.  ......|  .| |..||.||.|.|.|.||||||.|||. .| ...  |||||          |  .  | .. ..| .. .
EFCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKF

VGNMTY----SAPEIIAKEDDQNKIYSKKSDSYS-VGLLL
..  .|    .|||..       .|| |.|| .| ||. |
KWTQQYYQHIFAPEVYQ------NIYKKNSDLFSTVGYVL
Kinase 19409.AA CAMK 193-389 19 4.7e-38 119.7 In-house 1-324 (425) Show / Hide 
Range on Protein: 193-389
Range on HMM: 1-324/425
Sequence Identity: 19% (63 aa)

ILNFGSFGMVLSTKKVNLNN-----------KEIALKI---QKIV----------------------------NDQEIQNEIRIMQQ-------LKTPLV
.|  |||| |   .  | ..           .. | ||   .|.                             . .....||.||..       |. | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLYDHYVIEKA--------TAP------EKYVVFEL---EKCSC-----SLQDYLERQTK------------EGEFSDEQKLNIALQIIDSVNYIHCFN
..||..|  ..         |        .|.... .   | ||       | ||. ....            .| |. ..   .  ||.. |.|.|  |
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDIKPENFLVCLDG--------------NQLEIKLCDFGLSVQLGKDCEQI---------------------EVQCMVGNMTYSA-PEIIAKE----
|.|||.|||| |.. ..              |.  ||..|||.. .. .. ..                        . ..|   | | ||.. ..    
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----DDQNKIYSKKSDSYSVGLLL
     |.... |..|.|  |.| .|
MQNATDEEKPYYGPKCDMWSCGVIL
Kinase 19409.AA S_TKc 191-459 24 1e-32 115.94 SMART 1-231 (231) Show / Hide 
Range on Protein: 191-459
Range on HMM: 1-231/231
Sequence Identity: 24% (70 aa)

FQILNF---GSFGMVLSTKKVNLNNKEIALKIQKIVNDQEIQNEIRIMQQLKTPLVVQLYDHYVIEKATAPEKYVVFELEKCSC---SLQDYLERQTKEG
..||.    |.|| |   ....  ... |.|| |    . |..||.|... . | .|.|||...        ... . .| |.    .| ||.... ..|
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHG

E---FSDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLDGNQLEIKLCDFGLSVQLGKDCEQIEVQCMVGNMTYSAPEIIAKEDDQNKIYSK-KS
    |.  .   .. ||.. ..|.|  .|||||.|||| |..      .||.|||||. ||           ..|   | |||..         |.| |.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL--------GYGKCKC

DSYSVG-LLLSLLDNYLILNEIVGITFPSMAFEQYNEPFQNINIKRNTEIFEFIKLLVVWERVNRASLSTIVE----QNTNQFK
| .|.| .|  .|  |                 |... |..|      |  .||. . ...  .| .   . .     .  .. 
DWWSCGCILYEMLCGYPPFP-------------QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 19409.AA Ciliate-E1 194-383 28 1.1e-31 100.46 In-house 1-202 (202) Show / Hide 
Range on Protein: 194-383
Range on HMM: 1-202/202
Sequence Identity: 28% (60 aa)

LNFGSFGMVLSTKKVNLNNKEIALKIQKIV---N----DQEIQNEIRIMQQLKTPL-VVQLYDHYVIEKATAPEKYVVFELEKCSCSLQDYLE-------
.  |||..|.  |. | |....|.||...    |    ..||.... ||. .|.   ..|..| . |...    .  .. .|.|.|||.|||.       
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQN----YICIIIFECCCCSLKDYLQNHNRLEY

---RQTKEGEFSDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLDGNQLEIKLCDFGLSVQLGKDCEQIEVQCMVGNMTYSAPEII---AKEDDQ
    |.....|...||..|. |.|| ....| .|||||||||.| |.. . ... .   |||.| .| .  .|  ..    .. |. ...      | ..
WQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYC--DFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNK

NKIYSKKSDSY
|.....||| |
NQKINYKSDIY
Kinase 19409.AA Pkinase 188-389 27 9.2e-30 106.32 Pfam 1-202 (293) Show / Hide 
Range on Protein: 188-389
Range on HMM: 1-202/293
Sequence Identity: 27% (61 aa)

VNNFQILNFGSFGMVLSTKKVNLNNKEIALKIQKIVNDQEIQN-------EIRIMQQLKTPLVVQLYDHYVIEKATAPEKYVVFELEKCSC-----SLQD
    ...  |||| |   .... ..|. |.|| | ... . ..       ||.||. |. | .|.||| .        .... . .| | .     .| |
YHIGRKIGSGSFGCVYKCHHKG-TGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFD

YLERQTKEGEF--SDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLDGNQL--EIKLCDFGLSVQLGKDCEQIEVQCMVGNMTYSAPEIIAKEDD
|...  ..| |  |...  ....||.  ..|.|  .|||||.||||.|.  . ...   .|.|||||. |.     .   .  .|   | |||.|     
YIST-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR----

QNKIYSKKSDSYSVGLLL
 .. |..|.| .|.|..|
GGQYYGPKVDMWSCGCIL
Kinase 19409.AA CMGC 188-339 17 1.5e-29 93.53 In-house 1-251 (513) Show / Hide 
Range on Protein: 188-339
Range on HMM: 1-251/513
Sequence Identity: 17% (44 aa)

VNNFQILNFGSFGMVLSTKKVNLN-------------NKEIALKIQKIVNDQEIQ---------------NEIRIMQQLK-----------------TPL
  . . .  |..|.| . .  . |             |...|.|. | .   |.|                ||.|...|.                  . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVQLYDHYVIEKATAPEK-----------YVVFELEKCSCSLQDYLERQT--KEG----EFSDEQ------------KLNIA------LQIIDSVN--YI
.|.|||... .. . .|.           .. .  | . ..| .|....   . |    ..|. .            . ..        ||. ...  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HCFN--IIHRDIKPENFLVCLDGNQ-----------------LEIKLCDFGLS
|  .  |||||.|||| |.. ..                    ..|.|||||.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA
Kinase 19409.AA Ciliate-E2 188-389 22 1.3e-27 91.79 In-house 1-286 (365) Show / Hide 
Range on Protein: 188-389
Range on HMM: 1-286/365
Sequence Identity: 22% (67 aa)

VNNFQILNFGSFG-----MVLSTKKVN-----------------LNNKEIALKIQKIVNDQEIQNEIRIMQ----------------QLKTPLVVQLYDH
 .  ... .|.||      | ...|                    ..|..|.||.|  . ..| .||.||.                ||. | ....|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YVIEKATAPEKYVVFELEKCSC-SLQDYLERQ-TKE-------GEFSDEQKLNIALQIID---------------SVNYIHCFN-IIHRDIKPENFLVCL
.  ..    .... . .| |.  .|.||.. . .|.       . |.... ..|  ||..                ..|.|  | |||||||||| |.  
FQEKD----DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--

DGNQLEIKLCDFGLSVQLGKD---CEQIEVQCM---------------------------VGNMTYSAPEIIAKEDDQN----KIYSKKSDSYSVGLLL
      ||..||||| .. .|   . .  .||                            .|.  | ||||. .....|    | |..|.| .|.| .|
------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase 19409.AA STE 189-389 22 4.8e-25 85.44 In-house 1-258 (359) Show / Hide 
Range on Protein: 189-389
Range on HMM: 1-258/359
Sequence Identity: 22% (60 aa)

NNF-QILNFGSFG-MVLSTKKVNL-------------NNKEIALKIQKIVN--------------------DQEIQNEIRIMQQLK--TPLVVQLYDHYV
  . ...  |.||  ..  .. |              ... .| |. .. |                     |.|..||.||....   | .|. |..|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

IE---KATAPEKYVVFELEKCSC-SLQDYLER--QTKE---------GEFSDEQKLNIALQIIDS-VNYIHCFNIIHRDIKPENFLVCLDGNQLEIKLCD
 |   .    | ... |.  ..  || | ...   ...         . |. .|   |. ||.    .|.|  .|||||||| | |.        .||||
KEGHNHKNDDELWICMEY--MDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCD

FGLSVQLGKDCE------------QIEVQC--MVGNMTYSAPEIIAKEDDQ-NKIYSKKSDSYSVGLLL
||.. || ...              .  ..  .||   . |||.| ...   .| |. |.| .|.|...
FGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI
Kinase 19409.AA CAMK-Unique 188-367 20 6.3e-25 79.06 In-house 1-262 (363) Show / Hide 
Range on Protein: 188-367
Range on HMM: 1-262/363
Sequence Identity: 20% (53 aa)

VNNFQILNFGSFGMVLSTKK-VNLNNKEIALKIQK-----IVNDQ-----------------EIQNEIRIMQQLKTPLVVQLYDH----YVIEK------
. . .|. .|.||.|. ..  ..   . .. ...|     ....|                 .  .|..|.. .. |  ..|||     .. .|      
YKMHRIIGHGNFGHVYECMDRETGKKWACK-MVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDL

-----ATAPEKYVVFELEKCSCS-LQDYLERQTK-----------------EGEFSD--EQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLDGN--
        |. | | |.  | .  |.|.. .  .                 .| ||    . ..| ...   |.| |  .|.|||.|.|| .||  ..  
IIKTPRALPYMYIVMEY--CQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDN

-----------QLEIKLCDFGLSVQLGKDCEQIEVQCMVGNMTYSAP--------------EIIA
           .. ||||||||....    .    | |.|   | ||              |.|.
NHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVIN
Kinase 19409.AA TKL 289-389 24 1.5e-24 85.37 In-house 132-279 (364) Show / Hide 
Range on Protein: 289-389
Range on HMM: 132-279/364
Sequence Identity: 24% (36 aa)

EQKLNIALQIIDSVNYIHCFN--------IIHRDIKPENFLVCLDGN-----------QLEIKLCDFGLSVQLGKDCEQIEVQCM---------------
.|....||.|   .|| |  |        |||||.|..| ||  ...           .  .|.||||||  . .. ..   . .               
HQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTM

--VGNMTYSAPEIIAKEDDQNK-----------IYSKKSDSYSVGLLL
  .|.  . |||.. .... ..            ||.|.| || |..|
TQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL
Kinase 19409.AA TyrKc 188-454 20 2.5e-11 -39.4 SMART 1-280 (280) Show / Hide 
Range on Protein: 188-454
Range on HMM: 1-280/280
Sequence Identity: 20% (62 aa)

VNNFQILNFGSFGMVLSTKKVNLNNKEIALKIQK-IVNDQEIQNEIRIMQQL--KTPLVVQLYDHYVIEK----ATAPEKYVVFELEKCSCSLQDYLERQ
.   ..|  | || |   .       . | |  |     ... .|.||| .|  . | .|.||  .....      ..  ..|.|. .   .|.||| . 
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLY-GVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRKH

TKEGEFSDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLDGNQLEIKLCDFGLSVQLGKD------CEQIEV----QCM-VGNMTYSAPEIIAKE
 ..  .. ...|....|| .  .|.|  |.||||.   | ||  ..    .| .|||||  .. |       . . .    ..  .      ||| |   
RPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---

DDQNKIYSKKSDSYSVGLLL-----------SL-----LDNYLILNEIVGITFPSMAFEQYNEP--FQNINIKRNTEIFEFIKLLVVWERVNRASLSTIV
  . .... ||| .| | ..           .      ..|. ... .     .    . |  |  |        .|... .|     .  .| . |.|.
--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--PMSF----VCCPDEMYQIMKQCWHEDPEDRPTFSEIH

EQN
|. 
ECF
LRR_RI 19409.AA LRR_RI 518-545 35 0.000527 20.55 SMART 1-28 (28) Show / Hide 
Range on Protein: 518-545
Range on HMM: 1-28/28
Sequence Identity: 35% (10 aa)

EFQVVEIDLSENKIGAEGAKDLGTGIAQ
     |..|| ||.|.||.. |  |...
NCSLRELWLSNNKLGDEGCRQLCEGLKH