13785

Species: Tetrahymena
Alias: PreTt13785, TTHERM_00204120, 864, 17.m00392, 13785
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK

Sequence

Name Sequence Type Origin Length Description Download
13785.AA Protein None 420 None Fasta, JSON
13785.kin_dom Protein Kinase Domain None 283 None Fasta, JSON
13785.NA RNA None 1263 None Fasta, JSON

Protein domain

Protein domains of 13785.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 13785.AA ERK 52-334 40 5.3e-157 527.89 In-house 1-307 (307) Show / Hide
Range on Protein: 52-334
Range on HMM: 1-307/307
Sequence Identity: 40% (128 aa)

YRILKQIGFG-FNPTFTAIDQE-----YGQKVIIEVIKIENDDLIYMNQLIRQIKIENHFK-HENISSNLHIMMES-----KNLYIVREFIDTDLHRVNF
|.|.||||.| ......|||.|      ||||.|..|....|..||.....|.||...||| ||||.....|||..     ...|.|.|...||||....
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

SKQELTDDHIQYFTYQILSALFFLHSQNVYHTQLRLSNILLNKNCDLKISRFIGTNFPNE-----------IYSQYITSDYFLSPQQILNLPKNLSKTDI
|.|||.|||.|||.||||..|...||.||.|..|. ||||.|.||||||..|........           ....|...... .|...|...|. ...||
SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDI

WHVGVIILGLINRDTFFSNLSNQLGGGYLGLINAIFSYIGTPSGEELLQYQDYKGLYQYIIKYSK-----KSWQDVFPDAN--PLLCDLLDKMLVFNEDK
|..|.|. ....|...|.      |..|.. ||.||..||||..|| |||........||.....     |.|...||.||  |. .|||.|||||..||
WSCGCIFAEMLGRKPLFP------GKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDK

RYTVKECLQHPYF
|.||.|||.||||
RITVEECLEHPYF

Kinase 13785.AA Ciliate-E7 52-334 47 1.5e-133 450.02 In-house 1-290 (290) Show / Hide
Range on Protein: 52-334
Range on HMM: 1-290/290
Sequence Identity: 47% (139 aa)

YRILKQIGFGFNPTF--TAIDQEYGQKVIIEVIKIENDDLIYMNQLIRQIKIENHFKHENIS-SNLHIMMESKNLYIVREFIDTDLHRVNFSKQELTDDH
| |.. |    .  |   .||.||.||..| .|. |.  | |  . |. .|..||. ||.|  .|.|..||..|.|.|..| .| |  . .|.|.|||.|
YQIKREIWYDTYIYFCKAYIDREYQQKQFIYYIFYEQCYLKYIIKAIEIQKFLNHENHEKIYNFNFHSYMEINNMYVVSDFMQTNLKYITQSRQQLTDEH

IQYFTYQILSALFFLHSQNVYHTQLRLSNILLNKNCDLKISRFIG--TNFPNEIYSQYITSDYFLSPQQILNLPKNLSKTDIWHVGVIILGLINRDTFFS
|..| |||| || ..|||..|||||    |..| |||.||| ||.   |||.|| ..||   |..||. |. .. ..|||||||||.|.| ||.|  |||
IKWFMYQILRALHYIHSQKIYHTQLTPRFIQINQNCDIKISDFIWCIGNFPHEINKKYINKNYYMSPYYIVEQMETFSKTDIWHVGCIFLELIQRYKFFS

NLSNQLGGGYLGLINAIFSYIGTPSGE--ELLQYQDYKGLYQYII---KYSKKSWQDVFPDANPLLCDLLDKMLVFNEDKRYTVKECLQHPYF
       ..| |.| ..| ..| .. |   |..| .|.  |        | |.|||..|| ||||||||||||||||||||..||||||||||
DFCC---HDYNGVITQYFYFCGSQNEEDLDLKYYKQYNRQYNQLKMPKQYCKQSWQVQFPNANPLLCDLLDKMLVFNEDKRFNVKECLQHPYF

Kinase 13785.AA MAPK 52-334 35 2e-105 356.56 In-house 1-328 (328) Show / Hide
Range on Protein: 52-334
Range on HMM: 1-328/328
Sequence Identity: 35% (120 aa)

YRILKQIGFG-FNPTFTAIDQE------YGQKVIIEVIKIENDDLIYMNQLIRQIKIENHF-KHENISSNLHIMMES-----------KNLYIVREFIDT
|.|||.||.| .   . |||..      .|.|| |  |    ......   .| ||. .|| .|||| . |.|.. .           . .|||.|. .|
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLHRVNFSKQELTDDHIQYFTYQILSA--LFFLHSQNVYHTQLRLSNILLNKNCDLKISRF----IGTNFPNEIY-------------SQYITSDYFLSP
|||..  | |.|.|||||||.|||| .  |...|| || |  |  ||||.|.||||||  |    .  .. ....             ..|..  .  .|
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

QQILN--LPKNLSKTDIWHVGVIILGLIN-RDTFFSNLSNQLGGGYLGLINAIFSYIGTPSGEELLQYQD-YKGLYQYII------KYSKKSWQDVFPD-
  .||  . ..  . |.|.|| |   ... | ..|       |  |.  .| |....|||  ||..|.   ..  ..||       || ||.|...||. 
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFP------GKDYIDQWNLIMEVLGTP-SEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNA

---ANPLLCDLLDKMLVFNEDKRYTVKECLQHPYF
   |||. .|||.|||||. |||.||.|.||||||
NFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF

Kinase 13785.AA CMGC 52-334 18 1e-64 211.2 In-house 1-513 (513) Show / Hide
Range on Protein: 52-334
Range on HMM: 1-513/513
Sequence Identity: 18% (96 aa)

YRILKQIGFG-FNPTFTAID--------------QEYGQKVIIEVIKIENDDLIYMN----------QLIRQIKIENHFK-----------------HEN
| |.|.|| | .   . ..|               |....| |  || .  . . .             .| |||  |..                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

ISSNLHIMMESK-----------------NLYIVREFIDTDLHRVNFSKQ---------ELTDDH------------IQYFT------YQILSA--LFFL
| . . | . ..                 .||.| |..|.||...  ..|         .|.. |            |.||.      |||| .  |...
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSQN--VYHTQLRLSNILLNKNCDL--------------------KISRF---IGTNFP---------------------NEIYSQYITSDYFLSPQQIL
||..  . |. |  .|||.|.||.|                    ||  |     .. .                     |. |..|. . .  .|  .|
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

NL---------PKNLSKTDIWHVGVIILGLINR--------DTFFSNLSNQ-----LGGGYLGLINAIFSYIGTPS---------------GEELLQYQD
.           .  .. |.| || |.  ....        ...|   |..      |  ..  .. ||  .|||.                ||  .. .
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

--------------------YKGLYQYIIK------YSKKSWQDVFPD-----------------------------------ANPLLCDLLDKMLVFNE
                    ... ..|| .      . .|.|...||.                                   ..|.. |||.|||... 
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

DKRYTVKECLQHPYF
||| |....||||||
DKRITAEQALQHPYF

Kinase 13785.AA ERK5 52-334 31 3e-41 143.34 In-house 1-295 (295) Show / Hide
Range on Protein: 52-334
Range on HMM: 1-295/295
Sequence Identity: 31% (95 aa)

YRILKQIGFG-FNPTFTAIDQEYGQKVIIEVIKIENDDLIYMNQLIRQIKIENHFKHENISSNLHIMM------ESKNLYIVREFIDTDLHRVNFSKQEL
|.|. .|| | .     |. .  ||.| |  |    | .      .| .||  ||.|.||     |.|      | |. |.| . .. ||| .  | | .
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

TDDHIQYFTYQILSALFFLHSQNVYHTQLRLSNILLNKNCDLKISRF-----IGTNFPNE---IYSQYITSDYFLSPQQILNLPKNLSKTDIWHVGVIIL
| .|| || ||||  | ..|| .| |  |. ||.| | ||.|||  |     . |  |..      .|.   ..  |  .. .       |.| || |. 
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG

GLINRDTFFSNLSNQLGGGYLGLINAIFSYIGTPSGEELLQYQDYKGLYQYIIK----YSKKSWQDVFPDANPLLCDLLDKMLVFNEDKRYTVKECLQHP
 .| |  .|       |  |.  .. |   .|.|.   ..|      .| |. |       | |. |.| | .   ||| .||.|   .| || . ||||
EMIARRQMFP------GKNYIHQLQLIMMVLGMPP-PHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHP

YF
. 
FL

Kinase 13785.AA ERK1 52-334 34 5.8e-37 129.13 In-house 1-289 (289) Show / Hide
Range on Protein: 52-334
Range on HMM: 1-289/289
Sequence Identity: 34% (103 aa)

YRILKQIGFG-FNPTFTAIDQEYGQKVIIEVIKIENDDLIYMNQLIRQIKIENHFKHENISSNLHIMMES-----KNLYIVREFIDTDLHRVNFSKQELT
|  |. || | .     |.|.  .|.| |  |    .   |    .| ||| . ||||||     |.  .     . .||| . ..||| ..    |.| 
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKI-SPFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKL-LKTQHLS

DDHIQYFTYQILSALFFLHSQNVYHTQLRLSNILLNKNCDLKISRF--IGTNFPNE----IYSQYITSDYFLSPQQILNLPKNLSKTDIWHVGVIILGLI
 ||| || ||||  | ..|| || |  |. ||.|||. |||||  |       |.         |.   ..  |  .||        ||| || |.  ..
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML

NRDTFFSNLSNQLGGGYLGLINAIFSYIGTPSGEEL--LQYQDYKGLYQYIIKYSKKSWQDVFPDANPLLCDLLDKMLVFNEDKRYTVKECLQHPYF
     |       |  ||  .| | . .| || ..|  .  .  .   | .   .| .|. .||.| .   ||||||| || .|| || | | ||| 
SNRPIFP------GKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL

Kinase 13785.AA p38 117-334 33 7.7e-33 109.37 In-house 77-289 (289) Show / Hide
Range on Protein: 117-334
Range on HMM: 77-289/289
Sequence Identity: 33% (73 aa)

MMESKNLYIVREFIDTDLHRVNFSKQELTDDHIQYFTYQILSALFFLHSQNVYHTQLRLSNILLNKNCDLKISRFIGTNFPNEIYSQYITSDYFLSPQQI
|.. .. |.| .| ..||...    | |.|||||.  |||| .| . || .. |  |  ||| .| .|.|.|  |       .   .|.    ...|  .
MNDFQDVYMVTHFMGADLNNI-MKCQRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCDDEMTGYVATRWYRAPEIM

LNLPKNLSKTDIWHVGVIILGLINRDTFFSNLSNQLGGGYLGLINAIFSYIGTPSGEEL--LQYQDYKGLYQYIIKYSKKSWQDVFPDANPLLCDLLDKM
||  .   . ||| || |.  || . | |       |  ..  .. | . .|||. | .  .| .  .   | . .. ..  ..||. |||.  |||.||
LNWMHYTQTVDIWSVGCIMAELITGRTLFP------GDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKM

LVFNEDKRYTVKECLQHPYF
|.  .||| |..| .|||||
LELDPDKRITAEEAMQHPYF

Kinase 13785.AA S_TKc 52-334 21 1e-27 99.35 SMART 1-231 (231) Show / Hide
Range on Protein: 52-334
Range on HMM: 1-231/231
Sequence Identity: 21% (65 aa)

YRILKQIGFG-FNPTFTAIDQEYGQKVIIEVIKIENDDLIYMNQLIRQIKIENHFKHENISSNLHIMMESKNLYIVREFIDT---DLHRVNFSKQE----
|.||..|| | |   . ... . |..| | .||         ....| |.|  . .|.||   . .. . ..||.| |..|.   ||...  ...     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LTDDHIQYFTYQILSALFFLHSQNVYHTQLRLSNILLNKNCDLKI-----SRFIGTNFPNEIYSQYITSDYFLSPQQILNLPKNLS-KTDIWHVGVII
  ..  |.....|||..|| ..||... |  |  .||||..   .||     .|..         . .. . ....|  .    .    | |.| .|.|.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCIL

LGLINRDTFFSNLSNQLGGGYLGLINAIFSYIGTPSGEELLQYQDYKGLYQYIIKYSKKSWQDVFPDANPLLCDLLDKMLVFNEDKRYTVKECLQ-----
  .. . . |.             ....|  ||                                    | ..|...|.|... .||.|. |.||     
YEMLCGYPPFP------------QMQMMFKKIG-----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDI

--HPYF
  ||.|
KCHPWF

Kinase 13785.AA nmo 53-245 30 2.2e-26 77.62 In-house 2-204 (292) Show / Hide
Range on Protein: 53-245
Range on HMM: 2-204/292
Sequence Identity: 30% (62 aa)

RILKQIGFG-FNPTFTAIDQEYGQKVIIEVIKIENDDLIYMNQLIRQIKIENHFKHENISSNLHIMMESKN-----LYIVREFIDTDLHRVNFSKQELTD
.  . ||.| |   ..  |   |..| .  .     .|.      | .|.   |||.|. | | |.   .      .|.| | .  |||..  | |.|. 
QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIVSPQHLSS

DHIQYFTYQILSALFFLHSQNVYHTQLRLSNILLNKNCDLKISRFIGTNFPNEIYSQYITSD----YFLSPQQILNLPKNLSKTDIWHVGVIILGLINRD
||.. | ||||  | .||| |. |  ..  |.|.| || |||  |      ..  |. .| .    |.  |  ..   .  |  ||| || |   |. | 
DHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLGRR

TFF
  |
ILF

Kinase 13785.AA ERK7 106-191 39 1.7e-16 52.62 In-house 57-144 (292) Show / Hide
Range on Protein: 106-191
Range on HMM: 57-144/292
Sequence Identity: 39% (35 aa)

KHENISSNLHIMMESKN--LYIVREFIDTDLHRVNFSKQELTDDHIQYFTYQILSALFFLHSQNVYHTQLRLSNILLNKNCDLKISRF
.|.|| . . ..  . .  .|.| || .|||| |    . | | | ||  ||.| |. ..|| || |  |. |||||. .| .|.  |
CHPNIIRLINVIRADNDRDIYLVFEFMETDLHAVIRKGNILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDF

Kinase 13785.AA Pkinase 52-189 23 4.8e-15 54.27 Pfam 1-154 (293) Show / Hide
Range on Protein: 52-189
Range on HMM: 1-154/293
Sequence Identity: 23% (36 aa)

YRILKQIGFG-FNPTFTAIDQEYGQKVIIEVIKIENDDLIYMNQLIR--QIKIENHFKHENISSNLHIMMESKNLYIVREFIDT-----DLHRVNF--SK
|.|...|| | |   . .... .|..| . .|| ....     ...|   |.| ....|.||   ..........|.| |. .      ||...    ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

QEL--TDDHIQYFTYQILSALFFLHSQNVYHTQLRLSNILLNKNCDL----KIS
  .  ...... . ||||..| ..||... |  | ..|||...|...    ||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKIC

Kinase 13785.AA MAPK-Unclassified 97-188 37 2.8e-13 43.88 In-house 48-150 (575) Show / Hide
Range on Protein: 97-188
Range on HMM: 48-150/575
Sequence Identity: 37% (39 aa)

RQIKIENHFKHENISSNLHIMM--ESKN-----LYIVREFIDT---DLHRVNFSKQ-ELTDDHIQYFTYQILSALFFLHSQNVYHTQLRLSNILLNKNCD
| | |  .  |.||     | .  | .|     .||| ..  |   ||| .  | |  . . |||||.||||  |  ||| .. |  |  ||.|.| .| 
REIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIKSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCS

LKI
..|
VRI

Kinase 13785.AA ERK7 227-334 25 1.7e-11 35.24 In-house 189-292 (292) Show / Hide
Range on Protein: 227-334
Range on HMM: 189-292/292
Sequence Identity: 25% (28 aa)

DIWHVGVIILGLINRDTFFSNLSNQLGGGYLGLINAIFSYIGTPSGEEL--LQYQDYKGLYQYIIKYSKKSWQDVFPDANPLLCDLLDKMLVFNEDKRYT
| | .| |.  ..     |       |   .  |. |   |. |. |..  .. .    . . ...  .|. ....|.. .   ||| ..|||| .|| |
DMWSIGCILGEMLRGKPMFP------GTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLT

VKECLQHPYF
....||||| 
AEQALQHPYV

Kinase 13785.AA MAPK-Unclassified 296-334 32 2.1e-10 33.33 In-house 527-575 (575) Show / Hide
Range on Protein: 296-334
Range on HMM: 527-575/575
Sequence Identity: 32% (16 aa)

WQDVFPDANP----------LLCDLLDKMLVFNEDKRYTVKECLQHPYF
. | .. ..|          .  |...|||.||  ||.|  . |.||||
FTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF

Kinase 13785.AA nmo 309-334 50 3.7e-10 26.81 In-house 267-292 (292) Show / Hide
Range on Protein: 309-334
Range on HMM: 267-292/292
Sequence Identity: 50% (13 aa)

DLLDKMLVFNEDKRYTVKECLQHPYF
.|| .||.|. |||  .|. |.||| 
HLLCRMLHFDPDKRISCKDALAHPYL

Kinase 13785.AA Pkinase 299-334 27 5.8e-09 32.78 Pfam 259-293 (293) Show / Hide
Range on Protein: 299-334
Range on HMM: 259-293/293
Sequence Identity: 27% (10 aa)

VFPDANPLLCDLLDKMLVFNEDKRYTVKECLQHPYF
. . ... ..|.....| ..  ||.| ...||||.|
F-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase 13785.AA TyrKc 52-252 15 3.8e-05 -139.35 SMART 1-280 (280) Show / Hide
Range on Protein: 52-252
Range on HMM: 1-280/280
Sequence Identity: 15% (47 aa)

YRILKQIG--------FGFNPTFTAIDQEYGQKVIIEV-IKIENDDLIYMNQLIRQIKIENHF--KHENISSNLHIMMES-------KNLYIVREFIDT-
 . .|..|         |                 |.| .|  ..|   .  ..| ..|  ..  .|.||   . . ...       . |.|| |. .  
ITLGKKLGEGAFGEVYKGTWK--------------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG

DLHRVNFSKQE-LTDDHIQYFTYQILSALFFLHSQNVYHTQLRLSNILLNKNCDLKI-----SRFI-------------------GTN--FP--------
||.    .... |. ..  .| .|| .   .|||.|. |  |   |.|...|   ||     ||.|                   |..  .|        
DLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

--NEIYSQ----------------YITSDYF------LSPQQILNLPKNLSKTDIWHVG-------------VIILGLINRDT----FFSNLSNQL
    ...                 |  . |       .|.|..... |.    .. . .              |..   ..|      ||..  ..
INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF