Gene 7132 (Tetrahymena)

7132

Species: Tetrahymena
Alias: TTHERM_00420070, PreTt07132, 3679.m00037, 675, 46.m00187, 7132
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CK1
Family: CK1
Subfamily: CK1-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
7132.AA Protein None 525 None Fasta, JSON
7132.NA RNA None 1578 None Fasta, JSON
7132.kin_dom Protein Kinase Domain None 228 None Fasta, JSON

Protein domain

Protein domains of 7132.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 7132.AA CK1-Unclassified 14-246 66 3.8e-199 593.34 In-house 1-244 (244) Show / Hide 
Range on Protein: 14-246
Range on HMM: 1-244/244
Sequence Identity: 66% (162 aa)

YQVGQQFGQGSFGSIHLATNIETGEIVAVKMEDSKTKHPQLTFEAKIFKVLQGKA-------GIPTLYHCGQE--GGKNVMVIDLLGPSLEDLFNLCQRK
|.|..  |||||| |....|..|.| ||.|.|....|||||..|||| . ||. .       ||| .|.||||  |..|.|| ||||||||||||.|.||
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNRK

LSLKTVLMIVDQMLLRIETFHSSGFIHRDIKPDNFLIG-LGKKSNLLYIIDYGLGKRYLDS-KTKQHIPYRENKNLTGTARYASINAHLGIEQSRRDDME
.||||||||.|||. ||| .|. .||||||||||||.| |||... .||||.||.|||.|. ||..||||||||||||||||||||||||||||||||.|
FSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDLE

AIGYVIVYLLRGSLPWQGIKAQNKQEKYNKIMEKKMSTPVEMLC
..|||..|.|.||||||.|||.||.|||.||||.|||||||.||
SLGYVLIYFLKGSLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC
Kinase 7132.AA CK1 14-272 67 2e-191 642.22 In-house 1-271 (271) Show / Hide 
Range on Protein: 14-272
Range on HMM: 1-271/271
Sequence Identity: 67% (183 aa)

YQVGQQFGQGSFGSIHLATNIETGEI--VAVKMEDSKTKHPQLTFEAKIFKVLQG------KAGIPTLYHCGQE--GGKNVMVIDLLGPSLEDLFNLCQR
|.||.  |||||| |.|..|. .||   ||.|.|..|.||||| .|||| | |||        |||..|.||||  |  |.||.||||||||||||.|.|
YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFCNR

KLSLKTVLMIVDQMLLRIETFHSSGFIHRDIKPDNFLIGL-GKKSNLLYIIDYGLGKRYLDSKTKQHIPYRENKNLTGTARYASINAHLGIEQSRRDDME
|.||||||||.|||. ||| .|. .||||||||||||.|. ||... .||||.|| |||.|.||.|||||||||||||||||||||.|||||||||||||
KFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDME

AIGYVIVYLLRGSLPWQGIKAQNKQEKYNKIMEKKMSTPVEMLCKG-LPIEFSTYLNYCRSLRFDDKIDYL
..|||..|.|||||||||.||..|..||.||||||||||||.|||| .| || .||||||.|.|..| || 
SLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM
Kinase 7132.AA CK1-D 14-274 66 6.00000000001e-158 531.02 In-house 1-261 (261) Show / Hide 
Range on Protein: 14-274
Range on HMM: 1-261/261
Sequence Identity: 66% (173 aa)

YQVGQQFGQGSFGSIHLATNIETGEIVAVKMEDSKTKHPQLTFEAKIFKVLQGKAGIPTLYHCGQEGGKNVMVIDLLGPSLEDLFNLCQRKLSLKTVLMI
| .| . | |||| | . |||.|.| ||.|.|  ||||||| .|.|..|..||  |||..  |||||  ||||.|||||||||||| |.|| |||||||.
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLML

VDQMLLRIETFHSSGFIHRDIKPDNFLIGLGKKSNLLYIIDYGLGKRYLDSKTKQHIPYRENKNLTGTARYASINAHLGIEQSRRDDMEAIGYVIVYLLR
 |||. |||  |.  ||||||||||||.||||. |. ||||.|| ||| |..|.||||||||||||||||||||| |.|||||||||.|..|||..|  |
ADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNR

GSLPWQGIKAQNKQEKYNKIMEKKMSTPVEMLCKGLPIEFSTYLNYCRSLRFDDKIDYLHI
|||||||.|| .|..||..|.||||||... ||||.| ||..|.||||.|.|||| ||...
GSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase 7132.AA CK1-A 14-274 63 1.4e-149 503.24 In-house 1-261 (261) Show / Hide 
Range on Protein: 14-274
Range on HMM: 1-261/261
Sequence Identity: 63% (165 aa)

YQVGQQFGQGSFGSIHLATNIETGEIVAVKMEDSKTKHPQLTFEAKIFKVLQGKAGIPTLYHCGQEGGKNVMVIDLLGPSLEDLFNLCQRKLSLKTVLMI
|.. .. | |||| | |. ||. || ||.|||  | .|||| .|||....|||  |||.. . |.|   ||||.||||||||||||.|.|. ..|||||.
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLML

VDQMLLRIETFHSSGFIHRDIKPDNFLIGLGKKSNLLYIIDYGLGKRYLDSKTKQHIPYRENKNLTGTARYASINAHLGIEQSRRDDMEAIGYVIVYLLR
.|||. |||  |  .||||||||||||.|.|.  | |..||.|| |.| ||.|.||||||| |||||||||||||||||||||||||||..|||..|  |
ADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFNR

GSLPWQGIKAQNKQEKYNKIMEKKMSTPVEMLCKGLPIEFSTYLNYCRSLRFDDKIDYLHI
|.|||||.||..|. || || |||||||.|.|||| | ||. |.||||.|||... ||...
GKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase 7132.AA CK1-G 14-274 53 1.8e-136 459.71 In-house 1-266 (266) Show / Hide 
Range on Protein: 14-274
Range on HMM: 1-266/266
Sequence Identity: 53% (142 aa)

YQVGQQFGQGSFGSIHLATNIETGEIVAVKMEDSKTKHPQLTFEAKIFKVLQGKA-GIPTLYHCGQEGGKNVMVIDLLGPSLEDLFNLCQRKLSLKTVLM
|.||   | |.|| . . .|. ..| ||.|.|  |.. |||  | . .|.| |.. |||  |  ||.|  |.||.|||||||||||..| || |.|||.|
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKTVCM

IVDQMLLRIETFHSSGFIHRDIKPDNFLIGL--GKKSNLLYIIDYGLGKRYLDSKTKQHIPYRENKNLTGTARYASINAHLGIEQSRRDDMEAIGYVIVY
.  ||. |.|  ||   | ||.||||||||    |. ....|||.|. | | | .||||||||| | ||||||| ||| ||| ||||||||||.| .  |
VAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFMY

LLRGSLPWQGIKAQNKQEKYNKIMEKKMSTPVEMLCKG--LPIEFSTYLNYCRSLRFDDKIDYLHI
 ||||||||| || |  |.|.|| ..| .|..| ||..  .|..| ||| | |.| |... || ..
FLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL
Kinase 7132.AA CK1 14-274 36 2.6e-130 439.22 In-house 1-339 (339) Show / Hide 
Range on Protein: 14-274
Range on HMM: 1-339/339
Sequence Identity: 36% (126 aa)

YQVGQQFGQGSFG-SIHLA-----TNIETG-----EIVAVKMEDSKTK--HPQLTFEAKIFKVLQGK-------------------AGIPTLYHCGQEGG
..|... |.|.||  |...     ......     | .|.|.|  |..  ||||  |... | |||.                    ..| .|....|..
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

--KNVMVIDLLGPSLEDLFN---LCQRKLSLKTVLMIVDQMLLRIETFHSSGFIHRDIKPDNFLIGL------GKKSN--------LLYIIDYGLGK-RY
   |.||..||||.||||..   .|.||.|.||.||| .||| ..|  |. ||||||||||||..|.      ||. .         .|.||.|. . .|
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKH-HHEWNNEHRQVYMIDFGMARRKY

LDS-----------KTKQHIPYRE---NKNLTG-TARYASINAHLGIEQSRRDDMEAIGYVIVYLLRGS--LPWQGIKAQNK-------QEKYNKIMEKK
.|.           ||.||.|.||   .|...| ||||.|||.|||.||.||||... .|.....|.|.  ||||..|...|       ..||..|.|||
RDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKK

MSTPVEMLCKG-----LPIEFSTYLNYCRSLRFDDKIDYLHI
||||.. ||..     .| || ....|.|||...|. ||  |
MSTPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 7132.AA Worm6 14-274 27 1.4e-62 214.18 In-house 1-279 (279) Show / Hide 
Range on Protein: 14-274
Range on HMM: 1-279/279
Sequence Identity: 27% (78 aa)

YQVGQQFGQGSFGSIHLATNIETGE--IVAVKMED--SKTKHPQLTFEAKIFKVLQGKA--GIPTLYHCGQEGGK--NVMVIDLLGPSLEDLFNLC-QRK
..|..  |.|.||.. .... ....   .|.| |    . |...| .|. . | .  .   . ...  .|. . .  | .|. |.|..|.||   . .||
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

LSLKTVLMIVDQMLLRIETFHSSGFIHRDIKPDNFLIGL-----GKKSNLLYIIDYGLGK-RYLDSKTKQHIPYR-ENKNLTGTARYASINAHLGIEQSR
.|. | | |  |.| .||  |. ||||||.|| || ||       ...  .|..|.|. . .... | .. .. | ..    || |||....| |.||.|
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR

RDDMEAIGYVIVYLLRGSLPWQGIKAQNKQE-KYNKIMEKKMSTPVEMLCKGLPI-EFSTYLNYCRSLRFDDKIDYLHI
.||.|   |..| ...| |||...|. . .|  . ... .. ..  .|. .. |  ||.  . |  .... |..|| .|
KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase 7132.AA TTBKL 14-278 27 1e-52 176.36 In-house 1-288 (288) Show / Hide 
Range on Protein: 14-278
Range on HMM: 1-288/288
Sequence Identity: 27% (80 aa)

YQVGQQFGQGSFGSIHLATNIETGEIVAVKMEDSKT-KHPQ--LTFEAKIFKVLQ--GKAGIPTLYHCGQEGGKNVMVIDLLGPSLEDLFNLCQRK--LS
... .. |.| ||.. .. .... . .|.. | ...  .    . .|..... ||  |.  .|... .|.... | ||  |.||.| || .  ..|  .|
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

LKTVLMIVDQMLLRIETFHSSGFIHRDIKPDNFLIGLGKK----SNLLYIIDYGLGKRYLDS----------KTKQHIPYRE---NKNLTGTARYASINA
  |.. |  | |  .   |. ||||||.|| |. .|. ..    . ..|.||.|. ..|...          ..... . |.      . || ||.|.|.
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HLGIEQSRRDDMEAIGYVIVYLLRGSLPWQGIKAQNKQEKYNKIMEKKMSTPVEMLCKG------LPIEFSTYLNYCRSLRFDDKIDYLHIRKMF
|.. ||.| ||. .  |.|..|. | |||.... .       .|...|...  | |.|.      .| ||     . ||||. |  ||  |.. |
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKM------EIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase 7132.AA TTBK 14-274 35 3.1e-49 169.89 In-house 1-257 (257) Show / Hide 
Range on Protein: 14-274
Range on HMM: 1-257/257
Sequence Identity: 35% (93 aa)

YQVGQQFGQGSFGSIHLATNIETG-EIVAVKMEDSKTKHPQLTFEAKIFKVLQGKAGIPTLYHCGQEGGKNVMVIDLLGPSLEDL-FNLCQRKLSLKTVL
 .| .  |.| || |  |... .  | ||.|.| ....   |  |  . | |||.  .   . || .   | || .|.| .| ||  .  . . || | |
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL

MIVDQMLLRIETFHSSGFIHRDIKPDNFLIG-LGKKSNLLYIIDYGLGKRYLDSKTKQHIPYRENKNLTGTARYASINAHLGIEQSRRDDMEAIGYVIVY
 .  |.|  ||  || || |||||| || .| . .. .  |..|.||  .|. ..     | ||     ||.||||||||.  |  |.||.  . |. | 
RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPP-REVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVE

LLRGSLPWQGIKAQNKQEKYNKIMEKKMSTPVEMLCKGLPIEFSTYLNYCRSLRFDDKIDYLHI
 . | |||  ||        ... | |      || | .| ||.....  .|| . |. ||  |
FVQGQLPWRKIKDK------DQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 7132.AA Pkinase 14-265 20 9.4e-37 131.04 Pfam 1-258 (293) Show / Hide 
Range on Protein: 14-265
Range on HMM: 1-258/293
Sequence Identity: 20% (57 aa)

YQVGQQFGQGSFGSIHLATNIETGEIVAVKMEDSKTKHP----QLTF--EAKIFKVLQGKAGIPTLYHCGQEGGKNVMVIDLLGPSLEDLFNLC------
|..|.. |.||||.  ..... ||.|||||  . .....    ...   |..| | |. .  . ... .   ...  || ....  |. .. |.      
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLY-VMDLFDYISTW

-QRKL--SLKTVLMIVDQMLLRIETFHSSGFIHRDIKPDNFLIGLGKKSNL---LYIIDYGLGKRYLDSKTKQHIPYRENKNLTGTARYASINAHL-GIE
 ....  | ... ... |.|  .|  || |.||||.||.|.||   .. ..   . |.| || | .       . ... .. ..|| .|..   .. | .
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIRGGQY

QSRRDDMEAIGYVIVYLLRGSLPWQGI----KAQNKQEKYNKIMEKKMSTPVEMLCKGLPIEFSTYLNYCRSLRF
 ... || ..| .. ..| | .|..|     .  ........||... . . . .| . . .  ..   .. ...
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWT
Kinase 7132.AA Dual 85-218 31 3.4e-26 84.99 In-house 89-225 (282) Show / Hide 
Range on Protein: 85-218
Range on HMM: 89-225/282
Sequence Identity: 31% (43 aa)

MVIDLLGPSLEDLFN-LCQRKLSLKTVLMIVDQMLLRIETFHSSGFIHRDIKPDNFLIGLGKKSNLLYIIDYGLGKRYLDSKTKQHIPYRENKNLTGTAR
.|. . ||||..         ||  .   .  |||  |   || |..||.||| || .||| .   .|  |..... |.| ..|.| . | .    |..|
WVMSPYGPSLQEIRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGMDETTVYMQDFRIVRKYIDPENKKHRTARKKVKMYGCGR

YASINAHLGIEQSRRDDMEAIGYVIVYLL-RGS-LPW
||..   .  .| | ||.|.  | . .|.  .. ..|
YACRACMMQKDQGRKDDLECWIYMVFDLMDPEHGMSW
Kinase 7132.AA S_TKc 14-308 17 9.4e-16 54.07 SMART 1-231 (231) Show / Hide 
Range on Protein: 14-308
Range on HMM: 1-231/231
Sequence Identity: 17% (57 aa)

YQVGQQFGQGSFGSIHLATNIETGEIVAVKMEDSKTKHPQLTFEAKIFKVLQGKAGIPTLYHCGQEGGKNVMVIDLLGPSLEDLFNLCQRK--------L
|..... |.|.||. .......||.|||.|. .      ..  | .| |   .   | .|| . |. ..  || .... .| ||| . ...        .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SLKTVLMIVDQMLLRIETFHSSGFIHRDIKPDNFLIGLGKKSNLLYIIDYGLGKRYLDSKTKQHIPYRENKNLTGTARYASINAHLGIEQSR-RDDMEAI
.  ..  .. |... .|  || |.||||.||.| |.        . |.| || ...              . . ||  | .         .. . |. ..
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GYVIVYLLRGSLPWQGIKAQNKQEKYNKIMEKKMSTPVEMLCKGLPIEFSTYLNYCRSLRFDDKIDYLHIRKMFKELFYREKYDWDYLFDWCLPIDQQ--
| ..  .| |  |..     . |. ..||.                                                   .  .| . . ||  | .  
GCILYEMLCGYPPFP-----QMQMMFKKIG--------------------------------------------------SPEAKD-FIRKCLQKDPEKR

-----VK-------SSWK
      .         | 
PTAEALQDEWDIKCHPWF
Kinase 7132.AA TyrKc 14-245 21 2.2e-05 -135.61 SMART 1-280 (280) Show / Hide 
Range on Protein: 14-245
Range on HMM: 1-280/280
Sequence Identity: 21% (61 aa)

YQVGQQFGQGSFGSIHLATNIETGEIVAVKMEDSKTKHPQLTFEAKIFKVL--QGKAGIPTLYHCGQEGG-----KNVMVIDLLGP--SLEDLFNLCQRK
 . |.. | | || ....| .   . |||||  . . .  .  ||.| . |  . .  .  .  | |.|.     . .|..  . |  .| |    ...|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LSLKTVLMIVDQMLLRIETFHSSGFIHRDIKPDNFLIGLGKKSNLLYIIDYGLGKRYLDS----KTKQHIPYRENKNLT--GTARYA---SINAH-----
|..|. | .  |     |  || ..||||.   | |.| ..      | | || .   |       |. .  .| |.       |     .|| .     
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

---------------LGIEQSRRD---DMEAIGYVIVYLLRGSLPWQGIKAQ------NKQEKYNKIMEK----------KMSTPVEML
               .| .    .   .|...  || |. .|  . |   .         .| |. ||..           .|. .| .
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQ-EVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF