Gene 29899 (Tetrahymena)

29899

Species: Tetrahymena
Alias: PreTt29899, 894, TTHERM_00185770, 14.m00466, 29899
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: CDKL

Sequence

Name Sequence Type Origin Length Description Download
29899.AA Protein None 770 None Fasta, JSON
29899.kin_dom Protein Kinase Domain None 285 None Fasta, JSON
29899.NA RNA None 2313 None Fasta, JSON

Protein domain

Protein domains of 29899.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 29899.AA CDKL 4-288 61 5e-213 713.98 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-286/286
Sequence Identity: 61% (175 aa)

YEVKGVVGEGAYGVVLKCMNKENGEYVAIKKFKESDEDEVVKKTTLREVKILRMLKQENIVQLREAFRRKGKLYLVFEYVENNLLEILEERPNGLDQDDV
||  |.||||.||||.||.|||.|..|||||||||..|..|||...||.|.|..||.||||.|.|.||||.||.|||||.....|..|||.|||.|...|
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHELEEYPNGVDEHVV

RKYIYQLCKSISYCNSMDIIHRDIKPENLLIS-KDGTLKLCDFGFARVLPQKGGNLTDYVATRWYRAPELLLGYTDYGKEVDMWAVGCIMGELTDGQPLF
|||..|..|.|..|.....|||||||||.||. |.|..||||||||| |...| ..|||||||||||||||.|.|.|||.||.||.||.|.|..|||||.
RKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPLW

PGQNEIDQLYVIQKVLGPLTAEQQEVFLKHPGFLGVKLPEISKPETIEKRYLGKLSKKALSFMKNLLKMDPSQRMSADEALQHPYF
|||..|||||.|||.||||....||.|.|.| | |.|.|||...|..||||..|..||||.|||..|.|||..||.......||||
PGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIEHMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase 29899.AA CMGC 4-288 24 2e-137 454.57 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-513/513
Sequence Identity: 24% (127 aa)

YEVKGVVGEGAYGVVLKCMN--------------KENGEYVAIKKFKESDEDEVVKK----------TTLREVKILRMLK----------------QEN-
||. ...|||.|||| || .              .|..|.|||||.|.   .|  .|          ..|||.|||..|.                ..| 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVQLREAFRRKG-----------------KLYLVFEYVENNLLEILEE--------RPNGLDQDD------------VRKYI------YQLCKSIS--YC
||.|.. |..|.                 .|||||||....|......        ||..|..              .....      ||.....   ||
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

NSMD--IIHRDIKPENLLISKD--------------------GTLKLCDFGFARVLPQKGGN---------------------LTDYVATRWYRAPELLL
 |..  |||||.||||.||...                    |.||.||||.|| . .  ..                     .|.||.||||||||.||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GY---------TDYGKEVDMWAVGCIMGELTDG--------QPLFPGQNE-----------IDQLYVIQKVLGPLT---------------AE-------
|.         ..|....|||.||||..|.  |        .|||||..|           ||||. | ||||. |                |       
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

------------------QQEVFLKHPGFLGVKLPEISKP--ETIEKRYLG-------------------------------KLSKKALSFMKNLLKMDP
                  ..  | ... . . ..|.. ..  . .....                                 .....|. ..|..|..||
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

SQRMSADEALQHPYF
..|..|..|||||||
DKRITAEQALQHPYF
Kinase 29899.AA CDK 4-288 34 9.60000000001e-113 362.07 In-house 1-284 (284) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-284/284
Sequence Identity: 34% (110 aa)

YEVKGVVGEGAYGVVLKCMNKENG-----EYVAIKKFK-ESD----EDEVVKKTTLREVKILRMLKQENIVQLREAFRRK-----------GKLYLVFEY
||    .|||.|||| |. .|..|     ..||.||.. |..    |.| .  |..||...|. |  .|||.|.. .  |            |||.||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

VENNLLEILEERPNGLDQDDVRKYIYQLCKSISYCNSMDIIHRDIKPENLLISKDGT-----LKLCDFGFARVLPQ------KGGNLTDYVATRWYRAPE
..  | ....          .. |..|| . ..|| |  |.|||.|| |.||...|.     ||. |||.||          .   .|  | |.||||||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

LLLGYTDYG--KEVDMWAVGCIMGELTD---GQPLFPGQNEIDQLYVIQKVLGPLTAEQQEVFLKHPGFLGVKLPEISKPETIEKRYLGKLSKKALSFMK
|||| ..|.   ..|||.||||..|.     ..|||||..|||||  | ...|  | ..   . | |..                            .. 
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------DLLN

NLLKMDPSQRMSADEALQHPYF
..| .||..|.||..|||||||
KMLCYDPKKRISAEQALQHPYF
Kinase 29899.AA Pkinase 4-288 32 6.5e-105 359.65 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-293/293
Sequence Identity: 32% (100 aa)

YEVKGVVGEGAYGVVLKCMNKENGEYVAIKKFKESDEDEVVKKTTLR--EVKILRMLKQENIVQLREAFRRKGKLYLVFEYVEN-----NLLEILE-ERP
|......|.|..|.| ||..| .|. ||.|..| ..|.. ...| .|  |..|...|. .|||.|...|..|...|.|.||.|.      | .... .| 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

NGL--DQDDVRKYIYQLCKSISYCNSMDIIHRDIKPENLLISKDGTL----KLCDFGFARVL-PQKGGNLTDYVATRWYRAPELLLGYTDYGKEVDMWAV
...  . .....|.||... . || || |||||.||||.||...|..    |.||||.|...   ... .|... |.||.|||...|...||..||||..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCIMGELTDGQPLFPGQ----NEIDQLYVIQKVLGPLTAEQQEVFLKHPGFLGVKLPEISKPETIEKRYLGKLSKKALSFMKNLLKMDPSQRMSADEALQ
|||. |.  |.|.|||.    | .||...|....|| . .. .     . |  ..  . .   . ...   ..|. ...|.|..|..||..| .|...||
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQ

HPYF
||.|
HPWF
Kinase 29899.AA S_TKc 4-288 32 3.4e-104 353.36 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-231/231
Sequence Identity: 32% (97 aa)

YEVKGVVGEGAYGVVLKCMNKENGEYVAIKKFKESDEDEVVKKTTLREVKILRMLKQENIVQLREAFRRKGKLYLVFEYVEN---NLLEILEERPNG---
||.  ..|.||.|.| || .|. |..||||. |         ....||..||.. . .|||.| ..|.  ..||.|.||...   .|......|. .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LDQDDVRKYIYQLCKSISYCNSMDIIHRDIKPENLLISKDGTLKLCDFGFARVLPQKGGNLTDYVATRWYRAPELLLGYTDYGK-EVDMWAVGCIMGE
  ..  ..|.|.||.|. . || |. |||||.||||.|...  ..|.||||.||.|       | .. |.||.|||.|     ||| ..|.|..|||. |
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

LTDGQPLFPGQNEIDQLYVIQKVLGPLTAEQQEVFLKHPGFLGVKLPEISKPETIEKRYLGKLSKKALSFMKNLLKMDPSQRMSADEALQ-------HPY
.  |.|.||      |.... |..|                                      |. |..|....|..||..|..| ||||       ||.
MLCGYPPFP------QMQMMFKKIG--------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

F
|
F
Kinase 29899.AA RCK 4-288 36 2.6e-98 312.57 In-house 1-298 (298) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-298/298
Sequence Identity: 36% (111 aa)

YEVKGVVGEGAYGVVLKCMNKENGEYVAIKKFKE--SDEDEVVKKTTLREVKILRMLK-QENIVQLREAFRRKG--KLYLVFEYVENNLLEILEE---RP
| .   .|.|.||.|.|  |||.||.||||| |   .. .|. .   |||.| || |.  .||..|.| .| .    ||.||||...|| . ...   | 
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQKFYSWEECMN---LREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERR

NGLDQDD--VRKYIYQLCKSISYCNSMDIIHRDIKPENLLISK---------DGTLKLCDFGFARVLPQKGGNLTDYVATRWYRAPELLLGYTDYGKEVD
  | .    .....||........ .  . |||.||||.....         ....|..||| .|    |  . |||| ||||||||.||  | | . .|
KYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKP-PYTDYVSTRWYRAPECLLRCTYYNSPMD

MWAVGCIMGELTDGQPLFPGQNEIDQLYVIQKVLGPLTAEQQEVFLKHPGFLGVKLPEISKPETIEKRYLGKLSKKALSFMKNLLKMDPSQRMSADEALQ
.||||||| ||.  .|||||..||||.. | ||.|  . .  . . |.   .. ..|    .  ... ..  .|. ... |. .|. ||. | .| .|||
IWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCK-GMPLKQ-LIPNCSQDCIELMEKMLQWDPQKRITAQQALQ

HPYF
||||
HPYF
Kinase 29899.AA GSK 4-288 30 1.2e-88 270.78 In-house 1-328 (328) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-328/328
Sequence Identity: 30% (102 aa)

YEVKGVVGEGAYGVVLKCMNK----ENGEY----VAIKKFKESDEDEVVKKTT-LREVKILRML---KQENIVQLREAFRRKG-K-------LY-LVFEY
|| . |.| |. ||| .  ..    |..|     |||||          |..   ||..|..||   .  |||.|. .| ... |       .  ||.||
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKV------WQDKRYKCNRELQIMKMLGKLDHPNIVRLKYFFYMHYEKKDENHVYCNCLVMEY

VENNLLEILEE----RPNGLDQDDVRKYIYQLCKSISYCNSMDIIHRDIKPENLLIS-KDGTLKLCDFGFARVLPQKG-GNLTDYVATRWYRAPELLLGY
....| ... .    . . ..  ... | ||......| .|. | ||||||.|.|.  ..|.||.|||| |. |  ..    . |  .| ||||||..|.
MPQTLYQVIRHYVKNKQQ-MPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGC

TDYGKEVDMWAVGCIMGELTDGQPLFPGQNEIDQLYVIQKVLGPLTAEQQ-EVFLKHPGFLGV-----KLPEISKPETIEK-----------------RY
|.|.  .|.| .||.|.|.  |||||||....||| .| |.||  |.||  . . ..| |        ..  ....  ..|                 ..
TNYTCQIDVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPYWSFQQIKPHPWQKNDTKYEYQTYYHKKYRTVYMFKW

LGKLSKKALSFMKNLLKMDPSQRMSADEALQHPYF
..  .. .. ... .|..||..| |..||..||.|
CHTDMQDWIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase 29899.AA CDK5 4-288 37 1.3e-88 280.07 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-287/287
Sequence Identity: 37% (107 aa)

YEVKGVVGEGAYGVVLKCMNKENGEYVAIKKFKESDEDEVVKKTTLREVKILRMLKQENIVQLREAFRRKGKLYLVFEYVENNLLEILEERPNGLDQDDV
||    .||| ||.| |  ||| .|.||.|. .  .||| |  | .||. .|. || .||| |        || ||||.. . |   ....  ..|.. .
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

RKYIYQLCKSISYCNSMDIIHRDIKPENLLISKDGTLKLCDFGFARVLPQKGGNLTDYVATRWYRAPELLLGYTDYGKEVDMWAVGCIMGELT-DGQPLF
. ..||| | ...| .  . ||| || ||||.| |.||| ||| ||       . .  | | |||.|  |.|   |   .||| .|||. |.   |.|||
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

PGQNEIDQLYVIQKVLGPLTAEQQEVFLKHPGF-LGVKLPEISKPETIEKRYLGKLSKKALSFMKNLLKMDPSQRMSADEALQHPYF
|| .. |||  | |..|  . ..     | | .   ..  ..  ...  .    ||..| . .....|...| ||.||..||.||||
PGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase 29899.AA CDC2 4-219 40 3.5e-87 267.93 In-house 1-226 (301) Show / Hide 
Range on Protein: 4-219
Range on HMM: 1-226/301
Sequence Identity: 40% (92 aa)

YEVKGVVGEGAYGVVLKCMNKENGEYVAIKKFKESDEDEV--VKKTTLREVKILRMLK-QENIVQLREAFRRKGKLYLVFEYVENNLLEILE-ERP--NG
|.    .||| |||| || ... ...||.||..   |||   |  |..||  .|  ||  .|||.|.. .    |||.||||.. .| . .. . |    
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

LDQDDVRKYIYQLCKSISYCNSMDIIHRDIKPENLLISKDGTLKLCDFGFARVLPQKGGNLT--DYVATRWYRAPELLLGYTDYGKEVDMWAVGCIMGEL
.... |..|.||... ...| .. |.|||.|| |.||.|.|..|. ||| ||  .    ..|    | |.||||||.|||  .|  .||||..|||. |.
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---TDGQPLFPGQNEIDQLYVIQKVLG
       |||.|. |||||. | ..||
FMDVTKKPLFHGDSEIDQLFKIFRILG
Kinase 29899.AA CDK7 4-219 38 2.6e-84 224.35 In-house 1-220 (288) Show / Hide 
Range on Protein: 4-219
Range on HMM: 1-220/288
Sequence Identity: 38% (85 aa)

YEVKGVVGEGAYGVVLKCMNKENGEYVAIKKFK----ESDEDEVVKKTTLREVKILRMLKQENIVQLREAFRRKGKLYLVFEYVENNLLEILEERPNGLD
||    .||| ...| |   .. |. ||||| |     |. .  .  | .||.|||. .. .|.. |. .|  |  ..|||.. .  | .. .     | 
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

QDDVRKYIYQLCKSISYCNSMDIIHRDIKPENLLISKDGTLKLCDFGFARVLPQKGGNLTDYVATRWYRAPELLLGYTDYGKEVDMWAVGCIMGELTDGQ
. ..  |  .. . . ||    | |||.|| |||....| ||. ||| ||  .    ..|  | |||||||||| |   ||  ||||.||||. ||    
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

PLFPGQNEIDQLYVIQKVLG
| .||...|||| .| . ||
PYLPGDSDIDQLTRIFQTLG
Kinase 29899.AA MAPK 4-219 35 6.4e-84 285.12 In-house 1-252 (328) Show / Hide 
Range on Protein: 4-219
Range on HMM: 1-252/328
Sequence Identity: 35% (91 aa)

YEVKGVVGEGAYGVVLKCMNKE------NGEYVAIKKFKESDEDEVVKKTTLREVKILRML-KQENIVQLREAFRRK-----------GKLYLVFEYVEN
|.    .|.|||||| ... |.      .|..|||||.    ....  | |.||.|.||.. . |||. |.. |. .             .|.|.|. | 
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

NLLEILEERPNGLDQDDVRKYIYQLCKS--ISYCNSMDIIHRDIKPENLLISKDGTLKLCDFGFARVLPQKG--------------GNLTDYVATRWYRA
.|  |.. ..  |. | ..  .||...   . |  |...||||.||.|.|. ....||.|||| ||.. ..               . .|.|||||||||
DLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRA

PELLLG--YTDYGKEVDMWAVGCIMGELTD-GQPLFPGQNEIDQLYVIQKVLG
||..|.  ...| | ||||.||||..|.   ..|||||.. |||.  | .|||
PEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLG
Kinase 29899.AA ERK7 4-288 36 3.8e-78 265.92 In-house 1-292 (292) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-292/292
Sequence Identity: 36% (106 aa)

YEVKGVVGEGAYGVVLKCMNKENGEYVAIKKFKESDEDEVVKKTTLREVKILRMLK-QENIVQLREAFRRKGK--LYLVFEYVENNLLEILEERPNGLDQ
||..  .| ||||.| | . |  .. ||.||      ...    | ||. .|. ..  .||..| . .| .    .|||||. |  |  .   . | |  
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFMETDLHAVIR-KGNILKD

DDVRKYIYQLCKSISYCNSMDIIHRDIKPENLLISKDGTLKLCDFGFARVLPQKG------GNLTDYVATRWYRAPELLLGYTDYGKEVDMWAVGCIMGE
  ..  .||| . | |  | ..||||.|| |.|.  . ..|.|||| || . |.       . ||.||||||||||| ||| . | | |||| .|||.||
IHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGE

LTDGQPLFPGQNEIDQLYVIQKVLGPLTAEQQEVFLKHPGFLGVKLPEISKPETIEKRYLGKLSKKALSFMKNLLKMDPSQRMSADEALQHPYF
.  |.|.|||   ..|.  | ....  |.|  |    | .   ..  . .|..|... .  . .. |.. .|.|| . | .|..|..|||||| 
MLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMP-QCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase 29899.AA Pkinase_Tyr 4-151 30 6.8e-20 68.0 Pfam 1-161 (270) Show / Hide 
Range on Protein: 4-151
Range on HMM: 1-161/270
Sequence Identity: 30% (49 aa)

YEVKGVVGEGAYGVVLKCMNK----ENGEYVAIKKFKESDEDEV-VKKTTLREVKILRML-KQENIVQLREAFR-RKGK--LYLVFEYVEN-NLLEILEE
 .   . ||||.|.| |.  |    ...  ||.|. ||.  .|   ..  .||.||.. | . .|||.|  .   ...   .|.|.||... .||. | .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

R---PNGLDQDDVRKYIYQLCKSISYCNSMDIIHRDIKPENLLISKDGTLKLCDFGFARVL
.   .. |.  |  .. .| .|  .|  |. .||||.   | |...... | |||| || .
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI
Kinase 29899.AA TyrKc 4-288 22 1.6e-15 28.09 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-280/280
Sequence Identity: 22% (72 aa)

YEVKGVVGEGAYGVVLKCMNKENGEYVAIKKFKESDEDEVVKKTTLREVKILRML--KQENIVQLREAFRRK-------GKLYLVFEYVEN-NLLEILEE
 . . . ||||.|.| |.. |   . ||.|. ||.      ..  .|| .|...|  . .|||.|  . . .       . |..|.||... .|.. | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

RPNGLDQDDVRKYIYQLCKSISYCNSMDIIHRDIKPENLLISKDGTLKLCDFGFARVLPQK------GGNLT------DY--VATRWYRAPELLLGYTDY
. . |  .|  .. .| ..  .|  |. .||||.   | |.....| | .||| .| .  .      .   .          .  ||. ||| .  |  .
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKF

GKEVDMWAVGCIMGEL-TDGQPLFPGQNE--IDQLYVIQKVLGPLTAEQQEV----FLKHPGFLGVKLPEISKPETIEKRYLGKLSKKALSFMKNLLKMD
  . | |. |  | |. |.||.  ||. .  ..   ||..|      .| .                             .    ...  . ||   . |
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------------------F-VCCPDEMYQIMKQCWHED

PSQRMSADEALQHPYF
|..| .  |   | .|
PEDRPTFSEI--HECF
Kinase 29899.AA CDK7 258-288 32 1.4e-14 34.84 In-house 258-288 (288) Show / Hide 
Range on Protein: 258-288
Range on HMM: 258-288/288
Sequence Identity: 32% (10 aa)

SKKALSFMKNLLKMDPSQRMSADEALQHPYF
|  .| .|. .. |.|..|... ..|..|||
SDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase 29899.AA CDC2 233-288 33 1.6e-12 34.31 In-house 247-301 (301) Show / Hide 
Range on Protein: 233-288
Range on HMM: 247-301/301
Sequence Identity: 33% (19 aa)

PGFLGVKLPEISKPETIEKRYLGKLSKKALSFMKNLLKMDPSQRMSADEALQHPYF
| .   .| .| . .  .|     | .....  ...|  ||..| ||.||||||||
PRWKPQDLSKICPNNQKKKNQ-SCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF
Kinase 29899.AA MAPK 245-288 31 2e-12 39.09 In-house 282-328 (328) Show / Hide 
Range on Protein: 245-288
Range on HMM: 282-328/328
Sequence Identity: 31% (15 aa)

KPETIEKRYLG---KLSKKALSFMKNLLKMDPSQRMSADEALQHPYF
.. . || . .   . . .|. ... .| .||..| ...||||||||
PKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF