Gene 11145 (Tetrahymena)
11145
Sequence
Protein domains of 11145.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 11145.AA | MAPK | 227-555 | 31 | 8.49999999999e-123 | 414.25 | In-house | 1-328 (328) | Show / Hide |
Range on Protein: 227-555 Range on HMM: 1-328/328 Sequence Identity: 31% (111 aa) YTYSGYIGQGGYSQVYKFIDNQTNQP------VAIKFVN-LFHNEQDTKRVLRELYIQRHL-SHPNVMKIQNIYYN------KELHNFDRIYIVMEYYPF |.. .|||| | .| ..||. ||| |||| . |.|....||..||. ..||. |.|..|...|.. ..|..|. ||||||. YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET SLFDILYQYQQNLTWSHELVRIIFTQIVNG--LAYIHSRNIIHRDLKPSNILIDQNLNVKIADFTLSRQNTTANFQNNQSKKRSTKPAFQEQKSLNSGSR | |... | ..|.. .. .. || .| | |||| |.|||||||||||...| .||.|| |.|. . ....|.... .. ..... . . | DLHQIIKSQQ---PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDP-HC-FQKMHMTEYVATR YYRAPEIILL--NSNYGFQSDIWSLGCLYAELLQNYDRHNSLQGILFPGQTCNPITPPSKNDSDFLKQDQLFLIIDKLGRPKKEDCSFIE-KASAVKFVR .||||||.| .| . |.||.|| ||.|. .. .||| .||..||.. || |..|....|. .| .... WYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLT-------DRKPLFP---------------GKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQ GF---KCKPLYHFTQLYYS----TVYQEQFILQSTLQFSPNRRITAEQLLSTEYF .. ...| ....... . | |. |.|.|..|||.|. |. .|| SLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF |
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| Kinase | 11145.AA | MAPK-Unclassified | 379-555 | 32 | 2.3e-106 | 359.66 | In-house | 313-575 (575) | Show / Hide |
Range on Protein: 379-555 Range on HMM: 313-575/575 Sequence Identity: 32% (86 aa) QNTTANFQNNQSKK---------------------------------------------------------RSTKPAFQEQKSLNSGS-----------R ||...||.||.... ..||...|..|..|... | QNKQINFYNNKPQQNLNNYQQASNQLLQKADRQIDQKFLCIEGAHIYDFQNSNSYQKQQFIHQCNQFPAYEFCTKNKKQKHKQINDCHHCYHMTQYVVTR YYRAPEIILLNSNYGFQSDIWSLGCLYAELLQNYDRHN---SLQGILFPGQTCNPITPPSKNDSD-----FLKQDQLFLIIDKLGRPKKEDCSFIEKASA .||||||.|....|..|.||||.||..||..|.||||| |....|||||.|.||||...||.| ...|||...|.|.||.|..|||.||...|| WYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDCNFITCDSA VKFVRGFKCKPLYHFTQLYYSTVY----------QEQFILQSTLQFSPNRRITAEQLLSTEYF .|....||||...|||.|...... ......|..|||.|..||||.|.|...|| RKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF |
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| Kinase | 11145.AA | MAPK-Unclassified | 227-378 | 54 | 1.4e-105 | 357.05 | In-house | 1-157 (575) | Show / Hide |
Range on Protein: 227-378 Range on HMM: 1-157/575 Sequence Identity: 54% (85 aa) YTYSGYIGQGGYSQVYKFIDNQT-NQPVAIKFVN-LFHNEQDTKRVLRELYIQRHLSHPNVMKIQNIYYNKELHN--FDRIYIVMEYYPFSLFDILYQYQ |.|...||.|.|.||....|... ||.||||.|| .|||..|.||||||..|.|.|.|||...||.|.||||||| ||.|||||.|...||||...... YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK QNL-TWSHELVRIIFTQIVNGLAYIHSRNIIHRDLKPSNILIDQNLNVKIADFTLSR .|. .|.|......|.||..||.|.||..||||||||||.||.|...|.|.||..|| SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR |
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| Kinase | 11145.AA | CMGC | 227-555 | 22 | 4.4e-94 | 309.54 | In-house | 1-513 (513) | Show / Hide |
Range on Protein: 227-555
Range on HMM: 1-513/513
Sequence Identity: 22% (120 aa)
YTYSGYIGQGGYSQVYKFIDNQTNQP--------------VAIKFVNLFHNEQDTK----------RVLRELYIQRHLS-----------------HPNV
|. ..||.| |..||| .|..|||. |||| . . ..| . | | |||. | .||. |.|.
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI
MKIQNIYYNKE-------------LHNFDRIYIVMEYYPFSLFDILYQYQ------QNLTWSHEL------------VRIIF------TQIVNGLA--YI
|...|.| |. . .|. .|.|.|| . .|.......| ... |. .. .. || .||. |.
VKLYDIFYHKNSDGNEYEDKHIISQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC
HSRN--IIHRDLKPSNILIDQN--------------------LNVKIADFTLSRQNTTANFQNNQSKKRSTKPAF---------QEQKSLNSGSRYYRAP
||.. ||||||||.||||..| ..||.|| |.|. . ...|....| | ... . . .|.||||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQS----FKNVNKDDKPNRPYTHYVVTRWYRAP
EIILLN---------SNYGFQSDIWSLGCLYAELLQNYDRHNSL---QGILFPGQTCNPITPPSKNDSDFLK-------QDQLFLIIDKLGRP-------
||.| .|. . |.||.|| ||....|. || .||||....|. .||||.|.. || |
EILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQ---SLIFRGKPLFPGHSEYPN-----------DDKNGKSHIDQLFKIFKVLGTPTWMIQKG
---------KKEDCSFIE--------------------KASAVKFVRG---FKCKPLYHFTQLYYS----------------------------------
..|. ..|. . .| .... |. .| ....|.
KRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRK
-TVYQEQFILQSTLQFSPNRRITAEQLLSTEYF
| |. ||. |..|||||| |. .||
CCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
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| Kinase | 11145.AA | S_TKc | 227-555 | 23 | 5e-69 | 236.54 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 227-555
Range on HMM: 1-231/231
Sequence Identity: 23% (82 aa)
YTYSGYIGQGGYSQVYKFIDNQTNQPVAIKFVNLFHNEQDTKRVLRELYIQRHLSHPNVMKIQNIYYNKELHNFDRIYIVMEYYPF---SLFDILYQYQQ
|. ||.|....||| ... |.. |||| .. ....||. | .. |||. |. .... |..|.|||| . .|||.. ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGR
NLT---WSHELVRIIFTQIVNGLAYIHSRNIIHRDLKPSNILIDQNLNVKIADFTLSRQNTTANFQNNQSKKRSTKPAFQEQKSLNSGSRYYRAPEIILL
. . . .| .. ||...|.|.||..||||||||.|||.|. ..||.|| |.|| . |...|.|||..
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------------------TTFCGTPWYMAPEVL--
NSNYGF-QSDIWSLGCLYAELLQNYDRHNSLQGILFPGQTCNPITPPSKNDSDFLKQDQLFLIIDKLGRPKKEDCSFIEKASAVKFVRGFKCKPLYHFTQ
||. .|.||.||. .|.| | .|| |......|.|
--GYGKCKCDWWSCGCILYEMLCGY--------PPFP---------------------QMQMMFKKIG--------------------------------
LYYSTVYQEQFILQSTLQFSPNRRITAEQLLS-------TEYF
. ... ||. |..|.|| ..| ..|
-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
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| Kinase | 11145.AA | Pkinase | 227-555 | 26 | 1.3e-66 | 232.43 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 227-555
Range on HMM: 1-293/293
Sequence Identity: 26% (91 aa)
YTYSGYIGQGGYSQVYKFIDNQTNQPVAIKFVNLFHNEQDTKRVLR---ELYIQRHLSHPNVMKIQNIYYNKELHNFDRIYIVMEYYPF-----SLFDIL
|. . ||.|....||| .. |.. ||.| ... |.. . .. .| |..| ..|.|||. .. .... |.||.|||| . .|||..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI
Y-QYQQNLTWSHELVRIIFTQIVNGLAYIHSRNIIHRDLKPSNILIDQNLNV----KIADFTLSRQNTTANFQNNQSKKRSTKPAFQEQKSLNSGSRYYR
... ... | . .. ...||. ||.|.||..||||||||.|||||.| .. ||.|| |..| .. . |...|.
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---------------Y-NNS-MTTFCGTPWYM
APEIILLNSNYGFQSDIWSLGCLYAELLQNYDRHNSLQGILFPGQTCNPITPPSKND-SDFLKQDQLFLIIDKLGRPKKEDCSFIEKASAVKFVRGFKCK
|||.|. .. || .|.||.||. .|.| . || ... . ||...| ..|.| ..|.. | . .| . .
APEVIRGGQYYGPKVDMWSCGCILYEMLCGR--------------------PPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H
PLYHFTQLYYSTVYQEQFILQSTLQFSPNRRITAEQLLSTEYF
.. . . . . .. . |.. |..|.||||.| ..|
--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
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| Kinase | 11145.AA | CAMKL | 227-434 | 28 | 6.6e-52 | 163.86 | In-house | 1-223 (297) | Show / Hide |
Range on Protein: 227-434 Range on HMM: 1-223/297 Sequence Identity: 28% (70 aa) YTYSGYIGQGGYSQVYKFID-NQTNQPVAIKFVN--LFHN-------------EQDTKRVLRELYIQRHLS---HPNVMKIQNIYYNKEL--HNFDRIYI |. .|.|....| .. |.. ||||... | |.| |. || |...|. |||..|. .....| . . ||. YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYL VMEYYPFS---LFDILYQYQQNL-TWSHELVRIIFTQIVNGLAYIHSRNIIHRDLKPSNILIDQNL--NVKIADFTLSRQ---NTTANFQNNQSKKRSTK |||| . ||| . . . . | .|.||| ...|.||..|.|||.|| |||.|.| |.||.|| .| . . VMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPC---------------- PAFQEQK--SLNSGSRYYRAPEIILL--NSNYGFQSDIWSLG |.. . . || | ||||.. . .|.. ||||.| -IFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCG |
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| Kinase | 11145.AA | CAMK | 232-436 | 21 | 6.9e-51 | 161.81 | In-house | 1-323 (425) | Show / Hide |
Range on Protein: 232-436
Range on HMM: 1-323/425
Sequence Identity: 21% (69 aa)
YIGQGGYSQVYKFIDNQTN------------QPVAIKFVNLF---------------------------HNEQDTKRVLRELYIQRHLS-------HPNV
.|.|....|.. |. .|. | ||||... ....| |.|.||. | ..|. |||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
MKIQNIYYNKELH-------NFDR--------IYIVM---EYYPFS-LFDILYQYQQNL----------------TWSHELVRIIFTQIVNGLAYIHSRN
|. .| ... . .. .|.|| || . ||| |..| . . . .| .| ||. ...|.||.|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN
IIHRDLKPSNILIDQN-----------------LNVKIADFTLSRQNTTANFQNNQSKKRSTKPAFQE---------QKSLNSGSRYYRA-PEIILL---
|.|||||| |||.|.| |.||.|| .... . . ... |.. . . . |. .| | ||...
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH
----------NSNYGFQSDIWSLGCL
. ||...|.||.|..
CNMQNATDEEKPYYGPKCDMWSCGVI
|
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| Kinase | 11145.AA | STE | 227-436 | 25 | 1.1e-43 | 151.47 | In-house | 1-257 (359) | Show / Hide |
Range on Protein: 227-436 Range on HMM: 1-257/359 Sequence Identity: 25% (70 aa) YTYSGYIGQGGYSQVYKFIDN------QTNQP---------VAIKFVNLFHNE----------------QDTKRVLRELYIQRHLS--HPNVMKIQNIYY .. . ||.|.. .||| ... .|.. .||| .|| ... .. ...|.|. | .... |||. | |. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF NKE--LHNFDRIYIVMEYYPF-SLFDILY---QYQQNLTWSH--------ELVRIIFTQIVNG-LAYIHSRNIIHRDLKPSNILIDQNLNVKIADFTLSR .. .| | ..|.||| . || ||. ...|. . .....| ||. | |.|.|| .|||||.||.|||. ||..|| .. KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG QNTTANFQNNQSKKRSTKPA--------FQEQKSLNSGSRYYRAPEIILL-----NSNYGFQSDIWSLGCL | | . . | . . |.. |. . |||.|. .. |....|||||||. QLTDSMANI-Q-S------NNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCT |
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| Kinase | 11145.AA | Ciliate-E2 | 227-444 | 23 | 2.7e-43 | 146.45 | In-house | 1-293 (365) | Show / Hide |
Range on Protein: 227-444 Range on HMM: 1-293/365 Sequence Identity: 23% (71 aa) YTYSGYIGQGGYSQVYKFIDNQTNQ------------------PVAIKFVNLFHN-EQDTKRVLRELYIQR----------------HLSHPNVMKIQNI | ||||....||| . .... |.||.... . ... . ...|..| | .|.|||..|. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC YYNKELHNFDRIYIVMEYYPF-SLFDILY----QYQQNLT----WSHELVRIIFTQIVN---------------GLAYIHSRN-IIHRDLKPSNILIDQN ...| . . ||.||||. .|||... . ..... ... .. |..||.. .| |.||.| |||||.||.|||. FQEK---DDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--- LNVKIADFTLSRQNTTANFQNNQSKKRS-TKPAFQEQKSLNSG----------------SRYYRAPEIILLNSN--------YGFQSDIWSLGCLYAELL .||.|| ||..... | .. . |... .. . ..| .| . .| ||||. .. |....||||||.. |.| --IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML QNY .. FGK |
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| Kinase | 11145.AA | CDK | 227-374 | 30 | 1.4e-33 | 104.69 | In-house | 1-157 (284) | Show / Hide |
Range on Protein: 227-374 Range on HMM: 1-157/284 Sequence Identity: 30% (52 aa) YTYSGYIGQGGYSQVYKFIDNQTN-----QPVAIKFVNLFHN--EQDTKRVL----RELYIQRHLSHPNVMKIQNIYYNKELHNF------DRIYIVMEY | ||.| | .||| .| ||. | ||.| . . .. |.. . || . ..| |||. |. ... |.. . ..|.|.|| YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY YPFSLFDILYQYQQNLTWSHELVRIIFTQIVNGLAYIHSRNIIHRDLKPSNILIDQNLN-----VKIADF . | .. .. .. |. .||.|.||..|.||||||.||||. | . .||||| MDHDLKKYMD------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADF |
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| Kinase | 11145.AA | p38 | 227-379 | 34 | 2.9e-32 | 107.38 | In-house | 1-155 (289) | Show / Hide |
Range on Protein: 227-379 Range on HMM: 1-155/289 Sequence Identity: 34% (55 aa) YTYSGYIGQGGYSQVYKFIDNQTNQP---VAIK-FVNLFHNEQDTKRVLRELYIQRHLSHPNVMKIQNIYYN--KELHNFDRIYIVMEYYPFSLFDILYQ | ..|.| | || | .| .|.| |||| . | | . || ||| .|. | ||... ... ... .| .|.|.. .| |. . YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC YQQNLTWSHELVRIIFTQIVNGLAYIHSRNIIHRDLKPSNILIDQNLNVKIADFTLSRQ . | . .... || || |||| .||||||||||| . . ..| || |.|. QR----LSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARH |
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| Kinase | 11145.AA | ERK | 338-441 | 43 | 4.8e-22 | 78.98 | In-house | 116-211 (307) | Show / Hide |
Range on Protein: 338-441 Range on HMM: 116-211/307 Sequence Identity: 43% (47 aa) QIVNGLAYIHSRNIIHRDLKPSNILIDQNLNVKIADFTLSR-QNTTANFQNNQSKKRSTKPAFQEQKSLNSG---SRYYRAPEIILLNSNYGFQSDIWSL || .|| |||| |.|||||||||||. | ||.|| |.| .... .|.| . .... .. .|.||||||.| ...| |||| QILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDAS--YQENHE----------CNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDIWSC GCLYAELL || ||.| GCIFAEML |
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| Kinase | 11145.AA | ERK | 227-309 | 33 | 3e-18 | 64.67 | In-house | 1-90 (307) | Show / Hide |
Range on Protein: 227-309 Range on HMM: 1-90/307 Sequence Identity: 33% (30 aa) YTYSGYIGQGGYSQVYKFIDNQ-----TNQPVAIKFV-NLFHNEQDTKRVLRELYIQRHLS-HPNVMKIQNIYYNKELHNFDRIYIVMEY | . ||.|.| | . ||. |.|.|||| . | | .....|| |||. ..||. |.|. ....| . ... ||.| |. YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEEL |
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| Kinase | 11145.AA | Pkinase_Tyr | 241-378 | 34 | 2.8e-16 | 55.76 | Pfam | 19-159 (270) | Show / Hide |
Range on Protein: 241-378 Range on HMM: 19-159/270 Sequence Identity: 34% (50 aa) VYKFIDNQTNQPVAIKFVNLFHNEQD--TKRVLRELYIQRHL-SHPNVMKIQNIYYNKELHNFDRIYIVMEYYPF-SLFDILYQY---QQNLTWSHELVR ..| . .|..|||.| .. . ... . .||. | ..| .|||. . . . .. .| .||||||| | .| | | . .|.|| .. |. TWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKD-LLQ IIFTQIVNGLAYIHSRNIIHRDLKPSNILIDQNLNVKIADFTLSR . . || .|..| .|.|.||||| |.|.. |. |||.|| |.| MCW-QIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR |
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| Kinase | 11145.AA | p38 | 410-555 | 30 | 3.9e-16 | 51.39 | In-house | 167-289 (289) | Show / Hide |
Range on Protein: 410-555 Range on HMM: 167-289/289 Sequence Identity: 30% (45 aa) RYYRAPEIILLNSNYGFQSDIWSLGCLYAELLQNYDRHNSLQGILFPGQTCNPITPPSKNDSDFLKQDQLFLIIDKLGRPKKEDCSFIEKASAVKFVRGF | ||||||.|. | ||||.|| |||.. . .|||| ...| ||| |. .| |..| . |.. .| .... RWYRAPEIMLNWMHYTQTVDIWSVGCIMAELIT--------GRTLFPG--DDHI-------------DQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSY KCKPLYHFTQLYYSTVYQEQFILQSTLQFSPNRRITAEQLLSTEYF | |.... |. | |. | .|||||. .. .|| PQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF |
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| Kinase | 11145.AA | CDK | 410-555 | 24 | 4.1e-16 | 47.9 | In-house | 183-284 (284) | Show / Hide |
Range on Protein: 410-555
Range on HMM: 183-284/284
Sequence Identity: 24% (37 aa)
RYYRAPEIILLNSNYG--FQSDIWSLGCLYAELLQNYDRHNSLQGI-LFPGQTCNPITPPSKNDSDFLKQDQLFLIIDKLGRPKKEDCSFIEKASAVKFV
. |||||. | ..|. . |.||.|| ||.... ... ||||.. .||||.|.. .| | .. ..|
LWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTD------VTRKPLFPGDSE---------------IDQLFKIFRICGTPTEDNWPGVTKLPDY---
RGFKCKPLYHFTQLYYSTVYQEQFILQSTLQFSPNRRITAEQLLSTEYF
|.. |.. |..||.||| |. .||
-----------------------DLLNKMLCYDPKKRISAEQALQHPYF
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| Kinase | 11145.AA | TyrKc | 227-500 | 22 | 3.2e-12 | -25.06 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 227-500 Range on HMM: 1-280/280 Sequence Identity: 22% (70 aa) YTYSGYIGQGGYSQVYKFIDNQTNQPVAIKFVNLFHNEQDTKRVLRELYIQRHL--SHPNVMKIQNIYYNKELHNF---DRIYIVMEYYPF-SLFDILYQ | .| | . .||| . . ..||.| .. . . .||. | ..| .|||. .. . .. | . ..||||| | .| | | ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLRK YQQNLTWSHELVRIIFTQIVNGLAYIHSRNIIHRDLKPSNILIDQNLNVKIADFTLSRQNTTA-NFQNNQSKKRSTKPAFQEQKSLNS--GSR-----YY .. .|... .|. . . || .| .|.||.|.||||| |.|.. |. |||.|| ||| . . . .. .. . |.. HRPKLCMK-DLLSFCW-QIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-----------ESKDYYRKKEHKGGKTMLPIRW RAPEIILLNSNYGFQSDIWSLGCL-----------YAEL----LQNYDRHNSLQGILFPGQTCNPITPPSKN--------DSDFLKQDQLFLIIDK--LG ||| | . . ..||.|| | . | . . |.. .. .. . |. .| .| . | . MAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRM--------PQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPED RPKKEDCSFIEKA || ... .|. RPTFSEI--HECF |
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| Kinase | 11145.AA | Ciliate-E2 | 531-555 | 33 | 5.6e-05 | 13.01 | In-house | 336-365 (365) | Show / Hide |
Range on Protein: 531-555 Range on HMM: 336-365/365 Sequence Identity: 33% (10 aa) ILQS----TLQFSPNRRIT-AEQLLSTEYF ... || |. ||| .||.| ..| LIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | 11145.AA | CAMK | 532-555 | 33 | 0.000875 | 7.28 | In-house | 402-425 (425) | Show / Hide |
Range on Protein: 532-555 Range on HMM: 402-425/425 Sequence Identity: 33% (8 aa) LQSTLQFSPNRRITAEQLLSTEYF ... || |..|.|.|| |. . . IRKMLQVDPEKRMTIEQCLNHPWM |
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| Kinase | 11145.AA | STE | 532-555 | 38 | 0.000993 | 9.19 | In-house | 334-359 (359) | Show / Hide |
Range on Protein: 532-555 Range on HMM: 334-359/359 Sequence Identity: 38% (10 aa) LQSTLQFSPNRRITAEQLLS--TEYF .. || || | ||.|||. . . INKCLQKDPNKRPTASQLLKSEHPFI |
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| Kinase | 11145.AA | CAMKL | 531-555 | 24 | 0.001378 | 7.15 | In-house | 273-297 (297) | Show / Hide |
Range on Protein: 531-555 Range on HMM: 273-297/297 Sequence Identity: 24% (6 aa) ILQSTLQFSPNRRITAEQLLSTEYF .... || |..|.|..|... . . LIRKMLQVNPEKRPTIHQIMNHPWM |
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| Kinase | 11145.AA | ERK | 536-555 | 50 | 0.003231 | 8.06 | In-house | 288-307 (307) | Show / Hide |
Range on Protein: 536-555 Range on HMM: 288-307/307 Sequence Identity: 50% (10 aa) LQFSPNRRITAEQLLSTEYF |.| |. |||.|. |. .|| LVFDPDKRITVEECLEHPYF |
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| Kinase | 11145.AA | ERK | 477-507 | 28 | 0.246175 | 0.97 | In-house | 224-255 (307) | Show / Hide |
Range on Protein: 477-507 Range on HMM: 224-255/307 Sequence Identity: 28% (9 aa) DQLFLIIDKLGRP-KKEDCSFIEKASAVKFVR .|...|.. .| | .|| . |. | |... HQINRIFQIIGTPHSEEDLQYICSENAWKYIK |
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