26387

Species: Tetrahymena
Alias: 26387, 470.m00006, PreTt26387, 56, TTHERM_01565120
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C8

Sequence

Name Sequence Type Origin Length Description Download
26387.AA Protein None 276 None Fasta, JSON
26387.kin_dom Protein Kinase Domain None 197 None Fasta, JSON
26387.NA RNA None 831 None Fasta, JSON

Protein domain

Protein domains of 26387.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 26387.AA C8 42-254 57 5e-112 378.49 In-house 1-226 (226) Show / Hide
Range on Protein: 42-254
Range on HMM: 1-226/226
Sequence Identity: 57% (131 aa)

FKNFEYLSSGAYALVLKAQNSQQNRQVALKFLESSNKEGKDGIESLKKEYEMLQKFSQSECLVNVYDCFYLMEEKDDEDDDGNDIIVQTQNKSYFVMEME
|.||.|||.|||..||||.|...||...|||....||. ...|||..|||||.|.|.|....||.|||||.|.|. .|....|..||||..||.||||||
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME

LCENNLKQLFDFLRKQQVPPPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCDLGFASAVSKSKS-FMSKK----GTDAYFAP
|||.|||||.|..|..|....||||||||||||.|.|..|.||||||||||.|||||....|||.|||||.||||.|||.|| ..|||    ||.|||||
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAP

EVEAG------QSRIQ--VFNNSVIL
|.|..      |.|||  .|   ..|
EIEKKQDNQYKQYRIQSDLFSVGLVL

Kinase 26387.AA Ciliate-C8 51-256 55 6.1e-112 378.19 In-house 1-238 (238) Show / Hide
Range on Protein: 51-256
Range on HMM: 1-238/238
Sequence Identity: 55% (131 aa)

GAYALVLKAQNSQQNRQVALKFLESSNKEGKDGIESLKKEYEMLQKFSQSECLVNVYDCFYLMEEKDDEDDDGNDIIVQTQNK---SYFVMEMELCENN-
||...||||||..|||.|||||.|..||. |...|...|||||...|.|....|.||||||||||...|||||||.|||||.|   |.||||||.|..| 
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

-LKQLFDFLRKQQVPPPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCD------LGFASAVSKSKS-FMSKK--GTDAY---
 |||.||..||.|..| ..||||||||||...|.||..|||||||||.||||| ...|...|||||      .||||...|.|| ..|||  |||.|   
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--------FAPEVEAGQSRIQVFNNS-------VILFF
        ||||||..|||||    |       | | .
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL

Kinase 26387.AA C2 51-241 39 1.3e-56 191.87 In-house 1-216 (245) Show / Hide
Range on Protein: 51-241
Range on HMM: 1-216/245
Sequence Identity: 39% (85 aa)

GAYALVLKAQNSQQNRQVALKFLESSNKEGKDGIESLKKEYEMLQKFSQSECLVNVYDCFYLMEE-KDDEDDDGNDIIVQTQN--------KSYFVMEME
|| .||||| | .|||.||||  |    . . | ... |||....... .  ...||..||| .. |.||| | ...... .|        |. .|.|.|
GAFGLVLKAFNKKQNRHVALKIQECQSNDIN-GMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

LCENNLKQLFDFLRKQQVPPPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCD----------LGFASAVSKSKS--FMSK-K
 |. |||| |. .|||.  | ..||.|.||||. . | || ..| ||||||.|||.  ...    |||||          . |||.....||   .|| |
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK

GTDAY----FAPEVEAG
.| .|    |||||. .
WTQQYYQHIFAPEVYQN

Kinase 26387.AA CMGC 42-220 16 2.3e-29 92.92 In-house 1-256 (513) Show / Hide
Range on Protein: 42-220
Range on HMM: 1-256/513
Sequence Identity: 16% (44 aa)

FKNFEYLSSGAYALVLKAQN--------------SQQNRQVALKFLESS-NKEG------KDGIE-SLKKEYEMLQKFS---------------QSEC-L
... ... .|.|. | |...               . |..||.| . .  ..|.      |||.  .   | ..|....               . .  .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VNVYDCFYLMEEKDDEDDDGNDIIVQTQNKSYFVMEMELCENNLKQLFDFLR------KQQVPPPKE------------MKEII-----AIQMIEGLN--
|. ||.||  ... .|..| . |  .  .  .. . .|.....|.|. .  .      ...  .. .             | ..     . |...||.  
VKLYDIFYHKNSDGNEYEDKHII--SQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLK

NLHVKN--IMHRDIKPQNFLVCASKEY----------------GFSIKLCDLGFASAVSK
 .| ..  |.|||.||.| |..  .|.                 . .|.|| |.| ....
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHP

Kinase 26387.AA Pkinase 42-238 22 3.4e-27 97.23 Pfam 1-182 (293) Show / Hide
Range on Protein: 42-238
Range on HMM: 1-182/293
Sequence Identity: 22% (47 aa)

FKNFEYLSSGAYALVLKAQNSQQNRQVALKFLESSNKEGKDGIESLK-KEYEMLQKFSQSECLVNVYDCFYLMEEKDDEDDDGNDIIVQTQNKSYFVMEM
..  . . ||... | |...   ...||.| .. .... .  .. ..  | ...... .... |  ||.|.                     |..  | |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------------------KDHIYMVM

ELCENN--LKQLFDFLR--KQQVP--PPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCDLGFASA--VSKSKSFMSKKGTDA
|.||.   .  |||...  .. .   ...| | ..  |...||. .| ..|.|||.||.|.|.    . . ..|.|| |.|      ..  ...  ||  
EYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW

YFAPEV
| ||||
YMAPEV

Kinase 26387.AA CAMK 47-238 15 1.8e-26 81.72 In-house 1-291 (425) Show / Hide
Range on Protein: 47-238
Range on HMM: 1-291/425
Sequence Identity: 15% (46 aa)

YLSSGAYALVLKAQNSQQN------------RQVALKFLESS----------------NKEGKDG---------IESLKKEYEMLQKFS------QSECL
 | .|... | .... . .            ..|| |... .                .|.....          .....|.|...| .      . ...
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNVYDCFYL-----------MEEKDDEDDDGNDIIVQTQNKSYFVM-EMELCENN--LKQLFDFLRKQ---------------QVPPPKEMKEIIAIQMI
.. |. .               .|         ..  .... |.||  ||.|..   .  |||.....                  . .| . ..  |..
IKLYEVYEDPHYFKNTNDYET-SKQ--------VF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFR-QIC

EGLNNLHVKNIMHRDIKPQNFLVCASKEYG-------------FSIKLCDLGFASAVSKSK------------------------SFMSKKGTDAYFA-P
.... .| .||.|||.|| | |.. ...               . ||..| |||  . ...                         .    || .| | |
SAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAP

EV
||
EV

Kinase 26387.AA STE 42-238 18 4.4e-23 78.44 In-house 1-233 (359) Show / Hide
Range on Protein: 42-238
Range on HMM: 1-233/359
Sequence Identity: 18% (47 aa)

FKNFEYLSSGAYALVLKAQNS------QQNRQ---------VALKFLESSNKEG--------------KDGIESLKKEYEMLQKFSQ-SECLVNVYDCFY
... | . .||.  | || |       . ...         .| | .. .|..               .. .....|| ....|... ..  |. |.|..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

LMEEKDDEDDDGNDIIVQTQNKSYFVMEMELCE-NNLKQLFDFLRKQQVPPP------KEMKEIIA----IQMIEG-LNNLHVKNIMHRDIKPQNFLVCA
   ..             ..|...  . ||...   | .. .   . . | .      . ..| .      | ..| |. || ..|.||||||.| |.  
KEGHN-------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--

SKEYGFSIKLCDLGFASAVSK-----------------SKSFMSKKGTDAYFAPEV
       .|||| |... ...                 ..   .  ||  . ||||
-------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEV

Kinase 26387.AA Ciliate-E2 129-243 23 1.3e-18 60.52 In-house 102-263 (365) Show / Hide
Range on Protein: 129-243
Range on HMM: 102-263/365
Sequence Identity: 23% (41 aa)

QTQNKSYFVMEMELCENNLKQLFDFLRKQQVPPPKE--------MKEI--IAIQMIE---------------GLNNLHVKN-IMHRDIKPQNFLVCASKE
|....... . ||.|.   . |||......   ..|        .|||  |  | ..               .|. || || |.||||||.| |.     
QEKDDNNIYLVMEYCQG--GDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

YGFSIKLCDLGFASAVSKS----------KSFMSKK-----------------------GTDAYFAPEVEAGQS
    ||..|.|..  ....          | .|  |                       ||  | |||.  |..
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKK

Kinase 26387.AA TKL 169-238 24 1.1e-16 56.58 In-house 137-244 (364) Show / Hide
Range on Protein: 169-238
Range on HMM: 137-244/364
Sequence Identity: 24% (26 aa)

IAIQMIEGLNNLHV--------KNIMHRDIKPQNFLVCASKE----------YGFSIKLCDLGFASAVSKSKS--------------------FMSKKGT
.|...  |.| ||         ..| |||.|..| ||    .          .   .|.||.|..  .|.|..                     |.. ||
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT

DAYFAPEV
 .. ||||
PRWMAPEV

Kinase 26387.AA Ciliate-E1 140-237 28 2.3e-15 46.85 In-house 76-179 (202) Show / Hide
Range on Protein: 140-237
Range on HMM: 76-179/202
Sequence Identity: 28% (31 aa)

MELCENNLKQLFD---------FLRKQQVPPPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCDLGFAS-AVSKSKSFMSKKG
.|.|. .||. ..          ....|     . |. |..|.|.||. || .||.|||||||| |.. ...| ..    |.| ..   ..... . .||
FECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC----DFGISKFLKNNQNQQCQYKG

TDAYFAPE
   |..|.
YTHYYYPP

Kinase 26387.AA S_TKc 42-274 18 1.2e-13 23.27 SMART 1-231 (231) Show / Hide
Range on Protein: 42-274
Range on HMM: 1-231/231
Sequence Identity: 18% (53 aa)

FKNFEYLSSGAYALVLKAQNSQQNRQVALKFLESSNKEGKDGIESLKKEYEMLQKFSQSECLVNVYDCFYLMEEKDDEDDDGNDIIVQTQNKSYFVMEME
..  . . .||.. | |...   .|.||.| .           |....| ..|.|  . . .|. ||.|.                      ... | ||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD---------------------DHLYMVME

LCENNLKQLFDFLRKQQVP------PPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCDLGFASAVSKSKSFMSKKGTDAYFA
.|...|  |||...|.. .      |. . . ... |....|. .| ..|.|||.||.| |..        ||.|| |.|  .      ..  ||  | |
YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMA

PEVEAGQSR-------------------------IQVFNNSVILFFKVYLHQIVRSLFT------------R-------THFI
|||  | ..                          ..|.. .       . ...| ...            .         ..
PEVL-GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF

Kinase 26387.AA ULK 168-238 29 3e-13 43.4 In-house 130-218 (324) Show / Hide
Range on Protein: 168-238
Range on HMM: 130-218/324
Sequence Identity: 29% (26 aa)

IIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEY--------GFSIKLCDLGFASAVSKS----KSFMSKK------GTDAYFAPEV
.. .| ..|.  || .||.|||||||| |.   ...           .|..| |||  | .       ... .      ||  | ||..
QFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQI

Kinase 26387.AA Ciliate-E1 48-136 18 1.6e-08 24.35 In-house 1-108 (202) Show / Hide
Range on Protein: 48-136
Range on HMM: 1-108/202
Sequence Identity: 18% (20 aa)

LSSGAYALVLKA-QNSQQNRQVALKFLESSNKEGKDGIESLKKEYE-MLQKFSQSECLVNVYDCFY---------LMEEKDDEDDDGND---------II
...| ...|.|| |......|||.|. .   .. .. .....|||  ... | . .......|...         ..|. .... | ..         ..
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

VQTQNKSYF
 |.||. .|
QQNQNQFTF

Kinase 26387.AA ULK 42-111 22 1e-06 19.54 In-house 1-85 (324) Show / Hide
Range on Protein: 42-111
Range on HMM: 1-85/324
Sequence Identity: 22% (19 aa)

FKNFEYLSSGAYA-LVLKAQNSQQ---NRQVALKFLE-----SSNKE--GKDGIESLKKEYEMLQKFS--QSEC--LVNVYDCFY
.   . | .|...  | |. | ..   | .|| |  .      ...|  |.  ...||.| . ..|.   ...    |  ||.|.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFE

Kinase 26387.AA TyrKc 42-267 14 5e-06 -124.64 SMART 1-280 (280) Show / Hide
Range on Protein: 42-267
Range on HMM: 1-280/280
Sequence Identity: 14% (45 aa)

FKNFEYLSSGAYALVLKAQNSQQNRQVALKFLESSNKEGKDGIESLKKEYEMLQKF-SQSECLVNVYDCFYLMEEKDDEDDDGNDIIVQTQNKSYFVMEM
 .  . | .||.  | |.. .   .||| | | ..       .| . .| ... |.  . ...|. | .    ...                     . |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-------------FMYIEPLMIVM

ELCENNLKQLFDFLRKQQVPPPKEMKEIIAIQMIEGLNNLHVKNIMHRDIKPQNFLVCASKEYGFSIKLCDLGFASAVSKS-------KSFMSKK--GTD
|....    | |.||| .   . . .  ...|  .| . || ||. |||.   | || . .     .| .| | . ..          .  ..|.  |..
EYMPH--GDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK

-----AYFAPEVE------------------------AGQSRIQV----FNNSVILFFKVYL-------H------------------------------
        |||.                          .|    .     .|. .. .           .                              
TMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPT

--QIVRSL
  .|.. .
FSEIHECF

Kinase 26387.AA Ciliate-E2 42-116 14 1.1e-05 15.47 In-house 1-107 (365) Show / Hide
Range on Protein: 42-116
Range on HMM: 1-107/365
Sequence Identity: 14% (15 aa)

FKNFEYLSSGAYALVLKAQNSQQNRQVALK-----------------FLESSNKEGKDGIESLKKEYEMLQ---------------KFSQSECLVNVYDC
.|  . . .|... | |... ....|.|.|                 ..   .   |..||..|.|  ...               .. ..  ... |.|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FYLMEEK
|. . ..
FQEKDDN

Kinase 26387.AA TKL 48-107 13 0.024933 4.21 In-house 1-91 (364) Show / Hide
Range on Protein: 48-107
Range on HMM: 1-91/364
Sequence Identity: 13% (12 aa)

LSSGAYALVLKAQNSQQN--------RQVALKFLESSNKEGKDGIES----------------------LKKEYEMLQKFSQ-SECLVNVY
. ||... | |..  ...        . || | . | |   .. ..                        ..|.|.... .   . .|  .
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFM