Gene 18512 (Tetrahymena)

18512

Species: Tetrahymena
Alias: PreTt18512, 125.m00076, 706, 3672.m00009, 18512, TTHERM_00760270
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK

Sequence

Name Sequence Type Origin Length Description Download
18512.AA Protein None 413 None Fasta, JSON
18512.NA RNA None 1242 None Fasta, JSON
18512.kin_dom Protein Kinase Domain None 288 None Fasta, JSON

Protein domain

Protein domains of 18512.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 18512.AA ERK 40-327 58 5.70000000001e-217 727.09 In-house 1-307 (307) Show / Hide 
Range on Protein: 40-327
Range on HMM: 1-307/307
Sequence Identity: 58% (180 aa)

YRILEKIGQGAYGVVSAAIDQV-----KRKSVAIKKIEKAFDQRIYTKRTLRELKLLRLLT-HENVIGLESILLPKSREEFDDIYCVSELMETDLQQIIK
|.|...||.|||||| .|||.      ... |||||||.|||..||.||||||.||||... |||.|.|. |..|.|.|...|||||.|||||||.|||.
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

SDQQLTQDHCKFFIYQILRGLKYIHSANVIHRDLKPRNLLVNSNCDLKICDFGLAR----SVAN----TKNDLTDYVTTRWYRPPELLLSWTDYTCAMDV
|.|.|..|||..|.||||.|||||||||||||||||.|.|||||||||||||||||    |...    ..|..|.||.|||||.||..|||..||.|||.
SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDI

WSVGIIFAELIKRKPLLPGSSSSDQLLRIFDLIGTP-LENEIQMIPYDEYRKFIRELPK--REPKQFEKIFSKAP--KEALDLLKKMLTFDFNKRITVEE
||.|.||||...||||.|| .. .|. |||..||||  |...|.|......|.|..||.  |.||..|.||..|.  ..|.|||.|||.||..|||||||
WSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEE

ALKHPYL
.|.|||.
CLEHPYF
Kinase 18512.AA MAPK 40-327 53 6.30000000001e-189 633.93 In-house 1-328 (328) Show / Hide 
Range on Protein: 40-327
Range on HMM: 1-328/328
Sequence Identity: 53% (175 aa)

YRILEKIGQGAYGVVSAAIDQV------KRKSVAIKKIEKAFDQRIYTKRTLRELKLLRLL-THENVIGLESILLP------KSREEFDDIYCVSELMET
|.||..||||||||| .|||.       . | ||||||...|.  ...|||.||.|||| .  |||.|.|  |. |      .|.|||.|||.|.|||||
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLQQIIKSDQQLTQDHCKFFIYQILRG--LKYIHSANVIHRDLKPRNLLVNSNCDLKICDFGLARSVANTKN--------------DLTDYVTTRWYRPP
||.|||||.|.|. ||...|.||||||  |||||||||||||||| |.|||.||||||||||||||......              ..|.||.||||| |
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

ELLLS--WTDYTCAMDVWSVGIIFAELIK-RKPLLPGSSSSDQLLRIFDLIGTPLENEIQMIP-YDEYRKFIREL---PKREPKQFEKIFSK----APKE
|..|.  |..|| |.|.|||| ||||... ||||.||... ||. .|....||| |  || |. ....|..|. |   ||. .|..||.|..    |  .
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

ALDLLKKMLTFDFNKRITVEEALKHPYL
|.|||.|||.|| .||||||||| |||.
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 18512.AA CMGC 40-327 28 1.1e-138 458.77 In-house 1-513 (513) Show / Hide 
Range on Protein: 40-327
Range on HMM: 1-513/513
Sequence Identity: 28% (145 aa)

YRILEKIGQGAYGVVSAAIDQVKRKS--------------VAIKKIEKAFDQRIYTK----------RTLRELKLLRLLT-----------------HEN
| |..|||.|.||||  ..|.   .               |||||| ..|   .  |          |.|||.|.|. |                  |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VIGLESILLPKS--REEFD----------DIYCVSELMETDLQQIIKSDQ---------QLTQDH------------CKFFI------YQILRGLK--YI
...|  |. .|   ..|..          ..| | |.|..|| |.||. |          |.. |            .|.|.      ||||||||  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSAN--VIHRDLKPRNLLVNSNCDL--------------------KICDFGLARSVANTKND---------------------LTDYVTTRWYRPPELLL
||..  .||||||| |.|.|.||.|                    |||||||||.. . ...                     .|.|| |||||.||.||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

SW---------TDYTCAMDVWSVGIIFAELIKR--------KPLLPGSSS-----------SDQLLRIFDLIGTP----------------LENEIQMIP
.|         ..||...|.|||| ||||.. .        ||| ||.|.            ||| .||...|||                 |. ..||.
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

--------------------YDEYRKFIRE---LPKREPKQFEKIFSK-----------------------------------APKEALDLLKKMLTFDF
                    .. .|..|.    .|.. || ....| .                                   ....|.|||||||..| 
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

NKRITVEEALKHPYL
.||||.|.||.|||.
DKRITAEQALQHPYF
Kinase 18512.AA p38 40-327 48 4.4e-136 458.4 In-house 1-289 (289) Show / Hide 
Range on Protein: 40-327
Range on HMM: 1-289/289
Sequence Identity: 48% (142 aa)

YRILEKIGQGAYGVVSAAIDQVKRKS---VAIKKIEKAFDQRIYTKRTLRELKLLRLLTHENVIGLESILLP--KSREEFDDIYCVSELMETDLQQIIKS
|. |. .|.|||| |..|.|.  ..    |||||. . | . |. ||| |||.||... |||||.|  .  |  .|...| |.| |...|..||..|.|.
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

DQQLTQDHCKFFIYQILRGLKYIHSANVIHRDLKPRNLLVNSNCDLKICDFGLARSVANTKNDLTDYVTTRWYRPPELLLSWTDYTCAMDVWSVGIIFAE
 |.|. || .| .|||||||||||||..||||||| |. || .|.|.| ||||||    . ...|.|| ||||| || .|.| .|| . |.|||| | ||
-QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR---HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAE

LIKRKPLLPGSSSSDQLLRIFDLIGTPLENEIQMIPYDEYRKFIRELPKREPKQFEKIFSKAPKEALDLLKKMLTFDFNKRITVEEALKHPYL
|| ...| ||.   ||| ||  ..||| |  .| |  .| | .|. .|... . |...|..|   |.||| |||  |  ||||.|||..|||.
LITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase 18512.AA ERK5 40-327 51 1.9e-127 429.71 In-house 1-295 (295) Show / Hide 
Range on Protein: 40-327
Range on HMM: 1-295/295
Sequence Identity: 51% (153 aa)

YRILEKIGQGAYGVVSAAIDQVKRKSVAIKKIEKAFDQRIYTKRTLRELKLLRLLTHENVIGLESILLPKS-REEFDDIYCVSELMETDLQQIIKSDQQL
|.|.||||.||||||..|. .   . ||||||  |||.    |||.||||.||   |.|.| .  || ||    |. |.| | .||| || ||| |.| .
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

TQDHCKFFIYQILRGLKYIHSANVIHRDLKPRNLLVNSNCDLKICDFGLAR-----SVANTKNDLTDYVTTRWYRPPELLLSWTDYTCAMDVWSVGIIFA
| .| ..|.|||||||||.|||.|||||||| ||||| ||.||| |||.||     | .. .  .|.|| ||||| |||..|  ||| |.|||||| || 
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG

ELIKRKPLLPGSSSSDQLLRIFDLIGTPLENEIQMIPYDEYRKFIRE-LPKREPKQFEKIFSKAPKEALDLLKKMLTFDFNKRITVEEALKHPYL
|.| |. . ||    .||  | . .|.|    || .  |  . .. . .| |.||..||.. || . ||||| .|| |.  .|||| .||.||.|
EMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase 18512.AA ERK1 40-327 50 4.8e-117 395.14 In-house 1-289 (289) Show / Hide 
Range on Protein: 40-327
Range on HMM: 1-289/289
Sequence Identity: 50% (148 aa)

YRILEKIGQGAYGVVSAAIDQVKRKSVAIKKIEKAFDQRIYTKRTLRELKLLRLLTHENVIGLESILLPKSREEFDDIYCVSELMETDLQQIIKSDQQLT
|  |. ||.||||.|..|.|.|... ||||||   |.   | .|||||.|.|    |||.|... |.  .. |.. |.| | .|||||| ...|. |.| 
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKIS-PFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKT-QHLS

QDHCKFFIYQILRGLKYIHSANVIHRDLKPRNLLVNSNCDLKICDFGLARSVANTKND----LTDYVTTRWYRPPELLLSWTDYTCAMDVWSVGIIFAEL
 ||  .|.|||||||||||||||.|||||| |||.|  |||||||||||| .|  . |    ||.|| ||||| ||..|    || ..|.|||| | ||.
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEM

IKRKPLLPGSSSSDQLLRIFDLIGTPLENEIQMIPYDEYRKFIRELPKREPKQFEKIFSKAPKEALDLLKKMLTFDFNKRITVEEALKHPYL
.  .|. ||    |||  |  ..| | ..... |  .  | ... || ..   ....| || . ||||| |||||  .||||||||| ||||
LSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase 18512.AA ERK7 40-327 40 1.9e-109 369.92 In-house 1-292 (292) Show / Hide 
Range on Protein: 40-327
Range on HMM: 1-292/292
Sequence Identity: 40% (119 aa)

YRILEKIGQGAYGVVSAAIDQVKRKSVAIKKIEKAFDQRIYTKRTLRELKLLRLLT-HENVIGLESILLPKSREEFDDIYCVSELMETDLQQIIKSDQQL
| |....|.||||.|  |.|.  .. ||.|||  ||  ..   || ||  .|. .  |.|.| |  ..  .      ||| | | |||||  .|.  . |
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDR---DIYLVFEFMETDLHAVIRKGNIL

TQDHCKFFIYQILRGLKYIHSANVIHRDLKPRNLLVNSNCDLKICDFGLARSVANTK------NDLTDYVTTRWYRPPELLLSWTDYTCAMDVWSVGIIF
   | .. .||.|| .||.||.||||||||| |.|..|.| .|.||||||||.|...       .||.|| ||||| || ||. . || . | ||.| | 
KDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCIL

AELIKRKPLLPGSSSSDQLLRIFDLIGTPLENEIQMIPYDEYRKFIRELPKREPKQFEKIFSKAPKEALDLLKKMLTFDFNKRITVEEALKHPYL
.|... ||. ||.|  .|. .| ..|. | . .|. |  .   . . .......|...... .....|.||||..| |  .||.|.|.||.||| 
GEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase 18512.AA nmo 41-327 45 1.7e-106 328.56 In-house 2-292 (292) Show / Hide 
Range on Protein: 41-327
Range on HMM: 2-292/292
Sequence Identity: 45% (134 aa)

RILEKIGQGAYGVVSAAIDQVKRKSVAIKKIEKAFDQRIYTKRTLRELKLLRLLTHENVIGLESILLPKSREEFDDIYCVSELMETDLQQIIKSDQQLTQ
.    || ||.||| .  |    | ||.||. . | . . .||  ||||.|    |.||. .  || |   . |..|| | |||  || .|| | |.|. 
QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIVSPQHLSS

DHCKFFIYQILRGLKYIHSANVIHRDLKPRNLLVNSNCDLKICDFGLARSV-ANTKNDLTDYVTTRWYRPPELLLSWTDYTCAMDVWSVGIIFAELIKRK
|| | |.|||||||||.||||..|||.|| |||||||| ||||||||||    ... ..|  | | .|| ||.|.    || |.|.|||| |||||..|.
DHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLGRR

PLLPGSSSSDQLLRIFDLIGTPLENEIQMIPYDEYRKFIRELPKREP--KQFEKIFS--KAPKEALDLLKKMLTFDFNKRITVEEALKHPYL
 |    |  .||  | ||.|||   ....   .  .  .   |...|  ..  .. |  .|  || .||..|| || .||| ...||.||||
ILFQAQSPIQQLQMITDLLGTPSMEDMKYA-CEGAKAHMLRMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase 18512.AA CDK 40-327 35 2.7e-97 311.82 In-house 1-284 (284) Show / Hide 
Range on Protein: 40-327
Range on HMM: 1-284/284
Sequence Identity: 35% (115 aa)

YRILEKIGQGAYGVVSAAIDQVKR-----KSVAIKKIEKAF-----DQRIYTKRTLRELKLLRLLTHENVIGLESILLPKSRE----EF--DDIYCVSEL
| .|||||.|.||||  |.|.        . ||.|||         .       ..|| .||. | |.|.. |  . . |...     .    .| | | 
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

METDLQQIIKSDQQLTQDHCKFFIYQILRGLKYIHSANVIHRDLKPRNLLVNSNCD-----LKICDFGLARSVAN------TKNDLTDYVTTRWYRPPEL
|..|| ....         .| ...|.|||| |.|| ...|||||| |.|.|.|       ||| ||||||   .        . .|  | |.|||.|||
MDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPEL

LLSWTDYT--CAMDVWSVGIIFAELIK---RKPLLPGSSSSDQLLRIFDLIGTPLENEIQ-MIPYDEYRKFIRELPKREPKQFEKIFSKAPKEALDLLKK
||  ..|.  .. |.|||| ||||..    ||||.||.|  ||| .||...||| |.    .  . .|                           ||| |
LLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------DLLNK

MLTFDFNKRITVEEALKHPYL
||..| .|||. |.||.|||.
MLCYDPKKRISAEQALQHPYF
Kinase 18512.AA S_TKc 40-327 29 2.8e-93 317.1 SMART 1-231 (231) Show / Hide 
Range on Protein: 40-327
Range on HMM: 1-231/231
Sequence Identity: 29% (90 aa)

YRILEKIGQGAYGVVSAAIDQVKRKSVAIKKIEKAFDQRIYTKRTLRELKLLRLLTHENVIGLESILLPKSREEFDDIYCVSELMET---DLQQIIKSDQ
|.||.|||.||.|.|  ...    . ||||.|          ....||...|.   |.|.. |  .         |..| | |....   || ..||. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRG

Q------LTQDHCKFFIYQILRGLKYIHSANVIHRDLKPRNLLVNSNCDLKICDFGLARSVANTKNDLTDYVTTRWYRPPELLLSWTDYTC-AMDVWSVG
       ..  |..|..|||...|.|.|| ..||||||| |.|...   .||||||||| .       | .. |.||..||.|     |.. . |.||.|
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCG

IIFAELIKRKPLLPGSSSSDQLLRIFDLIGTPLENEIQMIPYDEYRKFIRELPKREPKQFEKIFSKAPKEALDLLKKMLTFDFNKRITVEEALK------
.|..|.. ..|. |      |. ..|..||                                     ..||.|...|.|..| .||.|. |||.      
CILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK

-HPYL
 ||..
CHPWF
Kinase 18512.AA Pkinase 40-327 31 3.7e-90 310.62 Pfam 1-293 (293) Show / Hide 
Range on Protein: 40-327
Range on HMM: 1-293/293
Sequence Identity: 31% (96 aa)

YRILEKIGQGAYGVVSAAIDQVKRKSVAIKKIEKAFDQRIYTKRTLR--ELKLLRLLTHENVIGLESILLPKSREEFDDIYCVSELMET-----DLQQII
|.|..|||.|..|.|  ....  .| ||.|.|.|  .     .. .|  |..... | |.|.. |  .         |.|| | |..|      ||  .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI

K--SDQQL--TQDHCKFFIYQILRGLKYIHSANVIHRDLKPRNLLVNSNCDL----KICDFGLARSV-ANTKNDLTDYVTTRWYRPPELLLSWTDYTCAM
.  ..  .  . ..|||..|||||||.|.|| ..||||||| |.|...|...    ||||||||. .    .  .|... |.||..||.... ..|. . 
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVWSVGIIFAELIKRKPLLPGS----SSSDQLLRIFDLIGTPLENEIQMIPYDEYRKFIRELPKREPKQFEKIFSKAPKEALDLLKKMLTFDFNKRITVE
|.||.|.|..|.. ..|. ||.    .  ||. .|.   |.||. ...      |.. .|  . .  . ...   ....|..|..|..|..| .||.| |
DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAE

EALKHPYL
..|.||..
QILQHPWF
Kinase 18512.AA MAPK-Unclassified 40-191 49 7.3e-77 261.66 In-house 1-159 (575) Show / Hide 
Range on Protein: 40-191
Range on HMM: 1-159/575
Sequence Identity: 49% (78 aa)

YRILEKIGQGAYGVVSAAIDQVK-RKSVAIKKIEKAFDQRIYTKRTLRELKLLRLLTHENVIGLESILLPKSREE--FDDIYCVSELMET---DLQQIIK
|   . ||.||||.|  |.|     . |||||. ..|   . .||.|||. .|| | |.|.| .  |. .|. .   ||||| | ..|.|   || ||||
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

SDQ-QLTQDHCKFFIYQILRGLKYIHSANVIHRDLKPRNLLVNSNCDLKICDFGLARSV
|.|  .   | . |.|||||||||.|||..||||||| |||.| .| ..|||||..||.
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSRSI
Kinase 18512.AA MAPK-Unclassified 192-327 33 1.3e-47 164.52 In-house 399-575 (575) Show / Hide 
Range on Protein: 192-327
Range on HMM: 399-575/575
Sequence Identity: 33% (59 aa)

ANTKNDLTDYVTTRWYRPPELLLSWTDYTCAMDVWSVGIIFAELIKR-----------KPLLPGSS--------------------SSDQLLRIFDLIGT
.... ..| || ||||| ||..||  .|. . | ||.| ||||.. .           .||.||..                    ..||.  |||  |.
CHHCYHMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGM

PLENEIQMIPYDEYRKFIRELPKREPKQFE-KIFSKAP---------KEALDLLKKMLTFDFNKRITVEEALKHPYL
| |  .. |  |  ||.|. . .  |  |   .|.|||          |..|...||| |. .|||| ..||.||| 
PPEEDCNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase 18512.AA Pkinase_Tyr 40-227 29 8.7e-18 60.87 Pfam 1-199 (270) Show / Hide 
Range on Protein: 40-227
Range on HMM: 1-199/270
Sequence Identity: 29% (61 aa)

YRILEKIGQGAYGVVSAAIDQ----VKRKSVAIKKIEKAFDQRI-YTKRTLRELKLLRLL-THENVIGLESILLPKSREEFDDIYCVSELMET-DLQQII
 ....|.|.||.|.|  ..       ..  ||.|..    ...  . .  .||.|... |  |.|.. |  . .....     || | |.|.  ||    
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLDYL

KS----DQQLTQDHCKFFIYQILRGLKYIHSANVIHRDLKPRNLLVNSNCDLKICDFGLARSVANTKNDLTDYVTT-------RWYRPPELLLSWTDYTC
..    .|.||  .   . .|| .|. | .| | |||||  || ||..|   ||||||||| .  .. |   |...       .|. .|| .     .| 
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI--YNDDYY-YRKRGGGKLPIKWM-APECINYGK-FTT

AMDVWS
. ||||
KSDVWS
Kinase 18512.AA TyrKc 40-327 23 4.3e-15 21.29 SMART 1-280 (280) Show / Hide 
Range on Protein: 40-327
Range on HMM: 1-280/280
Sequence Identity: 23% (72 aa)

YRILEKIGQGAYGVVSAAIDQVKRKSVAIKKIEKAFDQRIYTKRTLRELKLLRLL--THENVIGLESILLPKSREEF---DDIYCVSELMET-DLQQIIK
 . ..|.| ||.|.|  ..       ||.|.. .        .  .||..... |   |.|.. |  . . ..|  |   . .. | |.|.  ||.. ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLR

SDQQ-LTQDHCKFFIYQILRGLKYIHSANVIHRDLKPRNLLVNSNCDLKICDFGLARSVANT-------KND------LTDY-VTTRWYRPPELLLSWTD
. .  |. ..   | .|| .|  |.|| |.|||||  || ||..|   ||.||||.| . .        .         ... .  ||. .|| .     
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGK

YTCAMDVWSVGIIFAELIKRKPLLPGSSSSDQL----LRIFDLIGTPLENEIQMIPYDEYRKFIRELPKREPKQFEKIFSKAPKEALDLLKKMLTFDFNK
.| . |||| |.   |.  .     | .         .  ...|    . .  ..| . |   .              |  .|.|  .. |.   .| ..
FTTKSDVWSFGVCMWEIFTY-----GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS-------------FVCCPDEMYQIMKQCWHEDPED

RITVEEALKHPYL
| | .|   | ..
RPTFSEI--HECF