Gene 10873 (Tetrahymena)

10873

Species: Tetrahymena
Alias: TTHERM_00717780, 114.m00108, PreTt10873, 149, 3827.m00951, 10873
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: CDKL

Sequence

Name Sequence Type Origin Length Description Download
10873.AA Protein None 585 None Fasta, JSON
10873.kin_dom Protein Kinase Domain None 287 None Fasta, JSON
10873.NA RNA None 1758 None Fasta, JSON

Protein domain

Protein domains of 10873.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 10873.AA CDKL 4-290 62 1.9e-218 731.97 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-290
Range on HMM: 1-286/286
Sequence Identity: 62% (180 aa)

YEILGVNGEGAYGVVLKCRNKETQEIVAIKKFKETEDDEIAKKNIQREVKMLRQLRHKNIVDLIEAFKRKGRIYLVFEYVEKNLLEVLEEKPTGLDHEVI
||.||. |||.||||.|||||||..|||||||||.|||.. ||...||.|||.||.|.|||.|||.|.||....|||||.....|..|||.|.|.|..|.
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHELEEYPNGVDEHVV

RIIMYQLLKALHQCHKQDVIHRDVKPENLLVNPYNYELKLCDFGFARTLPSKQGEIITDYVATRWYRAPELLLKYPKYSKPVDIWAVACIMGELIDGQPL
| .|.|.|||...|||...||||.||||.|..|.|...||||||||| ...|.|||.|||||||||||||||.....|.|||||||..|.|.|.||||||
RKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFAR-MLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPL

FPGQNEIDQLYLIQKTLGPLTPEQKELFIKNPRFIGTKFPEINKPETIERRYLGKLSKKALNIMKLMLKMDPDERITAEEAMKHPYF
.|||..|||||.|||.||||.|...|.|.|||.|.| |||||...|..|.||..|..||||..|| .|.||||||.|.|..|.||||
WPGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIEHMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase 10873.AA CMGC 4-290 25 1.2e-136 451.99 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-290
Range on HMM: 1-513/513
Sequence Identity: 25% (131 aa)

YEILGVNGEGAYGVVLKCRN--------------KETQEIVAIKKFKETEDDEIAKK----------NIQREVKMLRQLR-----------------HKN
|||... |||.|||| |||.              .||.|||||||.|. . .|. .|           ..||.|.|..|.                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVDLIEAFKRKG-----------------RIYLVFEYVEKNLLEVLEEKPT--------GLDHEV------------IRIIM------YQLLKALH--QC
|| |.. |..|.                  .||||||....|.........        .|.. .            |. .|      ||.|..|.   |
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HKQD--VIHRDVKPENLLVNP-------------------YNYELKLCDFGFARTLPSKQGE--------------------IITDYVATRWYRAPELLL
|...  .|||| ||||.|.|.                    |..||.||||.|| . . ...                     .|.||.||||||||.||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

KYPKYS---------KPVDIWAVACIMGELIDG--------QPLFPGQNE-----------IDQLYLIQKTLGPLT---------------PE-------
 ...|.         .|.|.|.|.||..|.. |        .|||||..|           ||||..| |.||. |               .|       
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

------------------QKELFIKNPRFIGTKFPEINKP--ETIERRYLG-------------------------------KLSKKALNIMKLMLKMDP
                  ..  | .|..... .||.....  . .. ..                                 .....|.. .| ||..||
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

DERITAEEAMKHPYF
|.|||||.|..||||
DKRITAEQALQHPYF
Kinase 10873.AA CDK 4-290 34 2.6e-107 344.42 In-house 1-284 (284) Show / Hide 
Range on Protein: 4-290
Range on HMM: 1-284/284
Sequence Identity: 34% (111 aa)

YEILGVNGEGAYGVVLKCRNKETQ-----EIVAIKKFK-ETE----DDEIAKKNIQREVKMLRQLRHKNIVDLIEAFKRK-----------GRIYLVFEY
||.|   |||.|||| |.|.|.|.     .|||.||.. |.|    ..|       ||...|..| |.||| |.. .  |            ..|.||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

VEKNLLEVLEEKPTGLDHEVIRIIMYQLLKALHQCHKQDVIHRDVKPENLLVNPYNY----ELKLCDFGFARTLPSK-----QGEIITDYVATRWYRAPE
..  | ....          |. .|.|||..|| ||.. ..||| || |.|.|         ||. |||.||   .           |  | |.||||||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

LLLKYPKYS--KPVDIWAVACIMGELID---GQPLFPGQNEIDQLYLIQKTLGPLTPEQKELFIKNPRFIGTKFPEINKPETIERRYLGKLSKKALNIMK
|||   .||   |.|.|.| ||..|..    ..|||||..||||| .| ...|  |...   . | | .                           . . 
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------DLLN

LMLKMDPDERITAEEAMKHPYF
 || .||. ||.||.|..||||
KMLCYDPKKRISAEQALQHPYF
Kinase 10873.AA RCK 4-290 39 1.5e-102 326.21 In-house 1-298 (298) Show / Hide 
Range on Protein: 4-290
Range on HMM: 1-298/298
Sequence Identity: 39% (121 aa)

YEILGVNGEGAYGVVLKCRNKETQEIVAIKKFKETEDDEIAKKNIQREVKMLRQLR-HKNIVDLIEAFKRKG--RIYLVFEYVEKNLLEVLEE---KPTG
| |.   |.|.||.|.| .||||.||||||| | ..   .   .  ||.| || |  |.||. |.| .. .   . |.||||...|| . ...   . . 
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK-QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKY

LDHEV--IRIIMYQLLKALHQCHKQDVIHRDVKPENLLVNPY--------NYELKLCDFGFARTLPSKQGEIITDYVATRWYRAPELLLKYPKYSKPVDI
|  ..  |. ||||.|..|...||.   |||.||||.....         .. .|..||| .|   ||.    |||| ||||||||.||.  .|..|.||
LPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPP--YTDYVSTRWYRAPECLLRCTYYNSPMDI

WAVACIMGELIDGQPLFPGQNEIDQLYLIQKTLGPLTPEQKEL--FIKNPRFIGTKFPEINKPETIERRYLGKLSKKALNIMKLMLKMDPDERITAEEAM
||| ||| ||   .|||||..||||.. | | .|  || .|..  ..|  . .. .||    .  ..  ..  .|. ....|. ||. ||..||||..| 
WAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMG--TPNKKDWPDGYKLASQMNFNFPQCK-GMPLK-QLIPNCSQDCIELMEKMLQWDPQKRITAQQAL

KHPYF
.||||
QHPYF
Kinase 10873.AA S_TKc 4-290 31 3.1e-101 343.56 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-290
Range on HMM: 1-231/231
Sequence Identity: 31% (95 aa)

YEILGVNGEGAYGVVLKCRNKETQEIVAIKKFKETEDDEIAKKNIQREVKMLRQLRHKNIVDLIEAFKRKGRIYLVFEYVEK---NLLEVLEEKPTG---
|||| . |.||.|.| |||.|.|..|||||. |         ..|.||...|.. .|.||| |...|   ...|.|.||..    .|..........   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LDHEVIRIIMYQLLKALHQCHKQDVIHRDVKPENLLVNPYNYELKLCDFGFARTLPSKQGEIITDYVATRWYRAPELLLKYPKYSK-PVDIWAVACIM
  ..  ..| .|||...||  ||.. .||||.||||.|..    ..|.||||.|| |        | .. |.||.|||.|    .|.| ..|.|.. ||.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCIL

GELIDGQPLFPGQNEIDQLYLIQKTLGPLTPEQKELFIKNPRFIGTKFPEINKPETIERRYLGKLSKKALNIMKLMLKMDPDERITAEEAMK-------H
 |.. |.|.||      |.... | .|                                      |. |..... .|..||..|.|| ||..       |
YEMLCGYPPFP------QMQMMFKKIG--------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCH

PYF
|.|
PWF
Kinase 10873.AA Pkinase 4-290 30 6.4e-97 333.08 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-290
Range on HMM: 1-293/293
Sequence Identity: 30% (93 aa)

YEILGVNGEGAYGVVLKCRNKETQEIVAIKKFKETEDDEIAKKNIQR--EVKMLRQLRHKNIVDLIEAFKRKGRIYLVFEYVEK-----NLLEVLE-EKP
|.|... |.|..|.| ||..| |..|||.|..|  ....  ...  |  |..... |.|.||| |...| .|..||.|.||.|.      | .... .. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TGL--DHEVIRIIMYQLLKALHQCHKQDVIHRDVKPENLLVNPYNYEL----KLCDFGFARTL-PSKQGEIITDYVATRWYRAPELLLKYPKYSKPVDIW
...  . .... .|||.|..|  ||.. .||||.||||.|..  |...    |.||||.|. .   ...   |... |.||.|||.......|...||.|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

AVACIMGELIDGQPLFPGQ----NEIDQLYLIQKTLGPLTPEQKELFIKNPRFIGTKFPEINKPETIERRYLGKLSKKALNIMKLMLKMDPDERITAEEA
.. ||. |.. |.|.|||.    | .||...|....|| .... .  . ...|  ... .     . ...   ..|. .. ..| .|..|| .|.|||..
SCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQI

MKHPYF
..||.|
LQHPWF
Kinase 10873.AA MAPK 4-290 34 2.6e-95 322.95 In-house 1-328 (328) Show / Hide 
Range on Protein: 4-290
Range on HMM: 1-328/328
Sequence Identity: 34% (116 aa)

YEILGVNGEGAYGVVLKCRNKE------TQEIVAIKKFKETEDDEIAKKNIQREVKMLRQL-RHKNIVDLIEAFKRK-----------GRIYLVFEYVEK
|.||   |.|||||| ... |.      ....|||||.    ....  | ..||.|.|| . .|.||. |.. |. .             ||.|.|. | 
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

NLLEVLEEKPTGLDHEVIRIIMYQLLKA--LHQCHKQDVIHRDVKPENLLVNPYNYELKLCDFGFARTLPSKQGEI-------------ITDYVATRWYR
.|  ...  .  |... |. .|||.|..  |   |  .||||| ||.|.|||  | .||.|||| ||.. ... ..              |.||||||||
DLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVN-ENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYR

APELLLK--YPKYSKPVDIWAVACIMGELID-GQPLFPGQNEIDQLYLIQKTLGPLTPEQKEL-FIK---NPRFIGTKF--PEINKPETIERRYLG---K
|||..|   . .|.| ||.|.| ||..|..  ..|||||.. |||. || ..||  ||..  . .|.   ..|     .  .   .. . |  . .   .
APEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLG--TPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFN

LSKKALNIMKLMLKMDPDERITAEEAMKHPYF
 . .|.. .. || .|||.|||.|||. ||||
ANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 10873.AA CDC2 4-290 34 7.3e-88 270.06 In-house 1-301 (301) Show / Hide 
Range on Protein: 4-290
Range on HMM: 1-301/301
Sequence Identity: 34% (105 aa)

YEILGVNGEGAYGVVLKCRNKETQEIVAIKKFKETEDDEI--AKKNIQREVKMLRQLR-HKNIVDLIEAFKRKGRIYLVFEYVEKNLLEVLE-EKP--TG
|. .   ||| |||| ||....|..|||.||.. . .||.      . ||   |  |. |.||| | . ..   ..|.||||.. .| . .. ..|  . 
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

LDHEVIRIIMYQLLKALHQCHKQDVIHRDVKPENLLVNPYNYELKLCDFGFARTLPSKQGEIITD-YVATRWYRAPELLLKYPKYSKPVDIWAVACIMGE
.. .... .|||.|...| || . ..||| || |.|..  . ..|. ||| ||. .    .. |.  | |.||||||.||   .|| |||.|.. ||. |
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILID-KKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAE

L---IDGQPLFPGQNEIDQLYLIQKTLGPLTPEQKEL--FIKNPRFIGT--KFPEINKPETIERRYLGK----LSKKALNIMKLMLKMDPDERITAEEAM
.   .   |||.|. |||||. | ..||  ||  ...    ..| .  |  ......  . ..... .|    | .... . . ||  ||  ||.|.||.
MFMDVTKKPLFHGDSEIDQLFKIFRILG--TPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEAL

KHPYF
.||||
QHPYF
Kinase 10873.AA CDK5 4-290 37 4e-83 262.44 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-290
Range on HMM: 1-287/287
Sequence Identity: 37% (110 aa)

YEILGVNGEGAYGVVLKCRNKETQEIVAIKKFKETEDDEIAKKNIQREVKMLRQLRHKNIVDLIEAFKRKGRIYLVFEYVEKNLLEVLEEKPTGLDHEVI
|| .   ||| ||.| | |||||.||||.|. .  ..||       ||. .|. |.||||| |.       .. ||||.. . |   ...   ..| ..|
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

RIIMYQLLKALHQCHKQDVIHRDVKPENLLVNPYNYELKLCDFGFART--LPSKQGEIITDYVATRWYRAPELLLKYPKYSKPVDIWAVACIMGELI-DG
. .|||||| |  ||.. | ||| || |||.|  | |||| ||| ||    | .     .  | | |||.|  |.   .|| ..|.| . ||. |..  |
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLIN-KNGELKLADFGLARAFGIPVR---CYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAG

QPLFPGQNEIDQLYLIQKTLGPLTPEQKELFIKNPRFI--GTKFPEINKPETIERRYLGKLSKKALNIMKLMLKMDPDERITAEEAMKHPYF
.||||| .. ||| .| | .|  . ..     | | .    ...|  .  .. .    . |..| ..... ||...|..||.|..|..||||
RPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPK-LDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase 10873.AA ERK7 4-290 36 1.9e-76 260.32 In-house 1-292 (292) Show / Hide 
Range on Protein: 4-290
Range on HMM: 1-292/292
Sequence Identity: 36% (107 aa)

YEILGVNGEGAYGVVLKCRNKETQEIVAIKKFKETEDDEIAKKNIQREVKMLRQLR-HKNIVDLIEAFKRKGR--IYLVFEYVEKNLLEVLEEKPTGLDH
|||.   | ||||.| |   | |...||.||      ...      ||. .|.... | ||. ||. .. .    ||||||. |  |  |   |   |  
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFMETDLHAVIR-KGNILKD

EVIRIIMYQLLKALHQCHKQDVIHRDVKPENLLVNPYNYELKLCDFGFARTLPSKQ-----GEIITDYVATRWYRAPELLLKYPKYSKPVDIWAVACIMG
   . ||||||.|.   |  .|||||.|| |.|..  .  .|.|||| ||.. ...       ..|.||||||||||| ||   .| | || | . ||.|
IHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDS-ECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILG

ELIDGQPLFPGQNEIDQLYLIQKTLGPLTPEQKELFIKNPRFIGTKFPEINKPETIERRYLGKLSKKALNIMKLMLKMDPDERITAEEAMKHPYF
|.. |.|.|||   ..|. .| .|..  | |  |    . .    .  . .|..|..  .  . .. |....| .| . |..|.|||.|..||| 
EMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMP-QCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase 10873.AA ERK 4-221 39 4.3e-68 232.52 In-house 1-234 (307) Show / Hide 
Range on Protein: 4-221
Range on HMM: 1-234/307
Sequence Identity: 39% (93 aa)

YEILGVNGEGAYGVVLKCRNKE-----TQEIVAIKKFKETEDDEIAKKNIQREVKMLRQLR-HKNIVDLIEAFKRKGR-----IYLVFEYVEKNLLEVLE
|.|.   |.|||||| ....||     |...||||| ..  |..|  | . || |.|| .. |.||. |.  .. . .     ||.|.|. |  |  .  
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

EKPTGLDHEVIRIIMYQLLKALHQCHKQDVIHRDVKPENLLVNPYNYELKLCDFGFARTLPSKQGE-------IITDYVATRWYRAPELLLKYPKYSKPV
 ..  |  . .   |||.| .|   | ..||||| || |.|||  |  || ||||.||.. ... |       ..|.|||||||||||..|...||.|..
SQQ-ELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVN-SNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAM

DIWAVACIMGELIDGQPLFPGQNEIDQLYLIQKTLG
|||.. ||. |.. ..||||| . ..|. .| ...|
DIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIG
Kinase 10873.AA p38 4-221 39 1.8e-60 205.29 In-house 1-221 (289) Show / Hide 
Range on Protein: 4-221
Range on HMM: 1-221/289
Sequence Identity: 39% (89 aa)

YEILGVNGEGAYGVVLKCRNKETQEI---VAIKKFKETEDDEIAKKNIQREVKMLRQLRHKNIVDLIEAFKR-------KGRIYLVFEYVEKNLLEVLEE
|. |   |.|||| | | . ..|..    |||||. .   .||  | . ||.. |. .|| |...|.. |            .|.| .  .  |  ..  
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

KPTGLDHEVIRIIMYQLLKALHQCHKQDVIHRDVKPENLLVNPYNYELKLCDFGFARTLPSKQGEIITDYVATRWYRAPELLLKYPKYSKPVDIWAVACI
.   |  . |... ||.|..|   |  ..|||| || |. ||  . ||.  ||| ||    .. . .|.||||||||||| .|   .| . |||| | ||
QR--LSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVN-EDCELRILDFGLAR----HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCI

MGELIDGQPLFPGQNEIDQLYLIQKTLG
| ||| |..||||.. ||||  | | .|
MAELITGRTLFPGDDHIDQLQRIMKVCG
Kinase 10873.AA Pkinase_Tyr 11-101 31 8.4e-15 50.75 Pfam 8-111 (270) Show / Hide 
Range on Protein: 11-101
Range on HMM: 8-111/270
Sequence Identity: 31% (33 aa)

GEGAYGVVLKCRNK----ETQEIVAIKKFKETEDDEIA--KKNIQREVKMLRQL-RHKNIVDLIEAFK-RKGR--IYLVFEYVEK-NLLEVLEEK---PT
||||.|.| |.. |    .|.  ||.|. ||   .. .  ..   ||.|...|| .|.||| |. .   ...   ||.|.||... .||. | ..   . 
GEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQ

GLDHE
 |...
PLTMK
Kinase 10873.AA TyrKc 4-290 21 1e-14 15.18 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-290
Range on HMM: 1-280/280
Sequence Identity: 21% (68 aa)

YEILGVNGEGAYGVVLKCRNKETQEIVAIKKFKETEDDEIAKKNIQREVKMLRQL--RHKNIVDLIEAFKRK-------GRIYLVFEYVEK-NLLEVLEE
 . . . ||||.|.| |.. |   . ||.|. ||       .. . || .....|  .|.||| |. .   .       . ...|.||... .|.. | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

KPTGLDHEVIRIIMYQLLKALHQCHKQDVIHRDVKPENLLVNPYNYELKLCDFGFARTLPSK-----QGEIIT------DY--VATRWYRAPELLLKYPK
.   | ..    ...|  .     |.. .||||    | ||.  .   | .||| .| . ..      .. ..          .  ||. ||| . .| |
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGK

YSKPVDIWAVACIMGELI-DGQPLFPGQNE--IDQLYLIQKTLGPLTPEQKEL----FIKNPRFIGTKFPEINKPETIERRYLGKLSKKALNIMKLMLKM
..   |.|.    | |.  .||.  ||. .  ..   .|..      ..| .                             .    ...  .|||   . 
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------------------F-VCCPDEMYQIMKQCWHE

DPDERITAEEAMKHPYF
||..| | .|   | .|
DPEDRPTFSEI--HECF
Kinase 10873.AA p38 260-290 58 6.2e-13 40.26 In-house 259-289 (289) Show / Hide 
Range on Protein: 260-290
Range on HMM: 259-289/289
Sequence Identity: 58% (18 aa)

SKKALNIMKLMLKMDPDERITAEEAMKHPYF
. .|.. .  ||..||| ||||||||.||||
NPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase 10873.AA ERK 259-290 46 9.2e-11 36.48 In-house 276-307 (307) Show / Hide 
Range on Protein: 259-290
Range on HMM: 276-307/307
Sequence Identity: 46% (15 aa)

LSKKALNIMKLMLKMDPDERITAEEAMKHPYF
....|..  . ||  |||.|||.||. .||||
CNPQAIDLLEKMLVFDPDKRITVEECLEHPYF