Gene 18504 (Tetrahymena)

18504

Species: Tetrahymena
Alias: 3672.m00001, 707, 125.m00068, PreTt18504, 18504, TTHERM_00760190
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK

Sequence

Name Sequence Type Origin Length Description Download
18504.AA Protein None 426 None Fasta, JSON
18504.kin_dom Protein Kinase Domain None 296 None Fasta, JSON
18504.NA RNA None 1281 None Fasta, JSON

Protein domain

Protein domains of 18504.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 18504.AA ERK 40-335 57 3e-221 741.29 In-house 1-307 (307) Show / Hide 
Range on Protein: 40-335
Range on HMM: 1-307/307
Sequence Identity: 57% (175 aa)

YSIIDSIGQGAYGIVVAARDLN-CQDEENNLVAIKKIEKAFEHKIFTKRTLRELRLLRLLK-HENIIGINTLLLPRSREKFEDIYVVSELMETDLASIIK
|.||. ||.||||.|..|.| . |.||... |||||||.||.|.|..||||||..|||..| |||||.......|.|.|...|||.|.|||||||. ||.
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

SEQPLTDEHCQFFLYQILRGLKYIHSAKVVHRDLKPRNLLVNSNCDLKICDFGLAR----TIIPGLKCRAGMLTDYVATRWYRAPELLLSWRDYDEKVDV
|.|.|.|.|||.|.||||.||||||||.|.||||||.|.|||||||||||||||||    .. .. .|.....|.|||||||||||..|||..|....|.
SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDI

WSVGCIFAELLRRKPFLPGIDTRNQIELIFEYLGTP-SEQEINNIPREKFRKMVKNMPK--RQPKQFEKLFSKAS--KEAIDLLRKLLTFDFTKRITVDE
||.||||||.|.|||..|| |...||..||...||| ||.....|..|...|..||.|.  |.||..|..|..|.  ..|||||.|.|.||..|||||.|
WSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEE

ALSHPYL
.|.|||.
CLEHPYF
Kinase 18504.AA MAPK 40-335 52 1e-191 643.21 In-house 1-328 (328) Show / Hide 
Range on Protein: 40-335
Range on HMM: 1-328/328
Sequence Identity: 52% (171 aa)

YSIIDSIGQGAYGIVVAARDLN--CQDEENNLVAIKKIEKAFEHKIFTKRTLRELRLLRLL-KHENIIGINTLLLP------RSREKFEDIYVVSELMET
| |.  |||||||.|..|.|    ....... ||||||...|......|||.||..||| . .|||||...  . |      .|.|.|.|||.|.|||||
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLASIIKSEQPLTDEHCQFFLYQILRG--LKYIHSAKVVHRDLKPRNLLVNSNCDLKICDFGLARTIIPGLKCRAG----------MLTDYVATRWYRAP
||  ||||.|||.|.|.|.|.||||||  ||||||| |.|||||| |.|||.|||||||||||||.| |  ... .          ..|.||||||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

ELLLS--WRDYDEKVDVWSVGCIFAELLR-RKPFLPGIDTRNQIELIFEYLGTPSEQEINNIP-REKFRKMVKNM---PKRQPKQFEKLFSK----ASKE
|..|.  |..|...||.|||||||||.|. |||..|| |. .|..||.|.||||||. |..|.  |. |......   ||...|..||.|..    |. .
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

AIDLLRKLLTFDFTKRITVDEALSHPYL
||||| |.|.||  |||||.|||.|||.
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 18504.AA CMGC 40-335 27 8.99999999999e-138 455.77 In-house 1-513 (513) Show / Hide 
Range on Protein: 40-335
Range on HMM: 1-513/513
Sequence Identity: 27% (141 aa)

YSIIDSIGQGAYGIVVAARDLNCQ----------DEENNLVAIKKIEKAFEHKIFTK----------RTLRELRLLRLLK-----------------HEN
| ||. ||.|.||.|. .|| ...           | |..|||||| ..| ...  |          |.|||...|. |.                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IIGINTLLLPR---SREK---------FEDIYVVSELMETDLASIIKSEQ---------PLTDEH------------CQFFL------YQILRGLK--YI
|...   . ..   . |.         |...| | |.|..||. .||. |         ||.. |            ...|.      ||||||||  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSAK--VVHRDLKPRNLLVNSNCDL--------------------KICDFGLARTIIPGLKCRAG-----------------MLTDYVATRWYRAPELLL
||..  ..|||||| |.|.|.||.|                    ||||||||| . |  . ...                 ..|.||.||||||||.||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

SWRDYD---------EKVDVWSVGCIFAELLRR--------KPFLP-----------GIDTRNQIELIFEYLGTP----------------SEQEINNIP
.|..|.         ...|.|||||||||....        ||. |           | .. .|...||. ||||                .|. .| |.
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

--------------------REKFRKMVKN---MPKRQPKQFEKLFSK-----------------------------------ASKEAIDLLRKLLTFDF
                     |. |. ...    |...|| ...|| .                                   ....||||| |.|..| 
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

TKRITVDEALSHPYL
.||||...||.|||.
DKRITAEQALQHPYF
Kinase 18504.AA p38 40-335 45 5.9e-133 448.0 In-house 1-289 (289) Show / Hide 
Range on Protein: 40-335
Range on HMM: 1-289/289
Sequence Identity: 45% (135 aa)

YSIIDSIGQGAYGIVVAARDLNCQDEENNLVAIKKIEKAFEHKIFTKRTLRELRLLRLLKHENIIGINTLLLP--RSREKFEDIYVVSELMETDLASIIK
|  .  .|.|||| | .|.|  . ..    |||||. . |.  |. ||| ||||||....|||.|..     |  .|.. |.|.|.|...|..||  |.|
YQNLQPVGSGAYGQVCKAED-RRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMK

SEQPLTDEHCQFFLYQILRGLKYIHSAKVVHRDLKPRNLLVNSNCDLKICDFGLARTIIPGLKCRAGMLTDYVATRWYRAPELLLSWRDYDEKVDVWSVG
... |.|.| || .||||||||||||| ..|||||| |. || .|.|.| ||||||         .  .|.||||||||||| .|.| .|...||.||||
CQR-LSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR-------HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVG

CIFAELLRRKPFLPGIDTRNQIELIFEYLGTPSEQEINNIPREKFRKMVKNMPKRQPKQFEKLFSKASKEAIDLLRKLLTFDFTKRITVDEALSHPYL
|| |||. ...  || |  .|.. | . .|||.|  .. |  |. |  ....|... . |...|..|.  ||||| |.|  |  ||||. ||..|||.
CIMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase 18504.AA ERK5 40-335 49 1.6e-120 406.73 In-house 1-295 (295) Show / Hide 
Range on Protein: 40-335
Range on HMM: 1-295/295
Sequence Identity: 49% (148 aa)

YSIIDSIGQGAYGIVVAARDLNCQDEENNLVAIKKIEKAFEHKIFTKRTLRELRLLRLLKHENIIGINTLLLPRS-REKFEDIYVVSELMETDLASIIKS
| ||. ||.||||.| .||     ..    ||||||  ||.     |||.|||..||  .|.||| |  .| |.     . |.||| .||| ||  || |
YKIIEKIGNGAYGVVCSARRRKNGQQ----VAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHS

EQPLTDEHCQFFLYQILRGLKYIHSAKVVHRDLKPRNLLVNSNCDLKICDFGLARTIIP-GLKCRAGMLTDYVATRWYRAPELLLSWRDYDEKVDVWSVG
.||.| ||  .|||||||||||.|||.|.|||||| ||||| ||.||| |||.|| .       .   .|.||||||||||||..|  ||   .||||||
NQPFTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVG

CIFAELLRRKPFLPGIDTRNQIELIFEYLGTPSEQEINNIPREKFRKMVKN-MPKRQPKQFEKLFSKASKEAIDLLRKLLTFDFTKRITVDEALSHPYL
||| |.. |. . ||    .|..|| . ||.|. . |  .  .. .  ..  .| ||||..||.. || . |.||| ..| |.  .|||| .|| ||.|
CIFGEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase 18504.AA ERK1 40-335 50 1.7e-116 393.33 In-house 1-289 (289) Show / Hide 
Range on Protein: 40-335
Range on HMM: 1-289/289
Sequence Identity: 50% (150 aa)

YSIIDSIGQGAYGIVVAARDLNCQDEENNLVAIKKIEKAFEHKIFTKRTLRELRLLRLLKHENIIGINTLLLPRSREKFEDIYVVSELMETDLASIIKSE
|  .. ||.||||.|..| |      ... ||||||   |||. . .|||||...|   ||||||.|. ..   . |.. |.|.| .||||||  ..|. 
YTNLQYIGEGAYGMVCSAYD----TVHKQRVAIKKIS-PFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKT-

QPLTDEHCQFFLYQILRGLKYIHSAKVVHRDLKPRNLLVNSNCDLKICDFGLARTIIPGLKCRAGMLTDYVATRWYRAPELLLSWRDYDEKVDVWSVGCI
|.|  .|  .||||||||||||||| |.|||||| |||.|  ||||||||||||   |. .   | ||.|||||||||||..|  . |   .|.||||||
QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPE-HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCI

FAELLRRKPFLPGIDTRNQIELIFEYLGTPSEQEINNIPREKFRKMVKNMPKRQPKQFEKLFSKASKEAIDLLRKLLTFDFTKRITVDEALSHPYL
 ||.|  .|  ||     |. .|   || ||....| |  || |  .. .| ..   ...|| || . |.||| |.|||   |||||.||| ||||
LAEMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase 18504.AA ERK7 40-335 43 5.3e-112 378.39 In-house 1-292 (292) Show / Hide 
Range on Protein: 40-335
Range on HMM: 1-292/292
Sequence Identity: 43% (130 aa)

YSIIDSIGQGAYGIVVAARDLNCQDEENNLVAIKKIEKAFEHKIFTKRTLRELRLLRLLK-HENIIGINTLLLPRSREKFEDIYVVSELMETDLASIIKS
| |.  .|.||||||  | |   .    . ||.|||  ||  ..   || ||  .|. .. |.||| .   .     .   |||.| | |||||  .|. 
YEIRKRLGKGAYGIVWKAYDKRTK----QVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVI---RADNDRDIYLVFEFMETDLHAVIRK

EQPLTDEHCQFFLYQILRGLKYIHSAKVVHRDLKPRNLLVNSNCDLKICDFGLARTIIPGL--KCRAGMLTDYVATRWYRAPELLLSWRDYDEKVDVWSV
 . | | | |. .||.|| .||.||..|.|||||| |.|..|.| .|.|||||||.|      .   .|||.||||||||||| ||. . |   || ||.
GNILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSI

GCIFAELLRRKPFLPGIDTRNQIELIFEYLGTPSEQEINNIPREKFRKMVKNMPKRQPKQFEKLFSKASKEAIDLLRKLLTFDFTKRITVDEALSHPYL
||| .|.|| ||  ||  | ||||.| | .. |....|. |  .   .|...|.....|...... .....|||||..|| |   ||.|...||.||| 
GCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase 18504.AA nmo 44-335 44 1.7e-101 312.95 In-house 5-292 (292) Show / Hide 
Range on Protein: 44-335
Range on HMM: 5-292/292
Sequence Identity: 44% (131 aa)

DSIGQGAYGIVVAARDLNCQDEENNLVAIKKIEKAFEHKIFTKRTLRELRLLRLLKHENIIGINTLLLPRSREKFEDIYVVSELMETDLASIIKSEQPLT
  || ||.|.| .  |      .   ||.||. . |   . .||  |||..|   ||.|..    .| |   . |..|||| |||  ||  || | |.|.
RPIGYGAFGVVWSVTD----PRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIVSPQHLS

DEHCQFFLYQILRGLKYIHSAKVVHRDLKPRNLLVNSNCDLKICDFGLARTIIPGLKCRAGMLTDYVATRWYRAPELLLSWRDYDEKVDVWSVGCIFAEL
 .| . |||||||||||.|||...|||.|| |||||||| ||||||||||.  .     .  .|  | | .|||||.|.  | | . ||.||||||||||
SDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQ---DQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAEL

LRRKPFLPGIDTRNQIELIFEYLGTPSEQEINNIPREKFRKMVKNMPKRQPKQFEKLFSKAS-----KEAIDLLRKLLTFDFTKRITVDEALSHPYL
| |.         .|...| . ||||| .|      |  .  .  ||...| ....|.  .|      ||..|| ..| ||  ||| . .|| ||||
LGRRILFQAQSPIQQLQMITDLLGTPS-MEDMKYACEGAKAHMLRMPHKPP-CLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase 18504.AA CDK 40-335 33 6.3e-94 300.9 In-house 1-284 (284) Show / Hide 
Range on Protein: 40-335
Range on HMM: 1-284/284
Sequence Identity: 33% (111 aa)

YSIIDSIGQGAYGIVVAARDLNCQ-DEENNLVAIKKIEKAF-----EHKIFTKRTLRELRLLRLLKHENIIG------INTLLLPRSREKF-EDIYVVSE
| ... ||.|.||.|  |||.. .  . ...||.|||         |   |   ..||  ||. | |.||.        ...   . . |.   .| | |
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNN-KDKHENKLYMVFE

LMETDLASIIKSEQPLTDEHCQFFLYQILRGLKYIHSAKVVHRDLKPRNLLVNSNCD-----LKICDFGLARTI-IP-----GLKCRAGMLTDYVATRWY
 |..||.....         .. ...|.|||| |.|| ...|||||| |.|.|.|       ||| ||||||   ||      ...    .|  | |.||
YMDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRT----YTHEVVTLWY

RAPELLLSWRDYD--EKVDVWSVGCIFAELLR---RKPFLPGIDTRNQIELIFEYLGTPSEQ---EINNIPREKFRKMVKNMPKRQPKQFEKLFSKASKE
|||||||  ..|.    .|.|||||||||...   |||..||    .|...||. .|||.|.   ..   |                             
RAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------

AIDLLRKLLTFDFTKRITVDEALSHPYL
  ||| |.|..| .|||. ..||.|||.
--DLLNKMLCYDPKKRISAEQALQHPYF
Kinase 18504.AA S_TKc 40-335 29 1.6e-93 317.92 SMART 1-231 (231) Show / Hide 
Range on Protein: 40-335
Range on HMM: 1-231/231
Sequence Identity: 29% (92 aa)

YSIIDSIGQGAYGIVVAARDLNCQDEENNLVAIKKIEKAFEHKIFTKRTLRELRLLRLLKHENIIGINTLLLPRSREKFEDIYVVSELMET---DLASII
| |.. ||.||.| |  .|. .     . .||||.|          ....||...|.  .|.||. .            ...|.| |....   || ..|
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYI

KSEQP------LTDEHCQFFLYQILRGLKYIHSAKVVHRDLKPRNLLVNSNCDLKICDFGLARTIIPGLKCRAGMLTDYVATRWYRAPELLLSWRDYDE-
|. ..      ..  |..|..|||...|.|.|| ...|||||| |.|...   .||||||||| .           | .. |.||.|||.|     |.  
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL----GYGKC

KVDVWSVGCIFAELLRRKPFLPGIDTRNQIELIFEYLGTPSEQEINNIPREKFRKMVKNMPKRQPKQFEKLFSKASKEAIDLLRKLLTFDFTKRITVDEA
|.|.||.|||..|.| ..|  |      |....|. .|                                     |.||.|..||.|..| .||.|. ||
KCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EA

LS-------HPYL
|        ||..
LQDEWDIKCHPWF
Kinase 18504.AA Pkinase 40-335 29 2.5e-91 314.49 Pfam 1-293 (293) Show / Hide 
Range on Protein: 40-335
Range on HMM: 1-293/293
Sequence Identity: 29% (92 aa)

YSIIDSIGQGAYGIVVAARDLNCQDEENNLVAIKKIEKAFEHKIFTKRTLR--ELRLLRLLKHENIIGINTLLLPRSREKFEDIYVVSELMET-----DL
| |.  ||.|..| |  ... . ..    .||.|.|.|  |.. . .. .|  |..... |.|.||. .             .||.| |..|      ||
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDL

ASIIK--SEQPL--TDEHCQFFLYQILRGLKYIHSAKVVHRDLKPRNLLVNSNCDL----KICDFGLARTIIPGLKCRAGMLTDYVATRWYRAPELLLSW
...|.  .. ..  ....|.|..|||||||.|.|| ...|||||| |.|...|...    ||||||||. .      . . .|... |.||.|||.... 
FDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGG

RDYDEKVDVWSVGCIFAELLRRKPFLPGI----DTRNQIELIFEYLGTPSEQEINNIPREKFRKMVKNMPKRQPKQFEKLFSKASKEAIDLLRKLLTFDF
..|. |||.||.|||..|.| ..|  ||     . ..|...|.. .|.| . .. .  ..  .. ..  . .  . ....  ..|.|..|.....|..| 
QYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDP

TKRITVDEALSHPYL
.||.| ...| ||..
KKRPTAEQILQHPWF
Kinase 18504.AA MAPK-Unclassified 40-195 48 8.4e-73 248.18 In-house 1-159 (575) Show / Hide 
Range on Protein: 40-195
Range on HMM: 1-159/575
Sequence Identity: 48% (79 aa)

YSIIDSIGQGAYGIVVAARDLNCQDEENNLVAIKKIEKAFEHKIFTKRTLRELRLLRLLKHENIIGINTLLLPRSREK--FEDIYVVSELMET---DLAS
|  .  ||.||||.|. | |   |   |  |||||. ..|. .. .||.|||.|.|| | |.||| |.  . . . .   | |||.| ..|.|   || .
YEYQKNIGSGAYGQVCRAMDKKNQ---NQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQ

IIKSEQ-PLTDEHCQFFLYQILRGLKYIHSAKVVHRDLKPRNLLVNSNCDLKICDFGLARTI
|||| | .. ..| | |.|||||||||.||| ..|||||| |||.| .| ..|||||..| |
IIKSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSRSI
Kinase 18504.AA MAPK-Unclassified 204-335 36 2.7e-52 180.07 In-house 403-575 (575) Show / Hide 
Range on Protein: 204-335
Range on HMM: 403-575/575
Sequence Identity: 36% (63 aa)

GMLTDYVATRWYRAPELLLSWRDYDEKVDVWSVGCIFAELLRR-----------KPFLPGID--------------------TRNQIELIFEYLGTPSEQ
. .| ||.||||||||..||  .|| .|| ||.||||||.. .           .| .|| |                       || .||.|||.| |.
YHMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEE

EINNIPREKFRKMVKNMPKRQPKQFE-KLFSKAS---------KEAIDLLRKLLTFDFTKRITVDEALSHPYL
 .| |   . || ..   .  |  |    |.||.          |.||.. |.| |.  |||| |.||.||| 
DCNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase 18504.AA TyrKc 40-335 20 4.2e-15 21.42 SMART 1-280 (280) Show / Hide 
Range on Protein: 40-335
Range on HMM: 1-280/280
Sequence Identity: 20% (68 aa)

YSIIDSIGQGAYGIVVAARDLNCQDEENNLVAIKKIEKAFEHKIFTKRTLRELRLLRLL--KHENIIGINTLLLPRSREKF---EDIYVVSELMET-DLA
 . .. .| ||.|.|. ..           ||.|.. .        .  .||.|... |  .|.||. .    .  .|  |   | ...| |.|.  || 
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLK

SIIKSEQP-LTDEHCQFFLYQILRGLKYIHSAKVVHRDLKPRNLLVNSNCDLKICDFGLARTIIPG--------LKCRAG--MLTDYVATRWYRAPELLL
. ... .| |. ..   | .|| .|  |.|| ...||||  || ||..|   ||.||||.| |  .         .  ..     . .  ||. ||| . 
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-

SWRDYDEKVDVWSVGCI------FAELLRRKP---FLPGIDTRNQIELIFEYLGTPSE----QEINNIPREKFRKMVKNMPKRQPKQFEKLFSKASKEAI
  . . .| |||| |        . .     .   ... .. .....   ...  | .                                 |  ...|  
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVK-QGYRMPQPPNDYPMS----------------------------FVCCPDEMY

DLLRKLLTFDFTKRITVDEALSHPYL
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QIMKQCWHEDPEDRPTFSEI--HECF
Kinase 18504.AA Pkinase_Tyr 150-235 39 3.5e-12 41.88 Pfam 116-199 (270) Show / Hide 
Range on Protein: 150-235
Range on HMM: 116-199/270
Sequence Identity: 39% (34 aa)

FLYQILRGLKYIHSAKVVHRDLKPRNLLVNSNCDLKICDFGLARTIIPGLKC-RAGMLTDYVATRWYRAPELLLSWRDYDEKVDVWS
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MCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWM-APECINYGK-FTTKSDVWS
Kinase 18504.AA Pkinase_Tyr 40-104 23 7e-06 20.49 Pfam 1-67 (270) Show / Hide 
Range on Protein: 40-104
Range on HMM: 1-67/270
Sequence Identity: 23% (16 aa)

YSIIDSIGQGAYGIVVAARDLNCQDEENNLVAIKKIEKAFEHKI-FTKRTLRELRLLRLL-KHENII
 ...  .|.||.| |. ..   ..|...  ||.|..     |.  . .  .||..... | .|.||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIV