Gene 2817 (Tetrahymena)

2817

Species: Tetrahymena
Alias: TTHERM_01440780, 390.m00010, 2817, 86, PreTt02817
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C8

Sequence

Name Sequence Type Origin Length Description Download
2817.AA Protein None 734 None Fasta, JSON
2817.kin_dom Protein Kinase Domain None 202 None Fasta, JSON
2817.kin_dom2 Protein Kinase Domain None 203 None Fasta, JSON
2817.NA RNA None 2205 None Fasta, JSON

Protein domain

Protein domains of 2817.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 2817.AA Ciliate-C8 105-329 53 1.7e-117 396.61 In-house 1-238 (238) Show / Hide 
Range on Protein: 105-329
Range on HMM: 1-238/238
Sequence Identity: 53% (135 aa)

GAYALVLKAKNTKENRIVALKFLTSTNQEDANGIESMKKEYEMLQKFGQSDFLVNVYDCFYLMEEDVEEDEDGNEKTILTEEK---SFFVMEMELCKQN-
||...||||.|.|.||.|||||....|... |..|...|||||...| |..|.|.||||||||||...||.|||.|.. |.||   ||||||||.|.|| 
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

-LKQLFDFFRNTQ-PPPNEIKEVIAIQMLEGLNNLHVKNIMHRDIKPHNYLVSPSQTYGFTIKLCKKFQLSQNLSIQKIIKTKGDLGFASTVTKSKSHYL
 |||.||..|..| .| ...||.|||||....|.||..|||||||||||.||...|.|..|||||. |     . .|      .|.|||| ..|.||||.
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCD-F-----K-KQ------CDFGFASQLPKNKSHYH

SKK--GTDAY-----------FAPEVEKGQSRIQSDIFS-------LGLVL
|||  |||.|           |||||||.||||||||||       .||||
SKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 2817.AA C8 96-329 56 3.3e-116 392.35 In-house 1-226 (226) Show / Hide 
Range on Protein: 96-329
Range on HMM: 1-226/226
Sequence Identity: 56% (138 aa)

SKDLEYLSSGAYALVLKAKNTKENRIVALKFLTSTNQEDANGIESMKKEYEMLQKFGQSDFLVNVYDCFYLMEEDVEEDEDGNEKTILTEEKSFFVMEME
... .|||.|||..||||||.|.|| ..|||....|..| ..|||..|||||.|.| |.||.||.|||||.|.|..||....|||...|||||.||||||
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME

LCKQNLKQLFDFFRNTQPP-PNEIKEVIAIQMLEGLNNLHVKNIMHRDIKPHNYLVSPSQTYGFTIKLCKKFQLSQNLSIQKIIKTKGDLGFASTVTKSK
||.||||||.|..||.| . ..|.|| |||||..|.|..|.||||||||||||.|| ..|.|||.||||                   |.||||.|.|.|
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLC-------------------DFGFASQVSKNK

SHYLSKK----GTDAYFAPEVEKG------QSRIQSDIFSLGLVL
||..|||    ||.||||||.||.      |.|||||.||.||||
SHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 2817.AA C2 105-342 36 3.4e-62 211.25 In-house 1-245 (245) Show / Hide 
Range on Protein: 105-342
Range on HMM: 1-245/245
Sequence Identity: 36% (93 aa)

GAYALVLKAKNTKENRIVALKFLTSTNQEDANGIESMKKEYEMLQKFGQSDFLVNVYDCFYLMEEDVEEDEDGNEKTILTEEK---------SFFVMEME
|| .||||| | |.||.||||  .  .. | || ..  |||......  . ....||..||| ... | ..  |.  . ..|.         .|.|.|.|
GAFGLVLKAFNKKQNRHVALK-IQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

LCKQNLKQLFDFFRNTQ-PPPNEIKEVIAIQMLEGLNNLHVKNIMHRDIKPHNYLVSPSQTYGFTIKLCK---KFQLSQNLSIQKIIKTKGDLGFASTVT
 |. |||| |.  |. .  | ...|...||||. . | || ..| |||||| | |.. .|    |||||    ..|  .           .|. ||| . 
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQK-K-----------CDFDFASKLK

KSKS-HYLSK-KGTDAY----FAPEVEKGQSRIQSDIFS-LGLVLLELDNLNVLNDNW
..||  . || |.| .|    |||||...  . .||.|| .|.||||||| .  . . 
YNKSRIHFSKFKWTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 2817.AA CMGC 96-263 17 1.3e-22 70.34 In-house 1-246 (513) Show / Hide 
Range on Protein: 96-263
Range on HMM: 1-246/513
Sequence Identity: 17% (44 aa)

SKDLEYLSSGAYALVLKAKN--------------TKENRIVALKFLTST-NQEDAN------GIE-SMKKEYEMLQKFG---------------QSDF-L
 . .... .|.|. | |...              .. |.|||.| . .  ..|.|       |.  .   | ..|...                . .  .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VNVYDCFYLMEEDVEEDEDGNEKTILTEEKSFFVMEMELCKQNLKQLFDFFR-------NTQPPPNE------------IKEVI-----AIQMLEGLN--
|. ||.||  ..| .|.|| ..  |   .   . . .|.. ..|.|. .  .       .   .. .            ||  .     . |.|.||.  
VKLYDIFYHKNSDGNEYEDKHI--ISQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLK

NLHVKN--IMHRDIKPHNYLVSPSQTY----------------GFTIKLC
 .| ..  |.|||.|| | |...  ..                 ...|.|
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKIC
Kinase 2817.AA Pkinase 96-247 22 1.9e-17 62.79 Pfam 1-138 (293) Show / Hide 
Range on Protein: 96-247
Range on HMM: 1-138/293
Sequence Identity: 22% (36 aa)

SKDLEYLSSGAYALVLKAKNTKENRIVALKFLTSTNQEDANGIESMK-KEYEMLQKFGQSDFLVNVYDCFYLMEEDVEEDEDGNEKTILTEEKSFFVMEM
 . .. . ||... | |... ....|||.| .   ....   ..  .  | ...... .... |  ||.|.                     |.   | |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------------------KDHIYMVM

ELCKQNLKQLFDFF------RNTQP--PPNEIKEVIAIQMLEGLNNLHVKNIMHRDIKPHN
|.|   |. ..| |      |..    ...|.| ..  |.|.||. .| ..|.|||.|| |
EYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPEN
Kinase 2817.AA Ciliate-E2 96-332 17 4.1e-17 55.26 In-house 1-289 (365) Show / Hide 
Range on Protein: 96-332
Range on HMM: 1-289/365
Sequence Identity: 17% (57 aa)

SKDLEYLSSGAYALVLKAKNTKENRIVALKFLTSTN------------------QEDANGIESMKKEYEMLQ---------------KFGQSDFLVNVYD
 | .. . .|... | |.|. |... .|.|. . ..                  .   |.||..|.|  ...               .. ....... |.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

CFY------------LMEE----DVEEDEDGNEKTI------LTEEKSFFVMEMELC----KQNLKQLFDFFRNTQPPPNEIKEVIAIQMLEGLNNLHVK
||.            . .     |  .. . ... .      .||..  ..|.  |     |.                    | .. .....|. || |
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKA--------------------EFYIACIILALEYLHSK

N-IMHRDIKPHNYLVSPSQTYGFTIKLCKKFQLSQNLSIQKI---------IKTKGDLGFASTVTKSKSHYLSKK-----------GTDAYFAPEVEKGQ
| |.|||||| | |.         ||..  | ||...... .         ...        | ....                  ||  | |||. .|.
NNIIHRDIKPENILF---------IKII-DFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD------QIIQQNMFNTICGTPGYMAPEILNGK

SR----------IQSDIFSLGLVLLEL
.            ..||.||| .| |.
KYDNQQKQKGYDYKCDIWSLGVILYEM
Kinase 2817.AA S_TKc 96-395 18 2e-14 34.51 SMART 1-231 (231) Show / Hide 
Range on Protein: 96-395
Range on HMM: 1-231/231
Sequence Identity: 18% (60 aa)

SKDLEYLSSGAYALVLKAKNTKENRIVALKFLTSTNQEDANGIESMKKEYEMLQKFGQSDFLVNVYDCFYLMEEDVEEDEDGNEKTILTEEKSFFVMEME
 . |. . .||.. | |....| .||||.| .           |....| ..|.|  . ...|. ||.|.                      ... | ||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD---------------------DHLYMVME

LCKQNLKQLFDFFRNTQP-------PPNEIKEVIAIQMLEGLNNLHVKNIMHRDIKPHNYLVSPSQTYGFTIKLC-----KKFQLSQNLSIQKIIKTKGD
.| ..|  |||. .. ..       |. ... ... |....|. .| ..|.|||.|| | |..       .||.|     ...                 
YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-----------------

LGFASTVTKSKSHYLSKKGTDAYFAPEVEKGQSRIQSDIFSLGLVLLELDNLNVLNDNWIDLETKAEIYKGKAIASKYQIDRKSNIYKIAEICLKPNYLE
               .  ||  | ||||  | ..  .|. |.| .| |.     . .      . ....|             .    . . ||. .  .
--------------TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG---------SPEAKDFIRKCLQKDPEK

RKSSGDLLY--------ELI
| .  ..|         . .
RPTA-EALQDEWDIKCHPWF
Kinase 2817.AA Ciliate-E1 185-276 26 1.3e-13 41.03 In-house 67-169 (202) Show / Hide 
Range on Protein: 185-276
Range on HMM: 67-169/202
Sequence Identity: 26% (27 aa)

EEKSFFVMEMELCKQNLKQLFD---------FFRNTQPPPNEI-KEVIAIQMLEGLNNLHVKNIMHRDIKPHNYLVSPSQTYGFT-IKLCKKFQLSQNLS
..  ...  .|.|...||. ..          ....|   ..  |. |..|...||. || .||.||||||.| |.. .  | .. . ..|.....|| .
DQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQ

IQK
.|.
CQY
Kinase 2817.AA STE 96-263 19 2.8e-13 43.33 In-house 1-189 (359) Show / Hide 
Range on Protein: 96-263
Range on HMM: 1-189/359
Sequence Identity: 19% (42 aa)

SKDLEYLSSGAYALVLKAKNTK---------------ENRIVALKFLTSTNQE----------DANG----IESMKKEYEMLQKFGQ-SDFLVNVYDCFY
 ...| . .||.  | ||.| |                ..|.| | .   |..          . |     ... .|| ....|. . ... |. |.|..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LMEEDVEEDEDGNEKTILTEEKSFFVMEMELCK-QNLKQLFDFFRNTQPPP-----------NEIKEVIAIQMLEG-LNNLHVKNIMHRDIKPHNYLVSP
   ..             .....   . ||..    | .. .    .. |             ..  .|. | |.| |. || ..|.|||||| | |.  
KEGHN-------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--

SQTYGFTIKLC
       .|||
-------VKLC
Kinase 2817.AA Ciliate-E2-Unclassified 96-332 17 4.3e-12 38.26 In-house 1-263 (352) Show / Hide 
Range on Protein: 96-332
Range on HMM: 1-263/352
Sequence Identity: 17% (53 aa)

SKDLEYLSSGAYALVLKAKNTKENRIV-----ALKFLTSTNQEDANGIESMKKEYEMLQKFGQSDFL---------------VNVYDCFYLMEED-----
 | .. . .|... | |... |..  .     . |.     .   | .| | .. || .| . ...                 ... .||  . .     
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VEEDEDGNEKTILTEEKSF----------------FVMEMELC--KQNLKQLFDFFRNTQPPPNEIKEVIAIQMLEGLNNLHVKN-IMHRDIKPHNYLVS
| |  .|..     .....                 . | . .  |.                    . .. | |.||. || || | |||||| | |..
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKA--------------------KFYFAQILQGLEYLHHKNNIIHRDIKPENILFD

PSQTYGFTIKLCKKFQLSQNLSIQKIIKTKGDLGFASTVTKS---------------KSHYLSKKGTDAYF----APEVEKG-QSR----IQSDIFSLGL
 ..                     .      |.|...   ..               . .. .. ||  |     |||| .| .      ...||.||| 
NNGK--------------------NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGV

VLLEL
.| |.
ILYEM
Kinase 2817.AA CAMK 101-247 13 9.9e-12 33.35 In-house 1-209 (425) Show / Hide 
Range on Protein: 101-247
Range on HMM: 1-209/425
Sequence Identity: 13% (29 aa)

YLSSGAYALVLKAKNTKEN------------RIVALKFLTSTNQED-------------------------ANGIESMKKEYEMLQKFG------QSDFL
 | .|... | ...... .            . || |..  .   |                         ..  .....|.|...|        .   .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNVYDCFY-------LMEEDVEEDEDG-NEKT-ILTEEKSFFVMEM---ELCKQN--LKQLFDFFRNTQP----------------PPNEIKEVIAIQML
.. |. .                .. . . .. .  . .....| |   |.|     .  |||. .   .                .  | . ..  |..
IKLYEVYEDPHYFKNT-------ND-YET-SKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFR-QIC

EGLNNLHVKNIMHRDIKPHN
.... .| .||.|||.|| |
SAVHYCHSHNIVHRDLKPEN
Kinase 2817.AA TKL 282-332 17 7.5e-08 24.37 In-house 196-282 (364) Show / Hide 
Range on Protein: 282-332
Range on HMM: 196-282/364
Sequence Identity: 17% (15 aa)

GDLGFASTVTKSKS-------------------HYLSKKGTDAYFAPEV-----------------EKGQSRIQSDIFSLGLVLLEL
.|.|.. ....|..                   .  .. || .. ||||                 ....   ..|..| |.|| |.
CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
Kinase 2817.AA Ciliate-E1 102-166 22 2.7e-07 20.27 In-house 1-66 (202) Show / Hide 
Range on Protein: 102-166
Range on HMM: 1-66/202
Sequence Identity: 22% (15 aa)

LSSGAYALVLKAKNTKEN-RIVALKFLTSTNQEDANGIESMKKEYE-MLQKFGQSDFLVNVYDCFYL
...| ...|.|||. . | . ||.|.     ... | ... .|||  ... | . . .....|....
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKI
Kinase 2817.AA TKL 222-247 32 1.9e-05 15.59 In-house 137-170 (364) Show / Hide 
Range on Protein: 222-247
Range on HMM: 137-170/364
Sequence Identity: 32% (11 aa)

IAIQMLEGLNNLHV--------KNIMHRDIKPHN
.|...  |.| ||         ..| |||.|..|
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKN
Kinase 2817.AA STE 283-332 21 0.000247 11.35 In-house 190-261 (359) Show / Hide 
Range on Protein: 283-332
Range on HMM: 190-261/359
Sequence Identity: 21% (16 aa)

DLGFASTVTKS----------------KSHYLSKKGTDAYFAPEVEKG-QSR------IQSDIFSLGLVLLEL
| |... .|.|                ...  .  ||  . |||| .. ..       ...|| |||....|.
DFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase 2817.AA Pkinase 282-332 29 0.007044 11.26 Pfam 154-205 (293) Show / Hide 
Range on Protein: 282-332
Range on HMM: 154-205/293
Sequence Identity: 29% (16 aa)

GDLGFASTV-TKSKSHYLSKKGTDAYFAPEV--EKGQSRIQSDIFSLGLVLLEL
.| |.|  . . ..| . .  ||  | ||||  .       .|..|.|..| |.
CDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase 2817.AA C8 463-664 48 2.8e-103 349.43 In-house 1-226 (226) Show / Hide 
Range on Protein: 463-664
Range on HMM: 1-226/226
Sequence Identity: 48% (110 aa)

VNNFQILNFGSFGMVLSTKKVNLNNKEIALKIQKIVNDQEIQNEIRIMQQLKTPLVVQLYDHYVIEKATAPEKYVVFELEKCS-----------CSLQD-
.||||.|.||..||||..|.|. .|.||.||.||..|.|.|||...||.....|.|.|.||.||.|.....|.|.|||.||||           |.... 
FNNFQYLSFGAYGMVLKAKNVK-DNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEM

----------YLERQTKEGEFSDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLDGNQL-EIKLCDFGLSVQLGKDCEQIEVQCM--VGNMTYSA
          |.||..|...||.|.|..||.|.||.||||||.||.||||||.|||||||.|.. ||||||||.. |..|....|. . |  .|...|.|
ELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFA

PEIIAKEDDQNKIYSKKSDSYSVGLLL
|||..|.|.|.|.|...||..||||.|
PEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 2817.AA Ciliate-C8 472-664 40 1e-98 334.25 In-house 1-238 (238) Show / Hide 
Range on Protein: 472-664
Range on HMM: 1-238/238
Sequence Identity: 40% (97 aa)

GSFGMVLST------KKVNLNNKEIALKIQKIVNDQEIQNEIRIMQQLKTPLVVQLYDHYVIEKATAPEK-----------------YVVFELEKCS--C
|.|||||..      .||.|...|...||||.....||.....|||....|.|||.||..........|.                 ..|.|.|||.  |
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

SLQDYLER-QTKEGEFSDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLD-GNQLEIKLCD------FGLSVQLGKDCE---------QIEVQCM
.|..|..| . |....|...|..|| |.||||||.|||||.||||||.|||||.| ..|..|||||      ||.. || |...         ......|
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--VGNMTYSAPEIIAK-EDDQNKIYSKKSDSYSVGLLL
  .||..|.|||...| ...|..|.|||||||||||.|
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 2817.AA C2 472-664 30 1.5e-48 163.94 In-house 1-232 (245) Show / Hide 
Range on Protein: 472-664
Range on HMM: 1-232/245
Sequence Identity: 30% (73 aa)

GSFGMVLSTKKVNLN-NKEIALKIQKIVN-----DQEIQNEIRIMQQLK-TPLVVQLYD-HYVIEKATAP------------EK----------YVVFEL
|.||.||  |  | . |...|||||..        .|.|.|..||.|..  |.....|.  |. ..                |.           ||.|.
GAFGLVL--KAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQ

EKCSCSLQDYLERQTKEG-EFSDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLDGNQL-EIKLCD----------FGLSVQLGKDCEQIEVQCM
|.|.. |. |..|..|.  ......|  .| |..||.||.|.|.|.||||||.|||. .| ...  |||||          |  .  | .. ..| .. .
EFCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKF

VGNMTY----SAPEIIAKEDDQNKIYSKKSDSYS-VGLLL
..  .|    .|||..       .|| |.|| .| ||. |
KWTQQYYQHIFAPEVYQ------NIYKKNSDLFSTVGYVL
Kinase 2817.AA CAMK 468-664 19 4.7e-38 119.7 In-house 1-324 (425) Show / Hide 
Range on Protein: 468-664
Range on HMM: 1-324/425
Sequence Identity: 19% (63 aa)

ILNFGSFGMVLSTKKVNLNN-----------KEIALKI---QKIV----------------------------NDQEIQNEIRIMQQ-------LKTPLV
.|  |||| |   .  | ..           .. | ||   .|.                             . .....||.||..       |. | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLYDHYVIEKA--------TAP------EKYVVFEL---EKCSC-----SLQDYLERQTK------------EGEFSDEQKLNIALQIIDSVNYIHCFN
..||..|  ..         |        .|.... .   | ||       | ||. ....            .| |. ..   .  ||.. |.|.|  |
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDIKPENFLVCLDG--------------NQLEIKLCDFGLSVQLGKDCEQI---------------------EVQCMVGNMTYSA-PEIIAKE----
|.|||.|||| |.. ..              |.  ||..|||.. .. .. ..                        . ..|   | | ||.. ..    
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----DDQNKIYSKKSDSYSVGLLL
     |.... |..|.|  |.| .|
MQNATDEEKPYYGPKCDMWSCGVIL
Kinase 2817.AA S_TKc 466-733 24 2.7e-32 114.54 SMART 1-231 (231) Show / Hide 
Range on Protein: 466-733
Range on HMM: 1-231/231
Sequence Identity: 24% (70 aa)

FQILNF---GSFGMVLSTKKVNLNNKEIALKIQKIVNDQEIQNEIRIMQQLKTPLVVQLYDHYVIEKATAPEKYVVFELEKCSC---SLQDYLERQTKEG
..||.    |.|| |   ....  ... |.|| |    . |..||.|... . | .|.|||...        ... . .| |.    .| ||.... ..|
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHG

E---FSDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLDGNQLEIKLCDFGLSVQLGKDCEQIEVQCMVGNMTYSAPEIIAKEDDQNKIYSK-KS
    |.  .   .. ||.. ..|.|  .|||||.|||| |..      .||.|||||. ||           ..|   | |||..         |.| |.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL--------GYGKCKC

DSYSVG-LLLSLLDNYLILNEIVGITFPSMAFEQYNEPFQNINIKRNTEIFEFIKLLVVWERVNRASLSTITSSK-----QRQI
| .|.| .|  .|  |                 |... |..|      |  .||. . ...  .| .   .  .         .
DWWSCGCILYEMLCGYPPFP-------------QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 2817.AA Ciliate-E1 469-658 28 1.1e-31 100.46 In-house 1-202 (202) Show / Hide 
Range on Protein: 469-658
Range on HMM: 1-202/202
Sequence Identity: 28% (60 aa)

LNFGSFGMVLSTKKVNLNNKEIALKIQKIV---N----DQEIQNEIRIMQQLKTPL-VVQLYDHYVIEKATAPEKYVVFELEKCSCSLQDYLE-------
.  |||..|.  |. | |....|.||...    |    ..||.... ||. .|.   ..|..| . |...    .  .. .|.|.|||.|||.       
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQN----YICIIIFECCCCSLKDYLQNHNRLEY

---RQTKEGEFSDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLDGNQLEIKLCDFGLSVQLGKDCEQIEVQCMVGNMTYSAPEII---AKEDDQ
    |.....|...||..|. |.|| ....| .|||||||||.| |.. . ... .   |||.| .| .  .|  ..    .. |. ...      | ..
WQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYC--DFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNK

NKIYSKKSDSY
|.....||| |
NQKINYKSDIY
Kinase 2817.AA Pkinase 463-664 27 9.2e-30 106.32 Pfam 1-202 (293) Show / Hide 
Range on Protein: 463-664
Range on HMM: 1-202/293
Sequence Identity: 27% (61 aa)

VNNFQILNFGSFGMVLSTKKVNLNNKEIALKIQKIVNDQEIQN-------EIRIMQQLKTPLVVQLYDHYVIEKATAPEKYVVFELEKCSC-----SLQD
    ...  |||| |   .... ..|. |.|| | ... . ..       ||.||. |. | .|.||| .        .... . .| | .     .| |
YHIGRKIGSGSFGCVYKCHHKG-TGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFD

YLERQTKEGEF--SDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLDGNQL--EIKLCDFGLSVQLGKDCEQIEVQCMVGNMTYSAPEIIAKEDD
|...  ..| |  |...  ....||.  ..|.|  .|||||.||||.|.  . ...   .|.|||||. |.     .   .  .|   | |||.|     
YIST-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR----

QNKIYSKKSDSYSVGLLL
 .. |..|.| .|.|..|
GGQYYGPKVDMWSCGCIL
Kinase 2817.AA CMGC 463-614 17 1.5e-29 93.53 In-house 1-251 (513) Show / Hide 
Range on Protein: 463-614
Range on HMM: 1-251/513
Sequence Identity: 17% (44 aa)

VNNFQILNFGSFGMVLSTKKVNLN-------------NKEIALKIQKIVNDQEIQ---------------NEIRIMQQLK-----------------TPL
  . . .  |..|.| . .  . |             |...|.|. | .   |.|                ||.|...|.                  . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVQLYDHYVIEKATAPEK-----------YVVFELEKCSCSLQDYLERQT--KEG----EFSDEQ------------KLNIA------LQIIDSVN--YI
.|.|||... .. . .|.           .. .  | . ..| .|....   . |    ..|. .            . ..        ||. ...  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HCFN--IIHRDIKPENFLVCLDGNQ-----------------LEIKLCDFGLS
|  .  |||||.|||| |.. ..                    ..|.|||||.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA
Kinase 2817.AA Ciliate-E2 463-664 22 1.3e-27 91.79 In-house 1-286 (365) Show / Hide 
Range on Protein: 463-664
Range on HMM: 1-286/365
Sequence Identity: 22% (67 aa)

VNNFQILNFGSFG-----MVLSTKKVN-----------------LNNKEIALKIQKIVNDQEIQNEIRIMQ----------------QLKTPLVVQLYDH
 .  ... .|.||      | ...|                    ..|..|.||.|  . ..| .||.||.                ||. | ....|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YVIEKATAPEKYVVFELEKCSC-SLQDYLERQ-TKE-------GEFSDEQKLNIALQIID---------------SVNYIHCFN-IIHRDIKPENFLVCL
.  ..    .... . .| |.  .|.||.. . .|.       . |.... ..|  ||..                ..|.|  | |||||||||| |.  
FQEKD----DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--

DGNQLEIKLCDFGLSVQLGKD---CEQIEVQCM---------------------------VGNMTYSAPEIIAKEDDQN----KIYSKKSDSYSVGLLL
      ||..||||| .. .|   . .  .||                            .|.  | ||||. .....|    | |..|.| .|.| .|
------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase 2817.AA STE 464-664 22 4.8e-25 85.44 In-house 1-258 (359) Show / Hide 
Range on Protein: 464-664
Range on HMM: 1-258/359
Sequence Identity: 22% (60 aa)

NNF-QILNFGSFG-MVLSTKKVNL-------------NNKEIALKIQKIVN--------------------DQEIQNEIRIMQQLK--TPLVVQLYDHYV
  . ...  |.||  ..  .. |              ... .| |. .. |                     |.|..||.||....   | .|. |..|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

IE---KATAPEKYVVFELEKCSC-SLQDYLER--QTKE---------GEFSDEQKLNIALQIIDS-VNYIHCFNIIHRDIKPENFLVCLDGNQLEIKLCD
 |   .    | ... |.  ..  || | ...   ...         . |. .|   |. ||.    .|.|  .|||||||| | |.        .||||
KEGHNHKNDDELWICMEY--MDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCD

FGLSVQLGKDCE------------QIEVQC--MVGNMTYSAPEIIAKEDDQ-NKIYSKKSDSYSVGLLL
||.. || ...              .  ..  .||   . |||.| ...   .| |. |.| .|.|...
FGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI
Kinase 2817.AA TKL 564-664 24 1.5e-24 85.37 In-house 132-279 (364) Show / Hide 
Range on Protein: 564-664
Range on HMM: 132-279/364
Sequence Identity: 24% (36 aa)

EQKLNIALQIIDSVNYIHCFN--------IIHRDIKPENFLVCLDGN-----------QLEIKLCDFGLSVQLGKDCEQIEVQCM---------------
.|....||.|   .|| |  |        |||||.|..| ||  ...           .  .|.||||||  . .. ..   . .               
HQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTM

--VGNMTYSAPEIIAKEDDQNK-----------IYSKKSDSYSVGLLL
  .|.  . |||.. .... ..            ||.|.| || |..|
TQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL
Kinase 2817.AA Ciliate-E2-Unclassified 480-664 23 1.3e-18 61.2 In-house 45-260 (352) Show / Hide 
Range on Protein: 480-664
Range on HMM: 45-260/352
Sequence Identity: 23% (54 aa)

TKKVNLNNKEIALKIQKIVNDQEIQNEIRIMQQ--LKTPLVVQLYDHYVIEKATAPEKYVVFELEKC-SCSLQDYLERQTK--------------EGEFS
.|. ...|........|  ..|.  .  .||||  |  |  . ....|. ..    .... . .|.|   .|..|.. . |                .|.
NKD-EIMNEMKEMNNKKK-YHQR-KY-NKIMQQILLNHPHPFIVKMFYCFQD----KQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFT

DEQKL-----NIALQIIDSVNYIHCFN-IIHRDIKPENFLVCLDGNQLEIKLCDFGLSVQLGKDCE-------------QIEVQCMVGNMTYS----APE
..| .     ... ||..  .|.|  | |||||||||| |.  .|. ..||..|||.| ..... .             | . . ..|.  |     |||
EQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPE

IIAK-EDDQNKIYSKKSDSYSVGLLL
.. . . |. |   .|.| .|.| .|
VLQGQNYDHSKA--YKCDIWSLGVIL
Kinase 2817.AA TyrKc 463-733 19 2.9e-11 -40.67 SMART 1-280 (280) Show / Hide 
Range on Protein: 463-733
Range on HMM: 1-280/280
Sequence Identity: 19% (61 aa)

VNNFQILNFGSFGMVLSTKKVNLNNKEIALKIQK-IVNDQEIQNEIRIMQQL--KTPLVVQLYDHYVIEK----ATAPEKYVVFELEKCSCSLQDYLERQ
.   ..|  | || |   .       . | |  |     ... .|.||| .|  . | .|.||  .....      ..  ..|.|. .   .|.||| . 
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLY-GVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRKH

TKEGEFSDEQKLNIALQIIDSVNYIHCFNIIHRDIKPENFLVCLDGNQLEIKLCDFGLSVQLGKD------CEQIEV----QCM-VGNMTYSAPEIIAKE
 ..  .. ...|....|| .  .|.|  |.||||.   | ||  ..    .| .|||||  .. |       . . .    ..  .      ||| |   
RPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---

DDQNKIYSKKSDSYSVGLLL-----------SL-----LDNYLILNEIVGITFPSMAFEQYNEP--FQNINIKRNTEIFEFIKLLVVWERVNRASLSTIT
  . .... ||| .| | ..           .      ..|. ... .     .    . |  |  |        .|... .|     .  .| . |.| 
--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--PMSF----VCCPDEMYQIMKQCWHEDPEDRPTFSEI-

SSKQRQI
    ...
---HECF