Gene 5306 (Tetrahymena)
5306
Sequence
Protein domains of 5306.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 5306.AA | DYRK2 | 805-1101 | 55 | 4.2e-216 | 709.75 | In-house | 1-318 (318) | Show / Hide |
Range on Protein: 805-1101 Range on HMM: 1-318/318 Sequence Identity: 55% (178 aa) YEIKEFLGKGSFGQVLKVFDHKRKEYAALKVIRNKQKFHEQALIELNILHYIKEKDYDNQTNIVKIRDFVIFRNHVCLVFELLSINLYDLLRNNKFQGLS |||.|..||||||||.|..|||.|.. |.|.||||..||.||..|..|||.|...|.||..|.|...|...||||.|..|||||.|||.....|.|||.| YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS LELIRRFAIQLLNAISFLKENRIIHCDLKPENVLLKQPNKSGIKIADFGSSCFDDQ-VMYTYIQSRYYRSPEVILGIPYGTEIDMWSFGCIIAELFLGYP |.|.|||| ..|....||..|.||||||||||.||||.|.||||..|||||||..| .|||||||.||.||||||..||..|||||||||.|||. ||| LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYP IFPGEDENEQMGYIMELLGAPDSEFLKK-----CSRKKYFFD--------------QNDQPLQIPNSRGKIRMPNSKNWKSVIG-CTDDNFIDFIKKCLV .||||.||.|....||.||.|...|... |.|.||||. ....| ...|..||.|.|.||.||||. |.|.|||||||.|.. LFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCEDENFIDFIKRCFE WEPSQRLTPRDALLHPWI |.||.|.||..|| |||| WDPSERMTPSQALKHPWI |
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| Kinase | 5306.AA | DYRK | 805-1101 | 53 | 7.50000000001e-191 | 640.32 | In-house | 1-320 (320) | Show / Hide |
Range on Protein: 805-1101 Range on HMM: 1-320/320 Sequence Identity: 53% (171 aa) YEIKEFLGKGSFGQVLKVFDHKRKEYAALKVIRNKQKFHEQALIELNILHYIKEKDYDNQTNIVKIRDFVIFRNHVCLVFELLSINLYDLLRNNKFQGL- ||| |..|||||||| |..|||..|. |.|.|||...|| ||.||..||.|....| |.....|.. |. ..|||.|.||||||.|||..|.||.|||. YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF SLELIRRFAIQLLNAISFLKEN-RIIHCDLKPENVLLKQP-NKSGIKIADFGSSCFDDQVMYTYIQSRYYRSPEVILGIPYGTEIDMWSFGCIIAELFLG ||.|.|.|| |.|... ||..| .||||||||||..|||| |||.||..||||||| .|..|||||||.||.||||||.||...|||||.|||.||||.| SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTG YPIFPGEDENEQMGYIMELLGAPDSEFLKK--CSRKKYFFDQ------------ND------QPLQIPNSRGKIRMPNSKNWKSVIGCTDDNFIDFIKKC .|.||||.|..|. .|||.||.| .....| |.||..|||. |. .| ..|..||..|.|...||.... | |..|.|||||| WPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDCFMYCECDEWTKQNKITDHYMTPKCHPTKRGQRRPPGRRNWDPRHQCDDHQFKDFIKKC LVWEPSQRLTPRDALLHPWI |.|.|..|.|| .|| |||. LQWDPHKRITPSQALQHPWF |
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| Kinase | 5306.AA | CMGC | 805-1101 | 20 | 1.8e-122 | 404.55 | In-house | 1-513 (513) | Show / Hide |
Range on Protein: 805-1101 Range on HMM: 1-513/513 Sequence Identity: 20% (108 aa) YEIKEFLGKGSFGQVLKVFD--------------HKRKEYAALKVIRNKQKFHEQAL-------------IELNILHYIK-EKDYDN-----------QT ||| . .|.|..|.| | .| |. .|. |.| |.|.. ..|||. |. || ... ..| | YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN NIVKIRDFVIFRN-----------------HVCLVFELLSINLYDLLRNNK--------------------------FQGLSLELIRRFAIQLLNAIS-- ||||..|.. ..| |..||||.. .||....||. . ... .|| .. |.|... NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK FLKENR--IIHCDLKPENVLLKQPNKS------------------GIKIADFGSSCFDDQV------------------------MYTYIQSRYYRSPEV .. .. |||.||||||.|. . ... .||.|||.... .. ...|...|.||.||. YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI ILGIP----------YGTEIDMWSFGCIIAELFLG--------YPIFPGEDE-----------NEQMGYIMELLGAPDSEFLKK-------CSRKKYFFD .|| . |.|.|||||.|||.||...| .|.|||..| .|. |...|| |. ....| |.... ... LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPN QND-------------------------QPLQIPNSRGKIRMPNSKNWKSVIG--------------------------------CTDDNFIDFIKKCLV .. ...|..|. .... .. ||.. . | |. .||..||.|. MIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQ WEPSQRLTPRDALLHPWI ..|..|.|. .|| ||.. YDPDKRITAEQALQHPYF |
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| Kinase | 5306.AA | DYRK1 | 805-1044 | 51 | 4.6e-106 | 358.67 | In-house | 1-242 (321) | Show / Hide |
Range on Protein: 805-1044 Range on HMM: 1-242/321 Sequence Identity: 51% (124 aa) YEIKEFLGKGSFGQVLKVFDHKRKEYAALKVIRNKQKFHEQALIELNILHYIKEKDYDNQTNIVKIRDFVIFRNHVCLVFELLSINLYDLLRNNKFQGLS ||| .|||||||| | .||...|| |.|.|.||. | .||.||. .| . ..| ... .||... .||||.|||||||| |||||||| .|.| | YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS LELIRRFAIQLLNAISFLK--ENRIIHCDLKPENVLLKQPNKSGIKIADFGSSCFDDQVMYTYIQSRYYRSPEVILGIPYGTEIDMWSFGCIIAELFLGY | |.|.|| |.. |. |. | ||||||||||.|| | .| ||| |||||| .| .| |||||.||||||.|||.| ..||||| |||. |. | LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGE PIFPGEDENEQMGYIMELLGAPDSEFLKKCSRKKYFFDQNDQ |.| | .| .|| |.| || | .... . . . .|..... PLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDPD |
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| Kinase | 5306.AA | YAK | 805-1038 | 48 | 9.3e-103 | 347.68 | In-house | 1-239 (347) | Show / Hide |
Range on Protein: 805-1038 Range on HMM: 1-239/347 Sequence Identity: 48% (116 aa) YEIKEFLGKGSFGQVLKVFDHKRKEYAALKVIRNKQKFHEQALIELNILHYIKEKDYDNQTN----IVKIRDFVIFRNHVCLVFELLSINLYDLLRNNKF | . ||.| |||| | .| | ||| |.| . || | || .. | | |... || ...|| |||||.||.|||..| .||| YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF QGLSLELIRRFAIQLLNAISFLKENRIIHCDLKPENVLLKQPNKSGIKIADFGSSCFDDQVMYTYIQSRYYRSPEVILGIPYGTEIDMWSFGCIIAELFL |.| .||| . .| | .. |.. .||||||||||..|..||| ||| |||||| . .|||||.|.|||||.|....| | ||||| |||.||||| CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFL GYPIFPGEDENEQMGYIMELLGAPDSEFL-KKCSRKKYF | ||||| | .|. | . || | |. . . .. ||| GLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYF |
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| Kinase | 5306.AA | S_TKc | 805-1101 | 27 | 3.9e-91 | 310.01 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 805-1101
Range on HMM: 1-231/231
Sequence Identity: 27% (85 aa)
YEIKEFLGKGSFGQVLKVFDHKRKEYAALKVIRNKQKFHEQALIELNILHYIKEKDYDNQTNIVKIRDFVIFRNHVCLVFELLSI---NLYDLLRNNKFQ
||| . .|||.||.| |. ..| ... |.|.|. |... |..||. . ||||. |. .|...|.|... .|.|...... .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH
G----LSLELIRRFAIQLLNAISFLKENRIIHCDLKPENVLLKQPNKSGIKIADFGSSCFDDQVMYTYIQSRYYRSPEVILGIPYGT-EIDMWSFGCIIA
| .. .|... |...|. .. ...|||.||||||.|| . |||.|||.... .|.. ...|..|||. .||. ..|.||.|||..
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY
ELFLGYPIFPGEDENEQMGYIMELLGAPDSEFLKKCSRKKYFFDQNDQPLQIPNSRGKIRMPNSKNWKSVIGCTDDNFIDFIKKCLVWEPSQRLTPRDAL
|.. ||| || || .....| .. ..|||.|||...|..|.| .||
EMLCGYPPFP------QMQMMFKKIG------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EAL
L-------HPWI
|||.
QDEWDIKCHPWF
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| Kinase | 5306.AA | HIPK | 805-1044 | 44 | 1.8e-78 | 246.68 | In-house | 1-242 (329) | Show / Hide |
Range on Protein: 805-1044 Range on HMM: 1-242/329 Sequence Identity: 44% (108 aa) YEIKEFLGKGSFGQVLKVFDHKRKEYAALKVIRNKQKFHEQALIELNILHYIKEKDYDNQTNIVKIRDFVIFRNHVCLVFELLSINLYDLLRNNKFQGLS ||. ||||.| |||| | . .| |.|...| . | ||. ||| ..... | . ..|. .. .||.|||||.| |||| ...||| | YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENAD-EYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLP LELIRRFAIQLLNAISFLKENRIIHCDLKPENVLLKQPNKSG--IKIADFGS-SCFDDQVMYTYIQSRYYRSPEVILGIPYGTEIDMWSFGCIIAELFLG | || | | |. ||| .|| ||||||..| | . .|. |||| | . . | ||.|||||| ||.|||.|. ..|||| ||.||||||| LKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLG YPIFPGEDENEQMGYIMELLGAPDSEFLKKCSRKKYFFDQNDQ | .|| || .| || . . | |.. ..|. |||. | WPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRDKQ |
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| Kinase | 5306.AA | Pkinase | 805-1101 | 27 | 1.5e-69 | 242.21 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 805-1101 Range on HMM: 1-293/293 Sequence Identity: 27% (88 aa) YEIKEFLGKGSFGQVLKVFDHKRKEYAALKVIRNKQKFHEQ---ALI--ELNILHYIKEKDYDNQTNIVKIRDFVIFRNHVCLVFELLSI-----NLYDL |.|.. .|.||||.| | ... . |.|.|. . . ... .. |. |.. .. |||...|.. ..|...|.|.. |.|. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN------HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY LR---NNKFQGLSLELIRRFAIQLLNAISFLKENRIIHCDLKPENVLLKQPNKSGI----KIADFGSSCF---DDQVMYTYIQSRYYRSPEVIL-GIPYG .. ...| .| . ..... |.| .. .. ...|||.||||||.|.. |. | ||.|||.... .. |.|. ...|..||||. | .|| ISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQYYG TEIDMWSFGCIIAELFLGYPIFPGE----DENEQMGYIMELLGAPDSEFLKKCSRKKYFFDQNDQPLQIPNSRGKIRMPNSKNWKSVIGCTDDNFIDFIK ...||||.|||..|...|.|.|||. . ..|| | . .|.| .. . ... ||| .. . . . . ......|||| PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-------------F-HWTF-HNWSEECKDFIK KCLVWEPSQRLTPRDALLHPWI .|| . |..|.|....| |||. WCLCKDPKKRPTAEQILQHPWF |
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| Kinase | 5306.AA | CLK | 805-939 | 38 | 1e-56 | 168.21 | In-house | 1-147 (350) | Show / Hide |
Range on Protein: 805-939 Range on HMM: 1-147/350 Sequence Identity: 38% (57 aa) YEIKEFLGKGSFGQVLKVFDHKR-KEYAALKVIRNKQKFHEQALIELN-ILHYIKEK-DYDNQTN--IVKIRDFVIF-RNHVCLVFELLSINLYDLLRNN |||. || | || |... |||. | |.|||.||| |. |.| .|.| |. |.|| | .|. ..|..| . . .|.|.||||. ..||... | YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN K------FQGLSLELIRRFAIQLLNAISFLKENRIIHCDLKPENVLL . .... .. ||..| ||..|. || .....| |||||| .. NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICF |
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| Kinase | 5306.AA | CDK | 805-1101 | 25 | 1.8e-56 | 179.13 | In-house | 1-284 (284) | Show / Hide |
Range on Protein: 805-1101
Range on HMM: 1-284/284
Sequence Identity: 25% (88 aa)
YEIKEFLGKGSFGQVLKVFDHKRK-----EYAALKVIR---N-----KQKFHEQALIELNILHYIKEKDYDNQTNIVKIRDFVIFR-----------NHV
||. | .| |..|.| | |.... .. ||| || . | | |. | ..| . ||||..| .. | .
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-------HPNIVKLHDVCHTKNMDRNNKDKHENKL
CLVFELLSINLYDLLRNNKFQGLSLELIRRFAIQLLNAISFLKENRIIHCDLKPENVLLKQPNKSG------IKIADFGSSCFDDQ------VM--YT-Y
.||| . |. ... |. . |||...... .|.|.| |||| | |. |. | .|||||| .. . ||
YMVFEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILI---NNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHE
IQSRYYRSPEVIL-GIPYG--TEIDMWSFGCIIAELFL---GYPIFPGEDENEQMGYIMELLGAPDSEFLKKCSRKKYFFDQNDQPLQIPNSRGKIRMPN
. . ||.||. | |. |.|||||.|||.||.|. . |.|||. | .|. | ...| |. . .. ..
VVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------
SKNWKSVIGCTDDNFIDFIKKCLVWEPSQRLTPRDALLHPWI
|.. |.|. .|..|.. .|| ||.
----------------DLLNKMLCYDPKKRISAEQALQHPYF
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| Kinase | 5306.AA | PRP4 | 805-1042 | 36 | 1e-52 | 181.44 | In-house | 1-242 (320) | Show / Hide |
Range on Protein: 805-1042 Range on HMM: 1-242/320 Sequence Identity: 36% (89 aa) YEIKEFLGKGSFGQVLKVFDHKRKE-YAALKVIRNKQKFHEQALIELNILHYIKEK--DYDNQTNIVKIRDFVIFRNHVCLVFELLSINLYDLLRNN-KF |.. . |.| |. | . | | | |.|||. | | || || . .. | . .|.. . .|.| ||||| .| || ..| | YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD QGLSLELIRRFAIQLLNAISFLKENRIIHCDLKPENVLLKQPNKSGIKIADFGS-SCFDDQVMYTYIQSRYYRSPEVILGIPYGTEIDMWSFGCIIAELF ||.|. .| .| ||. | || . |.| |.|| |.| .|. .|. |||| | .. . | .||.||.||.|.|.|| ||||| || ..||. VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNILVNE-SKNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELY LGYPIFPGEDENEQMGYIMELLGAPDSEFLKKCSRKKYFFDQN | .||| |. . .|.. |. ..| | .|||| TGKIMFPGKTNNHMLKLFMDYKGKMPNKMIRKGQFKDNHFDQN |
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| Kinase | 5306.AA | DyrkP | 805-1005 | 37 | 2.6e-48 | 156.83 | In-house | 1-205 (323) | Show / Hide |
Range on Protein: 805-1005
Range on HMM: 1-205/323
Sequence Identity: 37% (77 aa)
YEIKEFLGKGSFGQVLKVFDHKRKEYAALKVIRNKQKFHEQALIELNILHYIKEKDYDNQTNIVKIRDFVIFRNHVCLVFELLSINLYDLL---RNNKFQ
| | |.|| | . .. | . .|.| | . . .|.. |. .|.|| |.... |. . |. .. ||| |||. | | |
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQQ
G-LSLELIRRFAIQLLNAISFLKENRIIHCDLKPENVLLKQPNKSGIKIADFGSSCFDDQVMYTYIQSRYYRSPEVILGIPYGTEIDMWSFGCIIAELFL
. . . |.| |. .. |.|||||||||.|.| | .|| ||||||| . |.||| || ||||.| | ||||| |||.|||.
RYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWT
GYPIF
| .|
GNVLF
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| Kinase | 5306.AA | CLK | 947-1101 | 34 | 3.3e-38 | 111.65 | In-house | 186-350 (350) | Show / Hide |
Range on Protein: 947-1101 Range on HMM: 186-350/350 Sequence Identity: 34% (57 aa) IKIADFGSSC---FDDQVMYTYIQSRYYRSPEVILGIPYGTEIDMWSFGCIIAELFLGYPIFPGEDENEQMGYIMELLGAPDSEFLKKCSR----KKYFF |.. |||| ||. .| ...| || |||||| .. . | ||.|||. || .|. |.. |. | . . ...| | . .| |. .| ICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYF DQNDQPLQIPNSRGKIRMPNSKNWKSVIGCTDDN---FIDFIKKCLVWEPSQRLTPRDALLHPWI .| || |. | | |. |. |.|. ..| |.|.| .||.|.| .||| ||. YHNRLDWDWHNSDGRYVMENCKPLKQYMDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF |
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| Kinase | 5306.AA | TyrKc | 805-1101 | 18 | 2.3e-11 | -39.07 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 805-1101
Range on HMM: 1-280/280
Sequence Identity: 18% (61 aa)
YEIKEFLGKGSFGQVLK-VFDHKRKEYAALKVIRNKQKFHEQALIELNILHYI--KEKDYDNQTNIVKIRDFVIFR-------NHVCLVFELLS-INLYD
. .. || | ||.| | . . . | |.... .| . |..|.. . . . |||.. .. ...|.|. . .| |
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA--REDFMREARIMCKLGGHHP------NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD
LLRNNKFQGLSLELIRRFAIQLLNAISFLKENRIIHCDLKPENVLLKQPNKSGIKIADFGSSCFDDQV-------MYTYI----QSR-----YYRSPEVI
||... . |... |..| . ..| ....|| || |.|.. .. .||.||| | . . | ... .||.|
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI
LGIPYGTEIDMWSFGCIIAELF-LGYPIFPGE----DENEQMGYIMELLGAPDSEFL----KKCSRKKYFFDQNDQPLQIPNSRGKIRMPNSKNWKSVIG
. |. | |||| . |.| .| . ||. .|... . . .. . .
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------------------F-VC
CTDDNFIDFIKKCLVWEPSQRLTPRDALLHPWI
|.|. . .|.| .|..| | .. | .
CPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
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| Kinase | 5306.AA | DyrkP | 1040-1101 | 35 | 5.1e-08 | 21.79 | In-house | 261-323 (323) | Show / Hide |
Range on Protein: 1040-1101 Range on HMM: 261-323/323 Sequence Identity: 35% (23 aa) DQNDQPLQIPNSRGKIRM--PNSKNWKSVIGCTDDNFIDFIKKCLVWEPSQRLTPRDALLHPWI ||.| . | . ||| . | | . . | ||||...|| . | | ..|| |||. DQQDMQRQRQKT-GKIQILVPKHSNLRARLRTDDHMFIDFVRQCLQIDFTRRPTAKEALQHPWF |
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| Kinase | 5306.AA | HIPK | 1073-1101 | 37 | 1e-06 | 16.43 | In-house | 301-329 (329) | Show / Hide |
Range on Protein: 1073-1101 Range on HMM: 301-329/329 Sequence Identity: 37% (11 aa) NFIDFIKKCLVWEPSQRLTPRDALLHPWI .|.. || ..|.. .|.|| .|| ||.. EFVHVLKKMCTWDAHKRITPCEALNHPFV |
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| Kinase | 5306.AA | PRP4 | 1076-1101 | 46 | 3e-06 | 18.91 | In-house | 295-320 (320) | Show / Hide |
Range on Protein: 1076-1101 Range on HMM: 295-320/320 Sequence Identity: 46% (12 aa) DFIKKCLVWEPSQRLTPRDALLHPWI |.. |||. |. | |. .|| || | DLLDKCLMLDPKKRITCNEALKHPFI |
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| Kinase | 5306.AA | DYRK1 | 1074-1101 | 46 | 1.6e-05 | 14.84 | In-house | 294-321 (321) | Show / Hide |
Range on Protein: 1074-1101 Range on HMM: 294-321/321 Sequence Identity: 46% (13 aa) FIDFIKKCLVWEPSQRLTPRDALLHPWI | | ||. | ..| ||.|| .|| |... FKDLIKRMLQYDPKQRITPYYALQHSFF |
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| Kinase | 5306.AA | YAK | 1074-1101 | 46 | 3e-05 | 13.38 | In-house | 320-347 (347) | Show / Hide |
Range on Protein: 1074-1101 Range on HMM: 320-347/347 Sequence Identity: 46% (13 aa) FIDFIKKCLVWEPSQRLTPRDALLHPWI ||||| | .| | .| | .|| | FIDFINQLLQLNPRERWKPMQAMQHPFI |
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