Gene 22349 (Tetrahymena)

22349

Species: Tetrahymena
Alias: 3701.m00134, 22349, TTHERM_00219210, 18.m00375, 510, PreTt22349
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: YAK

Sequence

Name Sequence Type Origin Length Description Download
22349.AA Protein None 1281 None Fasta, JSON
22349.kin_dom Protein Kinase Domain None 310 None Fasta, JSON
22349.NA RNA None 3846 None Fasta, JSON

Protein domain

Protein domains of 22349.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 22349.AA YAK 159-468 61 3.8e-255 853.91 In-house 1-347 (347) Show / Hide 
Range on Protein: 159-468
Range on HMM: 1-347/347
Sequence Identity: 61% (215 aa)

YIIEDMLGKGTFGQVAKCSKNGTNDLFAVKVIKNRPAYFQQAKNEILLLRVLNKQEEQNGENYQKRIVNLVDFFVFRNHFCLVFEMLELSLYDYLKNTKF
||..||||.||||||.||....||.||||||||||.||||||||||..|||||.|...|..||||.|....||||..||||||||||...||.|||..||
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

CGFSFSVIAQWTKSILEGMVIAESKQIIHCDLKPENIMLKK------QLILN----QTLKMATKFSQQK---------WMIYTTAIDMWSLGCILVELFL
|||||..|.||||.||.||...|.|||||||||||||||.|      ..|..    |..||.....||.         ||||.|.|||||||||..||||
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFL

GLPIFPGNSEYDQIKRIIDILGKPTNEVIEQGRFKNKFFKCLDG------------------EYIFKTKQEFEISEGIQLKESKTYFQVACLNDLKNYMY
|||||||||||.|||||||.||.|....|.|||||||.|.|.||                  .|||||||...|.|.|||||||||||..||||.|||||
GLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYFHCHDGSNSDDNNNNNNNNNGKPYYYIFKTKQDYQIDEKIQLKESKTYFQYKCLNDIKNYMY

NSQFRRNEDDTKNNRQFDLFLDLATQLLELNPRKRVKASIAMQHPFL
..||.||.|||||||..|.|.|...|||.||||.|.|...||||||.
FKQFMRNQDDTKNNRHRDCFIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase 22349.AA DYRK 159-468 35 1.2e-140 473.58 In-house 1-320 (320) Show / Hide 
Range on Protein: 159-468
Range on HMM: 1-320/320
Sequence Identity: 35% (119 aa)

YIIEDMLGKGTFGQVAKCSKNGTNDLFAVKVIKNRPAYFQQAKNEILLLRVLNKQEEQNGENYQKRIVNLVDFFVFRNHFCLVFEMLELSLYDYLKNTKF
| | ...|||.||||.|| ...||...|.|.|.|......||..|| .|. ||.|    ........|...|.|..|||.|.|||.|. .||..|||..|
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQ----DPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHF

CGF-SFSVIAQWTKSILEGMVIAESK-QIIHCDLKPENIMLKKQLILNQTLKMATK------------FSQQK---------WMIYTTAIDMWSLGCILV
.|| |..........||..... ... .||||||||||||||.. . ..|.|..              . |..         .. | .|||||||||||.
QGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQP-RNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILA

ELFLGLPIFPGNSEYDQIKRIIDILGKPTNEVIEQG--RFKNKFFKCLDGEYIFKTKQEFEISEGIQLKESKTYFQVACLNDLKNYMYNSQFRRNEDDTK
|||.| |.|||..||||...|...||.|....|..|  |.|.|||.|        .....  ..  | |....|....| .... ...... ||| |...
ELFTGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC--------FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRH

NNRQFDLFLDLATQLLELNPRKRVKASIAMQHPFL
. .....|.|. ...|...|.||...| |.|||..
Q-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase 22349.AA DYRK2 159-300 41 4.3e-49 157.6 In-house 1-138 (318) Show / Hide 
Range on Protein: 159-300
Range on HMM: 1-138/318
Sequence Identity: 41% (59 aa)

YIIEDMLGKGTFGQVAKCSKNGTNDLFAVKVIKNRPAYFQQAKNEILLLRVLNKQEEQNGENYQKRIVNLVDFFVFRNHFCLVFEMLELSLYDYLKNTKF
| |  ..||| ||||.||    |. . |.|.| |.  . .||  ||  |  . .|  .|  |    .| . |.|.||||.|..|| | ..||.|.|. .|
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMN----CVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHF

CGFSFSVIAQWTKSILEGMVIAESKQIIHCDLKPENIMLKKQ
 ||| . ..  ..|||....      |||||||||||.||..
QGFSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQW
Kinase 22349.AA S_TKc 159-468 20 1.5e-46 161.86 SMART 1-231 (231) Show / Hide 
Range on Protein: 159-468
Range on HMM: 1-231/231
Sequence Identity: 20% (71 aa)

YIIEDMLGKGTFGQVAKCSKNGTNDLFAVKVIKNRPAYFQQAKNEILLLRVLNKQEEQNGENYQKRIVNLVDFFVFRNHFCLVFEMLEL---SLYDYLKN
| | . .|||.||.| || ...|. ..|.|.||      .....|| .|.              . ||.| |.|.  .|...|.|...    .|.||.|.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-----------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKK

TKF----CGFSFSVIAQWTKSILEGMVIAESKQIIHCDLKPENIMLKKQLILNQTLK-----MATKFSQQKWMI-------------YTT-AIDMWSLGC
 .     ..|.  ... ... |....    |..|||.|||||||.| .      ..|     .|...      .             |.. ..|.||.||
RGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL----TTFCGTPWYMAPEVLGYGKCKCDWWSCGC

ILVELFLGLPIFPGNSEYDQIKRIIDILGKPTNEVIEQGRFKNKFFKCLDGEYIFKTKQEFEISEGIQLKESKTYFQVACLNDLKNYMYNSQFRRNEDDT
|| |.. | | ||      |........|                                                                       
ILYEMLCGYPPFP------QMQMMFKKIG-----------------------------------------------------------------------

KNNRQFDLFLDLATQLLELNPRKRVKASIAMQ-------HPFL
      . ..|.  ..|. .|.||  |  |.|       ||..
-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 22349.AA CMGC 319-468 21 2.4e-43 139.73 In-house 310-513 (513) Show / Hide 
Range on Protein: 319-468
Range on HMM: 310-513/513
Sequence Identity: 21% (46 aa)

MIYTTAIDMWSLGCILVELFLG--------LPIFPGNSE-----------YDQIKRIIDILGKPTNEVIEQGRFKNKFFKCLDGEYIFKTKQEFEISEG-
| |||.|||||.|||. |...|         |.|||.||           .||...|...||.|| ..|..|. .. |      . ..| ..|.    . 
MHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGK-RH-F------N-FCKHEEEWPNMIKL

-----------------IQLKESKTYFQVACLNDLKNYMYNSQFRRNEDD---------------------------TKNNRQFDLFLDLATQLLELNPR
                 .. .  ..|.|  .    ...   ...  . ..                           .|.... ....||  ..|...| 
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

KRVKASIAMQHPFL
|| .|. |.|||..
KRITAEQALQHPYF
Kinase 22349.AA CMGC 159-310 24 4e-43 138.95 In-house 1-246 (513) Show / Hide 
Range on Protein: 159-310
Range on HMM: 1-246/513
Sequence Identity: 24% (62 aa)

YIIEDMLGKGTFGQVAKCSK--------------NGTNDLFAVKVIKNRPAYFQQAK-------------NEILLLRVLNKQEEQNGE--------NYQK
| | . .|.||.|.| ||                . || . |.| |||.. |  |||              || .|. |||.... ..        .  .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

RIVNLVDFFVFRN-----------------HFCLVFEMLELSLYDYLKNTK--------------------------FCGFSFSVIAQWTKSILEGMV--
 ||.| |.|...|                 |..|||| .. .||.|.||..                           . |.   |  ... ||.|.   
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

IAESKQ--IIHCDLKPENIMLKKQLIL----------------NQTLKMA
   |.   |||.|||||||.. ..  |                | .|| .
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKIC
Kinase 22349.AA HIPK 159-297 41 7.3e-43 132.51 In-house 1-134 (329) Show / Hide 
Range on Protein: 159-297
Range on HMM: 1-134/329
Sequence Identity: 41% (58 aa)

YIIEDMLGKGTFGQVAKCSKNGTNDLFAVKVIKNRPAYFQQAKNEILLLRVLNKQEEQNGENYQKRIVNLVDFFVFRNHFCLVFEMLELSLYDYLKNTKF
| . ..||.||||||.|| | |||.. |.|..|| | |  | ..|. .|. |    ..| ..|.  .|   ..|  .||.||||||||  |||..|. ||
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCL---SQENADEYH--FVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKF

CGFSFSVIAQWTKSILEGMVIAESKQIIHCDLKPENIML
      .|   .. .|  ..   .  .|| |||||||||
MPLPLKHIRPILQQVLTALMKLKELGLIHADLKPENIML
Kinase 22349.AA DYRK1 159-297 41 7e-39 133.96 In-house 1-137 (321) Show / Hide 
Range on Protein: 159-297
Range on HMM: 1-137/321
Sequence Identity: 41% (58 aa)

YIIEDMLGKGTFGQVAKCSKNGTNDLFAVKVIKNRPAYFQQAKNEILLLRVLNKQEEQNGENYQKRIVNLVDFFVFRNHFCLVFEMLELSLYDYLKNTKF
| |. ..||| ||||.|   . .  . |.|.|||. ....||. || || ..||.....    . .||.|   |.|||| |||||.|   ||| |.||.|
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEM----KYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHF

CGFSFSVIAQWTKSILEGMVIAESK--QIIHCDLKPENIML
 | |  .. .. . ..  ..   .   .|||||||||||.|
RGVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILL
Kinase 22349.AA CLK 159-297 28 8e-35 101.31 In-house 1-147 (350) Show / Hide 
Range on Protein: 159-297
Range on HMM: 1-147/350
Sequence Identity: 28% (42 aa)

YIIEDMLGKGTFGQVAKCSKNGT-NDLFAVKVIKNRPAYFQQAKNEIL-LLRVLNKQEEQNGENYQKRIVNLVDFFVF-RNHFCLVFEMLELSLYDYLKN
| | . || |||| | .|  .   . . |.|.|.|   |  .|. ||   .. .|. .. |. . .. .. . | | .  .|.|.|||.. ||.|| .| 
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEH-CWKMNDWFDYGHGHICIVFELYGLSIYDFMKS

TK------FCGFSFSVIAQWTKSILEGMVIAESKQIIHCDLKPENIML
..      . ..  . | . .. ..| .   .. ...| ||||||| .
NNSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICF
Kinase 22349.AA Pkinase 159-308 31 1.3e-28 102.26 Pfam 1-152 (293) Show / Hide 
Range on Protein: 159-308
Range on HMM: 1-152/293
Sequence Identity: 31% (52 aa)

YIIEDMLGKGTFGQVAKCSKNGTNDLFAVKVIKNRPAYFQQAKN-----EILLLRVLNKQEEQNGENYQKRIVNLVDFFVFRNHFCLVFEMLEL-----S
| |.  .|.|.||.| || . ||....|||.|| | .  .. ..     || ... ||       .|    || | |.|  ..| ..|.| .|      .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN------HPN----IVRLYDWFEDKDHIYMVMEYCEGGLYVMD

LYDYLK---NTKFCGFSFSVIAQWTKSILEGMVIAESKQIIHCDLKPENIMLKKQLILNQTLK
|.||..   ...|  ||  ..  . . ||.|.    |. |||.|||||||.....  .. ..|
LFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVK
Kinase 22349.AA DYRK1 319-468 30 7.7e-27 90.95 In-house 178-321 (321) Show / Hide 
Range on Protein: 319-468
Range on HMM: 178-321/321
Sequence Identity: 30% (46 aa)

MIYTTAIDMWSLGCILVELFLGLPIFPGNSEYDQIKRIIDILGKPTNEVIEQGRFKNKFFKC-LDGEYIFKTKQEFEISEGIQLKESKTYFQVACLNDLK
. | .|||||||||||||.  | |.| | .| ||...|...|| | ...|.|.    |.|.   |. .  | ...       ..|. | . .    . | 
IEYDMAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDPDNTWYCKKTRD-------KKKHYKEPCTRKLHEILG

NYMYNSQFRRNEDDTKNNRQFDLFLDLATQLLELNPRKRVKASIAMQHPFL
      . || ..       .  | ||  ..|. .|..|..   |.||.|.
VETGGPGGRRKGEPGHSVEDYLKFKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase 22349.AA HIPK 324-468 28 1.7e-25 76.85 In-house 183-329 (329) Show / Hide 
Range on Protein: 324-468
Range on HMM: 183-329/329
Sequence Identity: 28% (42 aa)

AIDMWSLGCILVELFLGLPIFPGNSEYDQIKRIIDILGKPTNEVIEQGRFKNKFF----KCLDGEYIFKTKQEFEISEGIQLKESKTYFQVACLNDLKNY
..|||||||.. ||||| | .||..|||||  |.   ..|.   ..... |..||    .     .  |. .| | . ....|| ..|    || |  . 
NHDMWSLGCVIAELFLGWPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRDKQSKFRPWRLKHIEEHEQQTSVKSKEARKYI-FNCLDDMPEV

MYNSQFRRNEDDTKNNRQFDLFLDLATQLLELNPRKRVKASIAMQHPFL
..     | .   .    .  | ..  ... ... ||.  . |..||| 
NMLVDPERQDYRVE-KIDRREFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase 22349.AA CDK 320-367 47 3e-25 77.61 In-house 196-248 (284) Show / Hide 
Range on Protein: 320-367
Range on HMM: 196-248/284
Sequence Identity: 47% (25 aa)

IYT--TAIDMWSLGCILVELFL---GLPIFPGNSEYDQIKRIIDILGKPTNEV
.|.  |.|||||.|||..|.|.   . |.|||.|| ||...|..|.| || ..
HYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDN
Kinase 22349.AA DYRK2 321-378 41 6.8e-23 70.99 In-house 179-240 (318) Show / Hide 
Range on Protein: 321-378
Range on HMM: 179-240/318
Sequence Identity: 41% (26 aa)

YTTAIDMWSLGCILVELFLGLPIFPGNSEYDQIKRIIDILGKPTNEVIEQG----RFKNKFF
| .||||||.|||..||. | |.|||  | ||.  .. .||.|  .....     .|. | |
YGMAIDMWSFGCIMAELYTGYPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYF
Kinase 22349.AA MAPK 318-370 46 1.8e-22 74.32 In-house 208-261 (328) Show / Hide 
Range on Protein: 318-370
Range on HMM: 208-261/328
Sequence Identity: 46% (25 aa)

WMIYTTAIDMWSLGCILVELFL-GLPIFPGNSEYDQIKRIIDILGKPTNEVIEQ
|| ||.|.||||.|||. |.   . |.|||..  ||...|...||.|. |.|..
WMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQC
Kinase 22349.AA CDC2 321-366 44 7.9e-17 47.75 In-house 183-231 (301) Show / Hide 
Range on Protein: 321-366
Range on HMM: 183-231/301
Sequence Identity: 44% (22 aa)

YTTAIDMWSLGCILVEL---FLGLPIFPGNSEYDQIKRIIDILGKPTNE
|.|..||||.|||. |.       |.|.| || ||. .|  ||| |...
YSTPVDMWSIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQ
Kinase 22349.AA Pkinase 321-366 42 8.7e-12 42.75 Pfam 189-237 (293) Show / Hide 
Range on Protein: 321-366
Range on HMM: 189-237/293
Sequence Identity: 42% (21 aa)

YTTAIDMWSLGCILVELFLGLPIFPGN----SEYDQIKRIIDILGKPTNE
|....||||.|||| |...| |.|||     . .||...|  |.|.|. .
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHF
Kinase 22349.AA CDK 415-468 24 1.3e-10 29.99 In-house 254-284 (284) Show / Hide 
Range on Protein: 415-468
Range on HMM: 254-284/284
Sequence Identity: 24% (13 aa)

DLKNYMYNSQFRRNEDDTKNNRQFDLFLDLATQLLELNPRKRVKASIAMQHPFL
.| .|                       ||  ..| ..| ||..|. |.|||..
KLPDY-----------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase 22349.AA CDC2 225-300 30 2.7e-09 24.17 In-house 63-139 (301) Show / Hide 
Range on Protein: 225-300
Range on HMM: 63-139/301
Sequence Identity: 30% (24 aa)

IVNLVDFFVFRNHFCLVFEMLELSLYDYLK--NTKFCGFSFSVIAQWTKSILEGMVIAESKQIIHCDLKPENIMLKKQ
|| | | ..  |   .||| |.  |  |..  . |   .. ... . .. ||.|.    ...|.| |||| || . |.
IVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKK
Kinase 22349.AA CDC2 442-468 44 9.5e-09 22.47 In-house 275-301 (301) Show / Hide 
Range on Protein: 442-468
Range on HMM: 275-301/301
Sequence Identity: 44% (12 aa)

LDLATQLLELNPRKRVKASIAMQHPFL
.||  |.| ..| ||..|  |.|||..
IDLLMQMLQYDPQKRISAKEALQHPYF
Kinase 22349.AA CLK 326-351 42 3.2e-08 19.99 In-house 229-254 (350) Show / Hide 
Range on Protein: 326-351
Range on HMM: 229-254/350
Sequence Identity: 42% (11 aa)

DMWSLGCILVELFLGLPIFPGNSEYD
| || ||||.|| .|   |..... .
DVWSIGCILFELYTGFTLFQTHDNRE
Kinase 22349.AA CDK 225-297 26 4.4e-07 18.54 In-house 69-141 (284) Show / Hide 
Range on Protein: 225-297
Range on HMM: 69-141/284
Sequence Identity: 26% (22 aa)

IVNLVDFFVFR-----------NHFCLVFEMLELSLYDYLKNTKFCGFSFSVIAQWTKSILEGMVIAESKQIIHCDLKPENIML
||.| | ..             | . .||| ..  |. |..           |  ... .|.|.    |. |.| |||| ||..
IVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILI
Kinase 22349.AA TyrKc 159-468 15 6e-07 -110.26 SMART 1-280 (280) Show / Hide 
Range on Protein: 159-468
Range on HMM: 1-280/280
Sequence Identity: 15% (58 aa)

YIIEDMLGKGTFGQVAKCSKNGTNDLFAVKVIKNRPAYFQQAKNEILLLRVL--NKQEEQNGENYQKRIVNLVDFFVFR-------NHFCLVFEMLEL-S
   ...|| | ||.| |.  .      |||..|.     .   .|. ... |  .           . ||.|.   .            ..|.|  .. .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGH----------HPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGD

LYDYLKNTK-FCGFSFSVIAQWTKSILEGMVIAESKQIIHCDLKPENIMLKKQL------------ILNQ--------TLKM----ATKF-SQQKWM---
| |||....    .. .   ..   | .||   .||..|| ||   |.......            | .         . ..     .|.    .||   
LKDYLRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

-----IYTTAIDMWSLGCILVELF-LGLPIFPG-----NSEYDQIKRIIDI--LGKPTN--EVIEQGRFKNKFFKCLDGEYIFKTKQEFEISEGIQLKES
     ..||. | || |  . |.| .| .  ||      | .. |... .   . .| |  . .                                    
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MS-----------------------------------

KTYFQVACLNDLKNYMYNSQFRRNEDDTKNNRQFDLFLDLATQLLELNPRKRVKASIAMQHPFL
                    |          .  |   .. .|  . .| .|   |    | ..
--------------------F---------VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 22349.AA CLK 439-468 40 9e-07 15.56 In-house 321-350 (350) Show / Hide 
Range on Protein: 439-468
Range on HMM: 321-350/350
Sequence Identity: 40% (12 aa)

DLFLDLATQLLELNPRKRVKASIAMQHPFL
. . ||. ..||  | ||.... | |||| 
RQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase 22349.AA CDK 159-191 28 1.2e-05 13.85 In-house 1-38 (284) Show / Hide 
Range on Protein: 159-191
Range on HMM: 1-38/284
Sequence Identity: 28% (11 aa)

YIIEDMLGKGTFGQVAKCSKNGTN-----DLFAVKVIK
| . . .| ||.|.| |.    |.     .. | | |.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIR
Kinase 22349.AA CDC2 159-191 39 2.1e-05 12.01 In-house 1-33 (301) Show / Hide 
Range on Protein: 159-191
Range on HMM: 1-33/301
Sequence Identity: 39% (13 aa)

YIIEDMLGKGTFGQVAKCSKNGTNDLFAVKVIK
|    ..|.||.| | ||  . ||.. |.| |.
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIR
Kinase 22349.AA MAPK 439-468 33 4.2e-05 13.35 In-house 299-328 (328) Show / Hide 
Range on Protein: 439-468
Range on HMM: 299-328/328
Sequence Identity: 33% (10 aa)

DLFLDLATQLLELNPRKRVKASIAMQHPFL
.. .||  ..|...| ||  .  |.|||..
PQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 22349.AA MAPK 159-192 22 0.000646 9.17 In-house 1-40 (328) Show / Hide 
Range on Protein: 159-192
Range on HMM: 1-40/328
Sequence Identity: 22% (9 aa)

YIIEDMLGKGTFGQVAKCSKNG------TNDLFAVKVIKN
| |   .|.| .|.|...  .       ...  |.| | .
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISR
Kinase 22349.AA DYRK2 439-468 30 0.00106 7.54 In-house 289-318 (318) Show / Hide 
Range on Protein: 439-468
Range on HMM: 289-318/318
Sequence Identity: 30% (9 aa)

DLFLDLATQLLELNPRKRVKASIAMQHPFL
..|.|  .. .|  | .| ..| | .||..
ENFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase 22349.AA MAPK 282-295 64 0.00165 7.74 In-house 135-148 (328) Show / Hide 
Range on Protein: 282-295
Range on HMM: 135-148/328
Sequence Identity: 64% (9 aa)

SKQIIHCDLKPENI
| ..||.||||.||
SANVIHRDLKPSNI
Kinase 22349.AA Pkinase 441-468 32 0.03069 9.0 Pfam 266-293 (293) Show / Hide 
Range on Protein: 441-468
Range on HMM: 266-293/293
Sequence Identity: 32% (9 aa)

FLDLATQLLELNPRKRVKASIAMQHPFL
..|. . .|...| ||  |  ..|||..
CKDFIKWCLCKDPKKRPTAEQILQHPWF