Gene 15575 (Tetrahymena)

15575

Species: Tetrahymena
Alias: TTHERM_00294650, 591, 3692.m00038, 27.m00235, PreTt15575, 15575
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: PRP4

Sequence

Name Sequence Type Origin Length Description Download
15575.AA Protein None 940 None Fasta, JSON
15575.kin_dom Protein Kinase Domain None 926 None Fasta, JSON
15575.NA RNA None 2823 None Fasta, JSON

Protein domain

Protein domains of 15575.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 15575.AA PRP4 612-929 57 1.6e-242 811.94 In-house 1-320 (320) Show / Hide 
Range on Protein: 612-929
Range on HMM: 1-320/320
Sequence Identity: 57% (186 aa)

YRVIQKCGKGVFANVCKAEQLDNGK-MVAIKILRSNEIMRDSGEREKEIIQKLNLN--DKNDRKHIVRLKNVFEHQKHMCLVFECFAMNLRDALKEYGKG
|||...||.|||.|||.......|. ||||||.|.||||...|.||.||.||||..  ||||..|.||....|.|..||||||||..||||..||.|||.
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

KGFSLDVVRSYAYQIFVALTHLKKNNYIHADLKPDNLLISEDTKTLKMCDFGTALPIEENGIIKYLQSRFYRAPEVLIGYPPYNQIDVWSVGVTLYEIYT
.|..|..|||||.|.|.||.||||.|..|||.||||.|..|...||||||||.|..|.||.|..||.||||||||..||.|...|||.||||.||||.||
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNILVNESKNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELYT

QKILFDGSTNNEMLKLIMDSRGKFNKKMLQNGKYVEEYFDQNYNFKYTYVDKQTNQKYTTIITYGDIPKKDIYRLLQENKDGINLENQKKLSQFKDFLDK
.||.|.|.|||.||||.||..||...||...|......||||.||.|..|||.|.....|..|| ..|.||||..|.|....|.....||..||||.|||
GKIMFPGKTNNHMLKLFMDYKGKMPNKMIRKGQFKDNHFDQNCNFMYQEVDKVTEREKVTVMTY-IKPTKDIYQELIECNQRIPEDQMKKVHQFKDLLDK

CLQLDPKNRITPEEALEHPFL
||.||||.|||..|||.|||.
CLMLDPKKRITCNEALKHPFI
Kinase 15575.AA DYRK 612-929 37 2.8e-161 542.09 In-house 1-320 (320) Show / Hide 
Range on Protein: 612-929
Range on HMM: 1-320/320
Sequence Identity: 37% (121 aa)

YRVIQKCGKGVFANVCKAEQLDNGKMVAIKILRSNEIMRDSGEREKEIIQKLNLNDKNDRKHIVRLKNVFEHQKHMCLVFECFAMNLRDALKEYGKGKGF
|.... .|||.|..|.|...  ...||||||.|.|... ... .| .|...|| .|..|..|.|.... | |..|.|.|||.. |||.. ||.... ..|
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

SLDVVRSYAYQIFVALTHLKKN-NYIHADLKPDNLLISE--DTKTLKMCDFGTALPIEENGIIKYLQSRFYRAPEVLIGYPPYNQIDVWSVGVTLYEIYT
|| .||..|.||...| .|.|| |.||.||||.| .. .  .  |.|..||| .  ...  | .|.||||||||||..|.| . .||.||.|..|.|..|
SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQ-RIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFT

QKILFDGSTNNEMLKLIMDSRGKFNKKMLQNG--KYVEEYFDQNYNFKYTYVDKQTNQKYTTIITYG---DIPKKDIYRLLQENKDGINLENQKKLSQFK
...|| |......|..||. .|...|.|...|  ......||.   |.|...|..|.|...|  ...   .. |. ..|........... . .. .|||
GWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC---FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQFK

DFLDKCLQLDPKNRITPEEALEHPFL
||..||||.||..||||..||.||..
DFIKKCLQWDPHKRITPSQALQHPWF
Kinase 15575.AA CMGC 612-929 20 9.90000000001e-102 335.13 In-house 1-513 (513) Show / Hide 
Range on Protein: 612-929
Range on HMM: 1-513/513
Sequence Identity: 20% (106 aa)

YRVIQKCGKGVFANVCKAEQ--------------LDNGKMVAIKILRSNEIMRDSGE-------------REKEIIQKLNLN-----------DKNDRKH
| .|.|.|.| ...|.|.                 .....||||...... . . .              || .| ..|| |           |......
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVRLKNVFEHQK-----------------HMCLVFECFAMNLRDALKEYGK-------------------------GKGFSLDVVRSYAYQIFVALT--H
||.|...| | .                 |..||||.  ..| . .|.. .                          | |..  .| |.|||. .|   .
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

LKKNN--YIHADLKPDNLLISEDTKT-------------------LKMCDFGTALPIEENG-----------------------IIKYLQSRFYRAPEVL
. ...   || |||| |.||.....                    || |||| |  ....                        .  | ..|.|||||.|
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

IGYPPY----------NQIDVWSVGVTLYEIYTQ--------KILFDGSTN-----------NEMLKLIMDSRGKFNKKMLQNGKYVE-EYFDQNYNFKY
.|.. |           .||.||||  ..|.||         |.|| |...            ..|..|..  |... .|.|.|| .. . |... .  .
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGK-RHFN-FCKHEEEWP

TYVDKQTNQKYTT---------IIT------------YGDIPKKDIYRLLQENKDGINLENQK--------------------------KLSQFKDFLDK
.........|. .         ...            .. .|.|.. .|   ...... . .|                            .|. |.|.|
NMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDD-N-NKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKK

CLQLDPKNRITPEEALEHPFL
.||.||..|||.|.||.||..
MLQYDPDKRITAEQALQHPYF
Kinase 15575.AA S_TKc 612-929 26 4.1e-79 270.04 SMART 1-231 (231) Show / Hide 
Range on Protein: 612-929
Range on HMM: 1-231/231
Sequence Identity: 26% (87 aa)

YRVIQKCGKGVFANVCKAEQLDNGKMVAIKILRSNEIMRDSGEREKEIIQKLNLNDKNDRKHIVRLKNVFEHQKHMCLVFECFAM---NLRDALKEYGKG
|....| ||| |. |.|.   . |. |||||..      .. .|| .| .|       . ..||.|. ||.. .|...|.|.      .|.| .|..|..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

KG---FSLDVVRSYAYQIFVALTHLKKNNYIHADLKPDNLLISEDTKTLKMCDFGTALPIEENGIIKYLQSRFYRAPEVLIGYPPYN--QIDVWSVGVTL
..   |.  ..|.|.|||. || .. ... || ||||.|.|..|   ..| |||| |  .       .  ...|.|||||    .|.   .|.||.|..|
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCIL

YEIYTQKILFDGSTNNEMLKLIMDSRGKFNKKMLQNGKYVEEYFDQNYNFKYTYVDKQTNQKYTTIITYGDIPKKDIYRLLQENKDGINLENQKKLSQFK
|| .. . .|.  . ..|.|.|.                                                                         ...|
YEMLCGYPPFP--QMQMMFKKIG------------------------------------------------------------------------SPEAK

DFLDKCLQLDPKNRITPEEALE-------HPFL
||..|||| ||..|.|  |||.       ||..
DFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 15575.AA DYRK1 612-929 32 1.3e-50 174.46 In-house 1-321 (321) Show / Hide 
Range on Protein: 612-929
Range on HMM: 1-321/321
Sequence Identity: 32% (105 aa)

YRVIQKCGKGVFANVCKAEQLDNGKMVAIKILRSNEIMRDSGEREKEIIQKLNLNDKNDRKHIVRLKNVFEHQKHMCLVFECFAMNLRDALKEYGKGKGF
| ..   ||| |  | ||    . ..|||||..      .    |  ..  .| .||... .||.||. | .  |.|||||  . || | |.   . .| 
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRN-THFRGV

SLDVVRSYAYQIFVALTHLKKN--NYIHADLKPDNLLISEDTK-TLKMCDFGTALPIEENGIIKYLQSRFYRAPEVLIGYPPYNQIDVWSVGVTLYEIYT
|| ..| .| |.  ||  .     . || ||||.|.|.    .  .|. ||| .   ..  | .|.||||||.||||.| .   .||.||.|  | |. |
SLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHT

QKILFDGSTNNEMLKLIMDSRGKFNKKMLQNGKYVEEYFDQNYNFKYTYVDKQTNQKYTTIITYGDIPKKDIYRLL----QENKDGINLENQKKLSQFKD
   || ||   . .. |..  |   |.|.. .   . ||...   . |.. |.|..|. .   ..    ..|        .  . |      .  ..|||
GEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDP--DNTWYCKKTRDKKKHYKEPCTRKLHEILGVETGGPGGRRKGEPGHSVEDYLKFKD

FLDKCLQLDPKNRITPEEALEHPFL
 . . || |||.|||| .||.|.|.
LIKRMLQYDPKQRITPYYALQHSFF
Kinase 15575.AA Ciliate-E2 612-929 18 7e-49 165.91 In-house 1-365 (365) Show / Hide 
Range on Protein: 612-929
Range on HMM: 1-365/365
Sequence Identity: 18% (81 aa)

YRVIQKCGKGVFANVCKAEQLDNGKMVAIK---------------------ILRSNEIMRDSGEREKEIIQKLNLND-----------KNDRKHIVRLKN
| .|.|.|.| |. |.|...  ..|..|||                     . . .. .  . ..|. |....|  .           ... ..|.... 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYE

VFE--HQKHMCLVFE-CFAMNLRD--------ALKE--YGKGKGFSLDVVRSYAYQIFV---------------ALTHLKKNN-YIHADLKPDNLLISED
.|.   .... ||.| |  ..|.|         ..|    . | |..  .. . .||.                || .|...|  || |.||.|.|.   
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---

TKTLKMCDFGTALPIEEN----------GIIKYLQ------------------------SRFYRAPEVLIG--------YPPYN-QIDVWSVGVTLYEIY
   .| .|||..  . ..          ..... .                        .  | |||.| |          .|. ..|.||.||.|||  
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

TQKILFDGSTNNEMLKLIMDSRGKFNKKMLQNGKYVEEYFDQNYNFKYTYVDKQTNQKYTTIITYGDIPKKDIYRLLQENKDG-INLENQ----------
. |  |                                                                      .|..|.. |.. ..          
FGKPPF----------------------------------------------------------------------QQQIKQCKIDFPCPEWQKDTQCIQ

------KKLSQF-KDFLDK----CLQLDPKNRIT-PEEALEHPFL
      ||.||  ||.. |    .|| ||..||| .|..|.||..
CKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 15575.AA DYRK2 612-848 33 5.9e-47 150.55 In-house 1-242 (318) Show / Hide 
Range on Protein: 612-848
Range on HMM: 1-242/318
Sequence Identity: 33% (81 aa)

YRVIQKCGKGVFANVCKAEQLDNGKMVAIKILRSNEIMRDSGEREKEIIQKLNLNDKNDRKHIVRLKNVFEHQKHMCLVFECFAMNLRDALKEYGKGKGF
| .    ||| |. | |.    ....||||..|          .| .|....  .||.    .|.... |   .|.|..|| . ||| . .|.  . .||
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHF-QGF

SLDVVRSYAYQIFVALTHLKKNNYIHADLKPDNLLISEDTK-TLKMCDFGTALPIEENGIIKYLQSRFYRAPEVLIGYPPYNQIDVWSVGVTLYEIYTQK
||  ||  |..|  .|  |.||| ||.|||| | |  . .. ..|  |||      .  |  | |||||||||| .| .    || || | .. |.|| .
SLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGY

ILFDGSTNNEMLKLIMDSRGKFNKKMLQNG-----KYVEEYFD
.|| |.  |. . ..|   |. .||....      .. . .|.
PLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFN
Kinase 15575.AA HIPK 612-857 32 2.9e-46 143.42 In-house 1-247 (329) Show / Hide 
Range on Protein: 612-857
Range on HMM: 1-247/329
Sequence Identity: 32% (80 aa)

YRVIQKCGKGVFANVCKAEQLDNGKMVAIKILRSNEIMRDSGEREKEIIQKLNLNDKNDRKHIVRLKNVFEHQKHMCLVFECFAMNLRDALKEYGKGKGF
| |.   |.| |  | |. .   . |||||||. .      |. | .|...|   .  |  |.||   .|.|..|.|||||    || | .|.  |    
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQEN-ADEYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQN-KFMPL

SLDVVRSYAYQIFVALTHLKKNNYIHADLKPDNLLISEDTKT---LKMCDFGTALPIEENGIIKYLQSRFYRAPEVLIGYPPYNQIDVWSVGVTLYEIYT
 | ..|    |.  || .||.   |||||||.|... . |.     |  ||| |  . .     |||||.|||||...| |   ..|.|| |  . | . 
PLKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFL

QKILFDGSTNNEMLKLIMDSRGKFNKKMLQNGKYVEEYFDQNYNFKYTY
   |..|. . .    |    .. .. .|. .   . .||.  . |. .
GWPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRDKQSKFRP
Kinase 15575.AA Ciliate-E2-Unclassified 612-929 19 8.8e-44 149.75 In-house 1-352 (352) Show / Hide 
Range on Protein: 612-929
Range on HMM: 1-352/352
Sequence Identity: 19% (82 aa)

YRVIQKCGKGVFANVCKAEQLDNG------KMVAIKILRSNEIMRDSGEREKEIIQKLNLNDKNDRK----------------HIVRLKNVFEHQKHMCL
|..|...|.| |. |.|... ...       |  |.|  .. ||.   |   |...  |..  .. .                .||..  .|. ......
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VFE-CFAMNLRDALKEYGK--------------GKGFSLDVVR-----SYAYQIFVALTHLKKNN-YIHADLKPDNLLISEDTK--TLKMCDFGTALPIE
| | |   .|.. .|...|              .| |.   ..      |..|| ..| .| ..|  || |.||.|.|.... |   .| .||| .  ..
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

EN-----------------------GIIKYLQSRFYRAPEVLIGYPPYNQ----IDVWSVGVTLYEIYTQKILFDGSTNNE----------------MLK
.|                       | . |.  . | ||||| |  ....    .|.||.|| |||. ...  |.. . ..                ...
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMP-Q-YTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQ

LIMDSRGKFNKKMLQNGKYVEEYFDQNYNFKYTYVDKQTNQKYTTIITYGDIPKKDIYRLLQENKDGINLENQKKLS-QFKDFLD----KCLQLDPKNRI
 |..   .|.|   |.                                                         |..| . |||.     |.|. .|..||
NIKQKNIQFPKFPWQQ-------------------------------------------------------IPKHWSPEAKDFINDLLQKMLKKNPNKRI

TPEEALEHPFL
|.|..|.||..
TFEQILNHPWF
Kinase 15575.AA Pkinase 612-825 28 3.2e-37 132.69 Pfam 1-227 (293) Show / Hide 
Range on Protein: 612-825
Range on HMM: 1-227/293
Sequence Identity: 28% (67 aa)

YRVIQKCGKGVFANVCKAEQLDNGKMVAIKILRSNEIMRDSGER-----EKEIIQKLNLNDKNDRKHIVRLKNVFEHQKHMCLVFECFAM-----NLRDA
|....| |.| |. |.|.   ..||.||.||..  ..  .  ..     | .| ..||       ..||||. .||  .|...|.|.  .      | | 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN------HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

LK--EYGKGKGFSLDVVRSYAYQIFVALTHLKKNNYIHADLKPDNLLISEDTKT---LKMCDFGTALPIEENGIIKYLQ----SRFYRAPEVLI-GYPPY
..  ..|.   || .....|.|||. .| .. ... || ||||.|.||...  .   .| |||| |  .. .     ..    ...|.||||.  | .  
ISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYG

NQIDVWSVGVTLYEIYTQKILFDGS----TNNEMLKLI
  .|.||.|..||| .. . .|.|.    . ......|
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMI
Kinase 15575.AA ULK 612-810 23 6.7e-34 115.77 In-house 111-363 (329) Show / Hide 
Range on Protein: 612-810
Range on HMM: 111-363/329
Sequence Identity: 23% (60 aa)

YRVIQKCGKGVFANVCKAEQLDN----GKMVAIKILRSNEIMRDS-----------GEREKEIIQKLNLN--DKNDRKHIVRLKNVFEHQ--KHMCLVFE
| .... ||| |. |.|..  ..    ...||.|.. .... ...            ..| .|..||. .   ||  ..||.|. .|| .  ..  ...|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

CFAM-NLRDALKEYGK-------GKGFSLDVVRSYAYQIFVALTHLKKNNYIHADLKPDNLLISE-DTK----------TLKMCDFGTALPIEEN----G
     .|.. .|...|       .| .| . .... .||  .. .| |.|.|| |.||.| ||.. ..|          .|| .||| |  ....     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

IIKYLQ-------SRFYRAPEVLI----GYPPYNQ-IDVWSVGVTLYEIYTQK
....         .  | ||..|     . |.|.   |.||.|. .||. . |
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGK
Kinase 15575.AA CDK 777-929 23 3.4e-27 83.93 In-house 183-284 (284) Show / Hide 
Range on Protein: 777-929
Range on HMM: 183-284/284
Sequence Identity: 23% (38 aa)

RFYRAPEVLIGYPPYN---QIDVWSVGVTLYEIYT---QKILFDGSTNNEMLKLIMDSRGKFNKKMLQNGKYVEEYFDQNYNFKYTYVDKQTNQKYTTII
. |||||.| |   |.   .||.||||  ..|..|    | || |..  . |..| .  |  . ..  . .   .|                        
LWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------

TYGDIPKKDIYRLLQENKDGINLENQKKLSQFKDFLDKCLQLDPKNRITPEEALEHPFL
                                 |.|.|.|..|||.||. |.||.||..
---------------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase 15575.AA CDK 612-762 23 1.1e-22 69.3 In-house 257-416 (284) Show / Hide 
Range on Protein: 612-762
Range on HMM: 257-416/284
Sequence Identity: 23% (42 aa)

YRVIQKCGKGVFANVCKAEQLDNG-----KMVAIKILR--------SNEIMRDSGEREKEIIQKLNLNDKNDRKHIVRLKNVFEHQ-----------KHM
|  ..| | | .. | ||  ...|     ..||.| .|          | .  .  ||  . ..|        ..||.|. |. .            .  
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-------HPNIVKLHDVCHTKNMDRNNKDKHENKL

CLVFECFAMNLRDALKEYGKGKGFSLDVVRSYAYQIFVALTHLKKNNYIHADLKPDNLLISEDTK----TLKMCDFGTA
 .|||   . |   ..            ...| .|.  .| .. .|. .| |||| |.||... .    .||  ||| |
YMVFEYMDHDLKKYMD------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLA
Kinase 15575.AA DYRK2 902-929 46 5.6e-13 38.21 In-house 291-318 (318) Show / Hide 
Range on Protein: 902-929
Range on HMM: 291-318/318
Sequence Identity: 46% (13 aa)

FKDFLDKCLQLDPKNRITPEEALEHPFL
| ||. .|.. ||. |.||..||.||..
FIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase 15575.AA TyrKc 612-929 17 8e-13 -15.39 SMART 1-280 (280) Show / Hide 
Range on Protein: 612-929
Range on HMM: 1-280/280
Sequence Identity: 17% (63 aa)

YRVIQKCGKGVFANVCKAEQLDNGKMVAIKILRSNEIMRDSGEREKEIIQKLNLNDKN--DRKHIVRLKNVFEHQ-------KHMCLVFECFAM-NLRDA
 . ..| | | |  |.|..      .||.| |...         ...... ...  |   . ..||||  |  .|       . ...|.|  .  .|.| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LKEYGKGKGFSLDVVRSYAYQIFVALTHLKKNNYIHADLKPDNLLISEDTKTLKMCDFGTALPIEEN------GIIKYL----QSR-----FYRAPEVLI
|.....   ....   |...||     .| ..|.|| ||   | |..|.  | | .||| .  |..       .  .      ...        |||.. 
LRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

GYPPYNQIDVWSVGVTLYEIYTQ-KILFDG-----STNNEMLKLIMDSRGKFNKKMLQ----NGKYVEEYFDQNYNFKYTYVDKQTNQKYTTIITYGDIP
 .    . |||| ||...||.|  .    |      .| |......  .|.  ...                                            
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVK--QGYRMPQPPNDYPMS-------------------------------------

KKDIYRLLQENKDGINLENQKKLSQFKDFLDKCLQLDPKNRITPEEALEHPFL
                       .   .   .| . ||..| | .|   | ..
----------------F--VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 15575.AA Pkinase 873-929 19 1.1e-11 42.41 Pfam 217-293 (293) Show / Hide 
Range on Protein: 873-929
Range on HMM: 217-293/293
Sequence Identity: 19% (15 aa)

GDIPKKDIYRLLQENKDGINLENQKKL---------------------SQFKDFLDKCLQLDPKNRITPEEALEHPFL
....  | . .......... ..  ..                     . .|||...||..||| |.|.|..|.||..
WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 15575.AA ULK 900-929 40 3.4e-10 31.89 In-house 300-329 (329) Show / Hide 
Range on Protein: 900-929
Range on HMM: 300-329/329
Sequence Identity: 40% (12 aa)

SQFKDFLDKCLQLDPKNRITPEEALEHPFL
...||.. ..|| |.| ||. || ..||..
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 15575.AA HIPK 901-929 48 1e-06 16.58 In-house 301-329 (329) Show / Hide 
Range on Protein: 901-929
Range on HMM: 301-329/329
Sequence Identity: 48% (14 aa)

QFKDFLDKCLQLDPKNRITPEEALEHPFL
.| . | | . .|...|||| |||.||| 
EFVHVLKKMCTWDAHKRITPCEALNHPFV