Gene 26702 (Tetrahymena)

26702

Species: Tetrahymena
Alias: 26702, 3702.m00121, 11.m00399, PreTt26702, TTHERM_00144940, 492
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: RCK

Sequence

Name Sequence Type Origin Length Description Download
26702.AA Protein None 637 None Fasta, JSON
26702.kin_dom Protein Kinase Domain None 286 None Fasta, JSON
26702.NA RNA None 1914 None Fasta, JSON

Protein domain

Protein domains of 26702.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 26702.AA RCK 4-289 59 1.1e-227 729.94 In-house 1-298 (298) Show / Hide 
Range on Protein: 4-289
Range on HMM: 1-298/298
Sequence Identity: 59% (178 aa)

YKITKNLGDGTYGTVVEAINIEKNEKVAIKQMKQEFKSWEECINLREIKSLRKLN-HPNIVKLREVLKINN--ELYLVFEHMDINIYQYYLSFKEKKQKM
|.|.|.|||||||.|..|.|.|..|.||||.|||.|.|||||.|||||||||||| ||||.||.||...|.  .||.|||.|| |.||.. .|||.....
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKYL

PERV--IKSIIFQTALGLAYMHKHGYFHRDLKPENLLISED--------RQVLKICDFGLAREIRSRPPYTDYVSTRWYRAPELLLKSTTYNSPVDIFAL
||..  ||.|..|...|||.|||||.|||||||||......        ....||.||||.|||||.||||||||||||||||.||..|.||||.||.|.
PENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDIWAV

GCIMIELYMLNPLWAGASEIDHLYKMVETLGTPNQQTWPDGQKLANQTGIMFPQKQEKVPLQQYIPHASAEAVQLLEMMLQYDPSKRPTAAQVLQHPYF
||||.|||||.||..|.||||...|... .||||...||||.|||.|....|||.. ..||.|.||..| ....|.|.|||.||.||.||.|.||||||
GCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCK-GMPLKQLIPNCSQDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase 26702.AA MAK 4-289 46 2.8e-163 523.98 In-house 1-352 (352) Show / Hide 
Range on Protein: 4-289
Range on HMM: 1-352/352
Sequence Identity: 46% (165 aa)

YKITKNLGDGTYGTVVEAIN------------------------------IEKNEKVAIKQMKQEFKSWEECINLREIKSLRKLN-HPNIVKLREVLK--
| ..| |||||||.|. |.                               |.  ||||||.||. | |||||.||||.|||.||| |||||||.||.   
YQMIKQLGDGTYGCVMLAKRQFPLSNILGKQHDIRGTLMDQPKNGHQNYIIDTGEKVAIKRMKKKFYSWEECMNLREVKSLKKLNAHPNIVKLKEVIRDS

INNELYLVFEHMDINIYQYYLSFKEKKQ-KMPERVIKSIIFQTALGLAYMHKHGYFHRDLKPENLLISE----------------DRQVLKICDFGLARE
 |..||.||| |  | ||   . |. .   .|| ||..|..|   |||.|||||.||||.||||....                 |  ..|| |||||||
ENDHLYFVFEYMKENLYQ---MMKDRDRRHFPEPVIRNIMYQILQGLAFMHKHGFFHRDMKPENIMCMGPTQYFEKEYMNQIGYQDNELIKIADFGLARE

IRSRPPYTDYVSTRWYRAPELLLKSTTYNSPVDIFALGCIMIELYMLNPLWAGASEIDHLYKMVETLGTPNQQT----------------WPDGQKLANQ
|||.|||||||||||||||| ||.|| |.||.|. |.|||| |||.. ||  |.|||| ..| .. ||||. ..                |||| .||..
IRSKPPYTDYVSTRWYRAPEVLLRSTYYSSPIDMWAVGCIMAELYTFRPLFPGSSEIDQIFKICQVLGTPKKDDDFVNTNHITAPPPGGFWPDGYQLAHM

TGIMFPQKQE--KVPLQQYIPHASA-EAVQLLEMMLQYDPSKRPTAAQVLQHPYF
 .  ||| .    .||.. || .|  .|..|.. |||.|| |||||.| ...|||
MNFRFPQCVPPSIMPLKHLIPNCSQSDAIELMKDMLQWDPNKRPTAQQCCKYPYF
Kinase 26702.AA CMGC 4-289 26 6.7e-134 442.8 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-289
Range on HMM: 1-513/513
Sequence Identity: 26% (135 aa)

YKITKNLGDGTYGTVVEAIN--------------IEKNEKVAIKQMKQEFKSWEEC----------INLREIKSLRKLN-----------------HPNI
|.| | .| ||||.|.....              .| ||.|||| .|..|. ....          . ||||| |..||                 |.||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VKLREVLKINN-----------------ELYLVFEHMDINIYQYYLSFKE-----KKQKMPERV------------IKSII------FQTALGLA--YMH
|||..... .|                 .||||||.|| . |||  . .      ......| .            ||...      .|   ||.  |.|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

KHG--YFHRDLKPENLLISEDRQV-------------------LKICDFGLAR--EIRSRP--------------------PYTDYVSTRWYRAPELLLK
.|.   .||||||||.||... ..                   ||||||||||  ...|..                    |||.||.||||||||.|| 
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

STTYN---------SPVDIFALGCIMIELYM--------LNPLWAGASE-----------IDHLYKMVETLGTPN---------------QQ--------
.. |.         .|.|. ..|||. |.|.        . ||. | ||           ||.|.|....||||.               ..        
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

-----------------TWPDGQKLANQTGIMFPQKQEKVPLQQYIP----------------------------------HASAEAVQLLEMMLQYDPS
                 .|....... | .. ||... |   ... .                                  ... .|. ||. ||||||.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

KRPTAAQVLQHPYF
||.||.| ||||||
KRITAEQALQHPYF
Kinase 26702.AA CDK 4-289 35 2.6e-104 334.67 In-house 1-284 (284) Show / Hide 
Range on Protein: 4-289
Range on HMM: 1-284/284
Sequence Identity: 35% (114 aa)

YKITKNLGDGTYGTVVEAINIEKN-----EKVAIKQMK------QEFKSWEECINLREIKSLRKLNHPNIVKLREVLKIN-----------NELYLVFEH
|.. . .| ||||.|  |.. . .     . ||.|. .      .| |    .  .|||. |..| |||||||..|   .           | ||.|||.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

MDINIYQYYLSFKEKKQKMPERVIKSIIFQTALGLAYMHKHGYFHRDLKPENLLISEDRQ----VLKICDFGLAREIRS-------RPPYTDYVSTRWYR
||   ..|               ||....|   ||.|.|...  |||||| |.||... .    .||| ||||||.  .       . .||  | |.|||
MDHDLKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYR

APELLLKSTTYN--SPVDIFALGCIMIELYM---LNPLWAGASEIDHLYKMVETLGTPNQQTWPDGQKLANQTGIMFPQKQEKVPLQQYIPHASAEAVQL
|||||| |..|.   |.|. ..|||..|...     ||  | |||| | |  ...|||. ..||.  || .                           .|
APELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY--------------------------DL

LEMMLQYDPSKRPTAAQVLQHPYF
|. ||.|||.|| .| | ||||||
LNKMLCYDPKKRISAEQALQHPYF
Kinase 26702.AA CDC2 4-289 39 5.9e-98 301.65 In-house 1-301 (301) Show / Hide 
Range on Protein: 4-289
Range on HMM: 1-301/301
Sequence Identity: 39% (121 aa)

YKITKNLGDGTYGTVVEAINIEKNEKVAIKQMKQEFKSWE----ECINLREIKSLRKLN-HPNIVKLREVLKINNELYLVFEHMDINIYQYYLSFKEKKQ
|.  . .| |||| |  ... . |. ||.|. . |  . .    . . .|||  | .|. |||||||..|... | ||.||| .| .  .|    . |..
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTA-IREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNK

KMPERVIKSIIFQTALGLAYMHKHGYFHRDLKPENLLISEDRQVLKICDFGLAREIRS-RPPYT--DYVSTRWYRAPELLLKSTTYNSPVDIFALGCIMI
.||. ..||...|   |... | .. .|||||| |.||... . .|| |||||| .     .||    | |.||||||.|| . .|. |||. ..|||..
HMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN-IKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFA

ELYML---NPLWAGASEIDHLYKMVETLGTPNQQTWPDGQKLA--NQTGIMFPQKQEKVPLQQYIPH---------ASAEAVQLLEMMLQYDPSKRPTAA
|..|     || .| |||| |.|. ..||||| ||||.  .|   ..|   ||. ...  |....|          .  |...||. ||||||.|| .| 
EMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNT---FPRWKPQ-DLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAK

QVLQHPYF
. ||||||
EALQHPYF
Kinase 26702.AA S_TKc 4-289 30 1.4e-96 328.04 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-289
Range on HMM: 1-231/231
Sequence Identity: 30% (90 aa)

YKITKNLGDGTYGTVVEAINIEKNEKVAIKQMKQEFKSWEECINLREIKSLRKLNHPNIVKLREVLKINNELYLVFEHMDI---NIYQYYLSFKEKK--Q
|.| . .| |..|.|  ..... ...||||..|        .  .|||. |.| .||||||| .|    ..||.|.|..|    . ..|  . . ..  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

KMPERVIKSIIFQTALGLAYMHKHGYFHRDLKPENLLISEDRQVLKICDFGLAREIRSRPPYTDYVSTRWYRAPELLLKSTTYNS-PVDIFALGCIMIEL
..|| ...... |....|.|.|.||  ||||||||.|..|   ..|||||||||..      | .. |.||.|||.|     |.  ..|. ..|||..|.
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEM

YMLNPLWAGASEIDHLYKMVETLGTPNQQTWPDGQKLANQTGIMFPQKQEKVPLQQYIPHASAEAVQLLEMMLQYDPSKRPTAAQVLQ-------HPYF
.   |..    ... ..|..                                         | || .... .||.||.||||| ..||       ||.|
LCGYPPFP---QMQMMFKKIG----------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 26702.AA Pkinase 4-289 29 1.8e-95 328.26 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-289
Range on HMM: 1-293/293
Sequence Identity: 29% (89 aa)

YKITKNLGDGTYGTVVEAINIEKNEKVAIKQMKQEFKSWEECINLR---EIKSLRKLNHPNIVKLREVLKINNELYLVFEHMDIN----IYQYYLSFKEK
|.| . .| |..|.| .....  ...||.|..| . .........|   ||. ...|||||||.|...   ....|.|.|...          |.|  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-WR

KQKM--PERVIKSIIFQTALGLAYMHKHGYFHRDLKPENLLISEDRQV---LKICDFGLARE--IRSRPPYTDYVSTRWYRAPELLLKSTTYNSPVDIFA
. ..  .|...|... |.. ||.|.|..|  ||||||||.||... ..   .||||||||.   . . . .|... |.||.|||...... | ..||...
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGCIMIELYMLNPLWAGA----SEIDHLYKMVETLGTPNQQTWPDGQKLANQTGIMFPQKQEKVPLQQYIPHASAEAVQLLEMMLQYDPSKRPTAAQVLQ
.|||..|..  .|.. |.    . .|.........|.|.   ||      . . ... .      ..   . .| |. .... .|..||.|||||.|.||
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQ

HPYF
||.|
HPWF
Kinase 26702.AA CDKL 4-289 39 4.1e-89 302.36 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-289
Range on HMM: 1-286/286
Sequence Identity: 39% (115 aa)

YKITKNLGDGTYGTVVEAINIEKNEKVAIKQMKQ-EFKSWEECINLREIKSLRKLNHPNIVKLREVLKINNELYLVFEHMDINIYQYYLSFKEKKQKMPE
| .   .| | ||.|    | | .. ||||  |  |    .  | .|||| |. | |.||| |.|| . ...|.|||| .|...  .    .|. .  .|
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHE---LEEYPNGVDE

RVIKSIIFQTALGLAYMHKHGYFHRDLKPENLLISEDRQVLKICDFGLAREIRSRPP--YTDYVSTRWYRAPELLLKSTTYNSPVDIFALGCIMIELYML
 |......|.  .... |||   ||| ||||.||.    ..|.||||.|| . . |   ||||| ||||||||||.. | | .|||| |.||.|.|. . 
HVVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFAR-MLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDG

NPLWAGASEIDHLYKMVETLGTPNQQTWPDGQKLANQT----GIMFPQKQEKVPLQQYIPHAS-AEAVQLLEMMLQYDPSKRPTAAQVLQHPYF
.||| | |.|| ||. . .||.      |. |.. ..     |. ||. ..  || .  | .| ..|  .....|. ||..|.|..| ..||||
QPLWPGQSDIDQLYHIQKCLGP----LIPRHQEIFSKNPFFHGMKFPEIEHMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase 26702.AA MAPK 4-289 33 6.3e-83 281.82 In-house 1-328 (328) Show / Hide 
Range on Protein: 4-289
Range on HMM: 1-328/328
Sequence Identity: 33% (112 aa)

YKITKNLGDGTYGTVVEAINIE------KNEKVAIKQMKQEFKSWEECIN-LREIKSLRKL-NHPNIVKLREVLKIN-----------NELYLVFEHMDI
|.| |..| | ||.|. ||  .      ...||||| . . | .   |   .|||| || . .|.||.||.....             |..|.|.| |. 
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

NIYQYYLSFKEKKQKMPERVIKSIIFQTALG--LAYMHKHGYFHRDLKPENLLISEDRQVLKICDFGLAREIRSRPPY---------------TDYVSTR
. .|   | .    .. .  |.....|   |  | |.|  .  ||||||.|.|. |. .. ||||||||| | .   .               |.||.||
DLHQIIKSQQ----PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDL-KICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATR

WYRAPELLLK--STTYNSPVDIFALGCIMIELYM-LNPLWAGASEIDHLYKMVETLGTPNQQTWPDGQ--KLANQTGIMF--PQKQEKVPLQQYIP----
||||||..|   .. |.  ||. ..|||. |..    ||  | . || . ...|.|||| .. .   .  . | .    .  ..|. |.|... .|    
WYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANF

HASAEAVQLLEMMLQYDPSKRPTAAQVLQHPYF
.|. .|. ||| ||. ||.|| |... ||||||
NANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 26702.AA MOK 4-289 38 6.5e-81 253.25 In-house 1-283 (283) Show / Hide 
Range on Protein: 4-289
Range on HMM: 1-283/283
Sequence Identity: 38% (112 aa)

YKITKNLGDGTYGTVVEAINIEKNEKVAIKQMKQEFKSWEECINLREIKSLRKLN-HPNIVKLREVL--KINNELYLVFEHMDINIYQYYLSFKEKKQKM
||    .|.||.  |.    .   .  | |||||.|.| |.  |||||. .|.|| ||||..|.||.  .   .| |. | ||.|||      . ..  .
YKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQHFESIEQVNNLREIQAMRRLNPHPNILMLHEVVFDRKTGNLALICELMDMNIYEL---IRGRRHYL

PERVIKSIIFQTALGLAYMHKHGYFHRDLKPENLLISEDRQVLKICDFGLAREIRSRPPYTDYVSTRWYRAPELLLKSTTYNSPVDIFALGCIMIELYML
|.. |.  ..|    |  ||. | |||| ||||.|| .|  .||. |||  | . |. |||.|.||||||||| ||    |   .|... ||.  |.  |
PQKKIMHYMYQLCKSLDHMHRNGIFHRDVKPENILIKQD--HLKLADFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGYYTYQMDMWSVGCVFYEIASL

NPLWAGASEIDHLYKMVETLGTPNQQTWPDGQKLANQTGIMFPQKQEKVPLQQYIPHASAEAVQLLEMMLQYDPSKRPTAAQVLQHPYF
.||. |. |.| . |. . .||| |..    .. .      || |.    ... .| ..  ...... |  |||  | || ||.|||||
HPLFPGVNEVDQISKIHDVMGTPCQKILNKFKNQSRAMNYDFPFKKGSG-IEKLTPNLTKQCLEIMHKMCTYDPDERITAHQVIQHPYF
Kinase 26702.AA CDK5 4-289 36 2.5e-78 246.98 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-289
Range on HMM: 1-287/287
Sequence Identity: 36% (108 aa)

YKITKNLGDGTYGTVVEAINIEKNEKVAIKQMKQEFK-SWEECINLREIKSLRKLNHPNIVKLREVLKINNELYLVFEHMDINIYQYYLSFKEKKQKMPE
|.    .|.||||||  | | |  | ||.|. . .       .  .|||  |. | |.||| |  |.  .. | ||||..|  .  |  |...   .|  
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNG---EMDM

RVIKSIIFQTALGLAYMHKHGYFHRDLKPENLLISEDRQVLKICDFGLARE--IRSRPPYTDYVSTRWYRAPELLLKSTTYNSPVDIFALGCIMIELY-M
..|||...|   |||. |.|   |||||| ||||.   . ||  ||||||   |  |  |.  | | |||.|  |. | .|. ..|.   |||. |.   
HIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGE-LKLADFGLARAFGIPVR-CYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANA

LNPLWAGASEIDHLYKMVETLGTPNQQTWPDGQKLANQT--GIMFPQKQEKVPLQQYIPHASAEAVQLLEMMLQYDPSKRPTAAQVLQHPYF
. ||  |... | | .  . .|||.  .||   || .       .|  . . ..|| .|. ...   ||. |||..| .| .|.. |.||||
GRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase 26702.AA CDK7 105-289 41 1.2e-68 181.76 In-house 104-288 (288) Show / Hide 
Range on Protein: 105-289
Range on HMM: 104-288/288
Sequence Identity: 41% (77 aa)

IKSIIFQTALGLAYMHKHGYFHRDLKPENLLISEDRQVLKICDFGLAREIRS-RPPYTDYVSTRWYRAPELLLKSTTYNSPVDIFALGCIMIELYMLNPL
||..  .| .|| |.|..   |||||| |||..|. | ||| |||||| . |    ||  | ||||||||||     | . ||. . |||. ||   .| 
IKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQ-LKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRVPY

WAGASEIDHLYKMVETLGTPNQQTWPDGQKLANQTGIMFPQKQEKVPLQQYIPHASAEAVQLLEMMLQYDPSKRPTAAQVLQHPYF
  | |.|| | .  .|||||. ..||.  ....   .       ..||...   || ... |.. |.  .|.|| |..| |..|||
LPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase 26702.AA CDK7 4-83 31 1.4e-24 62.02 In-house 1-85 (288) Show / Hide 
Range on Protein: 4-83
Range on HMM: 1-85/288
Sequence Identity: 31% (27 aa)

YKITKNLGDGTYGTVVEAINIEKNEKVAIKQMK-----QEFKSWEECINLREIKSLRKLNHPNIVKLREVLKINNELYLVFEHMD
|.. | .| |...||  |   . ...||||  |      |.|   .   .|||| |. . |.|.. |. ..     ..|||. ||
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMD
Kinase 26702.AA Pkinase_Tyr 4-200 28 7.2e-19 64.53 Pfam 1-210 (270) Show / Hide 
Range on Protein: 4-200
Range on HMM: 1-210/270
Sequence Identity: 28% (61 aa)

YKITKNLGDGTYGTVVEAINI----EKNEKVAIKQMKQEFKSWE--ECINLREIKSLRKL-NHPNIVKLREVLK-INNE--LYLVFEHMDINIYQYYLSF
 .. | || | .|.|....      ... .||.| .|.   . .      .||.| ...| .|||||.|  |         .|.|.|.|       ||  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

K-EKKQKMPERVIKSIIFQTALGLAYMHKHGYFHRDLKPENLLISEDRQVLKICDFGLAREIRSRPPYTDYVST------RWYRAPELLLKSTTYNSPVD
. | ||. .   . .. .| | |..| . ... ||||   | |..|.. | ||||||||| | .   |  ....      .|. ||| .  .  ...  |
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENN-VVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWM-APECINYGK-FTTKSD

IFALGCIMIELYML
. . |  | |.. .
VWSFGVLMWEIFTY
Kinase 26702.AA TyrKc 4-289 22 2.3e-16 42.02 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-289
Range on HMM: 1-280/280
Sequence Identity: 22% (72 aa)

YKITKNLGDGTYGTVVEAINIEKNEKVAIKQMKQEFKSWEECINLREIKSLRKL--NHPNIVKLREVLKIN-------NELYLVFEHMDINIYQYYLSFK
 .  | || | .|.|.... .   ..||.| .| .    .| . .||.. ..||  .|||||.|  |             |..|.|.|.    . ||  .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDF-MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

EKKQKMPERVIKSIIFQTALGLAYMHKHGYFHRDLKPENLLISEDRQVLKICDFGLAREIRSR-------PPYT------DY--VSTRWYRAPELLLKST
..|   . .   |. .| | | .| |.... ||||   | |..|.. . ||.||||.|.| .          |.          .  ||. ||| . .  
RPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYG

TYNSPVDIFALGCIMIELYML-NPLWAGA----SEIDHLYKMVETLGTPNQQTW----PDGQKLANQTGIMFPQKQEKVPLQQYIPHASAEAVQLLEMML
....  |... |  | |.. .  . . |      . ..... |.. . . |                                . .....|  |. ..  
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------------F-VCCPDEMYQIMKQCW

QYDPSKRPTAAQVLQHPYF
..||..||| ...  | .|
HEDPEDRPTFSEI--HECF